$281+ Cheap flights from Myrtle Beach (MYR) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — SDQ
Oct 3 — Oct 101
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Myrtle Beach to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Myrtle Beach to Santo Domingo
Cheapest
Best
Last-minute
One-way
Cheapest flights from Myrtle Beach to Santo DomingoExplore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
Explore the most affordable flight options available from Myrtle Beach to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:30 pm -
1 stop10h 16m
Tue 10/201:10 pm -
1 stop20h 19m
Deal found 9/2![United Airlines logo]()
$599
This Faresmojo deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop7h 41m
Tue 11/103:55 pm -
1 stop8h 40m
Deal found 9/2![JetBlue logo]()
$695
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
2 stops10h 20m
Tue 11/107:00 am -
2 stops14h 57m
Deal found 8/31![American Airlines logo]()
$696
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:10 am -
1 stop12h 36m
Sat 9/196:00 am -
1 stop27h 00m
Deal found 8/29![United Airlines logo]()
$756
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:27 am -
1 stop11h 19m
Fri 11/64:18 pm -
1 stop25h 53m
Deal found 9/1![United Airlines logo]()
$771
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/182:11 pm -
2 stops19h 11m
Sun 10/2510:27 am -
2 stops11h 35m
Deal found 9/1![American Airlines logo]()
$781
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:12 pm -
2 stops13h 10m
Tue 10/2010:27 am -
2 stops12h 25m
Deal found 9/2![American Airlines logo]()
$847
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:38 am -
1 stop12h 08m
Sun 10/255:00 am -
1 stop29h 21m
Deal found 9/1![United Airlines logo]()
$875
Best flights from Myrtle Beach to Santo DomingoDiscover carefully curated flight deals from Myrtle Beach to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
Discover carefully curated flight deals from Myrtle Beach to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/186:00 am -
1 stop7h 15m
Mon 1/253:40 pm -
1 stop8h 55m
Deal found 9/2![Delta logo]()
$691
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/183:36 pm -
2 stops19h 16m
Mon 1/257:18 pm -
2 stops20h 48m
Deal found 8/30![American Airlines logo]()
$705
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:16 pm -
1 stop17h 19m
Tue 11/107:00 am -
2 stops14h 57m
Deal found 8/31![American Airlines logo]()
$717
Last-minute flights from Myrtle Beach to Santo DomingoDiscover last-minute flight deals from Myrtle Beach to Santo Domingo. Data last updated September 3, 2026 and is based on user searches.
Discover last-minute flight deals from Myrtle Beach to Santo Domingo. Data last updated September 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/511:33 am -
2 stops13h 21m
Mon 9/72:53 pm -
1 stop8h 37m
Deal found 8/31![Delta logo]()
$1,046
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:10 am -
1 stop12h 36m
Sat 9/196:00 am -
1 stop27h 00m
Deal found 8/29![United Airlines logo]()
$756
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am -
2 stops12h 07m
Sat 9/192:53 pm -
1 stop6h 48m
Deal found 8/29![Delta logo]()
$1,031
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:30 pm -
1 stop10h 16m
Tue 10/201:10 pm -
1 stop20h 19m
Deal found 9/2![United Airlines logo]()
$599
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:12 pm -
2 stops13h 10m
Tue 10/2010:27 am -
2 stops12h 25m
Deal found 9/2![American Airlines logo]()
$847
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/182:11 pm -
2 stops19h 11m
Sun 10/2510:27 am -
2 stops11h 35m
Deal found 9/1![American Airlines logo]()
$781
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:38 am -
1 stop12h 08m
Sun 10/255:00 am -
1 stop29h 21m
Deal found 9/1![United Airlines logo]()
$875
This Faresmojo deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Faresmojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop7h 41m
Tue 11/103:55 pm -
1 stop8h 40m
Deal found 9/2![JetBlue logo]()
$695
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
2 stops10h 20m
Tue 11/107:00 am -
2 stops14h 57m
Deal found 8/31![American Airlines logo]()
$696
One-way flights from Myrtle Beach to Santo DomingoSearch for one-way flight options from Myrtle Beach to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
Search for one-way flight options from Myrtle Beach to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:12 pm -
3 stops25h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/29![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:59 am -
3 stops23h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:45 am -
2 stops29h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/29![Multiple Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:08 am -
1 stop12h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/29![United Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm -
1 stop17h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/29![United Airlines logo]()
$413
Find flight deals from Myrtle Beach to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $599 (United Airlines) |
One-way from | $281 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Myrtle Beach to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Fri 9/25
6:12 pm-7:18 pm
3 stops25h 06m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$281
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Thu 9/17
2:46 pm-11:36 am
2 stops20h 50m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$312
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Tue 9/15
10:45 am-4:29 pm
2 stops29h 44m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$333
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Tue 9/15
10:08 am-10:46 pm
1 stop12h 38m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$343
Quickest round-trip
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Thu 9/17
12:00 pm-10:46 pm
1 stop10h 46m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$343
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Fri 9/25
6:55 pm-11:55 am
1 stop17h 00m
Santo Domingo Las Americas
Wed 12/31
12:00 am-11:30 pm
Nonstop0h 00m
$413
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Mon 1/18
6:00 am-2:15 pm
1 stop7h 15m
Santo Domingo Las Americas
Mon 1/25
3:40 pm-11:35 pm
1 stop8h 55m
$691
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Mon 1/18
3:36 pm-11:52 am
2 stops19h 16m
Santo Domingo Las Americas
Mon 1/25
7:18 pm-3:06 pm
2 stops20h 48m
$705
Myrtle BeachSanto Domingo
MYR Myrtle Beach Intl - SDQ Santo Domingo Las Americas
MYRSDQ
Myrtle Beach Intl
Fri 10/30
7:16 pm-12:35 pm
1 stop17h 19m
Santo Domingo Las Americas
Tue 11/10
7:00 am-8:57 pm
2 stops14h 57m
$717
Sorted by cheapest first
Compare providers for flights from Myrtle Beach to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Santo Domingo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Myrtle Beach-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Myrtle Beach-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Myrtle Beach to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Myrtle Beach with our price prediction graph.
MYR-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Myrtle Beach to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Myrtle Beach
Popular flights
Santo Domingo flight routes