$141+ Cheap flights from Des Moines to St. Louis (DSM - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Oct 14 — Oct 211
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to St. Louis
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Cheapest flights from Des Moines to St. LouisExplore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 14, 2026.
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:00 pm -
1 stop9h 25m
Mon 10/266:10 pm -
1 stop5h 05m
Deal found 9/11![Southwest logo]()
$289
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:11 pm -
1 stop6h 10m
Fri 10/168:00 am -
1 stop4h 34m
Deal found 9/9![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:31 pm -
1 stop4h 48m
Sun 10/255:00 am -
1 stop3h 56m
Deal found 9/9![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
2 stops9h 35m
Sun 11/224:50 pm -
1 stop5h 10m
Deal found 9/10![Southwest logo]()
$325
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:30 pm -
2 stops8h 10m
Sun 10/255:45 am -
1 stop5h 35m
Deal found 9/9![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:31 pm -
1 stop4h 48m
Sun 10/185:00 am -
1 stop3h 56m
Deal found 9/11![American Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:31 pm -
1 stop4h 48m
Mon 10/125:27 pm -
1 stop6h 47m
Deal found 9/13![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:55 pm -
1 stop4h 04m
Tue 10/61:29 pm -
1 stop4h 19m
Deal found 9/11![United Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:10 am -
2 stops9h 10m
Mon 10/192:25 pm -
1 stop7h 45m
Deal found 9/13![Southwest logo]()
$354
Best flights from Des Moines to St. LouisDiscover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
Discover carefully curated flight deals from Des Moines to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 14, 2026.
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:00 pm -
1 stop9h 25m
Mon 10/266:10 pm -
1 stop5h 05m
Deal found 9/9![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:31 pm -
1 stop4h 48m
Sun 10/255:00 am -
1 stop3h 56m
Deal found 9/9![American Airlines logo]()
$320
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:55 pm -
1 stop4h 04m
Tue 10/61:29 pm -
1 stop4h 19m
Deal found 9/11![United Airlines logo]()
$352
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:00 am -
2 stops7h 45m
Sun 11/224:30 pm -
2 stops6h 30m
Deal found 9/10![Southwest logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:31 pm -
1 stop4h 48m
Mon 10/125:27 pm -
1 stop6h 47m
Deal found 9/12![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:00 am -
1 stop6h 29m
Fri 10/306:00 am -
1 stop4h 32m
Deal found 9/9![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:30 pm -
2 stops8h 10m
Sun 10/255:45 am -
1 stop5h 35m
Deal found 9/9![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:10 am -
2 stops9h 10m
Mon 10/192:25 pm -
1 stop7h 45m
Deal found 9/13![Southwest logo]()
$354
Last-minute flights from Des Moines to St. LouisDiscover last-minute flight deals from Des Moines to St. Louis. Data last updated September 14, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to St. Louis. Data last updated September 14, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:55 pm -
1 stop4h 04m
Tue 10/61:29 pm -
1 stop4h 19m
Deal found 9/11![United Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:00 am -
1 stop4h 15m
Wed 10/78:00 am -
1 stop4h 34m
Deal found 9/11![United Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:31 pm -
1 stop4h 48m
Mon 10/125:27 pm -
1 stop6h 47m
Deal found 9/13![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:11 pm -
1 stop6h 10m
Fri 10/168:00 am -
1 stop4h 34m
Deal found 9/9![United Airlines logo]()
$297
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:10 am -
2 stops9h 10m
Mon 10/192:25 pm -
1 stop7h 45m
Deal found 9/13![Southwest logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:31 pm -
1 stop4h 48m
Sun 10/185:00 am -
1 stop3h 56m
Deal found 9/11![American Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:31 pm -
1 stop4h 48m
Sun 10/255:00 am -
1 stop3h 56m
Deal found 9/9![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:30 pm -
2 stops8h 10m
Sun 10/255:45 am -
1 stop5h 35m
Deal found 9/9![Southwest logo]()
$333
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/232:00 pm -
1 stop9h 25m
Mon 10/266:10 pm -
1 stop5h 05m
Deal found 9/11![Southwest logo]()
$289
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:50 am -
1 stop4h 39m
Fri 10/301:08 pm -
1 stop4h 19m
Deal found 9/10![United Airlines logo]()
$359
One-way flights from Des Moines to St. LouisSearch for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
Search for one-way flight options from Des Moines to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 14, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:11 pm -
1 stop6h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$141
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:30 pm -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Southwest logo]()
$146
This eDestinos deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:28 am -
2 stops29h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$167
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:29 am -
1 stop5h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![American Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:42 pm -
3 stops50h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/213:50 pm -
1 stop3h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:31 pm -
2 stops45h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:45 am -
3 stops28h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$349
Find flight deals from Des Moines to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $235 (American Airlines) |
One-way from | $141 (United Airlines) |
Popular in | February |
Cheapest in | May |
Average price | $579 |
Good round-trip deal | $462 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Mon 10/5
3:11 pm-9:21 pm
1 stop6h 10m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$141
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Mon 10/5
7:10 pm-11:50 pm
1 stop4h 40m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$141
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Wed 10/28
8:00 am-2:29 pm
1 stop6h 29m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$141
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Sun 10/18
8:28 am-1:31 pm
2 stops29h 03m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$167
Quickest round-trip
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Mon 9/21
3:50 pm-7:05 pm
1 stop3h 15m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$250
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Mon 9/21
9:31 pm-7:17 pm
2 stops45h 46m
Lambert-St Louis
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Fri 10/23
2:00 pm-11:25 pm
1 stop9h 25m
Lambert-St Louis
Mon 10/26
6:10 pm-11:15 pm
1 stop5h 05m
$289
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Thu 10/22
7:31 pm-12:19 am
1 stop4h 48m
Lambert-St Louis
Sun 10/25
5:00 am-8:56 am
1 stop3h 56m
$320
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Wed 11/18
6:00 am-1:45 pm
2 stops7h 45m
Lambert-St Louis
Sun 11/22
4:30 pm-11:00 pm
2 stops6h 30m
$330
Des MoinesSt. Louis
DSM Des Moines - STL Lambert-St Louis
DSMSTL
Des Moines
Thu 10/22
4:30 pm-12:40 am
2 stops8h 10m
Lambert-St Louis
Sun 10/25
5:45 am-11:20 am
1 stop5h 35m
$333
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Des Moines to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
DSM-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to St. Louis
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 14, 2026.
See what other customers who have flown with Southwest and American Airlines from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Boarding
8.1
Entertainment
7.5
Food
7.0
Overall
8.0
Crew
8.6
Comfort
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
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Des Moines and St. Louis flights
Browse other Des Moines and St. Louis flight options. Last updated on September 14, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 14, 2026.
Top 2 airlines flying from Des Moines to St. Louis
Discover the top 2 airlines that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$116 | Average$281 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$158 | Average$398 | FlexibilityNo cancel fee | On-time71% |