What are the cheapest airlines flying from Louisville to Panama City round-trip?

According to our current data, United Airlines ($423), Delta ($430), and American Airlines ($435) offers the cheapest pricing from Louisville to Panama City. United Airlines is currently priced 13% below the average price you’ll pay for this route.

What is the cheapest day to fly from Louisville to Panama City?

Travelers seeking maximum savings on their Louisville to Panama City flight should consider departing on Saturday evenings when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from Louisville to Panama City?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Louisville to Panama City.

What is the cheapest day to fly round-trip from Louisville to Panama City?

Wednesday flights are generally found to be more expensive for flights from Louisville to Panama City. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City.

What is the cheapest month to fly from Louisville to Panama City?

The best pricing can be found in the month of October. Prices to Panama City from Louisville average $488. You can even find prices in October for less than $488, as users have found deals to Panama City from as low as $335. The month of December appears to be one of the more expensive times to travel to Panama City from Louisville. Flying in the targeted month can save you up to 38%.

Can I find deals for flights from Louisville to Panama City that include hotel bookings?

Yes. In addition to deals on Louisville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Louisville to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama City.

Can I find deals for business class flights from Louisville to Panama City?

Yes. Cheapflights offers flight deals from Louisville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$179+ Flights from Louisville to Panama City

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Cheap flight deals from Louisville to Panama City

Round-trip from	$423 (United Airlines)
One-way from	$179 (United Airlines)
Popular in	December
Cheapest in	October
Average price	$400

From Louisville Intl to Panama City Tocumen Intl

Search Deals

One-way flight from Louisville Intl to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($71 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Louisville to Panama City

Cheapest flights from Louisville to Panama City
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Thu 7/249:35 amSDF - PTY

1 stop10h 02mUnited Airlines

Wed 7/307:55 amPTY - SDF

1 stop12h 56mUnited Airlines

Deal found 6/30

$423

Sat 9/276:00 amSDF - PTY

1 stop7h 55mDelta

Wed 10/12:10 pmPTY - SDF

1 stop8h 42mDelta

Deal found 7/1

$430

Sat 9/276:44 pmSDF - PTY

2 stops20h 47mAmerican Airlines

Wed 10/11:45 pmPTY - SDF

1 stop9h 11mAmerican Airlines

Deal found 7/1

$435

Wed 7/309:46 amSDF - PTY

2 stops29h 54mMultiple Airlines

Wed 8/65:25 pmPTY - SDF

3 stops23h 33mMultiple Airlines

Deal found 7/2

$595

Best flights from Louisville to Panama City
Discover carefully curated flight deals from Louisville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 2, 2025.

Thu 7/249:35 amSDF - PTY

1 stop10h 02mUnited Airlines

Wed 7/307:55 amPTY - SDF

1 stop12h 56mUnited Airlines

Deal found 6/30

$423

Sat 9/276:00 amSDF - PTY

1 stop7h 55mDelta

Wed 10/12:10 pmPTY - SDF

1 stop8h 42mDelta

Deal found 7/1

$430

Sat 9/276:44 pmSDF - PTY

2 stops20h 47mAmerican Airlines

Wed 10/11:45 pmPTY - SDF

1 stop9h 11mAmerican Airlines

Deal found 7/1

$435

Wed 7/309:46 amSDF - PTY

2 stops29h 54mMultiple Airlines

Wed 8/65:25 pmPTY - SDF

3 stops23h 33mMultiple Airlines

Deal found 7/2

$595

Last-minute flights from Louisville to Panama City
Discover last-minute flight deals from Louisville to Panama City. Data last updated July 2, 2025 and is based on user searches.

Sat 7/126:00 amSDF - PTY

2 stops9h 15mAmerican Airlines

Sat 7/193:10 pmPTY - SDF

2 stops18h 15mAmerican Airlines

Deal found 7/1

$468

Sat 7/126:00 amSDF - PTY

1 stop14h 03mDelta

Sat 7/198:10 amPTY - SDF

1 stop15h 22mDelta

Deal found 7/1

$579

Sat 7/129:43 pmSDF - PTY

3 stops41h 57mMultiple Airlines

Sat 7/199:55 amPTY - SDF

3 stops32h 13mMultiple Airlines

Deal found 7/1

$734

Thu 7/249:35 amSDF - PTY

1 stop10h 02mUnited Airlines

Wed 7/307:55 amPTY - SDF

1 stop12h 56mUnited Airlines

Deal found 6/30

$423

Thu 7/248:02 pmSDF - PTY

2 stops19h 13mAmerican Airlines

Sat 8/163:30 pmPTY - SDF

2 stops21h 42mAmerican Airlines

Deal found 7/1

$437

Fri 7/256:00 amSDF - PTY

1 stop14h 31mDelta

Wed 7/302:28 pmPTY - SDF

1 stop9h 04mDelta

Deal found 7/1

$443

Wed 7/309:46 amSDF - PTY

2 stops29h 54mMultiple Airlines

Wed 8/65:25 pmPTY - SDF

3 stops23h 33mMultiple Airlines

Deal found 7/2

$595

One-way flights from Louisville to Panama City
Search for one-way flight options from Louisville to Panama City. Find affordable one-way fares based on user searches. Data last updated July 2, 2025.

Mon 7/77:15 amSDF - PTY

1 stop9h 57mUnited Airlines

Deal found 7/1

$179

Mon 7/76:00 amSDF - PTY

2 stops9h 15mAmerican Airlines

Deal found 7/1

$199

Mon 7/712:15 pmSDF - PTY

3 stops33h 00mMultiple Airlines

Deal found 7/1

$377

Cheapflights Fare Finder

Use the filters below to find and compare flights from Louisville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Thu 7/24

9:35 am-6:37 pm

1 stop10h 02m

Panama City Tocumen Intl

Wed 7/30

7:55 am-9:51 pm

1 stop12h 56m

$423

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 9/27

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Wed 10/1

2:10 pm-11:52 pm

1 stop8h 42m

$430

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Sat 9/27

6:44 pm-2:31 pm

2 stops20h 47m

Panama City Tocumen Intl

Wed 10/1

1:45 pm-11:56 pm

1 stop9h 11m

$435

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Wed 7/30

9:46 am-2:40 pm

2 stops29h 54m

Panama City Tocumen Intl

Wed 8/6

5:25 pm-5:58 pm

3 stops23h 33m

$595

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 7/7

7:15 am-4:12 pm

1 stop9h 57m

$179

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 7/7

6:00 am-2:15 pm

2 stops9h 15m

$199

LouisvillePanama City

SDF - PTY

SDFPTY

Louisville Intl

Mon 7/7

12:15 pm-8:15 pm

3 stops33h 00m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from Louisville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama City

What is the cheapest month to book a flight from Louisville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Louisville to Panama City (average of $478). Flying from Louisville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SDF to PTY?

One of the essential ways to save on airfare from Louisville to Panama City is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 23% on airfare.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Louisville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,975 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,861 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,975 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Louisville to Panama City round-trip?
According to our current data, United Airlines ($423), Delta ($430), and American Airlines ($435) offers the cheapest pricing from Louisville to Panama City. United Airlines is currently priced 13% below the average price you’ll pay for this route.
Can I find deals for flights from Louisville to Panama City that include hotel bookings?
Yes. In addition to deals on Louisville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Louisville to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Panama City.
Can I find deals for business class flights from Louisville to Panama City?
Yes. Cheapflights offers flight deals from Louisville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Louisville to Panama City?
Currently, October is the cheapest month in which you can book a flight from Louisville to Panama City (average of $478). Flying from Louisville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Louisville to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$329	Average$488	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$338	Average$567	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$361	Average$513	FlexibilityNo cancel fee	On-timeN/A

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$179+ Cheap flights from Louisville (SDF) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/7. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Louisville to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Louisville to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Louisville to Panama City

Cheapest flights from Louisville to Panama CityExplore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Louisville to Panama City that are best for you.

Best time to book a flight from Louisville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Louisville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Panama City

What is the cheapest month to book a flight from Louisville to Panama City?

What is the cheapest time of day to fly from SDF to PTY?

Find hourly flight availability from Louisville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Louisville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Louisville to Panama City round-trip?

Can I find deals for flights from Louisville to Panama City that include hotel bookings?

How can I find direct flights from Louisville to Panama City?

Can I find deals for business class flights from Louisville to Panama City?

What is the cheapest month to book a flight from Louisville to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Louisville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Louisville to Panama City

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Travel Smart

Cheapest flights from Louisville to Panama City
Explore the most affordable flight options available from Louisville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.