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Santo Domingo

$384+ Cheap flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDQ
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Santo Domingo

Cheapest flights from Myrtle Beach to Santo Domingo
Explore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/123:18 pm
MYR
-
SDQ
1 stop25h 12m
Multiple Airlines
Sat 5/166:10 am
SDQ
-
MYR
1 stop11h 38m
Multiple Airlines
Deal found 2/12$384
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:07 pm
MYR
-
SDQ
2 stops15h 05m
American Airlines
Sat 11/211:12 pm
SDQ
-
MYR
2 stops11h 43m
American Airlines
Deal found 2/12$513
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:00 pm
MYR
-
SDQ
2 stops18h 20m
American Airlines
Sun 5/104:00 pm
SDQ
-
MYR
2 stops17h 58m
American Airlines
Deal found 2/12$518
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:04 am
MYR
-
SDQ
2 stops8h 55m
American Airlines
Sat 5/164:00 pm
SDQ
-
MYR
2 stops16h 24m
American Airlines
Deal found 2/12$553
This FlightHub deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/219:53 am
MYR
-
SDQ
1 stop17h 07m
Spirit Airlines
Fri 3/64:55 am
SDQ
-
MYR
1 stop11h 09m
Spirit Airlines
Deal found 2/10$564
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:17 pm
MYR
-
SDQ
2 stops17h 43m
American Airlines
Sat 3/75:07 pm
SDQ
-
MYR
2 stops15h 25m
American Airlines
Deal found 2/10$573
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:00 am
MYR
-
SDQ
1 stop8h 30m
Delta
Sat 3/73:42 pm
SDQ
-
MYR
1 stop9h 15m
Delta
Deal found 2/11$595
This Delta deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
MYR
-
SDQ
1 stop7h 12m
Delta
Sun 5/102:45 pm
SDQ
-
MYR
1 stop9h 12m
Delta
Deal found 2/12$597
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1411:10 am
MYR
-
SDQ
2 stops13h 25m
Delta
Sat 11/213:55 pm
SDQ
-
MYR
1 stop8h 40m
Delta
Deal found 2/10$611

Find flight deals from Myrtle Beach to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$288
(FlightHub)
Provider with most accurate pricing for Myrtle Beach Intl-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Santo Domingo Las Americas flights.
Search Deals
From Myrtle Beach Intl to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.

Fly from

Myrtle Beach

Fly to

Santo Domingo

Route

Depart

Return

Price

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/12

3:18 pm-4:30 pm

1 stop25h 12m

Santo Domingo Las Americas

Sat 5/16

6:10 am-5:48 pm

1 stop11h 38m

$384

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/5

6:31 pm-2:59 pm

2 stops20h 28m

Santo Domingo Las Americas

Sun 5/10

4:00 pm-8:24 am

2 stops16h 24m

$518

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/12

6:04 am-2:59 pm

2 stops8h 55m

Santo Domingo Las Americas

Sat 5/16

4:00 pm-8:24 am

2 stops16h 24m

$553

Myrtle BeachSanto Domingo

MYR - SDQ

MYRSDQ

Myrtle Beach Intl

Tue 5/5

6:00 am-1:12 pm

1 stop7h 12m

Santo Domingo Las Americas

Sun 5/10

2:45 pm-11:57 pm

1 stop9h 12m

$597

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Compare providers for flights from Myrtle Beach to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Santo Domingo in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Santo Domingo

What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $324). Flying from Myrtle Beach to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated February 12, 2026.
Peruse reviews from past customers who have flown with Delta from Myrtle Beach to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,187 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,187 reviews
Delta
7.9
Good
8,187 reviews

Comfort

7.9

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Santo Domingo?

    A quick flight from Myrtle Beach to Santo Domingo can take about 20h 28m. American Airlines provides one of the quickest options available for as low as $518. The distance between Myrtle Beach and Santo Domingo is about 1198 mi.

  • Can I find deals for flights from Myrtle Beach to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Santo Domingo.

  • Can I find deals for business class flights from Myrtle Beach to Santo Domingo?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Santo Domingo?

    Currently, January is the cheapest month in which you can book a flight from Myrtle Beach to Santo Domingo (average of $324). Flying from Myrtle Beach to Santo Domingo in June is currently the most expensive (average of $528). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top airline flying from Myrtle Beach to Santo Domingo

Discover the top airline that operate flights from Myrtle Beach to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$297Average$705FlexibilityNo cancel feeOn-timeN/A

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