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St. Louis

$69+ Cheap flights from Des Moines to St. Louis (DSM - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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1. Tell us where you want to go

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Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis
Explore the most affordable flight options available from Des Moines to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:15 pm
DSM
-
STL
1 stop6h 21m
Delta
Wed 2/256:00 am
STL
-
DSM
1 stop5h 19m
Delta
Deal found 1/21$157
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:00 am
DSM
-
STL
1 stop4h 33m
American Airlines
Tue 2/245:12 am
STL
-
DSM
1 stop5h 22m
American Airlines
Deal found 1/20$159
This Delta deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/175:15 pm
DSM
-
STL
1 stop6h 21m
Delta
Tue 2/246:35 am
STL
-
DSM
2 stops9h 05m
Delta
Deal found 1/20$198
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:55 am
DSM
-
STL
1 stop4h 53m
Delta
Sat 4/46:00 am
STL
-
DSM
1 stop4h 48m
Delta
Deal found 1/21$227
This Southwest deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:20 pm
DSM
-
STL
1 stop6h 25m
Southwest
Tue 5/125:35 am
STL
-
DSM
1 stop5h 50m
Southwest
Deal found 1/21$233
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/108:10 am
DSM
-
STL
1 stop7h 42m
United Airlines
Wed 2/116:00 pm
STL
-
DSM
1 stop5h 44m
United Airlines
Deal found 1/20$237
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:45 am
DSM
-
STL
1 stop7h 09m
Delta
Sat 5/237:20 am
STL
-
DSM
1 stop6h 05m
Delta
Deal found 1/21$243
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:10 am
DSM
-
STL
Nonstop1h 20m
Southwest
Sun 3/110:25 pm
STL
-
DSM
Nonstop1h 10m
Southwest
Deal found 1/20$250

Find flight deals from Des Moines to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$157
(Delta)

One-way from

$69
(Southwest)

Popular in

July

Cheapest in

September

Average price

$467

Good round-trip deal

$385 or less

Good one-way deal

$198 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
Search Deals
From Des Moines to Lambert-St Louis
Search Deals
One-way flight from Des Moines to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.
Search Deals
Price to beat on a one-way flight from Des Moines to Lambert-St Louis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Des Moines

Fly to

St. Louis

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 2/18

5:15 pm-11:36 pm

1 stop6h 21m

Lambert-St Louis

Wed 2/25

6:00 am-11:19 am

1 stop5h 19m

$157

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/17

5:00 am-9:33 am

1 stop4h 33m

Lambert-St Louis

Tue 2/24

5:12 am-10:34 am

1 stop5h 22m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/17

5:15 pm-11:36 pm

1 stop6h 21m

Lambert-St Louis

Tue 2/24

6:35 am-3:40 pm

2 stops9h 05m

$198

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Sat 3/28

6:55 am-11:48 am

1 stop4h 53m

Lambert-St Louis

Sat 4/4

6:00 am-10:48 am

1 stop4h 48m

$227

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 5/8

4:20 pm-10:45 pm

1 stop6h 25m

Lambert-St Louis

Tue 5/12

5:35 am-11:25 am

1 stop5h 50m

$233

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Tue 2/10

8:10 am-3:52 pm

1 stop7h 42m

Lambert-St Louis

Wed 2/11

6:00 pm-11:44 pm

1 stop5h 44m

$237

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 5/13

5:45 am-12:54 pm

1 stop7h 09m

Lambert-St Louis

Sat 5/23

7:20 am-1:25 pm

1 stop6h 05m

$243

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 2/20

6:32 am-10:03 am

1 stop3h 31m

Lambert-St Louis

Mon 2/23

6:36 pm-11:40 pm

1 stop5h 04m

$259

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 2/19

7:44 pm-11:48 pm

1 stop4h 04m

Lambert-St Louis

Sun 2/22

6:38 pm-11:40 pm

1 stop5h 02m

$259

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 3/27

10:51 am-5:05 pm

1 stop6h 14m

Lambert-St Louis

Sat 4/4

6:00 am-10:48 am

1 stop4h 48m

$261

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 18 results
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Compare providers for flights from Des Moines to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to St. Louis

What is the cheapest time of day to fly from DSM to STL?

Find hourly flight availability from Des Moines to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to St. Louis as you normally would.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 21, 2026.
See what other customers who have flown with Southwest from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,266 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,266 reviews
Southwest
8.0
Very good
4,266 reviews

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Des Moines to St. Louis?

    Lambert-St Louis is the airport most travelers will use when flying to St. Louis from Des Moines. Booking flights from Des Moines (DSM) to Lambert-St Louis (STL) should be relatively easy as there are 2 daily flights to St. Louis from 1 airline. 1h 05m is how long a flight from Des Moines to Lambert-St Louis will take if you book a nonstop flight.

  • How popular is this Des Moines to St. Louis flight route?

    This flight path from Des Moines to Lambert-St Louis was viewed by 29 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to St. Louis?

    A quick flight from Des Moines to St. Louis can take about 4h 33m. Delta provides one of the quickest options available for as low as $159. Airlines will cover a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What is the cheapest airline to fly from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $97. Users have found that Southwest is 70% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $358, our data shows the cheapest flight currently is $98. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $191 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Des Moines to St. Louis

Discover the top airline that operate flights from Des Moines to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$253FlexibilityNo cancel feeOn-time63%

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