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$269+ Cheap flights from Des Moines to Santa Fe (DSM - SAF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAF
Jul 20 — Jul 271
Mon 7/20
Mon 7/27
1 adult, Economy
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Cheap flight deals from Des Moines to Santa Fe

Cheapest flights from Des Moines to Santa Fe
Explore the most affordable flight options available from Des Moines to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 20, 2026.

This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:48 pm
DSM
-
SAF
1 stop6h 16m
American Airlines
Mon 7/205:23 pm
SAF
-
DSM
1 stop5h 35m
American Airlines
Deal found 6/16$304
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:35 pm
DSM
-
SAF
1 stop8h 32m
American Airlines
Sun 7/56:51 am
SAF
-
DSM
1 stop5h 14m
American Airlines
Deal found 6/16$334
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:00 am
DSM
-
SAF
1 stop4h 32m
United Airlines
Tue 11/31:20 pm
SAF
-
DSM
1 stop6h 12m
United Airlines
Deal found 6/17$384
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/184:48 pm
DSM
-
SAF
1 stop6h 16m
American Airlines
Fri 7/245:23 pm
SAF
-
DSM
1 stop5h 36m
American Airlines
Deal found 6/19$407
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:45 am
DSM
-
SAF
1 stop5h 01m
United Airlines
Wed 9/210:30 am
SAF
-
DSM
1 stop4h 49m
United Airlines
Deal found 6/15$425
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:30 am
DSM
-
SAF
1 stop5h 08m
American Airlines
Sun 7/56:51 am
SAF
-
DSM
1 stop5h 14m
American Airlines
Deal found 6/19$430
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:17 pm
DSM
-
SAF
1 stop4h 24m
United Airlines
Sun 7/56:00 pm
SAF
-
DSM
1 stop4h 44m
United Airlines
Deal found 6/16$440
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:37 am
DSM
-
SAF
1 stop6h 36m
American Airlines
Tue 11/39:58 am
SAF
-
DSM
1 stop5h 43m
American Airlines
Deal found 6/17$457
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:02 pm
DSM
-
SAF
2 stops19h 44m
United Airlines
Tue 9/86:00 pm
SAF
-
DSM
1 stop4h 33m
United Airlines
Deal found 6/17$511
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:12 am
DSM
-
SAF
1 stop5h 29m
American Airlines
Sun 7/125:23 pm
SAF
-
DSM
1 stop5h 35m
American Airlines
Deal found 6/16$518
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:41 am
DSM
-
SAF
2 stops10h 15m
American Airlines
Fri 7/175:23 pm
SAF
-
DSM
1 stop5h 36m
American Airlines
Deal found 6/15$521

Find flight deals from Des Moines to Santa Fe

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Fe (SAF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$304
(American Airlines)

One-way from

$269
(American Airlines)

Popular in

December

Cheapest in

October

Average price

$488
Provider with most accurate pricing for Des Moines-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santa Fe flights.
Search Deals
From Des Moines to Santa Fe
Search Deals
One-way flight from Des Moines to Santa Fe
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 9/15

4:14 pm-9:37 pm

1 stop6h 23m

Santa Fe

Sat 9/19

4:38 pm-11:13 pm

1 stop5h 35m

$304
Quickest round-trip

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 9/5

5:21 pm-8:36 pm

1 stop4h 15m

Santa Fe

Tue 9/8

6:00 pm-11:33 pm

1 stop4h 33m

$304

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 7/11

1:34 pm-9:08 pm

1 stop8h 34m

Santa Fe

Fri 7/17

5:23 pm-11:59 pm

1 stop5h 36m

$304

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 7/18

4:48 pm-10:04 pm

1 stop6h 16m

Santa Fe

Fri 7/24

5:23 pm-11:59 pm

1 stop5h 36m

$407

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Sat 8/29

5:45 am-9:46 am

1 stop5h 01m

Santa Fe

Wed 9/2

10:30 am-4:19 pm

1 stop4h 49m

$425

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

5:30 am-9:38 am

1 stop5h 08m

Santa Fe

Sun 7/5

6:51 am-1:05 pm

1 stop5h 14m

$430

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Wed 7/1

5:17 pm-8:41 pm

1 stop4h 24m

Santa Fe

Sun 7/5

6:00 pm-11:44 pm

1 stop4h 44m

$440

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Thu 7/16

5:12 am-9:41 am

1 stop5h 29m

Santa Fe

Thu 7/16

5:23 pm-11:58 pm

1 stop5h 35m

$532
Cheapest one-way

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 7/14

6:20 am-5:12 pm

2 stops11h 52m

$443
Quickest one-way

Des MoinesSanta Fe

DSM - SAF

DSMSAF

Des Moines

Tue 6/23

9:41 am-4:43 pm

1 stop8h 02m

$461

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Sorted by cheapest first

Compare providers for flights from Des Moines to Santa Fe

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Fe in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santa Fe flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Fe flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Fe flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santa Fe flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Fe flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Fe

How much does it cost to fly round-trip from Des Moines to Santa Fe?

Reviews of airlines servicing Santa Fe

Get insights into the airlines that provide service to Santa Fe. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Fe. Reviews last updated June 20, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Santa Fe have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,865 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,865 reviews
United Airlines
7.4
Good
9,865 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,715 reviews
United Airlines
7.4
Good
9,865 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santa Fe?

    Airlines like American Airlines and United Airlines fly from Des Moines to Santa Fe in about 4h 15m. The time it takes to get you to your destination can typically vary by up to 2h 08m. There are 785 mi between Des Moines and Santa Fe. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Santa Fe round-trip?

    American Airlines, at $244, was found to be the cheapest airline from Des Moines to Santa Fe. An alternate airline flying to your destination would be United Airlines. American Airlines is 47% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Des Moines to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Fe.

  • Can I find deals for business class flights from Des Moines to Santa Fe?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 2 airlines flying from Des Moines to Santa Fe

Discover the top 2 airlines that operate flights from Des Moines to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$244Average$488FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$265Average$403FlexibilityNo cancel feeOn-time69%

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