
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $260 (CheapOair) |
One-way from | $152 (Southwest) |
Popular in | February |
Cheapest in | May |
Average price | $381 |
Good round-trip deal | $462 or less |
Fly from
Fly to
Route
Depart
Return
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Sat 12/5
5:20 am-11:40 am
1 stop6h 20m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Wed 2/17
3:00 pm-9:00 pm
1 stop6h 00m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 12/4
4:53 pm-11:26 pm
1 stop6h 33m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 12/25
3:25 pm-10:00 pm
1 stop6h 35m
Lambert-St Louis
Sat 1/16
6:45 am-2:40 pm
1 stop7h 55m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 1/8
8:00 am-6:05 pm
2 stops10h 05m
Lambert-St Louis
Sat 1/9
10:45 am-8:20 pm
2 stops9h 35m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Tue 12/8
6:00 am-11:00 am
1 stop5h 00m
Lambert-St Louis
Thu 12/10
4:40 pm-10:05 pm
1 stop5h 25m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Wed 12/9
6:00 am-3:35 pm
2 stops9h 35m
Lambert-St Louis
Thu 12/10
4:40 pm-10:05 pm
1 stop5h 25m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Sat 12/5
12:59 pm-10:57 am
3 stops45h 58m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 12/11
4:25 pm-12:35 am
2 stops8h 10m
Lambert-St Louis
Sun 12/13
9:35 am-6:35 pm
1 stop9h 00m
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 12/4
6:00 am-1:50 pm
2 stops7h 50m
Lambert-St Louis
Fri 12/11
4:30 pm-11:05 pm
2 stops6h 35m
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
Food
Comfort
Entertainment
Overall
Boarding
Crew
Reviews
Ellen,Oct 2026
GRR - ATL
Food
Comfort
Entertainment
Overall
Boarding
Crew
Reviews
Ellen,Oct 2026
GRR - ATL
Food
Comfort
Entertainment
Overall
Boarding
Crew
Reviews
Ellen,Oct 2026
GRR - ATL
Food
Comfort
Entertainment
Overall
Boarding
Crew
Reviews
Ellen,Oct 2026
GRR - ATL
Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$180 | Average$354 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$244 | Average$381 | FlexibilityNo cancel fee | On-time69% |