$282+ Cheap flights from Santa Fe to Des Moines (SAF - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Fe to Des Moines
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Best
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One-way
Cheapest flights from Santa Fe to Des MoinesExplore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:11 pm -
1 stop6h 56m
Wed 10/214:12 pm -
1 stop6h 43m
Deal found 9/15![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:20 pm -
1 stop4h 16m
Wed 11/115:30 am -
1 stop4h 42m
Deal found 9/16![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 pm -
1 stop4h 48m
Wed 10/216:00 am -
2 stops28h 41m
Deal found 9/15![United Airlines logo]()
$577
Best flights from Santa Fe to Des MoinesDiscover carefully curated flight deals from Santa Fe to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Santa Fe to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:11 pm -
1 stop6h 56m
Wed 10/214:12 pm -
1 stop6h 43m
Deal found 9/15![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:26 pm -
1 stop6h 10m
Wed 11/115:30 am -
1 stop4h 42m
Deal found 9/12![United Airlines logo]()
$417
Last-minute flights from Santa Fe to Des MoinesDiscover last-minute flight deals from Santa Fe to Des Moines. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Fe to Des Moines. Data last updated September 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:11 pm -
1 stop6h 56m
Wed 10/214:12 pm -
1 stop6h 43m
Deal found 9/15![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 pm -
1 stop4h 48m
Wed 10/216:00 am -
2 stops28h 41m
Deal found 9/15![United Airlines logo]()
$577
One-way flights from Santa Fe to Des MoinesSearch for one-way flight options from Santa Fe to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Santa Fe to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:21 pm -
1 stop4h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$282
Find flight deals from Santa Fe to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Round-trip from | $337 (American Airlines) |
|---|---|
One-way from | $282 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Sun 11/8
5:21 pm-11:05 pm
1 stop4h 44m
Des Moines
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$282
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Thu 10/15
3:11 pm-11:07 pm
1 stop6h 56m
Des Moines
Wed 10/21
4:12 pm-9:55 pm
1 stop6h 43m
$337
Santa FeDes Moines
SAF Santa Fe - DSM Des Moines
SAFDSM
Santa Fe
Sat 11/7
1:26 pm-8:36 pm
1 stop6h 10m
Des Moines
Wed 11/11
5:30 am-9:12 am
1 stop4h 42m
$417
Sorted by cheapest first
Best time to book a flight from Santa Fe to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Fe with our price prediction graph.
SAF-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Santa Fe to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
West Des Moines
Boone
Norwalk
Ankeny
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