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Des Moines

$344+ Cheap flights from Santa Fe to Des Moines (SAF - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Santa Fe to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$274
(United Airlines)
Provider with most accurate pricing for Santa Fe-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Santa Fe-Des Moines flights.
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From Santa Fe to Des Moines
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Find flight deals from Santa Fe to Des Moines

Cheapest flights from Santa Fe to Des Moines
Explore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 pmSAF - DSM
1 stop4h 44mUnited Airlines
Tue 11/255:45 amDSM - SAF
1 stop4h 40mUnited Airlines
Deal found 11/6$344
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/219:58 amSAF - DSM
2 stops12h 43mAmerican Airlines
Tue 11/255:00 amDSM - SAF
2 stops10h 52mAmerican Airlines
Deal found 11/6$1,017

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.

Fly from

Santa Fe

Fly to

Des Moines

Route

Depart

Return

Price

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 11/21

6:00 pm-11:44 pm

1 stop4h 44m

Des Moines

Tue 11/25

5:45 am-9:25 am

1 stop4h 40m

$344

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Sat 2/21

6:00 pm-11:43 pm

1 stop4h 43m

Des Moines

Wed 2/25

1:32 pm-9:24 am

1 stop20h 52m

$432

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 11/21

9:58 am-11:41 pm

2 stops12h 43m

Des Moines

Tue 11/25

5:00 am-2:52 pm

2 stops10h 52m

$1,017

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

  • Most accurate provider: When it comes to deals on Santa Fe-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Fe-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Fe-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santa Fe-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Fe-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santa Fe to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santa Fe to Des Moines

What is the cheapest month to book a flight from Santa Fe to Des Moines?

Currently, October is the cheapest month in which you can book a flight from Santa Fe to Des Moines (average of $238). Flying from Santa Fe to Des Moines in February is currently the most expensive (average of $564). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Des Moines?

    A quick flight from Santa Fe to Des Moines can take about 4h 44m. United Airlines provides one of the quickest options available for as low as $344. Santa Fe and Des Moines are separated by a distance of 785 mi.

  • Can I find deals for flights from Santa Fe to Des Moines that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Des Moines.

  • Can I find deals for business class flights from Santa Fe to Des Moines?

    Yes. Cheapflights offers flight deals from Santa Fe to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santa Fe to Des Moines?

    Currently, October is the cheapest month in which you can book a flight from Santa Fe to Des Moines (average of $238). Flying from Santa Fe to Des Moines in February is currently the most expensive (average of $564). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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