$173+ Cheap flights from Des Moines to St. Louis (DSM - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Jul 30 — Aug 61
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to St. Louis
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Cheapest flights from Des Moines to St. LouisExplore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2026.
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2026.
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Sat 8/158:00 am
STL
- DSM
1 stop4h 18m
United Airlines
Deal found 6/27![United Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:55 am
DSM
- STL
1 stop3h 28m
Delta
Thu 8/206:20 am
STL
- DSM
1 stop3h 58m
Delta
Deal found 6/29![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am
DSM
- STL
1 stop3h 25m
Southwest
Sat 10/318:40 am
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/26![Southwest logo]()
$222
This Delta deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:59 pm
DSM
- STL
1 stop5h 17m
Delta
Tue 9/226:15 am
STL
- DSM
1 stop4h 02m
Delta
Deal found 6/25![Delta logo]()
$235
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Thu 8/2010:10 am
STL
- DSM
2 stops12h 00m
Southwest
Deal found 6/29![Southwest logo]()
$246
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:50 pm
DSM
- STL
1 stop6h 15m
Southwest
Wed 9/164:05 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/25![Southwest logo]()
$252
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am
DSM
- STL
1 stop3h 35m
Southwest
Tue 9/222:50 pm
STL
- DSM
2 stops6h 10m
Southwest
Deal found 6/25![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:00 am
DSM
- STL
1 stop5h 55m
American Airlines
Sat 8/158:06 pm
STL
- DSM
1 stop4h 29m
American Airlines
Deal found 6/24![American Airlines logo]()
$263
Best flights from Des Moines to St. LouisDiscover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 30, 2026.
Discover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 30, 2026.
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:55 am
DSM
- STL
1 stop3h 28m
Delta
Thu 8/206:20 am
STL
- DSM
1 stop3h 58m
Delta
Deal found 6/29![Delta logo]()
$215
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am
DSM
- STL
2 stops12h 45m
Southwest
Wed 9/164:05 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/25![Southwest logo]()
$257
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:29 am
DSM
- STL
1 stop5h 28m
United Airlines
Wed 9/2312:59 pm
STL
- DSM
1 stop4h 29m
United Airlines
Deal found 6/28![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop5h 55m
Southwest
Wed 7/295:55 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/24![Southwest logo]()
$263
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:10 am
DSM
- STL
1 stop5h 10m
Southwest
Mon 9/286:25 am
STL
- DSM
1 stop7h 20m
Southwest
Deal found 6/25![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:00 am
DSM
- STL
1 stop6h 23m
United Airlines
Sun 7/196:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 6/28![United Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:30 am
DSM
- STL
2 stops7h 05m
Southwest
Sat 8/157:50 am
STL
- DSM
2 stops11h 35m
Southwest
Deal found 6/24![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:24 pm
DSM
- STL
1 stop6h 02m
United Airlines
Sun 7/195:59 pm
STL
- DSM
1 stop4h 57m
United Airlines
Deal found 6/25![United Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:24 pm
DSM
- STL
1 stop6h 02m
United Airlines
Sat 7/185:59 pm
STL
- DSM
1 stop5h 01m
United Airlines
Deal found 6/29![United Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- STL
2 stops6h 10m
Southwest
Sun 7/191:30 pm
STL
- DSM
1 stop10h 20m
Southwest
Deal found 6/25![Southwest logo]()
$356
Last-minute flights from Des Moines to St. LouisDiscover last-minute flight deals from Des Moines to St. Louis. Data last updated June 30, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to St. Louis. Data last updated June 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/153:24 pm
DSM
- STL
1 stop6h 02m
United Airlines
Sat 7/185:59 pm
STL
- DSM
1 stop5h 01m
United Airlines
Deal found 6/29![United Airlines logo]()
$345
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:24 pm
DSM
- STL
1 stop3h 59m
United Airlines
Sat 7/185:59 pm
STL
- DSM
1 stop5h 01m
United Airlines
Deal found 6/25![United Airlines logo]()
$304
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- STL
2 stops6h 10m
Southwest
Sat 7/183:00 pm
STL
- DSM
1 stop7h 00m
Southwest
Deal found 6/25![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:40 pm
DSM
- STL
2 stops6h 10m
Southwest
Sun 7/191:30 pm
STL
- DSM
1 stop10h 20m
Southwest
Deal found 6/25![Southwest logo]()
$356
This Southwest deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- STL
1 stop5h 55m
Southwest
Wed 7/295:55 pm
STL
- DSM
1 stop4h 55m
Southwest
Deal found 6/24![Southwest logo]()
$263
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:18 pm
DSM
- STL
1 stop5h 57m
American Airlines
Sat 8/18:06 pm
STL
- DSM
1 stop12h 17m
American Airlines
Deal found 6/25![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/265:00 am
DSM
- STL
1 stop3h 37m
American Airlines
Tue 7/285:58 pm
STL
- DSM
1 stop6h 03m
American Airlines
Deal found 6/28![American Airlines logo]()
$277
This United Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:00 am
DSM
- STL
1 stop6h 11m
United Airlines
Sat 8/16:00 am
STL
- DSM
1 stop4h 17m
United Airlines
Deal found 6/24![United Airlines logo]()
$280
This Southwest deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:10 am
DSM
- STL
2 stops8h 40m
Southwest
Thu 8/66:05 am
STL
- DSM
1 stop5h 20m
Southwest
Deal found 6/29![Southwest logo]()
$295
One-way flights from Des Moines to St. LouisSearch for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 30, 2026.
Search for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated June 30, 2026.
This KAYAK deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:00 am
DSM
- STL
1 stop3h 37m
American Airlines
Deal found 6/26![American Airlines logo]()
$173
This KAYAK deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 pm
DSM
- STL
2 stops12h 45m
Southwest
Deal found 6/26![Southwest logo]()
$178
This Southwest deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/104:40 pm
DSM
- STL
1 stop6h 15m
Southwest
Deal found 6/28![Southwest logo]()
$230
This KAYAK deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:10 am
DSM
- STL
3 stops16h 40m
Southwest
Deal found 6/26![Southwest logo]()
$246
This Kiwi.com deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:38 pm
DSM
- STL
3 stops37h 02m
Multiple Airlines
Deal found 6/28![Multiple Airlines logo]()
$284
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/117:05 am
DSM
- STL
2 stops10h 19m
Delta
Deal found 6/29![Delta logo]()
$445
This Kiwi.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/113:20 pm
DSM
- STL
3 stops46h 01m
Multiple Airlines
Deal found 6/29![Multiple Airlines logo]()
$447
Find flight deals from Des Moines to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (United Airlines) |
One-way from | $173 (KAYAK) |
Popular in | July |
Cheapest in | May |
Average price | $371 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Thu 8/13
6:55 am-10:23 am
1 stop3h 28m
Lambert-St Louis
Thu 8/20
6:20 am-10:18 am
1 stop3h 58m
$215
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Mon 9/14
5:40 am-6:25 pm
2 stops12h 45m
Lambert-St Louis
Wed 9/16
4:05 pm-9:00 pm
1 stop4h 55m
$257
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/22
5:20 am-11:15 am
1 stop5h 55m
Lambert-St Louis
Wed 7/29
5:55 pm-10:50 pm
1 stop4h 55m
$263
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 9/23
6:10 am-11:20 am
1 stop5h 10m
Lambert-St Louis
Mon 9/28
6:25 am-1:45 pm
1 stop7h 20m
$271
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Tue 9/22
6:29 am-11:57 am
1 stop5h 28m
Lambert-St Louis
Wed 9/23
12:59 pm-5:28 pm
1 stop4h 29m
$279
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Sat 8/8
5:30 am-12:35 pm
2 stops7h 05m
Lambert-St Louis
Sat 8/15
7:50 am-7:25 pm
2 stops11h 35m
$306
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/15
8:00 am-2:23 pm
1 stop6h 23m
Lambert-St Louis
Sun 7/19
6:00 am-10:17 am
1 stop4h 17m
$345
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 7/17
3:24 pm-9:26 pm
1 stop6h 02m
Lambert-St Louis
Sun 7/19
5:59 pm-10:56 pm
1 stop4h 57m
$345
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Wed 7/15
3:24 pm-9:26 pm
1 stop6h 02m
Lambert-St Louis
Sat 7/18
5:59 pm-11:00 pm
1 stop5h 01m
$345
Des MoinesSt. Louis
DSM - STL
DSMSTL
Des Moines
Fri 7/17
4:40 pm-10:50 pm
2 stops6h 10m
Lambert-St Louis
Sun 7/19
1:30 pm-11:50 pm
1 stop10h 20m
$356
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
DSM-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 30, 2026.
See what other customers who have flown with Southwest and American Airlines from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Overall
7.9
Crew
8.6
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Fenton
Swansea
Fairview Heights
Eureka
Maryland Heights
Collinsville
Wentzville
Glencoe
Chesterfield
Alton
Farmington
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Des Moines and St. Louis flights
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Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 30, 2026.
Top 2 airlines flying from Des Moines to St. Louis
Discover the top 2 airlines that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$107 | Average$250 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$398 | FlexibilityNo cancel fee | On-time71% |