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$246+ Cheap flights from Des Moines to Harrisburg (DSM - MDT)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MDT
May 28 — Jun 41
Thu 5/28
Thu 6/4
1 adult, Economy
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Cheap flight deals from Des Moines to Harrisburg

Cheapest flights from Des Moines to Harrisburg
Explore the most affordable flight options available from Des Moines to Harrisburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.

This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:50 pm
DSM
-
MDT
1 stop4h 37m
United Airlines
Sat 5/306:30 am
MDT
-
DSM
1 stop4h 57m
United Airlines
Deal found 4/26$329
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:00 am
DSM
-
MDT
1 stop5h 07m
American Airlines
Sat 5/306:00 am
MDT
-
DSM
2 stops8h 18m
American Airlines
Deal found 4/26$334
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:00 am
DSM
-
MDT
2 stops7h 50m
United Airlines
Sat 6/275:55 pm
MDT
-
DSM
1 stop4h 45m
United Airlines
Deal found 4/25$352
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:15 am
DSM
-
MDT
2 stops6h 34m
United Airlines
Sat 10/316:00 am
MDT
-
DSM
2 stops7h 30m
United Airlines
Deal found 4/25$360
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:05 am
DSM
-
MDT
1 stop4h 35m
American Airlines
Sun 9/132:04 pm
MDT
-
DSM
1 stop4h 35m
American Airlines
Deal found 4/23$388
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1211:30 am
DSM
-
MDT
1 stop7h 00m
United Airlines
Tue 12/155:31 pm
MDT
-
DSM
1 stop4h 46m
United Airlines
Deal found 4/27$389
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:00 am
DSM
-
MDT
2 stops7h 03m
United Airlines
Tue 9/156:30 am
MDT
-
DSM
1 stop4h 41m
United Airlines
Deal found 4/27$393
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:00 am
DSM
-
MDT
1 stop4h 49m
American Airlines
Tue 9/156:30 pm
MDT
-
DSM
1 stop5h 58m
American Airlines
Deal found 4/27$395
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:45 pm
DSM
-
MDT
1 stop4h 18m
Delta
Sun 5/106:20 am
MDT
-
DSM
1 stop4h 26m
Delta
Deal found 4/24$399

Find flight deals from Des Moines to Harrisburg

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Harrisburg (MDT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$329
(United Airlines)

One-way from

$246
(Kiwi.com)

Popular in

March

Cheapest in

October

Average price

$498
Provider with most accurate pricing for Des Moines-Harrisburg flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Harrisburg flights.
Search Deals
From Des Moines to Harrisburg
Search Deals
One-way flight from Des Moines to Harrisburg
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($162 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Harrisburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from Des Moines to Harrisburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 5/23

6:50 pm-12:27 am

1 stop4h 37m

Harrisburg

Sat 5/30

6:30 am-10:27 am

1 stop4h 57m

$329
Quickest round-trip

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 6/2

5:56 pm-10:50 pm

1 stop3h 54m

Harrisburg

Tue 6/9

6:22 pm-10:31 pm

1 stop5h 09m

$329

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 5/12

11:40 am-4:53 pm

1 stop4h 13m

Harrisburg

Sat 5/16

6:15 am-10:37 am

1 stop5h 22m

$419

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 5/9

9:06 am-9:19 pm

2 stops11h 13m

Harrisburg

Wed 5/13

6:30 am-10:37 am

1 stop5h 07m

$424

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Tue 6/2

1:48 pm-10:12 pm

2 stops7h 24m

Harrisburg

Tue 6/9

6:00 am-1:03 pm

2 stops8h 03m

$438

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 10/9

8:49 am-8:31 pm

1 stop10h 42m

Harrisburg

Sun 10/11

5:14 pm-10:27 am

1 stop18h 13m

$442

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 10/9

7:30 am-2:31 pm

1 stop6h 01m

Harrisburg

Mon 10/12

4:45 pm-8:11 pm

1 stop4h 26m

$447

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 9/11

6:00 am-2:03 pm

2 stops7h 03m

Harrisburg

Tue 9/15

6:15 am-2:05 pm

2 stops8h 50m

$478

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Fri 7/31

6:00 am-1:42 pm

1 stop6h 42m

Harrisburg

Sun 8/2

6:30 am-10:22 am

1 stop4h 52m

$483
Cheapest one-way

Des MoinesHarrisburg

DSM - MDT

DSMMDT

Des Moines

Sat 8/1

4:47 pm-11:53 pm

1 stop6h 06m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Harrisburg

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Harrisburg in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Harrisburg flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Harrisburg flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Harrisburg flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Harrisburg flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Harrisburg flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Harrisburg

Have a flexible travel schedule? Discover the best time to fly to Harrisburg from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Harrisburg

What is the cheapest month to book a flight from Des Moines to Harrisburg?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $248). Flying from Des Moines to Harrisburg in March is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Harrisburg?

Reviews of airlines servicing Harrisburg

Get insights into the airlines that provide service to Harrisburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Harrisburg. Reviews last updated April 28, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Harrisburg by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,467 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,467 reviews
Delta
7.9
Good
8,467 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,672 reviews
Delta
7.9
Good
8,467 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,677 reviews
Delta
7.9
Good
8,467 reviews

Food

7.2

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Harrisburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Harrisburg?

    Airlines like United Airlines and Delta fly from Des Moines to Harrisburg in about 3h 54m. The time it takes to get you to your destination can typically vary by up to 43m. Airlines will cover a distance of 886 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Harrisburg round-trip?

    Flying on United Airlines is currently your cheapest option to Harrisburg, with prices starting at $219. Additional round-trip tickets that might be worth considering are offered by American Airlines and Delta, with the lowest prices starting at $226 and $248, respectively. Users have found that United Airlines is 43% cheaper than the other options available to this destination.

  • Can I find deals for flights from Des Moines to Harrisburg that include hotel bookings?

    Yes. In addition to deals on Des Moines to Harrisburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Harrisburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Harrisburg.

  • Can I find deals for business class flights from Des Moines to Harrisburg?

    Yes. Cheapflights offers flight deals from Des Moines to Harrisburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Harrisburg?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Harrisburg (average of $248). Flying from Des Moines to Harrisburg in March is currently the most expensive (average of $646). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Harrisburg?

Book flights to Harrisburg if you plan to visit one of these locations
Mechanicsburg
Hershey
Camp Hill
Carlisle

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Harrisburg

Discover the top 3 airlines that operate flights from Des Moines to Harrisburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$219Average$366FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$226Average$381FlexibilityNo cancel feeOn-time71%
DeltaCheapest$248Average$503FlexibilityNo cancel feeOn-timeN/A

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