Santiago

$318+ Cheap flights from Panama City (PTY) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/4. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
jul. 6 — jul. 131
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in August or October, booked 67 days in advance, depart on a Thursday or Monday and return on a Sunday

Cheap flight deals from Panama City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 1, 2025.

Round-trip from

$593
(Gotogate)

One-way from

$318
(FlightHub)

Popular in

January

Cheapest in

August

Average price

$505

Good round-trip deal

$604 or less
From Panama City Tocumen Intl to Santiago Arturo Merino Benitez
One-way flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez
Highest demand for flights based on searches. 8% potential increase in price ($51 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in July 2025
Price to beat on a round-trip flight from Panama City Tocumen Intl to Santiago Arturo Merino Benitez.

Find flight deals from Panama City to Santiago

Cheapest flights from Panama City to Santiago
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 1, 2025.

This Gotogate deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/33:20 amPTY - SCL
1 stop18h 10mAvianca
vie. 8/86:10 amSCL - PTY
1 stop11h 20mAvianca
Deal found 6/30$593
This Copa Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/313:08 pmPTY - SCL
Nonstop6h 32mCopa Airlines
sáb. 11/83:23 amSCL - PTY
Nonstop6h 53mCopa Airlines
Deal found 6/30$621
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/101:30 pmPTY - SCL
2 stops28h 35mMultiple Airlines
jue. 8/1411:55 pmSCL - PTY
1 stop22h 15mMultiple Airlines
Deal found 6/30$651

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.

Fly from

Panama City

Fly to

Santiago

Route

Depart

Return

Price

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

dom. 8/3

3:20 am-10:30 pm

1 stop18h 10m

Santiago Arturo Merino Benitez

vie. 8/8

6:10 am-4:30 pm

1 stop11h 20m

$593

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

vie. 10/31

11:48 am-8:20 pm

Nonstop6h 32m

Santiago Arturo Merino Benitez

mié. 11/5

12:20 pm-5:11 pm

Nonstop6h 51m

$621

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

dom. 8/10

1:30 pm-7:05 pm

2 stops28h 35m

Santiago Arturo Merino Benitez

jue. 8/14

11:55 pm-9:10 pm

1 stop22h 15m

$651

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

lun. 8/4

5:25 pm-4:15 am

1 stop9h 50m

$318

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

mié. 8/13

3:20 am-2:50 pm

2 stops34h 30m

$387

Panama CitySantiago

PTY - SCL

PTYSCL

Panama City Tocumen Intl

lun. 8/4

7:11 pm-2:46 am

Nonstop6h 35m

$739

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Panama City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santiago

How far ahead should I book a flight from Panama City to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santiago. Price data was last updated on June 27, 2025.

Booking 67 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from Panama City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SCL?

Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 1, 2025.

It’s optimal to fly from Panama City to Santiago at noon. By choosing this option you can save up to 16% on the cost of your flight, compared to a flight in the morning.

Weekly flight availability from Panama City to Santiago

Explore weekly flight availability from Panama City to Santiago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated julio 1, 2025.

The most flights from PTY to SCL are scheduled on a Monday (8 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated julio 1, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

7.8

Crew

8.1

Overall

7.5

Entertainment

6.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Boarding

7.8

Crew

8.1

Overall

7.5

Entertainment

6.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Boarding

7.8

Crew

8.1

Overall

7.5

Entertainment

6.8

Food

6.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airports do I use to fly from Panama City to Santiago?

    To fly from Panama City to Santiago, you need to book a flight from Tocumen Intl (PTY) to Arturo Merino Benitez (SCL). Nonstop flights to Santiago Arturo Merino Benitez from Panama City Tocumen Intl take 6h 32m on average. When it comes time to book airfare, you have a few options: there are 8 outbound flights from Tocumen Intl to Arturo Merino Benitez offered by 2 different airlines.

  • How popular is this Panama City to Santiago flight route?

  • What are the cheapest airlines flying from Panama City to Santiago round-trip?

    Cheapflights users have booked flights from Panama City to Santiago round-trip from $593. Another airline that can offer you cheap pricing is Copa Airlines.

  • What are the most reliable airlines from Panama City to Santiago?

    Consider Copa Airlines (89%), KLM (88%) or Turkish Airlines (87%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Santiago.

  • What are the cheapest flights from Panama City to Santiago?

    On average you can expect to pay $636 for a flight from Panama City to Santiago. The cheapest flight overall is $283 while the most popular route, (Panama City Tocumen Intl - Santiago Arturo Merino Benitez) is currently priced at $621.

  • Can I find deals for flights from Panama City to Santiago that include hotel bookings?

    Yes. In addition to deals on Panama City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santiago.

  • Can I find deals for business class flights from Panama City to Santiago?

    Yes. Cheapflights offers flight deals from Panama City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Panama City to Santiago (average of $752). Flying from Panama City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Panama City to Santiago

Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$354Average$457FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$454Average$638FlexibilityNo cancel feeOn-time70%

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