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Des Moines

$304+ Cheap flights from Santa Fe to Des Moines (SAF - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
SAF — DSM
Jul 15 — Jul 221
Wed 7/15
Wed 7/22
1 adult, Economy
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Cheap flight deals from Santa Fe to Des Moines

Cheapest flights from Santa Fe to Des Moines
Explore the most affordable flight options available from Santa Fe to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.

This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:53 pm
SAF
-
DSM
1 stop5h 37m
American Airlines
Sat 8/151:55 pm
DSM
-
SAF
1 stop8h 34m
American Airlines
Deal found 6/15$304
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/307:30 am
SAF
-
DSM
1 stop7h 33m
American Airlines
Tue 7/74:48 pm
DSM
-
SAF
1 stop6h 16m
American Airlines
Deal found 6/15$319
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:01 pm
SAF
-
DSM
1 stop4h 38m
United Airlines
Sat 10/316:00 am
DSM
-
SAF
1 stop4h 32m
United Airlines
Deal found 6/11$384
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:13 pm
SAF
-
DSM
1 stop5h 45m
American Airlines
Tue 6/234:48 pm
DSM
-
SAF
1 stop6h 04m
American Airlines
Deal found 6/12$394
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:13 pm
SAF
-
DSM
1 stop5h 45m
American Airlines
Tue 7/71:35 pm
DSM
-
SAF
1 stop8h 33m
American Airlines
Deal found 6/15$415
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/134:53 pm
SAF
-
DSM
1 stop5h 37m
American Airlines
Sun 8/166:34 am
DSM
-
SAF
1 stop6h 24m
American Airlines
Deal found 6/15$509
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:13 pm
SAF
-
DSM
1 stop5h 45m
American Airlines
Mon 7/61:35 pm
DSM
-
SAF
1 stop8h 32m
American Airlines
Deal found 6/15$524
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:30 am
SAF
-
DSM
1 stop4h 49m
United Airlines
Sat 8/225:21 pm
DSM
-
SAF
1 stop4h 15m
United Airlines
Deal found 6/14$549
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:22 pm
SAF
-
DSM
1 stop6h 08m
United Airlines
Tue 7/76:20 am
DSM
-
SAF
2 stops28h 24m
United Airlines
Deal found 6/15$568

Find flight deals from Santa Fe to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Santa Fe (SAF) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.

Round-trip from

$304
(American Airlines)
From Santa Fe to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santa Fe to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Santa Fe to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Thu 8/13

4:53 pm-11:30 pm

1 stop5h 37m

Des Moines

Sat 8/15

1:55 pm-9:29 pm

1 stop8h 34m

$304

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Tue 6/30

7:30 am-4:03 pm

1 stop7h 33m

Des Moines

Tue 7/7

4:48 pm-10:04 pm

1 stop6h 16m

$319

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 10/28

6:01 pm-11:39 pm

1 stop4h 38m

Des Moines

Sat 10/31

6:00 am-9:32 am

1 stop4h 32m

$384

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 7/1

5:13 pm-11:58 pm

1 stop5h 45m

Des Moines

Tue 7/7

1:35 pm-9:08 pm

1 stop8h 33m

$415
Quickest round-trip

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Tue 8/18

10:30 am-4:19 pm

1 stop4h 49m

Des Moines

Sat 8/22

5:21 pm-8:36 pm

1 stop4h 15m

$549

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Tue 6/30

1:22 pm-8:30 pm

1 stop6h 08m

Des Moines

Tue 7/7

6:20 am-9:44 am

2 stops28h 24m

$568

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Wed 7/1

3:22 pm-11:44 pm

1 stop7h 22m

Des Moines

Tue 7/7

6:20 am-9:44 am

2 stops28h 24m

$568

Santa FeDes Moines

SAF - DSM

SAFDSM

Santa Fe

Fri 8/14

6:48 am-1:25 pm

1 stop5h 37m

Des Moines

Sun 8/16

6:34 am-11:58 am

1 stop6h 24m

$608

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/15

Sorted by cheapest first

Best time to book a flight from Santa Fe to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Santa Fe with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santa Fe to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santa Fe to Des Moines?

    A quick flight from Santa Fe to Des Moines can take about 4h 38m. American Airlines provides one of the quickest options available for as low as $384. Santa Fe and Des Moines are separated by a distance of 785 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Santa Fe to Des Moines that include hotel bookings?

    Yes. In addition to deals on Santa Fe to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santa Fe to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santa Fe to Des Moines.

  • Can I find deals for business class flights from Santa Fe to Des Moines?

    Yes. Cheapflights offers flight deals from Santa Fe to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Clive
Boone
West Des Moines
Ankeny

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