$314+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Sep 9 — Sep 161
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santa Fe with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Santa Fe
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Best
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Cheapest flights from Des Moines to Santa FeExplore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:33 am -
1 stop6h 38m
Sat 9/510:30 am -
1 stop4h 49m
Deal found 8/7![United Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:45 am -
1 stop5h 01m
Sun 9/135:50 pm -
1 stop4h 43m
Deal found 8/8![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:13 pm -
1 stop6h 45m
Sun 8/236:48 am -
1 stop5h 37m
Deal found 8/7![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:13 am -
1 stop6h 33m
Tue 9/13:21 pm -
1 stop7h 23m
Deal found 8/5![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:45 am -
1 stop5h 01m
Wed 9/97:00 am -
1 stop4h 32m
Deal found 8/6![United Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:55 pm -
1 stop8h 34m
Sat 9/510:21 am -
2 stops13h 14m
Deal found 8/5![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
1 stop8h 28m
Tue 9/1512:35 pm -
2 stops10h 29m
Deal found 8/5![American Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:13 pm -
1 stop6h 45m
Mon 8/104:53 pm -
1 stop5h 32m
Deal found 8/6![American Airlines logo]()
$581
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:16 pm -
1 stop24h 55m
Mon 12/285:55 pm -
1 stop4h 52m
Deal found 8/7![United Airlines logo]()
$610
Best flights from Des Moines to Santa FeDiscover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from Des Moines to Santa Fe that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:55 pm -
1 stop8h 34m
Sat 9/56:48 am -
1 stop5h 37m
Deal found 8/9![American Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:33 am -
1 stop6h 38m
Sat 9/510:30 am -
1 stop4h 49m
Deal found 8/9![United Airlines logo]()
$314
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:13 am -
1 stop6h 33m
Tue 9/13:21 pm -
1 stop7h 23m
Deal found 8/5![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:45 am -
1 stop5h 01m
Wed 9/97:00 am -
1 stop4h 32m
Deal found 8/6![United Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
1 stop8h 28m
Tue 9/1512:35 pm -
2 stops10h 29m
Deal found 8/5![American Airlines logo]()
$531
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/245:16 pm -
1 stop24h 55m
Mon 12/285:55 pm -
1 stop4h 52m
Deal found 8/7![United Airlines logo]()
$610
Last-minute flights from Des Moines to Santa FeDiscover last-minute flight deals from Des Moines to Santa Fe. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santa Fe. Data last updated August 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:13 pm -
1 stop6h 45m
Mon 8/104:53 pm -
1 stop5h 32m
Deal found 8/6![American Airlines logo]()
$581
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:13 pm -
1 stop6h 45m
Sun 8/236:48 am -
1 stop5h 37m
Deal found 8/7![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:13 am -
1 stop6h 33m
Tue 9/13:21 pm -
1 stop7h 23m
Deal found 8/5![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:33 am -
1 stop6h 38m
Sat 9/510:30 am -
1 stop4h 49m
Deal found 8/7![United Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/11:55 pm -
1 stop8h 34m
Sat 9/510:21 am -
2 stops13h 14m
Deal found 8/5![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:45 am -
1 stop5h 01m
Wed 9/97:00 am -
1 stop4h 32m
Deal found 8/6![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:45 am -
1 stop5h 01m
Sun 9/135:50 pm -
1 stop4h 43m
Deal found 8/8![United Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:29 pm -
1 stop8h 28m
Tue 9/1512:35 pm -
2 stops10h 29m
Deal found 8/5![American Airlines logo]()
$531
Find flight deals from Des Moines to Santa Fe
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $314 (United Airlines) |
Popular in | December |
Cheapest in | August |
Average price | $304 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Tue 9/1
1:55 pm-9:29 pm
1 stop8h 34m
Santa Fe
Sat 9/5
6:48 am-1:25 pm
1 stop5h 37m
$314
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Tue 9/1
11:33 am-5:11 pm
1 stop6h 38m
Santa Fe
Sat 9/5
10:30 am-4:19 pm
1 stop4h 49m
$314
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Sat 8/29
9:13 am-2:46 pm
1 stop6h 33m
Santa Fe
Tue 9/1
3:21 pm-11:44 pm
1 stop7h 23m
$394
Quickest round-trip
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Thu 9/3
5:45 am-9:46 am
1 stop5h 01m
Santa Fe
Wed 9/9
7:00 am-12:32 pm
1 stop4h 32m
$418
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Fri 9/11
2:29 pm-9:57 pm
1 stop8h 28m
Santa Fe
Tue 9/15
12:35 pm-12:04 am
2 stops10h 29m
$531
Des MoinesSanta Fe
DSM Des Moines - SAF Santa Fe
DSMSAF
Des Moines
Thu 12/24
5:16 pm-5:11 pm
1 stop24h 55m
Santa Fe
Mon 12/28
5:55 pm-11:47 pm
1 stop4h 52m
$610
Sorted by cheapest first
Compare providers for flights from Des Moines to Santa Fe
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santa Fe
Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
DSM-SAF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Fe
Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated August 10, 2026.
See what other customers who have flown with United Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Boarding
7.7
Overall
7.4
Food
6.7
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
2.0
MediocreDawn,Aug 2026
ORD - DEN
Crew
8.1
Boarding
7.7
Overall
7.4
Food
6.7
Comfort
7.3
Entertainment
7.1
Reviews
1 / 20
2.0
MediocreDawn,Aug 2026
ORD - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Santa Fe by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Santa Fe, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Santa Fe flights
Browse other Des Moines and Santa Fe flight options. Last updated on August 10, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santa Fe
Explore flights to Santa Fe departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 10, 2026.
Top airline flying from Des Moines to Santa Fe
Discover the top airline that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$289 | Average$418 | FlexibilityNo cancel fee | On-time69% |