$548+ Cheap flights from Panama City (PTY) to Louisville (SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — SDF
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Louisville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Louisville
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Best
Last-minute
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Cheapest flights from Panama City to LouisvilleExplore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Panama City to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:00 am -
2 stops23h 38m
Wed 11/115:57 pm -
2 stops26h 05m
Deal found 9/13![United Airlines logo]()
$637
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/23:24 pm -
1 stop8h 35m
Tue 11/106:00 am -
1 stop8h 02m
Deal found 9/12![Delta logo]()
$645
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:41 pm -
2 stops24h 16m
Thu 11/121:45 pm -
1 stop30h 17m
Deal found 9/13![United Airlines logo]()
$662
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/294:33 pm -
2 stops21h 51m
Mon 2/157:13 pm -
2 stops20h 01m
Deal found 9/10![American Airlines logo]()
$693
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/298:55 am -
1 stop11h 00m
Mon 2/153:50 pm -
1 stop25h 22m
Deal found 9/10![United Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:00 am -
1 stop13h 30m
Tue 11/105:10 am -
2 stops14h 52m
Deal found 9/12![United Airlines logo]()
$714
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:24 pm -
1 stop8h 35m
Wed 11/46:00 am -
1 stop7h 59m
Deal found 9/13![Delta logo]()
$722
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:55 am -
1 stop28h 28m
Sun 11/85:57 pm -
2 stops26h 05m
Deal found 9/13![United Airlines logo]()
$735
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:02 pm -
2 stops23h 49m
Wed 11/46:02 am -
1 stop8h 11m
Deal found 9/13![American Airlines logo]()
$741
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm -
1 stop29h 40m
Mon 10/56:30 pm -
1 stop26h 01m
Deal found 9/10![United Airlines logo]()
$746
Best flights from Panama City to LouisvilleDiscover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Panama City to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:41 pm -
2 stops24h 21m
Tue 11/39:10 am -
1 stop10h 28m
Deal found 9/12![United Airlines logo]()
$701
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:00 am -
1 stop13h 30m
Tue 11/105:10 am -
2 stops14h 52m
Deal found 9/12![United Airlines logo]()
$714
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm -
1 stop29h 40m
Tue 10/67:25 am -
1 stop7h 49m
Deal found 9/13![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm -
2 stops20h 45m
Mon 10/51:25 pm -
1 stop31h 06m
Deal found 9/10![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:00 am -
2 stops22h 38m
Sun 11/15:10 am -
2 stops14h 28m
Deal found 9/10![United Airlines logo]()
$768
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/123:30 pm -
1 stop29h 40m
Mon 10/196:15 am -
1 stop14h 16m
Deal found 9/13![United Airlines logo]()
$778
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:45 am -
1 stop12h 56m
Tue 10/66:16 pm -
2 stops25h 21m
Deal found 9/12![United Airlines logo]()
$795
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:30 pm -
2 stops25h 10m
Mon 10/129:40 am -
1 stop9h 57m
Deal found 9/11![United Airlines logo]()
$799
Last-minute flights from Panama City to LouisvilleDiscover last-minute flight deals from Panama City to Louisville. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Louisville. Data last updated September 15, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:30 pm -
2 stops20h 38m
Tue 9/225:15 am -
2 stops14h 22m
Deal found 9/12![United Airlines logo]()
$791
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm -
2 stops20h 45m
Mon 10/55:15 am -
2 stops15h 16m
Deal found 9/10![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:30 pm -
2 stops20h 45m
Tue 10/65:15 am -
2 stops15h 16m
Deal found 9/12![United Airlines logo]()
$762
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:45 am -
1 stop12h 56m
Tue 10/66:16 pm -
2 stops25h 21m
Deal found 9/12![United Airlines logo]()
$795
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:30 pm -
1 stop27h 25m
Mon 10/1211:13 am -
1 stop9h 18m
Deal found 9/11![United Airlines logo]()
$799
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/129:45 am -
2 stops22h 49m
Mon 10/1911:13 am -
1 stop9h 18m
Deal found 9/13![United Airlines logo]()
$778
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2510:00 am -
2 stops22h 38m
Sun 11/15:10 am -
2 stops14h 28m
Deal found 9/10![United Airlines logo]()
$768
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:41 pm -
2 stops24h 21m
Tue 11/35:10 am -
2 stops14h 28m
Deal found 9/12![United Airlines logo]()
$701
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:24 pm -
1 stop8h 35m
Wed 11/46:00 am -
1 stop7h 59m
Deal found 9/13![Delta logo]()
$722
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:02 pm -
2 stops23h 49m
Wed 11/46:02 am -
1 stop8h 11m
Deal found 9/13![American Airlines logo]()
$741
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:41 pm -
2 stops24h 19m
Sun 11/85:57 pm -
2 stops26h 05m
Deal found 9/13![United Airlines logo]()
$735
One-way flights from Panama City to LouisvilleSearch for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Panama City to Louisville. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/84:55 pm -
2 stops19h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![American Airlines logo]()
$548
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/84:41 pm -
1 stop28h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![United Airlines logo]()
$557
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/83:20 pm -
1 stop8h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Delta logo]()
$603
Find flight deals from Panama City to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $637 (United Airlines) |
Popular in | January |
Cheapest in | November |
Average price | $685 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Panama City to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Fri 1/8
4:55 pm-12:39 pm
2 stops19h 44m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$548
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Fri 1/8
4:41 pm-9:30 pm
1 stop28h 49m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$557
Quickest round-trip
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Fri 1/8
3:20 pm-12:02 am
1 stop8h 42m
Louisville Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$603
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Tue 10/27
3:41 pm-5:02 pm
2 stops24h 21m
Louisville Intl
Tue 11/3
9:10 am-7:38 pm
1 stop10h 28m
$701
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Mon 11/2
10:00 am-11:30 pm
1 stop13h 30m
Louisville Intl
Tue 11/10
5:10 am-8:02 pm
2 stops14h 52m
$714
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Wed 9/23
3:30 pm-10:10 pm
1 stop29h 40m
Louisville Intl
Tue 10/6
7:25 am-2:14 pm
1 stop7h 49m
$746
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Wed 9/23
3:30 pm-1:15 pm
2 stops20h 45m
Louisville Intl
Mon 10/5
1:25 pm-7:31 pm
1 stop31h 06m
$746
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Sun 10/25
10:00 am-9:38 am
2 stops22h 38m
Louisville Intl
Sun 11/1
5:10 am-7:38 pm
2 stops14h 28m
$768
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Mon 10/12
3:30 pm-10:10 pm
1 stop29h 40m
Louisville Intl
Mon 10/19
6:15 am-7:31 pm
1 stop14h 16m
$778
Panama CityLouisville
PTY Panama City Tocumen Intl - SDF Louisville Intl
PTYSDF
Panama City Tocumen Intl
Sat 9/26
9:45 am-11:41 pm
1 stop12h 56m
Louisville Intl
Tue 10/6
6:16 pm-6:37 pm
2 stops25h 21m
$795
Showing 1-10 of 11 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Panama City with our price prediction graph.
PTY-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated September 15, 2026.
Peruse reviews from past customers who have flown with United Airlines from Panama City to Louisville to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Overall
7.4
Comfort
7.3
Food
6.7
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Crew
8.1
Overall
7.4
Comfort
7.3
Food
6.7
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
8.0
ExcellentAsha,Sep 2026
LGA - IAH
Related info for your journey
Find useful and relevant information for your journey from Panama City to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
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Complete your trip
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Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
Panama City and Louisville flights
Browse other Panama City and Louisville flight options. Last updated on September 15, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Louisville
Discover the top airline that operate flights from Panama City to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$380 | Average$730 | FlexibilityNo cancel fee | On-time69% |