How popular is this Panama City to Santiago flight route?

This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to Santiago round-trip?

Cheapflights users have booked flights from Panama City to Santiago round-trip from $554. Another airline that can offer you cheap pricing is Copa Airlines.

What is the cheapest day to fly from Panama City to Santiago?

Travelers seeking maximum savings on their Panama City to Santiago flight should consider departing on Monday afternoons when fares are most often at their lowest. Wednesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the cheapest flights from Panama City to Santiago?

On average you can expect to pay $636 for a flight from Panama City to Santiago. The cheapest flight overall is $283 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $562.

What are the most reliable airlines from Panama City to Santiago?

Consider Copa Airlines (87%), KLM (81%) or Turkish Airlines (80%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

What is the cheapest day to fly round-trip from Panama City to Santiago?

Flights from Panama City to Santiago are found to be more expensive on Tuesday. This shouldn't discourage you from searching as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Santiago.

How far in advance should I book a flight from Panama City to Santiago?

Travelers have found it’s best to book a flight 58 days in advance to save up to 16% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 58 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from Panama City to Santiago 1-2 weeks in advance for as low as $496, or $534 for flights within the next 24 hours.

What is the cheapest month to fly from Panama City to Santiago?

August is one of the best times of the year to fly to Santiago from Panama City. Prices for August average $540 per person but you can even find prices for as low as $294. The most expensive prices can be found in the month of January. Opting for a August flight can save you 17% on your journey compared to booking in January

What airports do I use to fly from Panama City to Santiago?

To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

Can I find deals for flights from Panama City to Santiago that include hotel bookings?

Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

Can I find deals for business class flights from Panama City to Santiago?

Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$296+ Flights from Panama City to Santiago

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in August or October, booked 67 days in advance, depart on a Thursday or Tuesday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Round-trip from	$554 (Priceline)
One-way from	$296 (Priceline)
Popular in	January
Cheapest in	August
Average price	$505
Good round-trip deal	$604 or less

From Panama City Tocumen Intl to Santiago Arturo Merino Benitez

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One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez

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Highest demand for flights based on searches. 8% potential increase in price ($51 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.

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Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Sun 9/283:20 amPTY - SCL

1 stop9h 05mAvianca

Sun 10/1212:55 amSCL - PTY

1 stop17h 35mAvianca

Deal found 7/10

$554

Fri 10/3111:48 amPTY - SCL

Nonstop6h 32mCopa Airlines

Sat 11/153:23 amSCL - PTY

Nonstop6h 53mCopa Airlines

Deal found 7/10

$564

Sun 8/2411:00 amPTY - SCL

2 stops25h 25mMultiple Airlines

Sat 8/302:30 pmSCL - PTY

1 stop20h 40mMultiple Airlines

Deal found 7/9

$587

Best flights from Panama City to Santiago
Discover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 11, 2025.

Sun 9/283:20 amPTY - SCL

1 stop9h 05mAvianca

Sun 10/1212:55 amSCL - PTY

1 stop17h 35mAvianca

Deal found 7/10

$554

Mon 8/411:48 amPTY - SCL

Nonstop6h 36mCopa Airlines

Mon 8/1111:29 amSCL - PTY

Nonstop6h 51mCopa Airlines

Deal found 7/10

$564

Sun 8/2411:00 amPTY - SCL

2 stops25h 25mMultiple Airlines

Sat 8/302:30 pmSCL - PTY

1 stop20h 40mMultiple Airlines

Deal found 7/9

$587

Last-minute flights from Panama City to Santiago
Discover last-minute flight deals from Panama City to Santiago. Data last updated July 11, 2025 and is based on user searches.

Mon 7/213:08 pmPTY - SCL

Nonstop6h 36mCopa Airlines

Mon 7/284:10 amSCL - PTY

Nonstop6h 53mCopa Airlines

Deal found 7/10

$739

Mon 7/2111:05 amPTY - SCL

1 stop10h 25mAvianca

Sat 7/266:10 amSCL - PTY

1 stop11h 20mAvianca

Deal found 7/9

$769

Mon 8/47:11 pmPTY - SCL

Nonstop6h 35mCopa Airlines

Sun 8/102:26 amSCL - PTY

Nonstop6h 50mCopa Airlines

Deal found 7/10

$564

Sat 8/233:20 amPTY - SCL

1 stop9h 05mAvianca

Sat 8/306:10 amSCL - PTY

1 stop16h 00mAvianca

Deal found 7/9

$554

Sun 8/2411:00 amPTY - SCL

2 stops25h 25mMultiple Airlines

Sat 8/302:30 pmSCL - PTY

1 stop20h 40mMultiple Airlines

Deal found 7/9

$587

One-way flights from Panama City to Santiago
Search for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated July 11, 2025.

Mon 8/253:25 amPTY - SCL

1 stop9h 00mAvianca

Deal found 7/9

$296

Mon 8/253:25 amPTY - SCL

2 stops23h 36mMultiple Airlines

Deal found 7/9

$298

Sun 8/103:08 pmPTY - SCL

Nonstop6h 36mCopa Airlines

Deal found 7/10

$635

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 9/28

3:20 am-2:25 pm

1 stop9h 05m

Santiago Arturo Merino Benitez

Sun 10/12

12:55 am-4:30 pm

1 stop17h 35m

$554

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Fri 10/31

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

Sat 11/15

3:23 am-8:16 am

Nonstop6h 53m

$564

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 8/24

11:00 am-1:25 pm

2 stops25h 25m

Santiago Arturo Merino Benitez

Sat 8/30

2:30 pm-10:10 am

1 stop20h 40m

$587

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 8/25

3:25 am-1:25 pm

1 stop9h 00m

$296

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Mon 8/25

3:25 am-4:01 am

2 stops23h 36m

$298

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

Sun 8/10

3:08 pm-10:44 pm

Nonstop6h 36m

$635

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/9

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Booking 67 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

It’s optimal to fly from Panama City to Santiago at noon. By choosing this option you can save up to 15% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from Panama City to Santiago

The most flights from PTY to SCL are scheduled on a Monday (8 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (8 on average).

How much does it cost to fly round-trip from Panama City to Santiago?

Reviews of airlines servicing Santiago

Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Copa Airlines

7.5

Good

1,475 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Copa Airlines

7.5

Good

1,475 reviews

Copa Airlines

7.5

Good

1,475 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Avianca

6.7

Okay

2,374 reviews

Copa Airlines

7.5

Good

1,475 reviews

Reviews

1 / 20

4.0

Okay

Paul,Jun 2025

PTY - MIA

Related info for your journey

What airports do I use to fly from Panama City to Santiago?
To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.
How popular is this Panama City to Santiago flight route?
This flight path from Panama City Tocumen Intl to Santiago Arturo Merino Benitez was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to Santiago round-trip?
Cheapflights users have booked flights from Panama City to Santiago round-trip from $554. Another airline that can offer you cheap pricing is Copa Airlines.
What are the most reliable airlines from Panama City to Santiago?
Consider Copa Airlines (87%), KLM (81%) or Turkish Airlines (80%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.
What are the cheapest flights from Panama City to Santiago?
On average you can expect to pay $636 for a flight from Panama City to Santiago. The cheapest flight overall is $283 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $562.
Can I find deals for flights from Panama City to Santiago that include hotel bookings?
Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.
Can I find deals for business class flights from Panama City to Santiago?
Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Santiago?
Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Complete your trip

Santiago car rentals

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Temuco car rentals

Lastarria car rentals

Other flights to Santiago

Top 2 airlines flying from Panama City to Santiago

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$354	Average$456	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$454	Average$639	FlexibilityNo cancel fee	On-time70%

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$296+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Santiago with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in August or October, booked 67 days in advance, depart on a Thursday or Tuesday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to SantiagoExplore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Panama City to Santiago?

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 11, 2025.

Weekly flight availability from Panama City to Santiago

Explore weekly flight availability from Panama City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 11, 2025.

How much does it cost to fly round-trip from Panama City to Santiago?

Reviews of airlines servicing Santiago

Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Santiago?

How popular is this Panama City to Santiago flight route?

What are the cheapest airlines flying from Panama City to Santiago round-trip?

What are the most reliable airlines from Panama City to Santiago?

What are the cheapest flights from Panama City to Santiago?

Can I find deals for flights from Panama City to Santiago that include hotel bookings?

How can I find direct flights from Panama City to Santiago?

Can I find deals for business class flights from Panama City to Santiago?

What is the cheapest month to book a flight from Panama City to Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Panama City to Santiago

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Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.