$214+ Cheap flights from Des Moines to Portland, ME (DSM - PWM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PWM
May 28 — Jun 41
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Portland with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Portland
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to PortlandExplore the most affordable flight options available from Des Moines to Portland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from Des Moines to Portland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/910:15 am
DSM
- PWM
1 stop5h 00m
Delta
Wed 9/163:00 pm
PWM
- DSM
1 stop5h 55m
Delta
Deal found 4/25![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DSM
- PWM
1 stop7h 26m
United Airlines
Sat 5/305:03 pm
PWM
- DSM
1 stop5h 42m
United Airlines
Deal found 4/25![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:04 pm
DSM
- PWM
2 stops9h 14m
Delta
Sat 5/306:02 am
PWM
- DSM
2 stops10h 13m
Delta
Deal found 4/25![Delta logo]()
$388
This deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:11 am
DSM
- PWM
1 stop6h 58m
American Airlines
Wed 5/277:19 pm
PWM
- DSM
1 stop5h 49m
American Airlines
Deal found 4/24![American Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:15 am
DSM
- PWM
1 stop4h 40m
Delta
Wed 5/2712:50 pm
PWM
- DSM
2 stops10h 42m
Delta
Deal found 4/27![Delta logo]()
$394
This deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:30 pm
DSM
- PWM
1 stop7h 16m
American Airlines
Wed 5/277:19 pm
PWM
- DSM
1 stop5h 49m
American Airlines
Deal found 4/24![American Airlines logo]()
$401
Best flights from Des Moines to PortlandDiscover carefully curated flight deals from Des Moines to Portland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from Des Moines to Portland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:20 am
DSM
- PWM
2 stops9h 40m
Delta
Wed 9/1612:50 pm
PWM
- DSM
1 stop4h 59m
Delta
Deal found 4/27![Delta logo]()
$390
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:40 pm
DSM
- PWM
1 stop6h 25m
Southwest
Sun 8/307:40 am
PWM
- DSM
1 stop4h 55m
Southwest
Deal found 4/27![Southwest logo]()
$409
This United Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:05 pm
DSM
- PWM
1 stop7h 46m
United Airlines
Wed 6/106:00 am
PWM
- DSM
1 stop5h 27m
United Airlines
Deal found 4/24![United Airlines logo]()
$468
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:25 am
DSM
- PWM
1 stop4h 57m
Delta
Wed 10/143:00 pm
PWM
- DSM
1 stop6h 00m
Delta
Deal found 4/26![Delta logo]()
$427
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:15 pm
DSM
- PWM
2 stops8h 34m
Delta
Thu 10/154:50 pm
PWM
- DSM
1 stop5h 02m
Delta
Deal found 4/26![Delta logo]()
$432
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:18 pm
DSM
- PWM
1 stop7h 33m
United Airlines
Wed 5/273:31 pm
PWM
- DSM
1 stop9h 13m
United Airlines
Deal found 4/27![United Airlines logo]()
$479
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/251:04 pm
DSM
- PWM
2 stops9h 05m
Delta
Thu 5/2811:03 am
PWM
- DSM
2 stops10h 33m
Delta
Deal found 4/27![Delta logo]()
$452
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:57 am
DSM
- PWM
2 stops10h 21m
Delta
Sun 5/176:00 am
PWM
- DSM
1 stop6h 08m
Delta
Deal found 4/27![Delta logo]()
$512
Last-minute flights from Des Moines to PortlandDiscover last-minute flight deals from Des Moines to Portland. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Portland. Data last updated April 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:11 am
DSM
- PWM
1 stop6h 58m
American Airlines
Wed 5/271:35 pm
PWM
- DSM
1 stop8h 08m
American Airlines
Deal found 4/25![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:15 am
DSM
- PWM
1 stop4h 40m
Delta
Wed 5/2712:50 pm
PWM
- DSM
2 stops10h 42m
Delta
Deal found 4/25![Delta logo]()
$356
This deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:15 am
DSM
- PWM
1 stop4h 40m
Delta
Sat 5/306:02 am
PWM
- DSM
1 stop6h 45m
Delta
Deal found 4/24![Delta logo]()
$405
This deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:11 am
DSM
- PWM
1 stop6h 58m
American Airlines
Tue 5/265:57 pm
PWM
- DSM
1 stop7h 20m
American Airlines
Deal found 4/24![American Airlines logo]()
$413
This deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/231:30 pm
DSM
- PWM
1 stop7h 16m
American Airlines
Wed 5/277:19 pm
PWM
- DSM
1 stop5h 49m
American Airlines
Deal found 4/24![American Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:15 am
DSM
- PWM
1 stop4h 40m
Delta
Wed 5/2712:50 pm
PWM
- DSM
2 stops10h 42m
Delta
Deal found 4/27![Delta logo]()
$394
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:27 am
DSM
- PWM
1 stop6h 38m
Delta
Thu 5/2811:03 am
PWM
- DSM
2 stops10h 33m
Delta
Deal found 4/27![Delta logo]()
$410
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DSM
- PWM
1 stop7h 26m
United Airlines
Sat 5/305:03 pm
PWM
- DSM
1 stop5h 42m
United Airlines
Deal found 4/25![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:04 pm
DSM
- PWM
2 stops9h 14m
Delta
Sat 5/306:02 am
PWM
- DSM
2 stops10h 13m
Delta
Deal found 4/25![Delta logo]()
$388
One-way flights from Des Moines to PortlandSearch for one-way flight options from Des Moines to Portland. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from Des Moines to Portland. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:41 pm
DSM
- PWM
1 stop7h 55m
American Airlines
Deal found 4/27![American Airlines logo]()
$214
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:25 pm
DSM
- PWM
2 stops9h 34m
Delta
Deal found 4/27![Delta logo]()
$219
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:01 pm
DSM
- PWM
1 stop6h 16m
American Airlines
Deal found 4/24![American Airlines logo]()
$224
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
DSM
- PWM
1 stop4h 40m
Delta
Deal found 4/26![Delta logo]()
$240
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:08 pm
DSM
- PWM
1 stop7h 52m
American Airlines
Deal found 4/28![American Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
DSM
- PWM
2 stops10h 35m
Southwest
Deal found 4/23![Southwest logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/319:00 am
DSM
- PWM
2 stops52h 31m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:59 pm
DSM
- PWM
2 stops52h 39m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- PWM
3 stops39h 04m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$301
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/181:37 pm
DSM
- PWM
1 stop8h 10m
American Airlines
Deal found 4/23![American Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:30 pm
DSM
- PWM
3 stops43h 56m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$315
Find flight deals from Des Moines to Portland
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Portland (PWM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $351 (Delta) |
One-way from | $214 (American Airlines) |
Popular in | April |
Cheapest in | September |
Average price | $756 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Portland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to Portland that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Wed 9/9
6:20 am-5:00 pm
2 stops9h 40m
Portland
Wed 9/16
12:50 pm-4:49 pm
1 stop4h 59m
$390
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Tue 8/25
2:40 pm-10:05 pm
1 stop6h 25m
Portland
Sun 8/30
7:40 am-11:35 am
1 stop4h 55m
$409
Quickest round-trip
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Tue 10/6
7:25 am-1:22 pm
1 stop4h 57m
Portland
Wed 10/14
3:00 pm-8:00 pm
1 stop6h 00m
$427
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Tue 10/6
2:15 pm-11:49 pm
2 stops8h 34m
Portland
Thu 10/15
4:50 pm-8:52 pm
1 stop5h 02m
$432
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Mon 5/25
1:04 pm-11:09 pm
2 stops9h 05m
Portland
Thu 5/28
11:03 am-8:36 pm
2 stops10h 33m
$452
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Sat 6/6
1:05 pm-9:51 pm
1 stop7h 46m
Portland
Wed 6/10
6:00 am-10:27 am
1 stop5h 27m
$468
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Sun 5/24
1:18 pm-9:51 pm
1 stop7h 33m
Portland
Wed 5/27
3:31 pm-11:44 pm
1 stop9h 13m
$479
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Wed 5/13
11:57 am-11:18 pm
2 stops10h 21m
Portland
Sun 5/17
6:00 am-11:08 am
1 stop6h 08m
$512
Cheapest one-way
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Sat 7/18
1:04 pm-9:17 pm
1 stop7h 13m
$214
Des MoinesPortland
DSM - PWM
DSMPWM
Des Moines
Fri 7/10
10:25 am-11:14 pm
2 stops11h 49m
$219
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Portland
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Portland in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Portland, Maine flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Portland, Maine flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Portland, Maine flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Portland, Maine flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Portland, Maine flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Portland
Have a flexible travel schedule? Discover the best time to fly to Portland from Des Moines with our price prediction graph.
DSM-PWM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Portland
Reviews of airlines servicing Portland
Get insights into the airlines that provide service to Portland. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Portland. Reviews last updated April 28, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Portland by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.9
Crew
8.5
Food
7.2
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Portland. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Portland?
Book flights to Portland if you plan to visit one of these locationsNorth Conway
Brunswick
Lewiston
Conway
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Des Moines
Popular flights
Portland flight routes
Alternative routes for Des Moines to Portland
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Portland by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Portland by cabin class
Find flights from Des Moines to Portland, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Portland flights
Browse other Des Moines and Portland flight options. Last updated on April 28, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Portland
Explore flights to Portland departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Top 3 airlines flying from Des Moines to Portland
Discover the top 3 airlines that operate flights from Des Moines to Portland. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$256 | Average$453 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$487 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$321 | Average$467 | FlexibilityNo cancel fee | On-time69% |