$250+ Cheap flights from Knoxville (TYS) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Jun 13 — Jun 201
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City
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Best
Last-minute
One-way
Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 14, 2026.
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:00 am
TYS
- PTY
1 stop7h 24m
American Airlines
Thu 8/131:24 pm
PTY
- TYS
1 stop9h 35m
American Airlines
Deal found 5/9![American Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Thu 8/273:30 pm
PTY
- TYS
1 stop25h 47m
United Airlines
Deal found 5/13![United Airlines logo]()
$536
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Fri 8/213:30 pm
PTY
- TYS
2 stops17h 18m
United Airlines
Deal found 5/12![United Airlines logo]()
$561
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 am
TYS
- PTY
1 stop8h 29m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$573
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 am
TYS
- PTY
1 stop7h 24m
American Airlines
Sat 8/221:24 pm
PTY
- TYS
1 stop9h 35m
American Airlines
Deal found 5/9![American Airlines logo]()
$587
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/157:00 am
TYS
- PTY
2 stops22h 04m
United Airlines
Sat 8/223:30 pm
PTY
- TYS
2 stops22h 07m
United Airlines
Deal found 5/9![United Airlines logo]()
$591
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$600
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:27 am
TYS
- PTY
1 stop6h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$603
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$610
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:27 am
TYS
- PTY
1 stop6h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$623
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 14, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 14, 2026.
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:00 am
TYS
- PTY
1 stop7h 24m
American Airlines
Thu 8/131:24 pm
PTY
- TYS
1 stop9h 35m
American Airlines
Deal found 5/9![American Airlines logo]()
$527
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Fri 8/213:30 pm
PTY
- TYS
2 stops17h 18m
United Airlines
Deal found 5/13![United Airlines logo]()
$561
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated May 14, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated May 14, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:27 am
TYS
- PTY
1 stop6h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$623
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:40 am
TYS
- PTY
1 stop8h 10m
Delta
Sat 6/132:27 pm
PTY
- TYS
1 stop18h 11m
Delta
Deal found 5/9![Delta logo]()
$653
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:27 am
TYS
- PTY
1 stop6h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$603
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:40 am
TYS
- PTY
1 stop8h 10m
Delta
Sat 6/132:27 pm
PTY
- TYS
1 stop18h 11m
Delta
Deal found 5/9![Delta logo]()
$633
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$600
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Sat 6/132:27 pm
PTY
- TYS
1 stop18h 11m
Delta
Deal found 5/9![Delta logo]()
$630
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:40 am
TYS
- PTY
1 stop8h 29m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$573
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:19 pm
TYS
- PTY
2 stops25h 12m
United Airlines
Mon 6/157:55 am
PTY
- TYS
2 stops24h 48m
United Airlines
Deal found 5/12![United Airlines logo]()
$651
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:45 am
TYS
- PTY
2 stops14h 46m
United Airlines
Sun 6/1410:55 pm
PTY
- TYS
2 stops23h 59m
United Airlines
Deal found 5/9![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:45 am
TYS
- PTY
2 stops14h 46m
United Airlines
Tue 6/163:30 pm
PTY
- TYS
2 stops28h 26m
United Airlines
Deal found 5/11![United Airlines logo]()
$631
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Thu 6/182:24 pm
PTY
- TYS
1 stop18h 14m
Delta
Deal found 5/9![Delta logo]()
$610
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Sat 6/132:27 pm
PTY
- TYS
1 stop18h 11m
Delta
Deal found 5/9![Delta logo]()
$640
One-way flights from Knoxville to Panama CitySearch for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated May 14, 2026.
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated May 14, 2026.
This KAYAK deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:45 am
TYS
- PTY
2 stops14h 46m
Avianca
Deal found 5/9![Avianca logo]()
$250
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:45 am
TYS
- PTY
2 stops14h 46m
United Airlines
Deal found 5/9![United Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:40 am
TYS
- PTY
1 stop8h 10m
Delta
Deal found 5/12![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:00 am
TYS
- PTY
2 stops23h 04m
United Airlines
Deal found 5/9![United Airlines logo]()
$281
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Deal found 5/9![Delta logo]()
$283
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:46 pm
TYS
- PTY
1 stop18h 23m
Delta
Deal found 5/9![Delta logo]()
$293
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:40 am
TYS
- PTY
1 stop8h 10m
Delta
Deal found 5/9![Delta logo]()
$301
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/117:03 pm
TYS
- PTY
2 stops18h 10m
American Airlines
Deal found 5/9![American Airlines logo]()
$316
This AranGrant deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure AranGrant is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:07 pm
TYS
- PTY
2 stops19h 07m
GOL
Deal found 5/10![GOL logo]()
$340
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
TYS
- PTY
1 stop7h 13m
American Airlines
Deal found 5/13![American Airlines logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:22 pm
TYS
- PTY
3 stops42h 26m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$403
This BusinessClass deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:15 am
TYS
- PTY
1 stop9h 57m
Copa Airlines
Deal found 5/10![Copa Airlines logo]()
$454
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $527 (American Airlines) |
One-way from | $250 (KAYAK) |
Popular in | March |
Cheapest in | September |
Average price | $550 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 8/6
6:00 am-12:24 pm
1 stop7h 24m
Panama City Tocumen Intl
Thu 8/13
1:24 pm-11:59 pm
1 stop9h 35m
$527
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 8/17
7:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Fri 8/21
3:30 pm-9:48 am
2 stops17h 18m
$561
Cheapest one-way
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 6/8
5:45 am-7:31 pm
2 stops14h 46m
$250
Quickest one-way
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Wed 6/10
7:35 am-1:09 pm
1 stop6h 34m
$251
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 5/28
1:53 pm-12:14 pm
2 stops23h 21m
$271
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 5/28
5:40 am-12:50 pm
1 stop8h 10m
$271
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Sat 6/6
6:00 am-4:04 am
2 stops23h 04m
$281
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Sat 6/6
5:40 am-12:50 pm
1 stop8h 10m
$281
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Fri 6/5
5:45 am-7:31 pm
2 stops14h 46m
$301
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 6/22
7:19 pm-2:14 pm
2 stops19h 55m
$316
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama City
What is the cheapest month to book a flight from Knoxville to Panama City?
Currently, September is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $467). Flying from Knoxville to Panama City in March is currently the most expensive (average of $910). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Panama City?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated May 14, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Food
6.6
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Food
6.6
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Crew
8.1
Overall
7.4
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Knoxville to Panama City
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama City by cabin class
Find flights from Knoxville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on May 14, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on May 14, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Panama City
Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$261 | Average$507 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$507 | Average$617 | FlexibilityNo cancel fee | On-time71% |