What are the cheapest airlines flying from Knoxville to Panama City round-trip?

Flying on American Airlines is currently your cheapest option to Panama City, with prices starting at $467. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $537 and $672, respectively. American Airlines is currently priced 24% below the average price you’ll pay for this route.

What is the cheapest day to fly from Knoxville to Panama City?

Travelers seeking maximum savings on their Knoxville to Panama City flight should consider departing on Friday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

What are the most popular airlines that fly from Knoxville to Panama City?

American Airlines, Delta and United Airlines are the most popular airlines when flying from Knoxville to Panama City.

What is the cheapest day to fly round-trip from Knoxville to Panama City?

Thursday is generally a great day to depart. Flying on this day could help you save up to 58%.

What is the cheapest month to fly from Knoxville to Panama City?

Our data shows that November tends to be the cheapest month to fly to Panama City from Knoxville. Users have commonly found prices around $618 for the month, but tickets can be as low as $427. Due to multiple factors, prepare for potentially higher prices in December.

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

Can I find deals for business class flights from Knoxville to Panama City?

Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$221+ Flights from Knoxville to Panama City

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Cheap flight deals from Knoxville to Panama City

Round-trip from	$467 (American Airlines)
One-way from	$221 (American Airlines)
Popular in	December
Cheapest in	November
Average price	$650

From Knoxville McGhee Tyson to Panama City Tocumen Intl

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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl

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Highest demand for flights based on searches. 17% potential increase in price ($132 potential increase over avg. RT price).

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Cheapest flight prices on average. 8% potential price decrease ($46 potential savings vs. average RT price).

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Average for round-trip flights in July 2025

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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Fri 9/126:00 amTYS - PTY

1 stop9h 31mAmerican Airlines

Fri 9/193:31 pmPTY - TYS

1 stop7h 19mAmerican Airlines

Deal found 7/8

$467

Sat 8/239:30 amTYS - PTY

1 stop10h 07mUnited Airlines

Sat 8/303:30 pmPTY - TYS

1 stop25h 40mUnited Airlines

Deal found 7/9

$537

Wed 8/134:15 pmTYS - PTY

3 stops32h 55mMultiple Airlines

Mon 8/183:25 amPTY - TYS

3 stops29h 39mMultiple Airlines

Deal found 7/8

$647

Sun 10/56:08 pmTYS - PTY

1 stop19h 39mDelta

Sat 10/112:12 pmPTY - TYS

1 stop23h 53mDelta

Deal found 7/9

$719

Tue 7/297:35 pmTYS - PTY

3 stops18h 00mAvianca

Tue 8/51:30 pmPTY - TYS

3 stops19h 57mAvianca

Deal found 7/10

$943

Best flights from Knoxville to Panama City
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 11, 2025.

Fri 9/126:00 amTYS - PTY

1 stop9h 31mAmerican Airlines

Fri 9/193:31 pmPTY - TYS

1 stop7h 19mAmerican Airlines

Deal found 7/8

$467

Sat 8/239:30 amTYS - PTY

1 stop10h 07mUnited Airlines

Sat 8/303:30 pmPTY - TYS

1 stop25h 40mUnited Airlines

Deal found 7/9

$537

Wed 8/134:15 pmTYS - PTY

3 stops32h 55mMultiple Airlines

Mon 8/183:25 amPTY - TYS

3 stops29h 39mMultiple Airlines

Deal found 7/8

$647

Sun 10/56:08 pmTYS - PTY

1 stop19h 39mDelta

Sun 10/122:12 pmPTY - TYS

1 stop17h 59mDelta

Deal found 7/9

$672

Tue 7/297:35 pmTYS - PTY

3 stops18h 00mAvianca

Tue 8/51:30 pmPTY - TYS

3 stops19h 57mAvianca

Deal found 7/10

$943

Last-minute flights from Knoxville to Panama City
Discover last-minute flight deals from Knoxville to Panama City. Data last updated July 11, 2025 and is based on user searches.

Wed 7/164:25 pmTYS - PTY

2 stops21h 29mAmerican Airlines

Sat 7/191:55 pmPTY - TYS

2 stops19h 33mAmerican Airlines

Deal found 7/10

$672

Wed 7/169:35 amTYS - PTY

1 stop7h 37mUnited Airlines

Sat 7/193:30 pmPTY - TYS

1 stop27h 31mUnited Airlines

Deal found 7/10

$678

Wed 7/164:09 pmTYS - PTY

3 stops30h 01mMultiple Airlines

Sat 7/199:55 amPTY - TYS

3 stops27h 26mMultiple Airlines

Deal found 7/10

$775

Tue 7/297:35 pmTYS - PTY

3 stops18h 00mAvianca

Tue 8/51:30 pmPTY - TYS

3 stops19h 57mAvianca

Deal found 7/10

$943

Wed 8/137:00 amTYS - PTY

1 stop8h 30mAmerican Airlines

Tue 8/193:30 pmPTY - TYS

1 stop7h 16mAmerican Airlines

Deal found 7/8

$507

Wed 8/134:15 pmTYS - PTY

3 stops32h 55mMultiple Airlines

Mon 8/183:25 amPTY - TYS

3 stops29h 39mMultiple Airlines

Deal found 7/8

$647

Sat 8/239:30 amTYS - PTY

1 stop10h 07mUnited Airlines

Sat 8/303:30 pmPTY - TYS

1 stop25h 40mUnited Airlines

Deal found 7/9

$537

One-way flights from Knoxville to Panama City
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated July 11, 2025.

Thu 8/147:00 amTYS - PTY

1 stop8h 30mAmerican Airlines

Deal found 7/10

$221

Thu 8/148:52 pmTYS - PTY

3 stops20h 47mMultiple Airlines

Deal found 7/10

$310

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/12

6:00 am-2:31 pm

1 stop9h 31m

Panama City Tocumen Intl

Fri 9/19

3:31 pm-11:50 pm

1 stop7h 19m

$467

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/23

9:30 am-6:37 pm

1 stop10h 07m

Panama City Tocumen Intl

Sat 8/30

3:30 pm-6:10 pm

1 stop25h 40m

$537

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/13

4:15 pm-12:10 am

3 stops32h 55m

Panama City Tocumen Intl

Mon 8/18

3:25 am-10:04 am

3 stops29h 39m

$647

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 10/5

6:08 pm-12:47 pm

1 stop19h 39m

Panama City Tocumen Intl

Sun 10/12

2:12 pm-9:11 am

1 stop17h 59m

$672

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 7/29

7:35 pm-12:35 pm

3 stops18h 00m

Panama City Tocumen Intl

Tue 8/5

1:30 pm-10:27 am

3 stops19h 57m

$943

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 8/14

7:00 am-2:30 pm

1 stop8h 30m

$221

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 8/14

8:52 pm-4:39 pm

3 stops20h 47m

$310

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/10

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PTY?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama City as you normally would.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Knoxville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,951 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,846 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Avianca

6.7

Okay

2,374 reviews

Delta

8.0

Very good

7,951 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Knoxville to Panama City round-trip?
Flying on American Airlines is currently your cheapest option to Panama City, with prices starting at $467. Additional round-trip tickets that might be worth considering are offered by United Airlines and Delta, with the lowest prices starting at $537 and $672, respectively. American Airlines is currently priced 24% below the average price you’ll pay for this route.
Can I find deals for flights from Knoxville to Panama City that include hotel bookings?
Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.
Can I find deals for business class flights from Knoxville to Panama City?
Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Panama City?
Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Knoxville to Panama City

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$387	Average$642	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$407	Average$582	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$427	Average$628	FlexibilityNo cancel fee	On-timeN/A

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$221+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

What is the cheapest time of day to fly from TYS to PTY?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 11, 2025.

Reviews of airlines servicing Panama City

Read through reviews of airlines operating flights from Knoxville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Panama City round-trip?

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

How can I find direct flights from Knoxville to Panama City?

Can I find deals for business class flights from Knoxville to Panama City?

What is the cheapest month to book a flight from Knoxville to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to Panama City

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 11, 2025.