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Panama City

$179+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 2, 2025.

Round-trip from

$512
(American Airlines)

One-way from

$179
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$650
From Knoxville McGhee Tyson to Panama City Tocumen Intl
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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
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Highest demand for flights based on searches. 17% potential increase in price ($132 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($46 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/295:19 pmTYS - PTY
2 stops20h 35mAmerican Airlines
Tue 8/51:55 pmPTY - TYS
2 stops20h 34mAmerican Airlines
Deal found 7/1$512
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2912:00 pmTYS - PTY
1 stop7h 37mUnited Airlines
Tue 8/53:30 pmPTY - TYS
1 stop21h 11mUnited Airlines
Deal found 7/1$537
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/278:54 pmTYS - PTY
3 stops28h 51mMultiple Airlines
Sat 8/23:20 amPTY - TYS
3 stops27h 42mMultiple Airlines
Deal found 6/30$643
This Priceline deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/155:45 amTYS - PTY
2 stops31h 50mAvianca
Tue 7/221:30 pmPTY - TYS
3 stops19h 57mAvianca
Deal found 7/1$1,380

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 7/29

5:19 pm-12:54 pm

2 stops20h 35m

Panama City Tocumen Intl

Tue 8/5

1:55 pm-11:29 am

2 stops20h 34m

$512

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 7/29

12:00 pm-6:37 pm

1 stop7h 37m

Panama City Tocumen Intl

Tue 8/5

3:30 pm-1:41 pm

1 stop21h 11m

$537

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 7/27

8:54 pm-12:45 am

3 stops28h 51m

Panama City Tocumen Intl

Sat 8/2

3:20 am-8:02 am

3 stops27h 42m

$643

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 7/15

5:45 am-12:35 pm

2 stops31h 50m

Panama City Tocumen Intl

Tue 7/22

1:30 pm-10:27 am

3 stops19h 57m

$1,380

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 8/31

9:12 pm-9:10 pm

2 stops24h 58m

$179

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 9/1

6:07 pm-2:30 pm

2 stops21h 23m

$221

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 8/29

9:30 am-6:37 pm

1 stop10h 07m

$241

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 9/9

7:25 pm-12:35 pm

3 stops18h 10m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PTY?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama City as you normally would.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated July 2, 2025.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as United Airlines, American Airlines, and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
8,861 reviews

Entertainment

7.0

Food

6.6

Overall

7.4

Boarding

7.7

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,861 reviews
United Airlines
7.4
Good
8,861 reviews

Entertainment

7.0

Food

6.6

Overall

7.4

Boarding

7.7

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,861 reviews

Entertainment

7.0

Food

6.6

Overall

7.4

Boarding

7.7

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
Avianca
6.7
Okay
2,363 reviews
United Airlines
7.4
Good
8,861 reviews

Entertainment

7.0

Food

6.6

Overall

7.4

Boarding

7.7

Crew

8.1

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on American Airlines is currently your cheapest option to Panama City, with prices starting at $512. Additional round-trip tickets that might be worth considering are offered by United Airlines and Avianca, with the lowest prices starting at $537 and $1,380, respectively. American Airlines is currently priced 17% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Knoxville to Panama City one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $221. Users have also found prices from $241 and $311 on United Airlines and Avianca, respectively.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Panama City

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Top 3 airlines flying from Knoxville to Panama City

Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$642FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$407Average$582FlexibilityNo cancel feeOn-time71%
DeltaCheapest$427Average$628FlexibilityNo cancel feeOn-timeN/A

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