$123+ Cheap flights from Myrtle Beach to Louisville (MYR - SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDF
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from Myrtle Beach to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Louisville
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Cheapest flights from Myrtle Beach to LouisvilleExplore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:35 pm -
1 stop3h 44m
Mon 11/164:35 pm -
1 stop4h 22m
Deal found 10/21![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 am -
1 stop4h 50m
Sun 12/65:40 am -
1 stop4h 25m
Deal found 10/20![Southwest logo]()
$254
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:10 am -
1 stop4h 50m
Fri 12/1112:05 pm -
1 stop6h 50m
Deal found 10/22![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:55 pm -
2 stops13h 10m
Mon 11/165:40 am -
1 stop4h 25m
Deal found 10/21![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:03 pm -
1 stop4h 43m
Tue 12/296:27 am -
1 stop5h 47m
Deal found 10/23![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:44 pm -
1 stop3h 36m
Wed 12/306:27 am -
1 stop5h 47m
Deal found 10/20![American Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:58 pm -
1 stop4h 15m
Wed 12/308:26 am -
1 stop4h 48m
Deal found 10/23![Delta logo]()
$331
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:45 am -
2 stops9h 50m
Wed 1/65:35 am -
1 stop4h 25m
Deal found 10/23![Southwest logo]()
$336
Best flights from Myrtle Beach to LouisvilleDiscover carefully curated flight deals from Myrtle Beach to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Myrtle Beach to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/188:07 am -
1 stop4h 20m
Wed 1/69:45 am -
1 stop5h 17m
Deal found 10/23![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:10 am -
1 stop4h 50m
Sun 12/65:40 am -
1 stop4h 25m
Deal found 10/20![Southwest logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:25 am -
2 stops24h 20m
Mon 11/910:25 am -
1 stop10h 57m
Deal found 10/24![Breeze Airways logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:58 pm -
1 stop26h 31m
Wed 12/307:36 pm -
2 stops36h 27m
Deal found 10/23![Multiple Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:10 am -
2 stops12h 25m
Fri 12/115:10 pm -
1 stop4h 55m
Deal found 10/22![Southwest logo]()
$266
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:44 pm -
1 stop3h 36m
Tue 12/296:27 am -
1 stop5h 47m
Deal found 10/20![American Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:20 am -
2 stops12h 45m
Tue 11/105:40 am -
1 stop4h 25m
Deal found 10/22![Southwest logo]()
$388
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/302:55 pm -
2 stops10h 00m
Thu 12/318:50 am -
2 stops10h 35m
Deal found 10/21![Southwest logo]()
$417
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:45 am -
2 stops11h 30m
Tue 12/292:10 pm -
2 stops7h 45m
Deal found 10/23![Southwest logo]()
$473
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:10 am -
2 stops13h 45m
Tue 12/292:10 pm -
2 stops7h 45m
Deal found 10/23![Southwest logo]()
$479
Last-minute flights from Myrtle Beach to LouisvilleDiscover last-minute flight deals from Myrtle Beach to Louisville. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Louisville. Data last updated October 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/58:35 pm -
1 stop3h 44m
Tue 11/106:04 am -
1 stop5h 28m
Deal found 10/22![American Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:45 am -
2 stops10h 20m
Tue 11/105:40 am -
1 stop4h 25m
Deal found 10/22![Southwest logo]()
$382
This Kiwi.com deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:25 am -
2 stops24h 20m
Mon 11/910:25 am -
1 stop10h 57m
Deal found 10/24![Breeze Airways logo]()
$384
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:20 am -
2 stops12h 45m
Tue 11/105:40 am -
1 stop4h 25m
Deal found 10/22![Southwest logo]()
$388
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:35 pm -
1 stop3h 44m
Mon 11/164:35 pm -
1 stop4h 22m
Deal found 10/21![American Airlines logo]()
$245
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:55 pm -
2 stops13h 10m
Mon 11/165:40 am -
1 stop4h 25m
Deal found 10/21![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:03 pm -
1 stop4h 43m
Tue 12/296:27 am -
1 stop5h 47m
Deal found 10/23![American Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:58 pm -
1 stop4h 15m
Wed 12/308:26 am -
1 stop4h 48m
Deal found 10/23![Delta logo]()
$331
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:45 am -
2 stops9h 50m
Wed 1/65:35 am -
1 stop4h 25m
Deal found 10/23![Southwest logo]()
$336
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:44 pm -
1 stop3h 36m
Wed 12/306:27 am -
1 stop5h 47m
Deal found 10/20![American Airlines logo]()
$311
One-way flights from Myrtle Beach to LouisvilleSearch for one-way flight options from Myrtle Beach to Louisville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Myrtle Beach to Louisville. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:51 pm -
1 stop5h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Delta logo]()
$123
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:27 am -
2 stops9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![United Airlines logo]()
$173
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:20 am -
2 stops12h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Southwest logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/199:36 am -
3 stops25h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$275
Find flight deals from Myrtle Beach to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (American Airlines) |
One-way from | $123 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Thu 11/19
11:27 am-5:37 pm
1 stop6h 10m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$123
Quickest round-trip
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Mon 11/9
6:51 pm-12:10 am
1 stop5h 19m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$123
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Wed 11/18
8:07 am-12:27 pm
1 stop4h 20m
Louisville Intl
Wed 1/6
9:45 am-3:02 pm
1 stop5h 17m
$245
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Thu 12/3
8:10 am-1:00 pm
1 stop4h 50m
Louisville Intl
Sun 12/6
5:40 am-10:05 am
1 stop4h 25m
$254
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Mon 12/7
8:10 am-8:35 pm
2 stops12h 25m
Louisville Intl
Fri 12/11
5:10 pm-10:05 pm
1 stop4h 55m
$266
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Thu 11/19
8:44 pm-12:20 am
1 stop3h 36m
Louisville Intl
Tue 12/29
6:27 am-12:14 pm
1 stop5h 47m
$294
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Thu 11/5
9:25 am-9:45 am
2 stops24h 20m
Louisville Intl
Mon 11/9
10:25 am-9:22 pm
1 stop10h 57m
$384
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Fri 11/6
8:20 am-9:05 pm
2 stops12h 45m
Louisville Intl
Tue 11/10
5:40 am-10:05 am
1 stop4h 25m
$388
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Wed 11/18
5:58 pm-8:29 pm
1 stop26h 31m
Louisville Intl
Wed 12/30
7:36 pm-8:03 am
2 stops36h 27m
$389
Myrtle BeachLouisville
MYR Myrtle Beach Intl - SDF Louisville Intl
MYRSDF
Myrtle Beach Intl
Wed 12/30
2:55 pm-12:55 am
2 stops10h 00m
Louisville Intl
Thu 12/31
8:50 am-7:25 pm
2 stops10h 35m
$417
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Myrtle Beach to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Louisville in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Myrtle Beach with our price prediction graph.
MYR-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated October 25, 2026.
Get a feel of what it's like to fly with American Airlines from Myrtle Beach to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Comfort
7.1
Boarding
7.4
Food
6.4
Crew
7.9
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Entertainment
6.8
Comfort
7.1
Boarding
7.4
Food
6.4
Crew
7.9
Overall
7.0
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Myrtle Beach and Louisville flights
Browse other Myrtle Beach and Louisville flight options. Last updated on October 25, 2026.
Other flights from Myrtle Beach
Browse through other flights departing from Myrtle Beach. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Myrtle Beach to Louisville
Discover the top airline that operate flights from Myrtle Beach to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$256 | Average$450 | FlexibilityNo cancel fee | On-time71% |