$44+ Cheap flights from South Carolina to Indiana
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from South Carolina to Indiana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to Indiana
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Cheapest flights from South Carolina to IndianaExplore the most affordable flight options available from South Carolina to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from South Carolina to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:52 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Mon 3/97:11 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/2![Frontier logo]()
$61
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Mon 2/2311:46 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/3![Frontier logo]()
$82
This Super.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/810:46 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Thu 3/126:55 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$85
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Sun 2/2211:50 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$87
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/51:24 pm
CLT
- ORD
1 stop6h 47m
Multiple Airlines
Sun 3/86:55 pm
ORD
- CLT
Nonstop2h 02m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$88
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:33 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Tue 3/38:16 pm
ORD
- CLT
1 stop11h 10m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$91
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:52 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Mon 3/98:16 pm
ORD
- CLT
1 stop11h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$93
This Super.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/139:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Sun 2/1511:50 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 1/31![Frontier logo]()
$97
This Super.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:46 pm
CLT
- ORD
1 stop21h 00m
Frontier
Sun 3/86:55 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:00 am
CLT
- ORD
1 stop12h 18m
Multiple Airlines
Sun 2/2211:50 am
ORD
- CLT
Nonstop2h 02m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$100
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Thu 3/55:15 am
ORD
- CHS
1 stop11h 25m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$103
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Mon 3/95:15 am
ORD
- CHS
1 stop11h 25m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$105
Best flights from South Carolina to IndianaDiscover carefully curated flight deals from South Carolina to Indiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from South Carolina to Indiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Thu 3/55:15 am
ORD
- CHS
1 stop11h 25m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$105
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:40 pm
CLT
- ORD
Nonstop2h 38m
United Airlines
Sat 6/206:15 pm
ORD
- CLT
Nonstop2h 14m
United Airlines
Deal found 2/1![United Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:35 pm
CHS
- MDW
1 stop22h 25m
Multiple Airlines
Mon 4/207:30 am
MDW
- CHS
1 stop6h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$154
This Cheapflightsfares deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:21 pm
SAV
- ORD
1 stop6h 38m
JetBlue
Wed 2/256:04 am
ORD
- SAV
1 stop9h 18m
JetBlue
Deal found 1/31![JetBlue logo]()
$172
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:00 am
CLT
- MDW
Nonstop2h 05m
Southwest
Mon 3/97:35 pm
MDW
- CLT
Nonstop1h 50m
Southwest
Deal found 2/2![Southwest logo]()
$177
This Frontier deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/191:17 pm
CLT
- CVG
1 stop11h 42m
Frontier
Mon 2/235:05 am
CVG
- CLT
1 stop9h 38m
Frontier
Deal found 1/31![Frontier logo]()
$181
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:30 am
CLT
- MDW
1 stop4h 16m
Delta
Sun 3/86:00 am
MDW
- CLT
1 stop6h 41m
Delta
Deal found 2/1![Delta logo]()
$197
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:31 am
GSP
- ORD
Nonstop2h 18m
American Airlines
Sat 5/164:40 pm
ORD
- GSP
Nonstop2h 04m
American Airlines
Deal found 2/2![American Airlines logo]()
$209
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/91:24 pm
CLT
- IND
1 stop9h 24m
Spirit Airlines
Wed 3/116:00 am
IND
- CLT
1 stop7h 43m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$112
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:21 am
CLT
- IND
1 stop14h 04m
Spirit Airlines
Mon 3/26:00 am
IND
- CLT
1 stop8h 17m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/212:27 pm
SAV
- ORD
1 stop13h 13m
Multiple Airlines
Mon 3/97:00 am
ORD
- SAV
1 stop15h 33m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$157
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:21 am
CLT
- IND
1 stop14h 04m
Spirit Airlines
Sun 3/16:00 am
IND
- CLT
1 stop17h 59m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/188:43 am
CLT
- IND
1 stop23h 49m
Multiple Airlines
Mon 2/236:10 pm
IND
- CLT
1 stop19h 41m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$158
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:15 am
CLT
- ORD
Nonstop2h 26m
United Airlines
Sun 3/87:10 am
ORD
- CLT
Nonstop2h 16m
United Airlines
Deal found 2/2![United Airlines logo]()
$177
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:30 pm
CLT
- IND
1 stop17h 41m
Frontier
Thu 4/239:07 am
IND
- CLT
1 stop5h 34m
Frontier
Deal found 2/3![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:54 pm
MYR
- ORD
1 stop12h 28m
Spirit Airlines
Mon 3/26:51 pm
ORD
- MYR
1 stop19h 04m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$147
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:20 pm
CLT
- MDW
Nonstop2h 10m
Southwest
Thu 3/127:35 pm
MDW
- CLT
Nonstop1h 50m
Southwest
Deal found 1/31![Southwest logo]()
$197
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:00 am
CLT
- MDW
1 stop3h 54m
Delta
Mon 3/910:45 am
MDW
- CLT
1 stop6h 35m
Delta
Deal found 2/2![Delta logo]()
$197
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:15 am
CLT
- IND
1 stop8h 44m
Multiple Airlines
Sat 4/116:00 am
IND
- CLT
1 stop7h 52m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$169
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:56 am
CLT
- IND
1 stop5h 59m
Frontier
Fri 5/86:11 pm
IND
- CLT
1 stop27h 27m
Frontier
Deal found 2/1![Frontier logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:05 pm
CAE
- ORD
2 stops24h 13m
Multiple Airlines
Mon 3/27:00 am
ORD
- CAE
1 stop10h 14m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$172
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:30 am
CAE
- ORD
Nonstop2h 30m
United Airlines
Sun 4/267:00 am
ORD
- CAE
Nonstop2h 06m
United Airlines
Deal found 1/31![United Airlines logo]()
$209
This Frontier deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:41 pm
CLT
- CVG
1 stop5h 39m
Frontier
Sun 4/196:00 am
CVG
- CLT
1 stop10h 46m
Frontier
Deal found 2/2![Frontier logo]()
$195
This Mytrip deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/49:09 am
MYR
- ORD
2 stops16h 31m
Spirit Airlines
Thu 3/58:16 pm
ORD
- MYR
1 stop10h 57m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$162
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:39 am
CLT
- MDW
1 stop3h 50m
Delta
Thu 3/129:35 am
MDW
- CLT
1 stop5h 31m
Delta
Deal found 1/31![Delta logo]()
$217
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:36 am
CAE
- ORD
Nonstop2h 24m
United Airlines
Wed 3/2511:49 am
ORD
- CAE
Nonstop2h 07m
United Airlines
Deal found 2/1![United Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1911:00 am
CLT
- CVG
1 stop24h 59m
Multiple Airlines
Mon 2/234:01 pm
CVG
- CLT
1 stop16h 25m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:35 pm
CHS
- ORD
2 stops24h 43m
Spirit Airlines
Fri 2/276:51 pm
ORD
- CHS
1 stop20h 14m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$163
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:35 am
CLT
- MDW
Nonstop2h 00m
Southwest
Sun 2/227:35 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Deal found 1/31![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:59 pm
CAE
- ORD
1 stop7h 17m
Delta
Sun 5/39:48 am
ORD
- CAE
1 stop4h 28m
Delta
Deal found 2/1![Delta logo]()
$229
Last-minute flights from South Carolina to IndianaDiscover last-minute flight deals from South Carolina to Indiana. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from South Carolina to Indiana. Data last updated February 3, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/139:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Sun 2/1511:50 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 1/31![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/197:00 am
CLT
- ORD
1 stop12h 18m
Multiple Airlines
Sun 2/2211:50 am
ORD
- CLT
Nonstop2h 02m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$100
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Mon 2/2311:46 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/3![Frontier logo]()
$82
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:21 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Sun 2/2211:50 am
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$87
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:33 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Tue 3/38:16 pm
ORD
- CLT
1 stop11h 10m
Multiple Airlines
Deal found 1/31![Multiple Airlines logo]()
$91
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:52 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Mon 3/97:11 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/2![Frontier logo]()
$61
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:52 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Mon 3/94:43 pm
ORD
- CLT
1 stop6h 13m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$93
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Mon 3/95:15 am
ORD
- CHS
1 stop11h 25m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$105
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Thu 3/55:15 am
ORD
- CHS
1 stop11h 25m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$103
This Super.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:46 pm
CLT
- ORD
1 stop21h 00m
Frontier
Sun 3/86:55 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$98
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:00 am
CLT
- ORD
1 stop12h 18m
Multiple Airlines
Sun 3/86:55 pm
ORD
- CLT
Nonstop2h 02m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$88
This Super.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/810:46 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Thu 3/126:55 pm
ORD
- CLT
Nonstop2h 02m
Frontier
Deal found 2/1![Frontier logo]()
$85
One-way flights from South Carolina to IndianaSearch for one-way flight options from South Carolina to Indiana. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from South Carolina to Indiana. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Orbitz deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$44
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$46
This Orbitz deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$48
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$50
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$53
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:35 pm
CHS
- ORD
1 stop6h 12m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$58
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:35 pm
CHS
- ORD
1 stop6h 12m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$60
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1412:04 pm
CHS
- ORD
1 stop13h 18m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$62
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:59 pm
MYR
- ORD
1 stop9h 41m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$64
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/195:00 pm
CHS
- ORD
1 stop8h 40m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$65
This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:55 am
CLT
- IND
1 stop6h 19m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$65
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:35 pm
CHS
- MDW
1 stop22h 25m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$66
Find flight deals from South Carolina to Indiana
Keep the following information in mind while searching for South Carolina to Indiana flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $61 (Mytrip) |
One-way from | $44 (Orbitz) |
Popular in | March |
Cheapest in | August |
Average price | $319 |
Good one-way deal | $119 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from South Carolina to Indiana that are best for you.
Fly from
South Carolina
Fly to
Indiana
Route
Depart
Return
Price
CharlestonChicago
CHS - ORD
CHSORD
Charleston
Mon 3/2
5:00 pm-12:40 am
1 stop8h 40m
Chicago O'Hare Intl
Thu 3/5
5:15 am-5:40 pm
1 stop11h 25m
$105
CharlotteIndianapolis
CLT - IND
CLTIND
Charlotte Douglas
Mon 3/9
1:24 pm-10:48 pm
1 stop9h 24m
Indianapolis
Wed 3/11
6:00 am-1:43 pm
1 stop7h 43m
$112
CharlotteIndianapolis
CLT - IND
CLTIND
Charlotte Douglas
Fri 2/27
9:21 am-11:25 pm
1 stop14h 04m
Indianapolis
Mon 3/2
6:00 am-2:17 pm
1 stop8h 17m
$136
CharlotteIndianapolis
CLT - IND
CLTIND
Charlotte Douglas
Fri 2/27
9:21 am-11:25 pm
1 stop14h 04m
Indianapolis
Sun 3/1
6:00 am-11:59 pm
1 stop17h 59m
$142
CharlotteChicago
CLT - ORD
CLTORD
Charlotte Douglas
Sat 6/13
6:40 pm-8:18 pm
Nonstop2h 38m
Chicago O'Hare Intl
Sat 6/20
6:15 pm-9:29 pm
Nonstop2h 14m
$147
Myrtle BeachChicago
MYR - ORD
MYRORD
Myrtle Beach Intl
Fri 2/27
9:54 pm-9:22 am
1 stop12h 28m
Chicago O'Hare Intl
Mon 3/2
6:51 pm-2:55 pm
1 stop19h 04m
$147
CharlestonChicago
CHS - MDW
CHSMDW
Charleston
Wed 4/15
3:35 pm-1:00 pm
1 stop22h 25m
Chicago Midway
Mon 4/20
7:30 am-2:40 pm
1 stop6h 10m
$154
SavannahChicago
SAV - ORD
SAVORD
Savannah/Hilton Head
Mon 3/2
12:27 pm-12:40 am
1 stop13h 13m
Chicago O'Hare Intl
Mon 3/9
7:00 am-11:33 pm
1 stop15h 33m
$157
CharlotteIndianapolis
CLT - IND
CLTIND
Charlotte Douglas
Wed 2/18
8:43 am-8:32 am
1 stop23h 49m
Indianapolis
Mon 2/23
6:10 pm-1:51 pm
1 stop19h 41m
$158
Myrtle BeachChicago
MYR - ORD
MYRORD
Myrtle Beach Intl
Wed 3/4
9:09 am-12:40 am
2 stops16h 31m
Chicago O'Hare Intl
Thu 3/5
8:16 pm-8:13 am
1 stop10h 57m
$162
Showing 1-10 of 60 results
Best time to book a flight from South Carolina to Indiana
Have a flexible travel schedule? Discover the best time to fly to Indiana from South Carolina with our price prediction graph.
CHS-ORD
MYR-ORD
CLT-IND
CHS-MDW
CLT-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to Indiana
USSC-USIN
CHS-ORD
MYR-ORD
CLT-IND
CHS-MDW
What is the cheapest month to book a flight from South Carolina to Indiana?
Currently, July is the cheapest month in which you can book a flight from South Carolina to Indiana (average of $45). Flying from South Carolina to Indiana in April is currently the most expensive (average of $246). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SC to IN?
Find hourly flight availability from South Carolina to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.
One of the essential ways to save on airfare from South Carolina to Indiana is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 72% on airfare.
What is the cheapest day to fly from South Carolina to Indiana?
Use this chart to determine the cheapest time to fly round-trip from South Carolina to Indiana. Price data was last updated on February 2, 2025.
Travelers seeking maximum savings on their South Carolina to Indiana flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from South Carolina to Indiana?
Reviews of airlines servicing Indiana
Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated February 3, 2026.
Read through reviews of airlines operating flights from South Carolina to Indiana, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Entertainment
7.8
Boarding
8.1
Food
7.2
Overall
7.9
Comfort
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from South Carolina to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for South Carolina to Indiana
See prices for flight routes from nearby airports that may be better suited for you.
Top 6 airlines flying from South Carolina to Indiana
Discover the top 6 airlines that operate flights from South Carolina to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$45 | Average$126 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$83 | Average$201 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$125 | Average$318 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$189 | Average$388 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$190 | Average$364 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$228 | Average$366 | FlexibilityNo cancel fee | On-time71% |