$269+ Cheap flights from Greensboro to Des Moines (GSO - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
GSO — DSM
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Greensboro to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greensboro to Des Moines
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Best
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One-way
Cheapest flights from Greensboro to Des MoinesExplore the most affordable flight options available from Greensboro to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Greensboro to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:31 pm -
1 stop6h 27m
Sat 10/172:01 pm -
1 stop7h 34m
Deal found 9/7![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
2 stops9h 15m
Sat 10/103:11 pm -
1 stop5h 02m
Deal found 9/3![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:20 am -
1 stop6h 44m
Mon 9/281:30 pm -
1 stop6h 40m
Deal found 9/4![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am -
1 stop4h 42m
Sun 10/256:54 pm -
1 stop4h 05m
Deal found 9/4![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop5h 01m
Sat 10/176:00 am -
2 stops7h 14m
Deal found 9/7![United Airlines logo]()
$344
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/192:08 pm -
1 stop6h 13m
Wed 9/231:30 pm -
1 stop6h 40m
Deal found 9/4![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
2 stops12h 28m
Wed 9/2311:32 am -
1 stop4h 42m
Deal found 9/4![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am -
1 stop5h 49m
Sun 12/276:42 pm -
1 stop4h 17m
Deal found 9/6![Delta logo]()
$359
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:37 am -
1 stop4h 43m
Mon 9/281:24 pm -
2 stops9h 33m
Deal found 9/4![United Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:10 am -
1 stop6h 39m
Sun 9/202:34 pm -
1 stop4h 11m
Deal found 9/2![Delta logo]()
$379
Best flights from Greensboro to Des MoinesDiscover carefully curated flight deals from Greensboro to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Greensboro to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am -
1 stop4h 42m
Sun 10/256:54 pm -
1 stop4h 05m
Deal found 9/4![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
2 stops7h 34m
Sat 10/176:00 am -
2 stops7h 14m
Deal found 9/7![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:49 pm -
1 stop5h 30m
Mon 11/303:25 pm -
1 stop6h 01m
Deal found 9/4![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
2 stops12h 28m
Wed 9/2311:32 am -
1 stop4h 42m
Deal found 9/4![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:10 am -
1 stop6h 39m
Sun 9/202:34 pm -
1 stop4h 11m
Deal found 9/2![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:37 am -
1 stop4h 43m
Mon 9/281:24 pm -
2 stops9h 33m
Deal found 9/4![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:11 pm -
2 stops8h 44m
Wed 11/111:27 pm -
2 stops9h 17m
Deal found 9/3![United Airlines logo]()
$409
Last-minute flights from Greensboro to Des MoinesDiscover last-minute flight deals from Greensboro to Des Moines. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Greensboro to Des Moines. Data last updated September 7, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:10 am -
1 stop6h 39m
Sun 9/202:34 pm -
1 stop4h 11m
Deal found 9/2![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/192:08 pm -
1 stop6h 13m
Wed 9/231:30 pm -
1 stop6h 40m
Deal found 9/4![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
2 stops12h 28m
Wed 9/2311:32 am -
1 stop4h 42m
Deal found 9/4![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:20 am -
1 stop6h 44m
Mon 9/281:30 pm -
1 stop6h 40m
Deal found 9/4![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:37 am -
1 stop4h 43m
Mon 9/281:24 pm -
2 stops9h 33m
Deal found 9/4![United Airlines logo]()
$364
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:00 am -
2 stops9h 15m
Sat 10/103:11 pm -
1 stop5h 02m
Deal found 9/3![United Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:31 pm -
1 stop6h 27m
Sat 10/172:01 pm -
1 stop7h 34m
Deal found 9/7![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 am -
1 stop5h 01m
Sat 10/176:00 am -
2 stops7h 14m
Deal found 9/7![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am -
1 stop4h 42m
Sun 10/256:54 pm -
1 stop4h 05m
Deal found 9/4![Delta logo]()
$339
One-way flights from Greensboro to Des MoinesSearch for one-way flight options from Greensboro to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Greensboro to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:33 pm -
1 stop5h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
2 stops9h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![United Airlines logo]()
$284
Find flight deals from Greensboro to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Greensboro (GSO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
One-way from | $269 (American Airlines) |
Popular in | January |
Cheapest in | April |
Average price | $353 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greensboro to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Greensboro to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Sun 10/4
7:33 pm-11:52 pm
1 stop5h 19m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$269
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Sun 10/4
6:00 am-2:15 pm
2 stops9h 15m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$284
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Fri 10/23
7:00 am-10:42 am
1 stop4h 42m
Des Moines
Sun 10/25
6:54 pm-11:59 pm
1 stop4h 05m
$339
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Wed 10/14
6:00 am-12:34 pm
2 stops7h 34m
Des Moines
Sat 10/17
6:00 am-2:14 pm
2 stops7h 14m
$349
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Sat 9/19
6:00 am-5:28 pm
2 stops12h 28m
Des Moines
Wed 9/23
11:32 am-5:14 pm
1 stop4h 42m
$354
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Wed 9/23
10:37 am-2:20 pm
1 stop4h 43m
Des Moines
Mon 9/28
1:24 pm-11:57 pm
2 stops9h 33m
$364
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Wed 11/25
7:49 pm-12:19 am
1 stop5h 30m
Des Moines
Mon 11/30
3:25 pm-10:26 pm
1 stop6h 01m
$379
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Fri 9/18
8:10 am-1:49 pm
1 stop6h 39m
Des Moines
Sun 9/20
2:34 pm-7:45 pm
1 stop4h 11m
$379
GreensboroDes Moines
GSO Greensboro/H. Point - DSM Des Moines
GSODSM
Greensboro/H. Point
Sat 11/7
2:11 pm-9:55 pm
2 stops8h 44m
Des Moines
Wed 11/11
1:27 pm-11:44 pm
2 stops9h 17m
$409
Sorted by cheapest first
Compare providers for flights from Greensboro to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greensboro to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greensboro-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greensboro-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greensboro-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greensboro-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greensboro-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greensboro to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Greensboro with our price prediction graph.
GSO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greensboro to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 7, 2026.
See what other customers who have flown with Delta and American Airlines from Greensboro to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Food
7.2
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Food
7.2
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Food
7.2
Crew
8.5
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Greensboro to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
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Greensboro and Des Moines flights
Browse other Greensboro and Des Moines flight options. Last updated on September 7, 2026.
Other flights from Greensboro
Browse through other flights departing from Greensboro. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Greensboro to Des Moines
Discover the top 2 airlines that operate flights from Greensboro to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$278 | Average$383 | FlexibilityNo cancel fee | On-time71% |