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Des Moines

$355+ Cheap flights from Santa Fe to Des Moines (SAF - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
May 30 — Jun 61
Sat 5/30
Sat 6/6
1 adult, Economy
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Cheap flight deals from Santa Fe to Des Moines

Cheapest flights from Santa Fe to Des Moines
Explore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.

This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:49 pm
SAF
-
DSM
1 stop4h 55m
United Airlines
Tue 5/195:30 am
DSM
-
SAF
1 stop4h 54m
United Airlines
Deal found 4/29$355
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1611:56 am
SAF
-
DSM
2 stops11h 03m
American Airlines
Tue 5/195:00 am
DSM
-
SAF
1 stop6h 07m
American Airlines
Deal found 4/29$440
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:51 am
SAF
-
DSM
1 stop5h 14m
American Airlines
Sat 8/12:26 pm
DSM
-
SAF
1 stop5h 30m
American Airlines
Deal found 4/28$508
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:19 pm
SAF
-
DSM
1 stop5h 57m
United Airlines
Thu 5/75:17 pm
DSM
-
SAF
1 stop4h 11m
United Airlines
Deal found 4/27$818
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:56 am
SAF
-
DSM
2 stops11h 03m
American Airlines
Thu 5/75:00 am
DSM
-
SAF
1 stop6h 07m
American Airlines
Deal found 4/27$828

Find flight deals from Santa Fe to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.

Round-trip from

$355
(United Airlines)
From Santa Fe to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Sat 5/16

5:49 pm-11:44 pm

1 stop4h 55m

Des Moines

Tue 5/19

5:30 am-9:24 am

1 stop4h 54m

$355

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Sat 5/16

11:56 am-11:59 pm

2 stops11h 03m

Des Moines

Tue 5/19

5:00 am-10:07 am

1 stop6h 07m

$440

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Thu 7/30

6:51 am-1:05 pm

1 stop5h 14m

Des Moines

Sat 8/1

2:26 pm-6:56 pm

1 stop5h 30m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Sorted by cheapest first

Best time to book a flight from Santa Fe to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Des Moines?

    A quick flight from Santa Fe to Des Moines can take about 4h 55m. United Airlines provides one of the quickest options available for as low as $355. Santa Fe and Des Moines are separated by a distance of 785 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Santa Fe to Des Moines that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Des Moines.

  • Can I find deals for business class flights from Santa Fe to Des Moines?

    Yes. Cheapflights offers flight deals from Santa Fe to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny

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