$49+ Cheap flights from Indiana to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Aug 27 — Sep 31
Round-trip
1 adult, Economy
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Find cheap flights from Indiana to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Indiana to South Carolina
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Cheapest flights from Indiana to South CarolinaExplore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:45 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Fri 8/149:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$91
This Mytrip deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Fri 8/149:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/208:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$99
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/134:09 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$101
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:29 pm
CVG
- MYR
Nonstop1h 36m
Allegiant Air
Thu 8/278:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$104
This Cheapflightsfares deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:30 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/208:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$105
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:45 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Mon 8/179:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$106
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3012:29 pm
CVG
- MYR
Nonstop1h 36m
Allegiant Air
Thu 9/38:10 pm
MYR
- CVG
Nonstop1h 31m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Sat 8/1510:07 am
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Mon 8/179:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$113
This Cheapflightsfares deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/612:25 pm
CVG
- MYR
Nonstop1h 31m
Allegiant Air
Thu 9/178:10 pm
MYR
- CVG
Nonstop1h 31m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$118
This Frontier deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:15 am
CVG
- CLT
1 stop9h 43m
Frontier
Tue 8/258:56 am
CLT
- CVG
1 stop4h 51m
Frontier
Deal found 7/25![Frontier logo]()
$200
Best flights from Indiana to South CarolinaDiscover carefully curated flight deals from Indiana to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
Discover carefully curated flight deals from Indiana to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
This Frontier deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Wed 8/268:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/22![Frontier logo]()
$200
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:05 am
ORD
- CHS
Nonstop2h 31m
United Airlines
Thu 9/104:58 pm
CHS
- ORD
Nonstop2h 32m
United Airlines
Deal found 7/27![United Airlines logo]()
$237
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/122:00 pm
ORD
- CHS
1 stop7h 15m
Delta
Wed 9/165:35 pm
CHS
- ORD
1 stop7h 24m
Delta
Deal found 7/27![Delta logo]()
$240
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:05 am
CVG
- CLT
1 stop5h 20m
Southwest
Thu 8/277:40 am
CLT
- CVG
1 stop5h 55m
Southwest
Deal found 7/23![Southwest logo]()
$257
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:30 am
ORD
- CHS
1 stop4h 53m
Delta
Tue 9/152:12 pm
CHS
- ORD
1 stop5h 33m
Delta
Deal found 7/27![Delta logo]()
$240
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
ORD
- CHS
1 stop7h 10m
United Airlines
Mon 8/1711:40 am
CHS
- ORD
Nonstop2h 33m
United Airlines
Deal found 7/23![United Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:16 am
CVG
- CLT
Nonstop1h 34m
American Airlines
Sun 8/163:50 pm
CLT
- CVG
Nonstop1h 28m
American Airlines
Deal found 7/27![American Airlines logo]()
$524
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:20 am
MDW
- CLT
1 stop8h 30m
Southwest
Wed 9/166:30 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 7/26![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:45 am
ORD
- SAV
1 stop4h 53m
United Airlines
Tue 8/253:23 pm
SAV
- ORD
1 stop7h 52m
United Airlines
Deal found 7/27![United Airlines logo]()
$252
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:40 am
ORD
- CHS
1 stop4h 14m
Delta
Tue 9/84:27 pm
CHS
- ORD
1 stop5h 29m
Delta
Deal found 7/23![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:15 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Tue 8/256:50 am
CLT
- MDW
1 stop5h 00m
Southwest
Deal found 7/25![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2211:22 am
ORD
- CHS
1 stop5h 36m
Delta
Sat 8/293:00 pm
CHS
- ORD
1 stop4h 59m
Delta
Deal found 7/23![Delta logo]()
$257
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:25 pm
ORD
- CLT
Nonstop2h 16m
United Airlines
Sat 9/510:25 am
CLT
- ORD
1 stop5h 02m
United Airlines
Deal found 7/27![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:55 pm
MDW
- CLT
Nonstop1h 50m
Southwest
Sat 10/246:30 am
CLT
- MDW
2 stops8h 30m
Southwest
Deal found 7/27![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:55 pm
ORD
- CLT
Nonstop2h 17m
United Airlines
Sat 10/317:55 pm
CLT
- ORD
1 stop4h 44m
United Airlines
Deal found 7/27![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:15 pm
MDW
- CLT
Nonstop1h 55m
Southwest
Mon 8/317:40 am
CLT
- MDW
2 stops8h 50m
Southwest
Deal found 7/24![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:29 am
MDW
- CLT
1 stop5h 37m
Delta
Mon 9/147:39 pm
CLT
- MDW
1 stop4h 05m
Delta
Deal found 7/26![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:50 am
ORD
- CLT
Nonstop2h 18m
United Airlines
Mon 9/287:50 pm
CLT
- ORD
1 stop4h 42m
United Airlines
Deal found 7/24![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:45 pm
MDW
- CLT
1 stop5h 20m
Southwest
Tue 9/158:30 am
CLT
- MDW
2 stops5h 35m
Southwest
Deal found 7/24![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:10 am
ORD
- CLT
1 stop4h 10m
Delta
Sat 10/311:09 pm
CLT
- ORD
1 stop4h 15m
Delta
Deal found 7/23![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:55 pm
ORD
- CLT
Nonstop2h 22m
United Airlines
Mon 9/147:55 pm
CLT
- ORD
1 stop4h 45m
United Airlines
Deal found 7/23![United Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:45 am
MDW
- CLT
2 stops6h 40m
Southwest
Mon 9/141:05 pm
CLT
- MDW
1 stop4h 10m
Southwest
Deal found 7/25![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:45 am
ORD
- CLT
1 stop5h 47m
Delta
Tue 12/11:29 pm
CLT
- ORD
1 stop6h 04m
Delta
Deal found 7/26![Delta logo]()
$294
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:27 am
ORD
- MYR
Nonstop2h 26m
United Airlines
Sat 8/293:24 pm
MYR
- ORD
Nonstop2h 36m
United Airlines
Deal found 7/27![United Airlines logo]()
$277
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:50 pm
MDW
- CLT
2 stops8h 05m
Southwest
Mon 9/76:30 pm
CLT
- MDW
Nonstop2h 00m
Southwest
Deal found 7/27![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:50 am
ORD
- GSP
1 stop3h 59m
Delta
Sun 10/2512:00 pm
GSP
- ORD
1 stop5h 57m
Delta
Deal found 7/23![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:29 am
ORD
- GSP
Nonstop2h 06m
United Airlines
Mon 9/216:10 pm
GSP
- ORD
Nonstop2h 22m
United Airlines
Deal found 7/25![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:35 pm
MDW
- MYR
Nonstop2h 00m
Southwest
Mon 9/211:55 pm
MYR
- MDW
1 stop6h 25m
Southwest
Deal found 7/26![Southwest logo]()
$288
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:59 pm
CVG
- CLT
1 stop7h 51m
American Airlines
Sun 8/2312:04 pm
CLT
- CVG
Nonstop1h 39m
American Airlines
Deal found 7/27![American Airlines logo]()
$562
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:40 pm
ORD
- GSP
1 stop3h 57m
Delta
Wed 9/1612:00 pm
GSP
- ORD
1 stop5h 37m
Delta
Deal found 7/26![Delta logo]()
$299
Last-minute flights from Indiana to South CarolinaDiscover last-minute flight deals from Indiana to South Carolina. Data last updated July 28, 2026 and is based on user searches.
Discover last-minute flight deals from Indiana to South Carolina. Data last updated July 28, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Fri 8/149:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$96
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:45 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Fri 8/149:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$91
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/134:09 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Sat 8/1510:07 am
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$112
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Mon 8/179:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$118
This Cheapflightsfares deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:45 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Mon 8/179:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$106
This Cheapflightsfares deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:30 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/208:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Thu 8/208:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Mon 8/179:40 pm
MYR
- CVG
Nonstop1h 39m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$113
This Frontier deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:15 am
CVG
- CLT
1 stop9h 43m
Frontier
Tue 8/258:56 am
CLT
- CVG
1 stop4h 51m
Frontier
Deal found 7/25![Frontier logo]()
$200
This Cheapflightsfares deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:29 pm
CVG
- MYR
Nonstop1h 36m
Allegiant Air
Thu 8/278:19 pm
MYR
- CVG
Nonstop1h 33m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$104
This Cheapflightsfares deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3012:29 pm
CVG
- MYR
Nonstop1h 36m
Allegiant Air
Thu 9/38:10 pm
MYR
- CVG
Nonstop1h 31m
Allegiant Air
Deal found 7/25![Allegiant Air logo]()
$108
One-way flights from Indiana to South CarolinaSearch for one-way flight options from Indiana to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
Search for one-way flight options from Indiana to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
This Super.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:36 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$49
This Super.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$55
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:45 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/26![Allegiant Air logo]()
$61
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:50 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$62
This Super.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/31:40 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/22![Allegiant Air logo]()
$63
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:43 pm
CVG
- MYR
Nonstop1h 31m
Allegiant Air
Deal found 7/24![Allegiant Air logo]()
$76
This Super.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:40 pm
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$81
This Super.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:30 am
CVG
- MYR
Nonstop1h 32m
Allegiant Air
Deal found 7/23![Allegiant Air logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:05 am
ORD
- SAV
1 stop8h 50m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:11 am
ORD
- SAV
1 stop8h 04m
Multiple Airlines
Deal found 7/24![Multiple Airlines logo]()
$96
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:15 am
ORD
- MYR
Nonstop2h 19m
American Airlines
Deal found 7/26![American Airlines logo]()
$99
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:35 pm
MDW
- MYR
Nonstop2h 00m
Southwest
Deal found 7/26![Southwest logo]()
$99
Find flight deals from Indiana to South Carolina
Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated July 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $91 (Cheapflightsfares) |
One-way from | $49 (Super.com) |
Popular in | March |
Cheapest in | August |
Average price | $197 |
Good round-trip deal | $86 or less |
Good one-way deal | $59 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisCharlotte
IND - CLT
INDCLT
Indianapolis
Wed 8/19
9:59 pm-10:59 am
1 stop13h 00m
Charlotte Douglas
Wed 8/26
8:56 am-6:38 pm
1 stop9h 42m
$200
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Mon 9/7
7:05 am-10:36 am
Nonstop2h 31m
Charleston
Thu 9/10
4:58 pm-6:30 pm
Nonstop2h 32m
$237
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Sat 9/12
2:00 pm-10:15 pm
1 stop7h 15m
Charleston
Wed 9/16
5:35 pm-11:59 pm
1 stop7h 24m
$240
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Sat 9/12
5:30 am-11:23 am
1 stop4h 53m
Charleston
Tue 9/15
2:12 pm-6:45 pm
1 stop5h 33m
$240
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Thu 8/13
7:00 am-3:10 pm
1 stop7h 10m
Charleston
Mon 8/17
11:40 am-1:13 pm
Nonstop2h 33m
$247
ChicagoSavannah
ORD - SAV
ORDSAV
Chicago O'Hare Intl
Sat 8/22
8:45 am-2:38 pm
1 stop4h 53m
Savannah/Hilton Head
Tue 8/25
3:23 pm-10:15 pm
1 stop7h 52m
$252
CincinnatiCharlotte
CVG - CLT
CVGCLT
Cincinnati Cinci./N. Kentucky
Mon 8/24
7:05 am-12:25 pm
1 stop5h 20m
Charlotte Douglas
Thu 8/27
7:40 am-1:35 pm
1 stop5h 55m
$257
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Sat 9/5
6:40 am-11:54 am
1 stop4h 14m
Charleston
Tue 9/8
4:27 pm-8:56 pm
1 stop5h 29m
$257
ChicagoCharleston
ORD - CHS
ORDCHS
Chicago O'Hare Intl
Sat 8/22
11:22 am-5:58 pm
1 stop5h 36m
Charleston
Sat 8/29
3:00 pm-6:59 pm
1 stop4h 59m
$257
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
Wed 9/9
8:20 am-5:50 pm
1 stop8h 30m
Charlotte Douglas
Wed 9/16
6:30 pm-7:30 pm
Nonstop2h 00m
$269
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indiana to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
CVG-MYR
CVG-CLT
ORD-SAV
ORD-MYR
MDW-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indiana to South Carolina
USIN-USSC
CVG-MYR
CVG-CLT
ORD-SAV
ORD-MYR
What is the cheapest month to book a flight from Indiana to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $269). Flying from Indiana to South Carolina in March is currently the most expensive (average of $424). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IN to SC?
Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2026.
One of the essential ways to save on airfare from Indiana to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 50% on airfare.
How much does it cost to fly round-trip from Indiana to South Carolina?
Airfare is below average for this route at the moment.
Indiana to South Carolina flights typically cost between $282 and $441 in August.The cheapest round-trip price found within the last 5 days was $235 on Multiple Airlines (Aug 17-Aug 20).
How far ahead should I book a flight from Indiana to South Carolina?
The best time to book flights from Indiana to South Carolina is 87 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 28, 2026.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Southwest,Delta, andUnited Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Crew
8.6
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Indiana to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Indiana to South Carolina by cabin class
Find flights from Indiana to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indiana and South Carolina flights
Browse other Indiana and South Carolina flight options. Last updated on July 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Indiana after your stay in South Carolina
Indiana to South Carolina flights
Consider these flights traveling from Indiana to South Carolina.
Top 5 airlines flying from Indiana to South Carolina
Discover the top 5 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$74 | Average$136 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$158 | Average$369 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$166 | Average$418 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$213 | Average$373 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$279 | Average$402 | FlexibilityNo cancel fee | On-time63% |