To save up to 56% on this flight, we recommend booking at least 30 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Des Moines to Chicago Midway Airport from $314 1-2 weeks out and tickets from $402 for flights departing within the next 72 hours.
September can be a great time to fly to Chicago Midway Airport from Des Moines with a flight ticket averaging about $269. Cheapflights users have found deals in the month of September for as cheap as $153. The most expensive prices can be found in the month of March.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Chicago Midway Airport as you normally would.