$337+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santa Fe with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Santa Fe
Cheapest
Best
Last-minute
Cheapest flights from Des Moines to Santa FeExplore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:05 am -
1 stop7h 28m
Sun 12/65:21 pm -
1 stop4h 44m
Deal found 9/26![American Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:06 am -
1 stop7h 20m
Wed 10/145:26 pm -
1 stop4h 41m
Deal found 9/24![American Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:31 pm -
1 stop7h 25m
Sat 11/145:21 pm -
1 stop5h 09m
Deal found 9/24![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
1 stop4h 42m
Sat 11/145:55 pm -
1 stop4h 47m
Deal found 9/27![United Airlines logo]()
$437
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:00 am -
1 stop8h 15m
Mon 12/285:46 pm -
1 stop5h 13m
Deal found 9/24![United Airlines logo]()
$586
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am -
1 stop4h 36m
Sun 10/46:00 pm -
1 stop4h 48m
Deal found 9/23![United Airlines logo]()
$588
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 am -
1 stop7h 33m
Sun 11/85:21 pm -
1 stop4h 44m
Deal found 9/26![American Airlines logo]()
$610
Best flights from Des Moines to Santa FeDiscover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:06 am -
1 stop7h 20m
Wed 10/145:26 pm -
1 stop4h 41m
Deal found 9/24![American Airlines logo]()
$367
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
1 stop4h 42m
Sat 11/145:55 pm -
1 stop4h 47m
Deal found 9/26![United Airlines logo]()
$437
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:23 am -
2 stops13h 21m
Sat 11/145:21 pm -
1 stop5h 09m
Deal found 9/24![American Airlines logo]()
$519
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:29 am -
2 stops11h 09m
Sat 10/175:26 pm -
1 stop4h 41m
Deal found 9/27![American Airlines logo]()
$525
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:00 am -
1 stop8h 15m
Mon 12/285:46 pm -
1 stop5h 13m
Deal found 9/24![United Airlines logo]()
$586
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/237:29 am -
1 stop6h 30m
Thu 2/256:30 am -
1 stop7h 19m
Deal found 9/28![American Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:00 am -
1 stop7h 33m
Sun 11/85:21 pm -
1 stop4h 44m
Deal found 9/26![American Airlines logo]()
$610
Last-minute flights from Des Moines to Santa FeDiscover last-minute flight deals from Des Moines to Santa Fe. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santa Fe. Data last updated September 29, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am -
1 stop4h 36m
Sun 10/46:00 pm -
1 stop4h 48m
Deal found 9/23![United Airlines logo]()
$588
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:41 am -
2 stops11h 07m
Sun 10/44:38 pm -
1 stop5h 34m
Deal found 9/23![American Airlines logo]()
$802
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:06 am -
1 stop7h 20m
Wed 10/145:26 pm -
1 stop4h 41m
Deal found 9/24![American Airlines logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:14 am -
2 stops12h 24m
Sat 10/1711:56 am -
2 stops10h 11m
Deal found 9/27![American Airlines logo]()
$771
Find flight deals from Des Moines to Santa Fe
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $337 (American Airlines) |
Popular in | December |
Cheapest in | October |
Average price | $394 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Sat 10/10
5:06 am-11:26 am
1 stop7h 20m
Santa Fe
Wed 10/14
5:26 pm-11:07 pm
1 stop4h 41m
$367
Quickest round-trip
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Tue 11/10
5:30 am-9:12 am
1 stop4h 42m
Santa Fe
Sat 11/14
5:55 pm-11:42 pm
1 stop4h 47m
$437
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Wed 11/11
7:23 am-7:44 pm
2 stops13h 21m
Santa Fe
Sat 11/14
5:21 pm-11:30 pm
1 stop5h 09m
$519
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Tue 10/13
7:29 am-5:38 pm
2 stops11h 09m
Santa Fe
Sat 10/17
5:26 pm-11:07 pm
1 stop4h 41m
$525
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Tue 2/23
7:29 am-12:59 pm
1 stop6h 30m
Santa Fe
Thu 2/25
6:30 am-2:49 pm
1 stop7h 19m
$565
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Thu 12/24
5:00 am-12:15 pm
1 stop8h 15m
Santa Fe
Mon 12/28
5:46 pm-11:59 pm
1 stop5h 13m
$586
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Thu 11/5
5:00 am-11:33 am
1 stop7h 33m
Santa Fe
Sun 11/8
5:21 pm-11:05 pm
1 stop4h 44m
$610
Sorted by cheapest first
Compare providers for flights from Des Moines to Santa Fe
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santa Fe
Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
DSM-SAF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Fe
Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated September 29, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Crew
8.1
Boarding
7.7
Overall
7.4
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Comfort
7.3
Crew
8.1
Boarding
7.7
Overall
7.4
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Comfort
7.3
Crew
8.1
Boarding
7.7
Overall
7.4
Food
6.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santa Fe?
Book flights to Santa Fe if you plan to visit one of these locationsSanta Rosa
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Des Moines and Santa Fe flights
Browse other Des Moines and Santa Fe flight options. Last updated on September 29, 2026.
Other flights from Des Moines
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Top 2 airlines flying from Des Moines to Santa Fe
Discover the top 2 airlines that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$488 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$302 | Average$429 | FlexibilityNo cancel fee | On-time69% |