St. Louis

$137+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Jun 13 — Jun 201
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Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.

This Booking.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:16 pm
DSM
-
STL
1 stop5h 07m
Frontier
Sun 5/318:08 pm
STL
-
DSM
1 stop17h 23m
Frontier
Deal found 5/12$242
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:25 am
DSM
-
STL
1 stop7h 05m
Southwest
Wed 7/11:45 pm
STL
-
DSM
1 stop7h 55m
Southwest
Deal found 5/10$293
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:00 pm
DSM
-
STL
1 stop4h 55m
Southwest
Sun 7/55:50 am
STL
-
DSM
1 stop5h 35m
Southwest
Deal found 5/13$305
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:30 pm
DSM
-
STL
1 stop4h 40m
Southwest
Fri 6/56:30 pm
STL
-
DSM
1 stop5h 00m
Southwest
Deal found 5/13$309
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am
DSM
-
STL
2 stops8h 20m
Southwest
Sun 9/610:30 am
STL
-
DSM
2 stops11h 40m
Southwest
Deal found 5/9$315
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:02 pm
DSM
-
STL
1 stop4h 57m
American Airlines
Sun 7/55:58 pm
STL
-
DSM
1 stop6h 03m
American Airlines
Deal found 5/12$317
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:25 am
DSM
-
STL
2 stops8h 40m
Southwest
Wed 11/42:20 pm
STL
-
DSM
2 stops7h 45m
Southwest
Deal found 5/12$320
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:04 pm
DSM
-
STL
1 stop3h 42m
Delta
Sun 5/318:53 am
STL
-
DSM
1 stop3h 31m
Delta
Deal found 5/12$321

Find flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$242
(Booking.com)

One-way from

$137
(Kiwi.com)

Popular in

July

Cheapest in

September

Average price

$237

Good round-trip deal

$462 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
From Des Moines to Lambert-St Louis
One-way flight from Des Moines to Lambert-St Louis
Highest demand for flights based on searches. 14% potential increase in price ($56 potential increase over avg. RT price).
Cheapest flight prices on average. 8% potential price decrease ($25 potential savings vs. average RT price).
Average for round-trip flights in May 2026
Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 6/24

5:20 am-2:50 pm

2 stops9h 30m

Lambert-St Louis

Wed 7/1

1:45 pm-9:40 pm

1 stop7h 55m

$298

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 9/2

6:10 am-11:20 am

1 stop5h 10m

Lambert-St Louis

Sun 9/6

4:30 pm-9:15 pm

1 stop4h 45m

$305
Quickest round-trip

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 6/3

5:30 am-9:30 am

1 stop4h 00m

Lambert-St Louis

Fri 6/5

6:30 pm-11:30 pm

1 stop5h 00m

$309

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 7/1

5:20 am-2:45 pm

2 stops9h 25m

Lambert-St Louis

Sun 7/5

5:50 am-11:25 am

1 stop5h 35m

$310

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 10/31

6:50 am-7:15 pm

2 stops12h 25m

Lambert-St Louis

Tue 11/3

2:20 pm-10:05 pm

2 stops7h 45m

$315

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 7/3

1:30 pm-8:20 pm

1 stop6h 50m

Lambert-St Louis

Sun 7/5

5:50 am-11:25 am

1 stop5h 35m

$317

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 6/25

4:40 pm-10:50 pm

1 stop6h 10m

Lambert-St Louis

Thu 7/2

6:30 pm-11:30 pm

1 stop5h 00m

$317

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 6/8

4:40 pm-10:50 pm

1 stop6h 10m

Lambert-St Louis

Mon 6/15

6:30 pm-11:30 pm

1 stop5h 00m

$317
Cheapest one-way

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sun 7/26

4:15 pm-10:50 pm

1 stop6h 35m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 6/20

6:00 am-12:11 pm

1 stop6h 11m

$159

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/9

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

How much does it cost to fly round-trip from Des Moines to St. Louis?

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated May 14, 2026.
See what other customers who have flown with Southwest and American Airlines from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Food

7.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How popular is this Des Moines to St. Louis flight route?

  • How long is the flight from Des Moines to St. Louis?

    A quick flight from Des Moines to St. Louis can take about 9h 30m. Southwest provides one of the quickest options available for as low as $298. Airlines will cover a distance of 259 mi.

  • What are the cheapest airlines flying from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $107. Another airline that can offer you cheap pricing is American Airlines. Users have found that Southwest is 67% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $494, our data shows the cheapest flight currently is $414. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $305 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Wentzville
Glencoe
Chesterfield
Alton
Farmington
Festus

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Top 2 airlines flying from Des Moines to St. Louis

Discover the top 2 airlines that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$107Average$253FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$158Average$398FlexibilityNo cancel feeOn-time71%

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