St. Louis

$152+ Cheap flights from Des Moines to St. Louis (DSM - STL)

DSM — STL
Dec 10 — Dec 171
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Cheap flight deals from Des Moines to St. Louis

Cheapest flights from Des Moines to St. Louis

Sun 12/138:39 pm -
1 stop14h 18m
Wed 12/167:54 pm -
1 stop23h 37m
Deal found 11/9$260
Fri 12/48:00 am -
1 stop4h 22m
Fri 12/116:30 am -
1 stop6h 09m
Deal found 11/5$271
Fri 12/253:25 pm -
1 stop6h 35m
Sat 1/166:45 am -
1 stop7h 55m
Deal found 11/5$276
Tue 12/84:53 pm -
1 stop6h 33m
Wed 12/96:03 am -
1 stop4h 18m
Deal found 11/9$303
Tue 12/86:00 am -
2 stops7h 45m
Wed 12/92:35 pm -
1 stop6h 15m
Deal found 11/9$308
Tue 12/86:00 am -
1 stop5h 00m
Thu 12/104:40 pm -
1 stop5h 25m
Deal found 11/9$318
Fri 12/43:25 pm -
1 stop6h 35m
Fri 12/114:30 pm -
2 stops6h 35m
Deal found 11/5$338
Sat 12/125:20 am -
2 stops8h 50m
Mon 12/1411:55 am -
2 stops10h 10m
Deal found 11/8$343

Find flight deals from Des Moines to St. Louis

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$260
(CheapOair)

One-way from

$152
(Southwest)

Popular in

February

Cheapest in

May

Average price

$381

Good round-trip deal

$462 or less
Provider with most accurate pricing for Des Moines-Lambert-St Louis flight deals.
Provider most trusted by Cheapflights users for Des Moines-Lambert-St Louis flights.
From Des Moines to Lambert-St Louis
One-way flight from Des Moines to Lambert-St Louis
Highest demand for flights based on searches. 4% potential increase in price ($20 potential increase over avg. RT price).
Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
Average for round-trip flights in November 2026
Price to beat on a round-trip flight from Des Moines to Lambert-St Louis.

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Des Moines to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Sat 12/5

5:20 am-11:40 am

1 stop6h 20m

Lambert-St Louis

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$152
Quickest round-trip

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 2/17

3:00 pm-9:00 pm

1 stop6h 00m

Lambert-St Louis

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$152

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 12/4

4:53 pm-11:26 pm

1 stop6h 33m

Lambert-St Louis

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$177

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 12/25

3:25 pm-10:00 pm

1 stop6h 35m

Lambert-St Louis

Sat 1/16

6:45 am-2:40 pm

1 stop7h 55m

$276

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 1/8

8:00 am-6:05 pm

2 stops10h 05m

Lambert-St Louis

Sat 1/9

10:45 am-8:20 pm

2 stops9h 35m

$281

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Tue 12/8

6:00 am-11:00 am

1 stop5h 00m

Lambert-St Louis

Thu 12/10

4:40 pm-10:05 pm

1 stop5h 25m

$318

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Wed 12/9

6:00 am-3:35 pm

2 stops9h 35m

Lambert-St Louis

Thu 12/10

4:40 pm-10:05 pm

1 stop5h 25m

$323

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Sat 12/5

12:59 pm-10:57 am

3 stops45h 58m

Lambert-St Louis

Wed 12/31

12:00 am-12:00 am

Nonstop0h 00m

$347

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 12/11

4:25 pm-12:35 am

2 stops8h 10m

Lambert-St Louis

Sun 12/13

9:35 am-6:35 pm

1 stop9h 00m

$376

Des MoinesSt. Louis

DSM Des Moines - STL Lambert-St Louis

DSMSTL

Des Moines

Fri 12/4

6:00 am-1:50 pm

2 stops7h 50m

Lambert-St Louis

Fri 12/11

4:30 pm-11:05 pm

2 stops6h 35m

$395

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/7

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to St. Louis in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Des Moines with our price prediction graph.
Estimated round-trip price

Reviews of airlines servicing St. Louis

See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to St. Louis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Food

7.2

Comfort

7.8

Entertainment

7.8

Overall

7.8

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Ellen,Oct 2026

GRR - ATL

The flight was delayed more then 30 minutes after I hurried and stressed to get to my connecting gate in Atlanta.

Related info for your journey

  • How popular is this Des Moines to St. Louis flight route?

  • How long is the flight from Des Moines to St. Louis?

    A quick flight from Des Moines to St. Louis can take about 6h 35m. Southwest provides one of the quickest options available for as low as $276. Airlines will cover a distance of 259 mi.

  • What are the cheapest airlines flying from Des Moines to St. Louis round-trip?

    Cheapflights users have booked flights from Des Moines to St. Louis round-trip from $158. Other airlines that can offer you cheap pricing are Delta, from $180, and United Airlines, from $244. Users have found that American Airlines is 60% cheaper than the other options available to this destination.

  • What are the cheapest flights from Des Moines to St. Louis?

    While on average a flight from Des Moines to St. Louis is generally $494, our data shows the cheapest flight currently is $414. When looking at the most popular route, (Des Moines - Lambert-St Louis), you can expect to pay $318 for that flight.

  • Can I find deals for flights from Des Moines to St. Louis that include hotel bookings?

    Yes. In addition to deals on Des Moines to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to St. Louis.

  • Can I find deals for business class flights from Des Moines to St. Louis?

    Yes. Cheapflights offers flight deals from Des Moines to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Fairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Edwardsville
Glencoe

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Des Moines to St. Louis

AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$158Average$398FlexibilityNo cancel feeOn-time71%
DeltaCheapest$180Average$354FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$244Average$381FlexibilityNo cancel feeOn-time69%

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