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South America

$106+ Cheap flights from Panama City (PTY) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated July 1, 2025.

Round-trip from

$200
(Copa Airlines)

One-way from

$106
(FlightHub)

Popular in

January

Cheapest in

May

Average price

$540

Good round-trip deal

$132 or less

Good one-way deal

$79 or less
From Panama City Tocumen Intl to South America
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One-way flight from Panama City Tocumen Intl to South America
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Highest demand for flights based on searches. 6% potential increase in price ($32 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to South America.
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Price to beat on a one-way flight from Panama City Tocumen Intl to South America.
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/179:46 amPTY - CTG
Nonstop1h 15mCopa Airlines
Sun 7/209:38 amCTG - PTY
Nonstop1h 19mCopa Airlines
Deal found 6/30$200
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1711:20 amPTY - CTG
1 stop6h 25mAvianca
Thu 7/314:22 amCTG - PTY
1 stop4h 33mAvianca
Deal found 6/30$202
This Avianca deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/243:20 amPTY - BOG
Nonstop1h 34mAvianca
Sun 7/278:15 amBOG - PTY
Nonstop1h 55mAvianca
Deal found 7/1$208
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/611:20 amPTY - MDE
Nonstop1h 10mAvianca
Sun 9/145:55 pmMDE - PTY
Nonstop1h 20mAvianca
Deal found 7/1$223
This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/257:51 amPTY - BOG
Nonstop1h 38mCopa Airlines
Sun 7/274:59 amBOG - PTY
Nonstop1h 50mCopa Airlines
Deal found 6/30$228
This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/16:54 amPTY - MDE
Nonstop1h 23mCopa Airlines
Tue 8/59:42 amMDE - PTY
Nonstop1h 25mCopa Airlines
Deal found 6/30$228
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/511:20 amPTY - MDE
Nonstop1h 10mMultiple Airlines
Sat 7/128:49 amMDE - PTY
Nonstop1h 27mMultiple Airlines
Deal found 6/30$285
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/293:20 amPTY - CTG
1 stop8h 38mMultiple Airlines
Fri 8/112:01 pmCTG - PTY
Nonstop1h 17mMultiple Airlines
Deal found 6/30$299
This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2011:53 amPTY - PEI
Nonstop1h 30mCopa Airlines
Mon 10/203:19 pmPEI - PTY
Nonstop1h 31mCopa Airlines
Deal found 6/30$327
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/93:20 amPTY - PEI
1 stop5h 30mAvianca
Sun 7/137:53 pmPEI - PTY
1 stop4h 17mAvianca
Deal found 7/1$330
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/511:53 amPTY - PEI
Nonstop1h 30mMultiple Airlines
Thu 8/143:13 pmPEI - PTY
1 stop5h 57mMultiple Airlines
Deal found 6/30$379
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/203:19 amPTY - CUZ
1 stop10h 56mAvianca
Sun 11/303:25 pmCUZ - PTY
1 stop8h 55mAvianca
Deal found 6/30$391

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Thu 7/17

9:46 am-11:01 am

Nonstop1h 15m

Cartagena Rafael Nunez

Sat 7/26

6:20 am-7:39 am

Nonstop1h 19m

$200

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Thu 7/17

11:20 am-5:45 pm

1 stop6h 25m

Cartagena Rafael Nunez

Thu 7/31

4:22 am-8:55 am

1 stop4h 33m

$202

Panama CityBogotá

PTY - BOG

PTYBOG

Panama City Tocumen Intl

Thu 7/24

10:05 pm-11:39 pm

Nonstop1h 34m

Bogotá El Dorado

Mon 7/28

8:15 am-10:10 am

Nonstop1h 55m

$208

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 10/17

11:20 am-12:30 pm

Nonstop1h 10m

Medellín Jose Maria Cordova Intl

Tue 10/21

1:25 pm-2:40 pm

Nonstop1h 15m

$223

Panama CityBogotá

PTY - BOG

PTYBOG

Panama City Tocumen Intl

Fri 7/25

7:51 am-9:29 am

Nonstop1h 38m

Bogotá El Dorado

Sun 7/27

4:59 am-6:49 am

Nonstop1h 50m

$228

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 8/1

6:54 am-8:17 am

Nonstop1h 23m

Medellín Jose Maria Cordova Intl

Tue 8/5

9:42 am-11:07 am

Nonstop1h 25m

$228

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Tue 7/29

3:20 am-11:58 am

1 stop8h 38m

Cartagena Rafael Nunez

Fri 8/1

12:01 pm-1:18 pm

Nonstop1h 17m

$299

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 8/27

3:20 am-7:29 pm

2 stops16h 09m

Medellín Jose Maria Cordova Intl

Sun 8/31

1:25 pm-2:40 pm

Nonstop1h 15m

$300

Panama CityPereira

PTY - PEI

PTYPEI

Panama City Tocumen Intl

Sat 9/20

11:53 am-1:23 pm

Nonstop1h 30m

Pereira Matecana

Mon 10/20

3:19 pm-4:50 pm

Nonstop1h 31m

$327

Panama CityPereira

PTY - PEI

PTYPEI

Panama City Tocumen Intl

Thu 7/17

3:20 am-8:50 am

1 stop5h 30m

Pereira Matecana

Sun 7/20

6:35 pm-12:10 am

1 stop5h 35m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Showing 1-10 of 58 results
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Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City to South America (average of $359). Flying from Panama City to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to South America as you normally would.

Weekly flight availability from Panama City to South America

Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 1, 2025.

The most flights from PTY to 0SA are scheduled on a Monday (15 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 1, 2025.
Peruse reviews from past customers who have flown with Azul, Copa Airlines, and United Airlines from Panama City to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Azul
8.0
Very good
789 reviews
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Copa Airlines
7.5
Good
1,465 reviews
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
United Airlines
7.4
Good
8,858 reviews
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
American Airlines
7.2
Good
10,000 reviews
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Avianca
6.7
Okay
2,363 reviews
Azul
8.0
Very good
789 reviews

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Food

7.1

Comfort

7.9

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    If you book a flight to South America from Panama City, you will be flying from Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How popular is this Panama City to South America flight route?

    This flight path from Panama City Tocumen Intl to South America was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to South America one-way?

    One-way options have recently been found by users for as low as $106 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $123 and American Airlines from $429 one-way.

  • What are the most popular routes from Panama City to South America?

    While some choose either Panama City Tocumen Intl - Lima J Chavez Intl or Panama City Tocumen Intl - Buenos Aires Ministro Pistarini, Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl is the most popular route from Panama City to South America.

  • What are the most reliable airlines from Panama City to South America?

    The top 3 most reliable airlines when flying from Panama City to South America are Avianca Ecuador (100%), Turkish Airlines (98%) and Copa Airlines (95%).

  • What are the cheapest flights from Panama City to South America?

    Looking for the cheapest flight from Panama City to South America? While on average our users pay $299, our data indicates the cheapest price to be $122. The most popular route (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl), is priced around $139.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City to South America (average of $359). Flying from Panama City to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Panama City to South America

Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$73Average$155FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$116Average$461FlexibilityNo cancel feeOn-time70%
AviancaCheapest$171Average$363FlexibilityNo cancel feeOn-time71%

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