How long is the flight from Des Moines to Santa Fe?

Airlines like American Airlines and United Airlines fly from Des Moines to Santa Fe in about 5h 17m. The time it takes to get you to your destination can typically vary by up to 01m. There are 785 mi between Des Moines and Santa Fe. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Des Moines to Santa Fe round-trip?

American Airlines, at $299, was found to be the cheapest airline from Des Moines to Santa Fe. An alternate airline flying to your destination would be United Airlines. American Airlines is 33% cheaper than the average price of flights available within the next 90 days to this destination.

In terms of precipitation, rainfall in Santa Fe ranges from 0.5 - 2.6 inches per month. August is typically the wettest month, when rainfall can reach 2.6 in. February is typically the driest time to visit Santa Fe when rainfall is around 0.5 in.

If weather is an important factor for your trip to Santa Fe, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

What is the cheapest time of day to fly from DSM to SAF?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Santa Fe as you normally would.

Most accurate provider : When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santa Fe?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

Can I find deals for business class flights from Des Moines to Santa Fe?

Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$377+ Cheap Flights from Des Moines to Santa Fe

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Cheap flight deals from Des Moines to Santa Fe

Cheapest

Best

Last-minute

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.

Thu 11/265:23 am -

1 stop5h 18m

Mon 11/305:39 pm -

1 stop4h 39m

Deal found 11/10

$377

Sat 12/55:15 pm -

1 stop4h 44m

Tue 12/87:00 am -

1 stop4h 28m

Deal found 11/7

$447

Thu 12/35:15 pm -

1 stop4h 44m

Sun 12/67:00 am -

1 stop4h 21m

Deal found 11/8

$462

Tue 12/295:30 am -

1 stop5h 17m

Sun 1/35:46 pm -

1 stop5h 13m

Deal found 11/7

$468

Thu 12/245:30 am -

1 stop5h 17m

Mon 12/285:46 pm -

1 stop5h 13m

Deal found 11/9

$492

Thu 11/191:27 pm -

1 stop4h 43m

Sun 11/225:55 pm -

1 stop4h 47m

Deal found 11/8

$507

Wed 11/115:30 am -

1 stop4h 42m

Sat 11/147:00 am -

1 stop4h 31m

Deal found 11/10

$567

Tue 12/225:30 am -

1 stop5h 17m

Tue 12/295:46 pm -

2 stops28h 31m

Deal found 11/9

$638

Sat 12/121:15 pm -

2 stops24h 35m

Wed 12/1610:45 am -

1 stop4h 28m

Deal found 11/10

$642

Best flights from Des Moines to Santa Fe
Discover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.

Thu 11/265:23 am -

1 stop5h 18m

Mon 11/305:39 pm -

1 stop4h 39m

Deal found 11/10

$377

Tue 12/225:30 am -

1 stop5h 17m

Tue 12/295:46 pm -

1 stop5h 13m

Deal found 11/9

$447

Sat 12/125:15 pm -

1 stop4h 44m

Wed 12/163:20 pm -

1 stop4h 13m

Deal found 11/10

$447

Sat 12/55:15 pm -

1 stop4h 44m

Tue 12/87:00 am -

1 stop4h 28m

Deal found 11/7

$447

Thu 12/245:30 am -

1 stop5h 17m

Mon 12/285:46 pm -

1 stop5h 13m

Deal found 11/10

$492

Thu 11/191:27 pm -

1 stop4h 43m

Sun 11/225:55 pm -

1 stop4h 47m

Deal found 11/8

$507

Last-minute flights from Des Moines to Santa Fe
Discover last-minute flight deals from Des Moines to Santa Fe. Data last updated November 11, 2026 and is based on user searches.

Wed 11/115:30 am -

1 stop4h 42m

Sat 11/147:00 am -

1 stop4h 31m

Deal found 11/10

$567

Thu 11/191:27 pm -

1 stop4h 43m

Sun 11/225:55 pm -

1 stop4h 47m

Deal found 11/8

$507

Thu 11/265:23 am -

1 stop5h 18m

Mon 11/305:39 pm -

1 stop4h 39m

Deal found 11/10

$377

Thu 12/35:15 pm -

1 stop4h 44m

Sun 12/67:00 am -

1 stop4h 21m

Deal found 11/8

$462

Sat 12/55:15 pm -

1 stop4h 44m

Tue 12/87:00 am -

1 stop4h 28m

Deal found 11/7

$447

Sat 12/121:15 pm -

2 stops24h 35m

Wed 12/1610:45 am -

1 stop4h 28m

Deal found 11/10

$642

Tue 12/225:30 am -

1 stop5h 17m

Tue 12/295:46 pm -

2 stops28h 31m

Deal found 11/9

$638

Thu 12/245:30 am -

1 stop5h 17m

Mon 12/285:46 pm -

1 stop5h 13m

Deal found 11/9

$492

Tue 12/295:30 am -

1 stop5h 17m

Sun 1/35:46 pm -

1 stop5h 13m

Deal found 11/7

$468

Find flight deals from Des Moines to Santa Fe

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$377 (American Airlines)
Popular in	December
Cheapest in	October
Average price	$364

Provider with most accurate pricing for Des Moines-Santa Fe flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Santa Fe flights.

Search Deals

From Des Moines to Santa Fe

Search Deals

Highest demand for flights based on searches. 23% potential increase in price ($136 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 8% potential price decrease ($36 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in November 2026

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Thu 11/26

5:23 am-9:41 am

1 stop5h 18m

Santa Fe

Mon 11/30

5:39 pm-11:18 pm

1 stop4h 39m

$377

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Tue 12/22

5:30 am-9:47 am

1 stop5h 17m

Santa Fe

Tue 12/29

5:46 pm-11:59 pm

1 stop5h 13m

$447

Quickest round-trip

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Sat 12/12

5:15 pm-8:59 pm

1 stop4h 44m

Santa Fe

Wed 12/16

3:20 pm-8:33 pm

1 stop4h 13m

$447

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Sat 12/5

5:15 pm-8:59 pm

1 stop4h 44m

Santa Fe

Tue 12/8

7:00 am-12:28 pm

1 stop4h 28m

$447

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Thu 12/24

5:30 am-9:47 am

1 stop5h 17m

Santa Fe

Mon 12/28

5:46 pm-11:59 pm

1 stop5h 13m

$492

Des MoinesSanta Fe

DSM Des Moines - SAF Santa Fe

DSMSAF

Des Moines

Thu 11/19

1:27 pm-5:10 pm

1 stop4h 43m

Santa Fe

Sun 11/22

5:55 pm-11:42 pm

1 stop4h 47m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/10

Sorted by cheapest first

Compare providers for flights from Des Moines to Santa Fe

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in November.

Provider	Price Accuracy	Trust Score*
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
Expedia	Price Accuracy1 star	Trust Score*3 stars
eDreams	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.

DSM-SAF

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santa Fe

See what other customers who have flown with United Airlines and American Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

United Airlines

7.3

Good

10,471 reviews

Reviews

1 / 20

8.0

Excellent

Asha,Sep 2026

LGA - IAH

The flight was on time and boardi g was very organized and timely. Snacks are awful and having one little glass of juice was terrible. Fortunately, I had my water to keep me hydrated.

United Airlines

7.3

Good

10,471 reviews

United Airlines

7.3

Good

10,471 reviews

Reviews

1 / 20

8.0

Excellent

Asha,Sep 2026

LGA - IAH

The flight was on time and boardi g was very organized and timely. Snacks are awful and having one little glass of juice was terrible. Fortunately, I had my water to keep me hydrated.

American Airlines

7.0

Good

12,224 reviews

United Airlines

7.3

Good

10,471 reviews

Reviews

1 / 20

8.0

Excellent

Asha,Sep 2026

LGA - IAH

The flight was on time and boardi g was very organized and timely. Snacks are awful and having one little glass of juice was terrible. Fortunately, I had my water to keep me hydrated.

Related info for your journey

How long is the flight from Des Moines to Santa Fe?
Airlines like American Airlines and United Airlines fly from Des Moines to Santa Fe in about 5h 17m. The time it takes to get you to your destination can typically vary by up to 01m. There are 785 mi between Des Moines and Santa Fe. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Des Moines to Santa Fe round-trip?
American Airlines, at $299, was found to be the cheapest airline from Des Moines to Santa Fe. An alternate airline flying to your destination would be United Airlines. American Airlines is 33% cheaper than the average price of flights available within the next 90 days to this destination.
Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?
Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santa Fe?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.
Can I find deals for business class flights from Des Moines to Santa Fe?
Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Santa Rosa

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Complete your trip

Flights by cabin class

Other flight options

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Top 2 airlines flying from Des Moines to Santa Fe

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$299	Average$364	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$302	Average$429	FlexibilityNo cancel fee	On-time69%

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$377+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santa Fe with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa FeExplore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.

Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.

Best flights from Des Moines to Santa FeDiscover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.

Discover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.

Last-minute flights from Des Moines to Santa FeDiscover last-minute flight deals from Des Moines to Santa Fe. Data last updated November 11, 2026 and is based on user searches.

Discover last-minute flight deals from Des Moines to Santa Fe. Data last updated November 11, 2026 and is based on user searches.

Find flight deals from Des Moines to Santa Fe

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Compare providers for flights from Des Moines to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in November.

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.

Reviews of airlines servicing Santa Fe

See what other customers who have flown with United Airlines and American Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

How long is the flight from Des Moines to Santa Fe?

What are the cheapest airlines flying from Des Moines to Santa Fe round-trip?

Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

How can I find direct flights from Des Moines to Santa Fe?

Can I find deals for business class flights from Des Moines to Santa Fe?

Traveling to a place near Santa Fe?

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Alternative routes for Des Moines to Santa Fe

See prices for flight routes from nearby airports that may be better suited for you.

Complete your trip

Complete your trip to Santa Fe by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Des Moines to Santa Fe by cabin class

Find flights from Des Moines to Santa Fe, based on your preferred cabin class, be it economy, premium economy, business, or first class.

Des Moines and Santa Fe flights

Browse other Des Moines and Santa Fe flight options. Last updated on November 11, 2026.

Other flights from Des Moines

Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on November 11, 2026.

Popular flight searches

Check out other popular destinations found by fellow travelers in 2026

Other flights to Santa Fe

Explore flights to Santa Fe departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 11, 2026.

Top 2 airlines flying from Des Moines to Santa Fe

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Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 11, 2026.

Best flights from Des Moines to Santa Fe
Discover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 11, 2026.

Last-minute flights from Des Moines to Santa Fe
Discover last-minute flight deals from Des Moines to Santa Fe. Data last updated November 11, 2026 and is based on user searches.