$245+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
Nov 27 — Dec 41
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Harrisburg with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Harrisburg
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Cheapest flights from Des Moines to HarrisburgExplore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2026.
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2026.
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:29 pm -
1 stop4h 37m
Wed 11/256:23 pm -
1 stop5h 12m
Deal found 10/25![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:36 am -
1 stop5h 01m
Sat 11/146:00 am -
1 stop4h 46m
Deal found 10/28![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:50 am -
1 stop6h 04m
Fri 11/276:30 am -
1 stop5h 02m
Deal found 10/25![United Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:00 am -
2 stops9h 36m
Sat 11/148:15 am -
1 stop5h 05m
Deal found 10/28![United Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop5h 15m
Thu 11/266:00 am -
1 stop4h 46m
Deal found 10/25![Delta logo]()
$432
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:30 am -
2 stops8h 12m
Tue 12/225:07 am -
1 stop4h 59m
Deal found 10/25![American Airlines logo]()
$433
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:05 am -
2 stops11h 31m
Thu 11/266:30 am -
1 stop5h 02m
Deal found 10/25![United Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop4h 32m
Sun 11/18:15 am -
2 stops8h 52m
Deal found 10/25![United Airlines logo]()
$449
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 am -
1 stop7h 02m
Sun 11/17:52 pm -
1 stop5h 34m
Deal found 10/26![American Airlines logo]()
$459
Best flights from Des Moines to HarrisburgDiscover carefully curated flight deals from Des Moines to Harrisburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2026.
Discover carefully curated flight deals from Des Moines to Harrisburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2026.
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/232:59 pm -
1 stop7h 51m
Thu 11/266:00 am -
1 stop4h 46m
Deal found 10/25![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/38:00 am -
1 stop4h 30m
Wed 2/105:40 pm -
1 stop6h 34m
Deal found 10/24![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/32:39 pm -
2 stops8h 20m
Wed 2/103:05 pm -
2 stops10h 21m
Deal found 10/24![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:36 am -
1 stop5h 01m
Sat 11/146:00 am -
1 stop4h 46m
Deal found 10/28![Delta logo]()
$369
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/206:15 am -
1 stop4h 47m
Tue 12/226:15 am -
1 stop4h 40m
Deal found 10/25![Delta logo]()
$389
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3011:22 am -
1 stop6h 49m
Wed 2/36:20 am -
1 stop5h 21m
Deal found 10/27![United Airlines logo]()
$439
Last-minute flights from Des Moines to HarrisburgDiscover last-minute flight deals from Des Moines to Harrisburg. Data last updated October 28, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Harrisburg. Data last updated October 28, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop4h 32m
Sun 11/18:15 am -
2 stops8h 52m
Deal found 10/25![United Airlines logo]()
$449
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:05 am -
1 stop7h 02m
Sun 11/17:52 pm -
1 stop5h 34m
Deal found 10/26![American Airlines logo]()
$459
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:36 am -
1 stop5h 01m
Sat 11/146:00 am -
1 stop4h 46m
Deal found 10/28![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:00 am -
2 stops9h 36m
Sat 11/148:15 am -
1 stop5h 05m
Deal found 10/28![United Airlines logo]()
$374
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:29 pm -
1 stop4h 37m
Thu 11/266:00 am -
1 stop4h 46m
Deal found 10/25![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:00 am -
2 stops11h 06m
Wed 11/256:23 pm -
1 stop5h 12m
Deal found 10/25![Delta logo]()
$488
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/239:50 am -
1 stop6h 04m
Fri 11/276:30 am -
1 stop5h 02m
Deal found 10/25![United Airlines logo]()
$370
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:05 am -
2 stops11h 31m
Thu 11/266:30 am -
1 stop5h 02m
Deal found 10/25![United Airlines logo]()
$444
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:30 am -
1 stop5h 15m
Thu 11/266:00 am -
1 stop4h 46m
Deal found 10/25![Delta logo]()
$432
One-way flights from Des Moines to HarrisburgSearch for one-way flight options from Des Moines to Harrisburg. Find affordable one-way fares based on user searches. Data last updated October 28, 2026.
Search for one-way flight options from Des Moines to Harrisburg. Find affordable one-way fares based on user searches. Data last updated October 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:05 pm -
1 stop19h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Allegiant Air logo]()
$245
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1511:38 am -
1 stop5h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$284
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:00 am -
2 stops9h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/305:30 am -
2 stops8h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1512:28 pm -
3 stops54h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Allegiant Air logo]()
$326
This KAYAK deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:13 am -
1 stop4h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Delta logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:39 am -
3 stops55h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Allegiant Air logo]()
$336
This KAYAK deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:25 am -
2 stops12h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![American Airlines logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/303:52 pm -
3 stops41h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Allegiant Air logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:12 pm -
3 stops26h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![United Airlines logo]()
$685
Find flight deals from Des Moines to Harrisburg
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (Delta) |
One-way from | $284 (Delta) |
Popular in | March |
Cheapest in | December |
Average price | $414 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 28, 2026.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Mon 1/4
5:23 pm-11:34 pm
1 stop5h 11m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$284
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Tue 12/15
11:38 am-5:45 pm
1 stop5h 07m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$284
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Wed 11/25
8:00 am-6:36 pm
2 stops9h 36m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$289
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Mon 1/4
5:00 am-2:00 pm
2 stops8h 00m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$289
Quickest round-trip
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Thu 11/12
6:13 am-11:29 am
1 stop4h 16m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$331
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Wed 12/16
11:39 am-7:57 pm
3 stops55h 18m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$336
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Mon 11/23
2:59 pm-11:50 pm
1 stop7h 51m
Harrisburg
Thu 11/26
6:00 am-9:46 am
1 stop4h 46m
$339
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Wed 2/3
8:00 am-1:30 pm
1 stop4h 30m
Harrisburg
Wed 2/10
5:40 pm-11:14 pm
1 stop6h 34m
$339
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Thu 11/12
9:25 am-10:46 pm
2 stops12h 21m
Harrisburg
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$347
Des MoinesHarrisburg
DSM Des Moines - MDT Harrisburg
DSMMDT
Des Moines
Wed 2/3
2:39 pm-11:59 pm
2 stops8h 20m
Harrisburg
Wed 2/10
3:05 pm-12:26 am
2 stops10h 21m
$349
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Harrisburg
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Harrisburg in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Harrisburg flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Harrisburg flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Harrisburg flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Harrisburg flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Harrisburg flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Harrisburg
Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
DSM-MDT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Harrisburg
What is the cheapest month to book a flight from Des Moines to Harrisburg?
Currently, December is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $357). Flying from Des Moines to Harrisburg in March is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Harrisburg?
Airfare is typical for this route at the moment.
Des Moines to Harrisburg flights typically cost between $338 and $409 in November.The cheapest round-trip price found within the last 5 days was $339 on Delta (Nov 21-Nov 25).
Reviews of airlines servicing Harrisburg
Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated October 28, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.8
Comfort
7.8
Entertainment
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Harrisburg?
Book flights to Harrisburg if you plan to visit one of these locationsHershey
Mechanicsburg
Camp Hill
Carlisle
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Des Moines and Harrisburg flights
Browse other Des Moines and Harrisburg flight options. Last updated on October 28, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Harrisburg
Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$268 | Average$587 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$274 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$349 | Average$484 | FlexibilityNo cancel fee | On-time69% |