$90+ Cheap flights from Des Moines to St. Louis (DSM - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Apr 27 — May 41
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to St. Louis
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Best
Last-minute
One-way
Cheapest flights from Des Moines to St. LouisExplore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- STL
1 stop4h 00m
Southwest
Tue 4/283:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/23![Southwest logo]()
$202
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- STL
1 stop6h 55m
Delta
Tue 4/145:35 pm
STL
- DSM
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$205
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- STL
2 stops6h 05m
Southwest
Wed 4/153:55 pm
STL
- DSM
1 stop6h 15m
Southwest
Deal found 3/26![Southwest logo]()
$215
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
DSM
- STL
1 stop6h 32m
United Airlines
Tue 5/125:28 pm
STL
- DSM
1 stop5h 56m
United Airlines
Deal found 3/26![United Airlines logo]()
$219
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 am
DSM
- STL
2 stops7h 20m
Southwest
Tue 4/143:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/25![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:10 pm
DSM
- STL
1 stop7h 05m
Southwest
Tue 4/218:35 am
STL
- DSM
1 stop5h 30m
Southwest
Deal found 3/26![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- STL
2 stops8h 00m
Southwest
Tue 5/123:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/26![Southwest logo]()
$227
Best flights from Des Moines to St. LouisDiscover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
Discover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- STL
1 stop4h 00m
Southwest
Tue 4/283:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/23![Southwest logo]()
$202
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:45 am
DSM
- STL
1 stop6h 11m
Delta
Thu 5/76:21 am
STL
- DSM
1 stop6h 03m
Delta
Deal found 3/23![Delta logo]()
$239
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Wed 6/35:10 am
STL
- DSM
1 stop5h 32m
United Airlines
Deal found 3/23![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:55 am
DSM
- STL
2 stops6h 05m
Southwest
Thu 6/46:30 pm
STL
- DSM
1 stop5h 00m
Southwest
Deal found 3/23![Southwest logo]()
$236
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Tue 4/282:30 pm
STL
- DSM
2 stops7h 40m
Southwest
Deal found 3/25![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- STL
1 stop6h 25m
Southwest
Mon 4/2710:15 am
STL
- DSM
2 stops12h 50m
Southwest
Deal found 3/25![Southwest logo]()
$277
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- STL
1 stop3h 55m
Southwest
Tue 4/213:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/25![Southwest logo]()
$278
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:25 am
DSM
- STL
2 stops9h 30m
Southwest
Thu 5/77:20 am
STL
- DSM
1 stop4h 25m
Southwest
Deal found 3/23![Southwest logo]()
$286
Last-minute flights from Des Moines to St. LouisDiscover last-minute flight deals from Des Moines to St. Louis. Data last updated March 28, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to St. Louis. Data last updated March 28, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- STL
1 stop6h 55m
Delta
Tue 4/145:35 pm
STL
- DSM
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$205
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 am
DSM
- STL
2 stops7h 20m
Southwest
Tue 4/143:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/25![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:55 am
DSM
- STL
2 stops6h 05m
Southwest
Wed 4/153:55 pm
STL
- DSM
1 stop6h 15m
Southwest
Deal found 3/26![Southwest logo]()
$215
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/182:10 pm
DSM
- STL
1 stop7h 05m
Southwest
Tue 4/218:35 am
STL
- DSM
1 stop5h 30m
Southwest
Deal found 3/26![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 am
DSM
- STL
1 stop4h 00m
Southwest
Tue 4/283:55 pm
STL
- DSM
1 stop5h 20m
Southwest
Deal found 3/23![Southwest logo]()
$202
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:21 pm
DSM
- STL
1 stop6h 31m
United Airlines
Tue 4/289:10 am
STL
- DSM
1 stop5h 15m
United Airlines
Deal found 3/25![United Airlines logo]()
$239
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:56 am
DSM
- STL
2 stops9h 48m
Delta
Sat 5/210:50 am
STL
- DSM
1 stop6h 12m
Delta
Deal found 3/26![Delta logo]()
$244
One-way flights from Des Moines to St. LouisSearch for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
Search for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- STL
1 stop5h 17m
Frontier
Deal found 3/27![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
- STL
1 stop29h 07m
Frontier
Deal found 3/25![Frontier logo]()
$91
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:41 pm
DSM
- STL
1 stop5h 18m
Delta
Deal found 3/25![Delta logo]()
$100
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2210:56 am
DSM
- STL
1 stop5h 54m
Delta
Deal found 3/26![Delta logo]()
$103
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:00 am
DSM
- STL
2 stops6h 05m
Delta
Deal found 3/26![Delta logo]()
$105
This Expedia deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/262:16 pm
DSM
- STL
1 stop5h 07m
Frontier
Deal found 3/26![Frontier logo]()
$115
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/252:44 pm
DSM
- STL
1 stop4h 27m
Delta
Deal found 3/26![Delta logo]()
$120
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:23 pm
DSM
- STL
1 stop6h 50m
Delta
Deal found 3/24![Delta logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- STL
2 stops33h 15m
Frontier
Deal found 3/25![Frontier logo]()
$127
Find flight deals from Des Moines to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $202 (Southwest) |
One-way from | $90 (Frontier) |
Popular in | July |
Cheapest in | September |
Average price | $243 |
Good round-trip deal | $462 or less |
Good one-way deal | $261 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 4/21
5:30 am-9:30 am
1 stop4h 00m
Lambert-St Louis
Tue 4/28
3:55 pm-9:15 pm
1 stop5h 20m
$202
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 6/2
6:55 am-1:00 pm
2 stops6h 05m
Lambert-St Louis
Thu 6/4
6:30 pm-11:30 pm
1 stop5h 00m
$236
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 5/4
5:45 am-11:56 am
1 stop6h 11m
Lambert-St Louis
Thu 5/7
6:21 am-12:24 pm
1 stop6h 03m
$239
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 4/24
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Tue 4/28
2:30 pm-10:10 pm
2 stops7h 40m
$248
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 6/2
6:00 am-12:11 pm
1 stop6h 11m
Lambert-St Louis
Wed 6/3
5:10 am-10:42 am
1 stop5h 32m
$269
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 4/24
4:20 pm-10:45 pm
1 stop6h 25m
Lambert-St Louis
Mon 4/27
10:15 am-11:05 pm
2 stops12h 50m
$277
Quickest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 4/7
5:30 am-9:25 am
1 stop3h 55m
Lambert-St Louis
Tue 4/21
3:55 pm-9:15 pm
1 stop5h 20m
$278
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 5/4
5:25 am-2:55 pm
2 stops9h 30m
Lambert-St Louis
Thu 5/7
7:20 am-11:45 am
1 stop4h 25m
$286
Cheapest one-way
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 5/20
6:41 pm-11:59 pm
1 stop5h 18m
$100
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 5/27
6:15 am-1:10 pm
1 stop6h 55m
$100
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
DSM-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated March 28, 2026.
See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus
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Des Moines and St. Louis flights
Browse other Des Moines and St. Louis flight options. Last updated on March 28, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on March 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 28, 2026.
Top airline flying from Des Moines to St. Louis
Discover the top airline that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$97 | Average$253 | FlexibilityNo cancel fee | On-time63% |