$367+ Cheap flights from Santa Fe to Des Moines (SAF - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/17. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Santa Fe to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to Des Moines
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Best
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Cheapest flights from Santa Fe to Des MoinesExplore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:55 pm -
1 stop4h 47m
Sat 11/211:27 pm -
1 stop4h 45m
Deal found 11/2![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:55 pm -
1 stop4h 47m
Sat 11/285:30 am -
1 stop5h 15m
Deal found 10/28![United Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:55 pm -
1 stop4h 47m
Thu 11/191:27 pm -
1 stop4h 43m
Deal found 10/30![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1712:21 pm -
2 stops10h 57m
Sat 11/215:00 am -
1 stop7h 30m
Deal found 11/2![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:21 pm -
2 stops11h 05m
Thu 11/197:11 am -
2 stops12h 14m
Deal found 10/30![American Airlines logo]()
$1,038
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:16 pm -
2 stops11h 03m
Sat 11/285:00 am -
2 stops12h 37m
Deal found 10/28![American Airlines logo]()
$1,184
Best flights from Santa Fe to Des MoinesDiscover carefully curated flight deals from Santa Fe to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Santa Fe to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:55 pm -
1 stop4h 47m
Sat 11/211:27 pm -
1 stop4h 45m
Deal found 11/2![United Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:55 pm -
1 stop4h 47m
Sat 11/285:30 am -
1 stop5h 15m
Deal found 10/28![United Airlines logo]()
$391
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/201:24 pm -
1 stop6h 14m
Sat 1/231:42 pm -
1 stop4h 29m
Deal found 10/31![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:24 pm -
1 stop6h 14m
Sat 1/95:07 pm -
1 stop4h 26m
Deal found 10/28![United Airlines logo]()
$437
Last-minute flights from Santa Fe to Des MoinesDiscover last-minute flight deals from Santa Fe to Des Moines. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to Des Moines. Data last updated November 2, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:55 pm -
1 stop4h 47m
Thu 11/191:27 pm -
1 stop4h 43m
Deal found 10/30![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:21 pm -
2 stops11h 05m
Thu 11/197:11 am -
2 stops12h 14m
Deal found 10/30![American Airlines logo]()
$1,038
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:55 pm -
1 stop4h 47m
Sat 11/211:27 pm -
1 stop4h 45m
Deal found 11/2![United Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1712:21 pm -
2 stops10h 57m
Sat 11/215:00 am -
1 stop7h 30m
Deal found 11/2![American Airlines logo]()
$630
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/225:55 pm -
1 stop4h 47m
Sat 11/285:30 am -
1 stop5h 15m
Deal found 10/28![United Airlines logo]()
$391
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2212:16 pm -
2 stops11h 03m
Sat 11/285:00 am -
2 stops12h 37m
Deal found 10/28![American Airlines logo]()
$1,184
Find flight deals from Santa Fe to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | eDreams 2 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $367 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Tue 11/17
5:55 pm-11:42 pm
1 stop4h 47m
Des Moines
Sat 11/21
1:27 pm-5:12 pm
1 stop4h 45m
$367
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Sun 11/22
5:55 pm-11:42 pm
1 stop4h 47m
Des Moines
Sat 11/28
5:30 am-9:45 am
1 stop5h 15m
$391
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Wed 1/20
1:24 pm-8:38 pm
1 stop6h 14m
Des Moines
Sat 1/23
1:42 pm-5:11 pm
1 stop4h 29m
$437
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Wed 1/6
1:24 pm-8:38 pm
1 stop6h 14m
Des Moines
Sat 1/9
5:07 pm-8:33 pm
1 stop4h 26m
$437
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Fe-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santa Fe-Des Moines flight deals on Cheapflights vs. eDreams 90-95% of the time. Price accuracy is based on data collected from Santa Fe-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Fe-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Fe to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Fe with our price prediction graph.
SAF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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