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Des Moines

$129+ Cheap flights from St. Louis to Des Moines (STL - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
May 22 — May 291
Fri 5/22
Fri 5/29
1 adult, Economy
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Cheap flight deals from St. Louis to Des Moines

Cheapest flights from St. Louis to Des Moines
Explore the most affordable flight options available from St. Louis to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 22, 2026.

This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:05 am
STL
-
DSM
1 stop6h 32m
Delta
Tue 5/265:28 pm
DSM
-
STL
1 stop5h 53m
Delta
Deal found 4/22$212
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:35 am
STL
-
DSM
1 stop5h 50m
Southwest
Tue 5/263:15 pm
DSM
-
STL
1 stop6h 55m
Southwest
Deal found 4/19$216
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:35 am
STL
-
DSM
1 stop5h 50m
Southwest
Wed 5/276:55 am
DSM
-
STL
2 stops6h 05m
Southwest
Deal found 4/21$218
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:21 am
STL
-
DSM
1 stop6h 03m
Delta
Thu 6/46:41 pm
DSM
-
STL
1 stop5h 18m
Delta
Deal found 4/20$249
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:40 am
STL
-
DSM
1 stop5h 50m
Southwest
Sun 6/145:10 am
DSM
-
STL
1 stop4h 20m
Southwest
Deal found 4/20$264
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:14 pm
STL
-
DSM
1 stop6h 58m
American Airlines
Sun 5/317:10 pm
DSM
-
STL
1 stop4h 44m
American Airlines
Deal found 4/21$283

Find flight deals from St. Louis to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$212
(American Airlines)

One-way from

$129
(KAYAK)

Popular in

January

Cheapest in

October

Average price

$585

Good one-way deal

$194 or less
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Lambert-St Louis to Des Moines
Search Deals
One-way flight from Lambert-St Louis to Des Moines
Search Deals
Highest demand for flights based on searches. 35% potential increase in price ($212 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals
Price to beat on a one-way flight from Lambert-St Louis to Des Moines.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/19

7:05 am-1:37 pm

1 stop6h 32m

Des Moines

Tue 5/26

5:28 pm-11:21 pm

1 stop5h 53m

$212

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/19

2:30 pm-10:10 pm

2 stops7h 40m

Des Moines

Tue 5/26

5:30 am-3:10 pm

2 stops9h 40m

$274

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 5/20

3:10 pm-10:10 pm

2 stops7h 00m

Des Moines

Wed 5/27

5:30 am-3:10 pm

2 stops9h 40m

$278

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 5/30

5:14 pm-12:12 am

1 stop6h 58m

Des Moines

Sun 5/31

7:10 pm-11:54 pm

1 stop4h 44m

$283
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 5/8

5:36 pm-9:12 pm

1 stop3h 36m

Des Moines

Mon 5/11

6:41 pm-11:59 pm

1 stop5h 18m

$290

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/2

3:55 pm-9:15 pm

1 stop5h 20m

Des Moines

Fri 6/5

5:10 am-9:10 am

1 stop4h 00m

$298

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 5/12

3:10 pm-10:10 pm

2 stops7h 00m

Des Moines

Sun 5/17

5:20 am-9:30 am

1 stop4h 10m

$303

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 5/15

2:10 pm-11:05 pm

2 stops8h 55m

Des Moines

Sat 5/16

5:35 am-10:30 am

1 stop4h 55m

$312

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 7/2

6:21 am-10:14 am

1 stop3h 53m

Des Moines

Sun 7/5

6:39 pm-11:56 pm

1 stop5h 17m

$317

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 5/15

5:51 am-10:31 am

1 stop4h 40m

Des Moines

Fri 5/22

4:48 pm-11:59 pm

1 stop7h 11m

$321

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/21

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from St. Louis to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Des Moines

How much does it cost to fly round-trip from St. Louis to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 22, 2026.
Read reviews from past customers who have flown Southwest from St. Louis to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,330 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,330 reviews
Southwest
8.0
Very good
4,330 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this St. Louis to Des Moines flight route?

    The Lambert-St Louis to Des Moines flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Des Moines?

    Departing from St. Louis to Des Moines will take you 3h 36m. The distance between St. Louis and Des Moines is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from St. Louis to Des Moines round-trip?

    Flying on Southwest is currently your cheapest option to Des Moines, with prices starting at $77. Southwest is currently priced 80% below the average price you’ll pay for this route.

  • What are the cheapest flights from St. Louis to Des Moines?

    On average you can expect to pay $194 for a flight from St. Louis to Des Moines. The cheapest flight overall is $175 while the most popular route, (Lambert-St Louis - Des Moines) is currently priced at $213.

  • Can I find deals for flights from St. Louis to Des Moines that include hotel bookings?

    Yes. In addition to deals on St. Louis to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Des Moines.

  • Can I find deals for business class flights from St. Louis to Des Moines?

    Yes. Cheapflights offers flight deals from St. Louis to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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Top airline flying from St. Louis to Des Moines

Discover the top airline that operate flights from St. Louis to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$316FlexibilityNo cancel feeOn-time63%

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