$319+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Harrisburg with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Harrisburg
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Cheapest flights from Des Moines to HarrisburgExplore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:01 pm -
1 stop7h 18m
Mon 10/128:09 pm -
1 stop5h 05m
Deal found 9/6![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:26 pm -
1 stop7h 35m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/6![United Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:45 am -
2 stops10h 07m
Sun 9/276:25 am -
1 stop5h 06m
Deal found 9/6![United Airlines logo]()
$359
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:56 pm -
1 stop4h 57m
Mon 9/216:54 pm -
1 stop6h 10m
Deal found 9/7![American Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:50 pm -
1 stop4h 08m
Sun 10/116:13 am -
1 stop4h 29m
Deal found 9/7![Delta logo]()
$384
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:11 pm -
1 stop5h 21m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/9![United Airlines logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop6h 27m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/6![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
2 stops6h 59m
Sat 10/172:55 pm -
2 stops7h 28m
Deal found 9/6![United Airlines logo]()
$422
Best flights from Des Moines to HarrisburgDiscover carefully curated flight deals from Des Moines to Harrisburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Des Moines to Harrisburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/141:51 pm -
1 stop7h 28m
Sun 1/178:16 pm -
1 stop5h 24m
Deal found 9/8![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:26 pm -
2 stops9h 03m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/6![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:50 pm -
1 stop4h 08m
Sun 10/116:13 am -
1 stop4h 29m
Deal found 9/7![Delta logo]()
$384
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
2 stops9h 28m
Wed 2/36:00 am -
2 stops9h 34m
Deal found 9/8![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop6h 27m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/7![United Airlines logo]()
$416
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:32 am -
1 stop4h 20m
Sat 9/266:30 am -
1 stop7h 02m
Deal found 9/7![United Airlines logo]()
$449
Last-minute flights from Des Moines to HarrisburgDiscover last-minute flight deals from Des Moines to Harrisburg. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Harrisburg. Data last updated September 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:56 pm -
1 stop4h 57m
Mon 9/216:54 pm -
1 stop6h 10m
Deal found 9/7![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:45 am -
2 stops10h 07m
Sun 9/276:25 am -
1 stop5h 06m
Deal found 9/6![United Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop6h 27m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/6![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:50 pm -
1 stop4h 08m
Sun 10/116:13 am -
1 stop4h 29m
Deal found 9/7![Delta logo]()
$384
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:11 pm -
1 stop5h 21m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/9![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:01 pm -
1 stop7h 18m
Mon 10/128:09 pm -
1 stop5h 05m
Deal found 9/6![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:26 pm -
1 stop7h 35m
Sun 10/116:25 am -
1 stop5h 05m
Deal found 9/6![United Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
2 stops6h 59m
Sat 10/172:55 pm -
2 stops7h 28m
Deal found 9/6![United Airlines logo]()
$422
One-way flights from Des Moines to HarrisburgSearch for one-way flight options from Des Moines to Harrisburg. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Des Moines to Harrisburg. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:09 pm -
1 stop7h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$424
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:24 am -
2 stops6h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:39 am -
3 stops21h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$519
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2011:29 am -
3 stops21h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$599
Find flight deals from Des Moines to Harrisburg
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
Popular in | March |
Cheapest in | October |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Thu 1/14
1:51 pm-10:19 pm
1 stop7h 28m
Harrisburg
Sun 1/17
8:16 pm-12:40 am
1 stop5h 24m
$319
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Sat 10/10
1:26 pm-11:29 pm
2 stops9h 03m
Harrisburg
Sun 10/11
6:25 am-10:30 am
1 stop5h 05m
$344
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Fri 10/9
5:50 pm-10:58 pm
1 stop4h 08m
Harrisburg
Sun 10/11
6:13 am-9:42 am
1 stop4h 29m
$384
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Sat 1/30
8:00 am-6:28 pm
2 stops9h 28m
Harrisburg
Wed 2/3
6:00 am-2:34 pm
2 stops9h 34m
$409
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Thu 10/8
6:00 am-1:27 pm
1 stop6h 27m
Harrisburg
Sun 10/11
6:25 am-10:30 am
1 stop5h 05m
$416
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Thu 9/17
1:09 pm-9:15 pm
1 stop7h 06m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$424
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Sun 9/20
10:35 am-6:13 pm
1 stop6h 38m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$424
Quickest round-trip
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Sun 9/20
6:24 am-1:39 pm
2 stops6h 15m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$439
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Tue 9/22
11:32 am-4:52 pm
1 stop4h 20m
Harrisburg
Sat 9/26
6:30 am-12:32 pm
1 stop7h 02m
$449
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Sun 9/20
11:29 am-10:13 am
3 stops21h 44m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$599
Sorted by cheapest first
Compare providers for flights from Des Moines to Harrisburg
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Harrisburg in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Harrisburg flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Harrisburg flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Harrisburg flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Harrisburg flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Harrisburg flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Harrisburg
Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
DSM-MDT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Harrisburg
What is the cheapest month to book a flight from Des Moines to Harrisburg?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $293). Flying from Des Moines to Harrisburg in March is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Harrisburg?
Airfare is below average for this route at the moment.
Des Moines to Harrisburg flights typically cost between $406 and $592 in October.The cheapest round-trip price found within the last 5 days was $319 on American Airlines (Oct 10-Oct 12).
Reviews of airlines servicing Harrisburg
Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated September 9, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Overall
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Harrisburg?
Book flights to Harrisburg if you plan to visit one of these locationsHershey
Mechanicsburg
Camp Hill
Carlisle
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Des Moines and Harrisburg flights
Browse other Des Moines and Harrisburg flight options. Last updated on September 9, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Harrisburg
Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$219 | Average$398 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$268 | Average$402 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$558 | FlexibilityNo cancel fee | On-timeN/A |