$323+ Cheap flights from Panama City (PTY) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SCL
Oct 24 — Oct 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Panama City to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santiago Arturo Merino Benitez are usually found in March or November, booked 70 days in advance, depart on a Thursday or Monday and return on a Wednesday
Cheap flight deals from Panama City to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to SantiagoExplore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Panama City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This Avianca deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:10 pm -
1 stop11h 35m
Wed 11/117:30 am -
1 stop11h 45m
Deal found 9/22![Avianca logo]()
$599
This Avianca deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:10 pm -
1 stop11h 35m
Tue 11/107:30 am -
1 stop11h 45m
Deal found 9/20![Avianca logo]()
$609
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:24 pm -
Nonstop6h 22m
Tue 11/101:22 am -
Nonstop6h 57m
Deal found 9/21![Copa Airlines logo]()
$619
This Avianca deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:10 pm -
1 stop9h 35m
Fri 11/62:10 am -
1 stop9h 00m
Deal found 9/20![Avianca logo]()
$629
This Avianca deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:05 am -
1 stop17h 40m
Sun 11/87:30 am -
1 stop9h 45m
Deal found 9/21![Avianca logo]()
$639
This Copa Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:11 pm -
Nonstop6h 27m
Mon 11/161:02 am -
Nonstop6h 57m
Deal found 9/20![Copa Airlines logo]()
$649
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1210:05 am -
1 stop13h 00m
Fri 12/254:15 pm -
1 stop11h 05m
Deal found 9/24![Avianca logo]()
$657
This Avianca deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:10 am -
1 stop12h 10m
Tue 9/294:20 pm -
1 stop10h 15m
Deal found 9/23![Avianca logo]()
$658
This Avianca deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/124:25 am -
1 stop17h 55m
Fri 10/164:20 pm -
1 stop10h 15m
Deal found 9/19![Avianca logo]()
$659
This Avianca deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:10 am -
1 stop12h 10m
Fri 10/164:20 pm -
1 stop10h 15m
Deal found 9/19![Avianca logo]()
$669
This Avianca deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:25 am -
1 stop8h 50m
Fri 10/302:10 am -
1 stop15h 05m
Deal found 9/21![Avianca logo]()
$670
Best flights from Panama City to SantiagoDiscover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Panama City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:11 pm -
Nonstop6h 27m
Tue 11/1012:15 pm -
Nonstop6h 56m
Deal found 9/20![Copa Airlines logo]()
$619
This Copa Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:15 pm -
Nonstop6h 31m
Fri 11/63:19 am -
Nonstop6h 57m
Deal found 9/22![Copa Airlines logo]()
$649
This Copa Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/13:51 pm -
Nonstop6h 28m
Sun 11/85:07 am -
Nonstop6h 56m
Deal found 9/19![Copa Airlines logo]()
$649
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:08 pm -
Nonstop6h 31m
Sun 11/85:07 am -
Nonstop6h 56m
Deal found 9/24![Copa Airlines logo]()
$649
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:01 pm -
Nonstop6h 31m
Tue 10/61:07 am -
Nonstop6h 48m
Deal found 9/21![Copa Airlines logo]()
$694
This Copa Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/19:24 pm -
Nonstop6h 33m
Wed 1/61:12 am -
Nonstop6h 47m
Deal found 9/19![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/13:08 pm -
Nonstop6h 31m
Tue 3/1612:30 pm -
Nonstop6h 51m
Deal found 9/24![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1311:48 am -
Nonstop6h 23m
Tue 12/223:48 am -
Nonstop6h 57m
Deal found 9/19![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/133:08 pm -
Nonstop6h 27m
Sat 12/2612:20 pm -
Nonstop6h 51m
Deal found 9/19![Copa Airlines logo]()
$695
This Copa Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:11 pm -
Nonstop6h 35m
Thu 1/73:53 am -
Nonstop6h 52m
Deal found 9/22![Copa Airlines logo]()
$695
Last-minute flights from Panama City to SantiagoDiscover last-minute flight deals from Panama City to Santiago. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Santiago. Data last updated September 24, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:10 am -
1 stop12h 10m
Tue 9/294:20 pm -
1 stop10h 15m
Deal found 9/23![Avianca logo]()
$658
This Copa Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:01 pm -
Nonstop6h 31m
Sun 11/153:19 am -
Nonstop6h 57m
Deal found 9/23![Copa Airlines logo]()
$694
This Avianca deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1110:10 am -
1 stop12h 10m
Fri 10/164:20 pm -
1 stop10h 15m
Deal found 9/19![Avianca logo]()
$669
This Avianca deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/124:25 am -
1 stop17h 55m
Fri 10/164:20 pm -
1 stop10h 15m
Deal found 9/19![Avianca logo]()
$659
This Avianca deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/124:25 am -
1 stop17h 55m
Sun 10/184:20 pm -
1 stop10h 15m
Deal found 9/20![Avianca logo]()
$681
This Avianca deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/164:25 am -
1 stop8h 50m
Fri 10/161:30 am -
1 stop17h 30m
Deal found 9/21![Avianca logo]()
$673
This Avianca deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:25 am -
1 stop8h 50m
Fri 10/302:10 am -
1 stop15h 05m
Deal found 9/21![Avianca logo]()
$670
This Copa Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:08 pm -
Nonstop6h 31m
Fri 10/3012:23 pm -
Nonstop6h 48m
Deal found 9/23![Copa Airlines logo]()
$679
This Avianca deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:10 pm -
1 stop9h 35m
Fri 11/62:10 am -
1 stop9h 00m
Deal found 9/20![Avianca logo]()
$629
This Avianca deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3010:05 am -
1 stop13h 00m
Sun 11/292:10 am -
1 stop15h 05m
Deal found 9/21![Avianca logo]()
$660
This Copa Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:08 pm -
Nonstop6h 31m
Sun 11/85:07 am -
Nonstop6h 56m
Deal found 9/23![Copa Airlines logo]()
$649
One-way flights from Panama City to SantiagoSearch for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Panama City to Santiago. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:08 pm -
Nonstop6h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Copa Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/229:24 am -
3 stops33h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:40 pm -
1 stop11h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$434
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/89:45 pm -
1 stop29h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1812:04 pm -
1 stop14h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![Multiple Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:45 pm -
1 stop12h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$445
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/109:24 am -
2 stops26h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$446
This Kiwi.com deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/238:00 pm -
1 stop14h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/24![Multiple Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:40 pm -
1 stop11h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$449
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:10 pm -
1 stop9h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$468
Find flight deals from Panama City to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $599 (Avianca) |
One-way from | $323 (Copa Airlines) |
Popular in | August |
Cheapest in | March |
Average price | $640 |
Good round-trip deal | $674 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Panama City to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Mon 11/9
3:08 pm-11:36 pm
Nonstop6h 28m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$323
Quickest round-trip
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Wed 11/4
9:24 pm-5:46 am
Nonstop6h 22m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$323
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Thu 10/22
9:24 am-9:03 pm
3 stops33h 39m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$422
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Mon 12/14
12:04 pm-5:03 am
1 stop14h 59m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$449
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Fri 12/18
12:04 pm-9:34 am
2 stops19h 30m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$472
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Sat 3/13
8:10 am-12:08 am
2 stops13h 58m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$505
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Fri 1/29
12:55 pm-1:13 am
1 stop10h 18m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$520
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Tue 11/3
7:11 pm-3:38 am
Nonstop6h 27m
Santiago Arturo Merino Benitez
Tue 11/10
12:15 pm-5:11 pm
Nonstop6h 56m
$619
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Thu 10/29
6:15 pm-2:46 am
Nonstop6h 31m
Santiago Arturo Merino Benitez
Fri 11/6
3:19 am-8:16 am
Nonstop6h 57m
$649
Panama CitySantiago
PTY Panama City Tocumen Intl - SCL Santiago Arturo Merino Benitez
PTYSCL
Panama City Tocumen Intl
Sun 11/1
3:51 pm-12:19 am
Nonstop6h 28m
Santiago Arturo Merino Benitez
Sun 11/8
5:07 am-10:03 am
Nonstop6h 56m
$649
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Panama City to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Santiago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Panama City with our price prediction graph.
PTY-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Santiago
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Santiago?
Booking 69 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Panama City to Santiago?
Currently, March is the cheapest month in which you can book a flight from Panama City to Santiago (average of $561). Flying from Panama City to Santiago in August is currently the most expensive (average of $653). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SCL?
Find hourly flight availability from Panama City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 24, 2026.
When flying from Panama City to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Panama City to Santiago delayed?
About 10% of weekly flights between Panama City and Santiago have experienced delays in the past year, with the average delay time being 116 minutes.
What is the most punctual flight time for Panama City to Santiago flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Friday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Santiago flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 10% of flights being delayed.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 24, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to Santiago to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Crew
8.1
Comfort
7.4
Food
6.9
Overall
7.6
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Crew
8.1
Comfort
7.4
Food
6.9
Overall
7.6
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Crew
8.1
Comfort
7.4
Food
6.9
Overall
7.6
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Flights by cabin class
Other flight options
Other flights from Panama City
Popular flights
Santiago flight routes
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to Santiago by cabin class
Find flights from Panama City to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and Santiago flights
Browse other Panama City and Santiago flight options. Last updated on September 24, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 24, 2026.
Top 2 airlines flying from Panama City to Santiago
Discover the top 2 airlines that operate flights from Panama City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$282 | Average$608 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$353 | Average$649 | FlexibilityNo cancel fee | On-time70% |