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$40+ Cheap flights from South Carolina to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from South Carolina to Indiana

Keep the following information in mind while searching for South Carolina to Indiana flight deals. Data was last updated July 31, 2025.

Round-trip from

$94
(Mytrip)

One-way from

$40
(Mytrip)

Popular in

March

Cheapest in

June

Average price

$416

Good round-trip deal

$48 or less

Good one-way deal

$38 or less
From South Carolina to Indiana
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One-way flight from South Carolina to Indiana
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Highest demand for flights based on searches. 32% potential increase in price ($182 potential increase over avg. RT price).
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Cheapest flight prices on average. 9% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from South Carolina to Indiana.
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Price to beat on a one-way flight from South Carolina to Indiana.
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Find flight deals from South Carolina to Indiana

Cheapest flights from South Carolina to Indiana
Explore the most affordable flight options available from South Carolina to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/212:18 pmMYR - ORD
Nonstop2h 25mSpirit Airlines
Sun 8/2410:12 amORD - MYR
Nonstop2h 01mSpirit Airlines
Deal found 7/29$89
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/305:20 pmCLT - MDW
Nonstop2h 00mSouthwest
Sun 8/314:45 pmMDW - CLT
Nonstop1h 55mSouthwest
Deal found 7/30$141
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/35:50 pmCLT - ORD
Nonstop2h 15mAmerican Airlines
Sun 9/75:00 amORD - CLT
Nonstop2h 05mAmerican Airlines
Deal found 7/30$141
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:40 amCLT - ORD
Nonstop2h 20mUnited Airlines
Sun 9/77:10 amORD - CLT
Nonstop2h 14mUnited Airlines
Deal found 7/30$143
This Frontier deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/18:44 pmCLT - ORD
Nonstop2h 30mFrontier
Thu 9/47:40 amORD - CLT
Nonstop2h 20mFrontier
Deal found 7/31$144
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/73:25 pmCLT - ORD
Nonstop2h 22mMultiple Airlines
Sun 11/99:18 amORD - CLT
1 stop8h 29mMultiple Airlines
Deal found 7/31$145
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/154:48 pmCLT - ORD
1 stop8h 11mSpirit Airlines
Mon 8/188:12 pmORD - CLT
1 stop12h 04mSpirit Airlines
Deal found 7/29$160
This Booking.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/144:20 pmCAE - ORD
1 stop7h 02mSpirit Airlines
Sun 8/176:56 amORD - CAE
1 stop7h 22mSpirit Airlines
Deal found 7/30$174
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/295:32 pmCLT - MDW
1 stop7h 52mFrontier
Sun 8/313:36 pmMDW - CLT
1 stop5h 17mFrontier
Deal found 7/29$176
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/136:16 pmCHS - ORD
Nonstop2h 33mAmerican Airlines
Sat 9/208:07 amORD - CHS
Nonstop2h 23mAmerican Airlines
Deal found 7/30$180
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/196:35 amCHS - MDW
Nonstop2h 05mSouthwest
Wed 8/276:05 pmMDW - CHS
Nonstop2h 10mSouthwest
Deal found 7/29$181
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:03 pmCLT - CVG
1 stop6h 16mFrontier
Mon 8/185:10 amCVG - CLT
1 stop5h 31mFrontier
Deal found 7/29$186

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from South Carolina to Indiana that are best for you.

Fly from

South Carolina

Fly to

Indiana

Route

Depart

Return

Price

Myrtle BeachChicago

MYR - ORD

MYRORD

Myrtle Beach Intl

Thu 8/21

2:18 pm-3:43 pm

Nonstop2h 25m

Chicago O'Hare Intl

Sun 8/24

10:12 am-1:13 pm

Nonstop2h 01m

$89

CharlotteChicago

CLT - MDW

CLTMDW

Charlotte Douglas

Sat 8/30

5:20 pm-6:20 pm

Nonstop2h 00m

Chicago Midway

Sun 8/31

4:45 pm-7:40 pm

Nonstop1h 55m

$141

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Wed 9/3

5:50 pm-7:05 pm

Nonstop2h 15m

Chicago O'Hare Intl

Sun 9/7

5:00 am-8:05 am

Nonstop2h 05m

$141

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Fri 9/5

6:40 am-8:00 am

Nonstop2h 20m

Chicago O'Hare Intl

Sun 9/7

7:10 am-10:24 am

Nonstop2h 14m

$143

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Mon 9/1

8:44 pm-10:14 pm

Nonstop2h 30m

Chicago O'Hare Intl

Thu 9/4

7:40 am-11:00 am

Nonstop2h 20m

$144

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Wed 8/20

4:48 pm-11:59 pm

1 stop8h 11m

Chicago O'Hare Intl

Fri 8/22

1:47 pm-5:03 pm

Nonstop2h 16m

$146

CharlotteChicago

CLT - ORD

CLTORD

Charlotte Douglas

Fri 8/15

4:48 pm-11:59 pm

1 stop8h 11m

Chicago O'Hare Intl

Mon 8/18

8:12 pm-9:16 am

1 stop12h 04m

$160

ColumbiaChicago

CAE - ORD

CAEORD

Columbia Metropolitan

Thu 8/14

4:20 pm-10:22 pm

1 stop7h 02m

Chicago O'Hare Intl

Sun 8/17

6:56 am-3:18 pm

1 stop7h 22m

$174

CharlotteChicago

CLT - MDW

CLTMDW

Charlotte Douglas

Fri 8/29

5:32 pm-12:24 am

1 stop7h 52m

Chicago Midway

Sun 8/31

3:36 pm-9:53 pm

1 stop5h 17m

$176

CharlestonChicago

CHS - ORD

CHSORD

Charleston

Sat 9/13

6:16 pm-7:49 pm

Nonstop2h 33m

Chicago O'Hare Intl

Sat 9/20

8:07 am-11:30 am

Nonstop2h 23m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indiana

What is the cheapest month to book a flight from South Carolina to Indiana?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Indiana (average of $297). Flying from South Carolina to Indiana in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IN?

Find hourly flight availability from South Carolina to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Indiana as you normally would.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated July 31, 2025.
Read through reviews of airlines operating flights from South Carolina to Indiana, such as Southwest, Delta, and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
JetBlue
7.3
Good
2,914 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this South Carolina to Indiana flight route?

    The South Carolina to Indiana flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from South Carolina to Indiana one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $40. Users have also found prices from $47 and $72 on Spirit Airlines and Southwest, respectively.

  • Can I find deals for flights from South Carolina to Indiana that include hotel bookings?

    Yes. In addition to deals on South Carolina to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indiana.

  • Can I find deals for business class flights from South Carolina to Indiana?

    Yes. Cheapflights offers flight deals from South Carolina to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Indiana?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Indiana (average of $297). Flying from South Carolina to Indiana in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Indiana

Discover the top 6 airlines that operate flights from South Carolina to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$45Average$133FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$149Average$251FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$190Average$396FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$198Average$376FlexibilityNo cancel feeOn-time71%
DeltaCheapest$198Average$363FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$286Average$406FlexibilityNo cancel feeOn-time63%

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