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$116+ Cheap flights from Myrtle Beach to Louisville (MYR - SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDF
Apr 4 — Apr 111
Sat 4/4
Sat 4/11
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Louisville

Cheapest flights from Myrtle Beach to Louisville
Explore the most affordable flight options available from Myrtle Beach to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 5, 2026.

This Cheapflightsfares deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:52 am
MYR
-
SDF
1 stop5h 12m
Spirit Airlines
Mon 4/206:06 pm
SDF
-
MYR
1 stop5h 23m
Spirit Airlines
Deal found 3/1$196
This Cheapflightsfares deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:52 am
MYR
-
SDF
1 stop5h 12m
Spirit Airlines
Sun 5/316:06 pm
SDF
-
MYR
1 stop5h 23m
Spirit Airlines
Deal found 3/4$216
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:01 am
MYR
-
SDF
1 stop3h 50m
American Airlines
Wed 4/16:00 am
SDF
-
MYR
1 stop3h 57m
American Airlines
Deal found 3/5$255
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:55 pm
MYR
-
SDF
1 stop5h 17m
United Airlines
Tue 4/219:07 am
SDF
-
MYR
1 stop5h 10m
United Airlines
Deal found 3/1$268
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:02 pm
MYR
-
SDF
1 stop4h 57m
Delta
Tue 4/216:00 am
SDF
-
MYR
1 stop3h 40m
Delta
Deal found 3/4$273
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:00 am
MYR
-
SDF
2 stops7h 45m
American Airlines
Wed 4/296:00 am
SDF
-
MYR
1 stop5h 35m
American Airlines
Deal found 3/3$280
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:27 am
MYR
-
SDF
1 stop24h 47m
Multiple Airlines
Mon 3/239:13 pm
SDF
-
MYR
1 stop20h 20m
Multiple Airlines
Deal found 3/4$287
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2212:05 pm
MYR
-
SDF
1 stop23h 09m
Spirit Airlines
Wed 3/2512:09 pm
SDF
-
MYR
1 stop22h 56m
Spirit Airlines
Deal found 3/1$291
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/165:00 am
MYR
-
SDF
1 stop3h 38m
American Airlines
Mon 4/206:00 am
SDF
-
MYR
2 stops7h 27m
American Airlines
Deal found 3/1$296
This Mytrip deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:52 am
MYR
-
SDF
1 stop5h 12m
Spirit Airlines
Mon 4/206:06 pm
SDF
-
MYR
2 stops20h 38m
Spirit Airlines
Deal found 3/1$306

Find flight deals from Myrtle Beach to Louisville

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$196
(Cheapflightsfares)

One-way from

$116
(Kiwi.com)

Popular in

March

Cheapest in

May

Average price

$555
Provider with most accurate pricing for Myrtle Beach Intl-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Louisville Intl flights.
Search Deals
From Myrtle Beach Intl to Louisville Intl
Search Deals
One-way flight from Myrtle Beach Intl to Louisville Intl
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sat 4/25

3:15 pm-8:16 pm

1 stop5h 01m

Louisville Intl

Wed 4/29

5:00 am-10:18 am

1 stop5h 18m

$273

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 4/9

5:00 am-8:38 am

1 stop3h 38m

Louisville Intl

Mon 4/13

6:00 am-12:04 pm

1 stop6h 04m

$291

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 3/31

7:45 am-3:55 pm

2 stops8h 10m

Louisville Intl

Wed 4/1

11:50 am-9:10 pm

2 stops9h 20m

$317

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 7/2

11:55 am-10:50 pm

2 stops10h 55m

Louisville Intl

Wed 7/8

10:45 am-9:05 pm

2 stops10h 20m

$357

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 5/28

1:45 pm-10:10 pm

2 stops8h 25m

Louisville Intl

Sun 5/31

10:55 am-7:20 pm

2 stops8h 25m

$357

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 4/16

11:57 am-7:42 pm

2 stops7h 45m

Louisville Intl

Tue 4/21

5:00 am-5:02 pm

2 stops12h 02m

$361

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 8/6

10:50 am-10:35 pm

2 stops11h 45m

Louisville Intl

Mon 8/10

11:50 am-7:20 pm

2 stops7h 30m

$373

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sat 4/25

11:50 am-8:50 pm

2 stops9h 00m

Louisville Intl

Wed 4/29

6:20 am-5:35 pm

2 stops11h 15m

$391

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Sun 3/15

1:01 pm-5:15 pm

1 stop4h 14m

Louisville Intl

Thu 3/19

6:00 am-9:33 am

1 stop3h 33m

$439

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Tue 3/17

1:01 pm-5:15 pm

1 stop4h 14m

Louisville Intl

Sat 3/21

5:58 pm-12:04 am

1 stop6h 06m

$439

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/2

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Compare providers for flights from Myrtle Beach to Louisville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Louisville in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Louisville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Louisville

What is the cheapest month to book a flight from Myrtle Beach to Louisville?

Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $31). Flying from Myrtle Beach to Louisville in January is currently the most expensive (average of $105). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Louisville

Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated March 5, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Myrtle Beach to Louisville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,248 reviews

Entertainment

7.8

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,248 reviews
Delta
7.9
Good
8,248 reviews

Entertainment

7.8

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,381 reviews
Delta
7.9
Good
8,248 reviews

Entertainment

7.8

Comfort

7.9

Crew

8.5

Boarding

8.1

Overall

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Louisville?

    For as low as $291, United Airlines can have you in Louisville from Myrtle Beach in 3h 38m. Airlines will cover a distance of 491 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Myrtle Beach to Louisville round-trip?

    Our cheapest airline available from Myrtle Beach to Louisville is Delta. Our recent data shows that you can find tickets from as low as $127 on this airline. An additional option worth looking into is American Airlines, starting at $256. These flights start at 60% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Myrtle Beach to Louisville one-way?

    One-way options have recently been found by users for as low as $42 on Spirit Airlines. Other airlines that offer cheap prices include Delta from $88 and American Airlines from $108 one-way.

  • Can I find deals for flights from Myrtle Beach to Louisville that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Louisville.

  • Can I find deals for business class flights from Myrtle Beach to Louisville?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Louisville?

    Currently, May is the cheapest month in which you can book a flight from Myrtle Beach to Louisville (average of $31). Flying from Myrtle Beach to Louisville in January is currently the most expensive (average of $105). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Myrtle Beach to Louisville

Discover the top 2 airlines that operate flights from Myrtle Beach to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$127Average$321FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$256Average$370FlexibilityNo cancel feeOn-time71%

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