$319+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
Oct 12 — Oct 191
Round-trip
1 adult, Economy
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Find cheap flights from Harrisburg to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Harrisburg to Des Moines
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Cheapest flights from Harrisburg to Des MoinesExplore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:54 pm -
1 stop4h 29m
Wed 10/146:00 am -
1 stop6h 27m
Deal found 9/9![United Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 am -
1 stop5h 01m
Sat 10/33:11 pm -
1 stop5h 50m
Deal found 9/9![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:15 am -
2 stops9h 09m
Tue 12/1511:27 am -
1 stop4h 31m
Deal found 9/10![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:54 pm -
1 stop6h 10m
Mon 9/281:09 pm -
1 stop7h 06m
Deal found 9/8![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:55 pm -
2 stops7h 28m
Mon 9/283:11 pm -
1 stop5h 39m
Deal found 9/10![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/247:55 pm -
1 stop5h 24m
Tue 12/11:58 pm -
2 stops8h 05m
Deal found 9/11![American Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:54 pm -
1 stop4h 34m
Sat 9/261:26 pm -
1 stop7h 24m
Deal found 9/9![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:39 pm -
1 stop4h 46m
Wed 12/91:15 pm -
1 stop6h 38m
Deal found 9/9![United Airlines logo]()
$399
Best flights from Harrisburg to Des MoinesDiscover carefully curated flight deals from Harrisburg to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
Discover carefully curated flight deals from Harrisburg to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 am -
1 stop5h 01m
Sat 10/33:11 pm -
1 stop5h 50m
Deal found 9/9![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:54 pm -
1 stop6h 10m
Wed 9/302:29 pm -
2 stops7h 42m
Deal found 9/8![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:15 am -
2 stops9h 09m
Tue 12/1511:27 am -
1 stop4h 31m
Deal found 9/10![United Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:39 pm -
1 stop4h 46m
Wed 12/91:15 pm -
1 stop6h 38m
Deal found 9/8![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:54 pm -
1 stop6h 41m
Tue 9/293:11 pm -
1 stop5h 39m
Deal found 9/10![United Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:30 am -
1 stop7h 04m
Mon 9/283:11 pm -
1 stop5h 39m
Deal found 9/9![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:55 pm -
2 stops7h 28m
Wed 9/303:11 pm -
1 stop5h 39m
Deal found 9/10![United Airlines logo]()
$479
Last-minute flights from Harrisburg to Des MoinesDiscover last-minute flight deals from Harrisburg to Des Moines. Data last updated September 12, 2026 and is based on user searches.
Discover last-minute flight deals from Harrisburg to Des Moines. Data last updated September 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:54 pm -
1 stop4h 34m
Sat 9/261:26 pm -
1 stop7h 24m
Deal found 9/9![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:30 am -
1 stop5h 01m
Sat 10/33:11 pm -
1 stop5h 50m
Deal found 9/9![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:54 pm -
1 stop6h 10m
Mon 9/281:09 pm -
1 stop7h 06m
Deal found 9/8![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:54 pm -
1 stop6h 41m
Wed 9/303:11 pm -
1 stop5h 39m
Deal found 9/8![United Airlines logo]()
$411
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:54 pm -
1 stop6h 10m
Wed 9/302:29 pm -
2 stops7h 42m
Deal found 9/8![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:55 pm -
2 stops7h 28m
Mon 9/283:11 pm -
1 stop5h 39m
Deal found 9/10![United Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:54 pm -
1 stop4h 29m
Wed 10/146:00 am -
1 stop6h 27m
Deal found 9/9![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:06 pm -
1 stop4h 37m
Tue 10/137:29 am -
1 stop6h 16m
Deal found 9/11![American Airlines logo]()
$408
One-way flights from Harrisburg to Des MoinesSearch for one-way flight options from Harrisburg to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
Search for one-way flight options from Harrisburg to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:45 am -
1 stop7h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:38 pm -
3 stops28h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$454
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:15 am -
2 stops7h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$472
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:54 pm -
1 stop4h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![United Airlines logo]()
$564
Find flight deals from Harrisburg to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (United Airlines) |
Popular in | April |
Cheapest in | September |
Average price | $308 |
Cheapflights Fare Finder
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Wed 9/23
6:30 am-10:31 am
1 stop5h 01m
Des Moines
Sat 10/3
3:11 pm-10:01 pm
1 stop5h 50m
$334
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Thu 11/26
6:15 am-2:24 pm
2 stops9h 09m
Des Moines
Tue 12/15
11:27 am-4:58 pm
1 stop4h 31m
$344
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Sat 12/5
5:39 pm-9:25 pm
1 stop4h 46m
Des Moines
Wed 12/9
1:15 pm-8:53 pm
1 stop6h 38m
$399
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Fri 9/25
6:54 pm-12:04 am
1 stop6h 10m
Des Moines
Wed 9/30
2:29 pm-11:11 pm
2 stops7h 42m
$422
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Sun 9/20
5:45 am-12:31 pm
1 stop7h 46m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$424
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Fri 9/25
5:54 pm-11:35 pm
1 stop6h 41m
Des Moines
Tue 9/29
3:11 pm-9:50 pm
1 stop5h 39m
$429
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Sun 9/20
3:38 pm-7:33 pm
3 stops28h 55m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$454
Quickest round-trip
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Sun 9/20
6:15 am-12:16 pm
2 stops7h 01m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$472
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Thu 9/24
6:30 am-12:34 pm
1 stop7h 04m
Des Moines
Mon 9/28
3:11 pm-9:50 pm
1 stop5h 39m
$474
HarrisburgDes Moines
MDT Harrisburg - DSM Des Moines
MDTDSM
Harrisburg
Sat 9/26
2:55 pm-9:23 pm
2 stops7h 28m
Des Moines
Wed 9/30
3:11 pm-9:50 pm
1 stop5h 39m
$479
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Harrisburg to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Harrisburg-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Harrisburg-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Harrisburg to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
MDT-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Harrisburg to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 12, 2026.
Peruse reviews from past customers who have flown with Delta,United Airlines, andAmerican Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Food
7.2
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 12, 2026.
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Find flights from Harrisburg to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Harrisburg and Des Moines flights
Browse other Harrisburg and Des Moines flight options. Last updated on September 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Harrisburg to Des Moines
Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$428 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$293 | Average$348 | FlexibilityNo cancel fee | On-time71% |