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Panama City

$386+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Jul 30 — Aug 61
Thu 7/30
Thu 8/6
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 30, 2026.

This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
TYS
-
PTY
1 stop7h 39m
American Airlines
Fri 9/41:39 pm
PTY
-
TYS
1 stop9h 12m
American Airlines
Deal found 6/26$587
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:45 am
TYS
-
PTY
2 stops10h 46m
United Airlines
Thu 8/2710:55 pm
PTY
-
TYS
2 stops24h 04m
United Airlines
Deal found 6/28$591
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:15 am
TYS
-
PTY
1 stop9h 57m
United Airlines
Mon 9/2810:00 am
PTY
-
TYS
1 stop10h 55m
United Airlines
Deal found 6/28$607
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:15 am
TYS
-
PTY
1 stop9h 57m
United Airlines
Thu 10/110:00 am
PTY
-
TYS
2 stops22h 45m
United Airlines
Deal found 6/28$611
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/297:15 am
TYS
-
PTY
1 stop9h 57m
United Airlines
Tue 9/293:30 pm
PTY
-
TYS
1 stop29h 25m
United Airlines
Deal found 6/28$617
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:27 pm
TYS
-
PTY
2 stops19h 09m
American Airlines
Thu 11/122:43 pm
PTY
-
TYS
2 stops19h 36m
American Airlines
Deal found 6/26$621
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:15 am
TYS
-
PTY
1 stop12h 22m
United Airlines
Mon 9/2810:00 am
PTY
-
TYS
1 stop10h 55m
United Airlines
Deal found 6/28$622
This United Airlines deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:00 am
TYS
-
PTY
2 stops13h 37m
United Airlines
Tue 9/293:30 pm
PTY
-
TYS
2 stops28h 30m
United Airlines
Deal found 6/28$626
This Delta deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/305:40 am
TYS
-
PTY
1 stop8h 25m
Delta
Wed 9/302:23 pm
PTY
-
TYS
1 stop8h 32m
Delta
Deal found 6/28$627

Find flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$587
(American Airlines)

One-way from

$386
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$883
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
Search Deals
From Knoxville McGhee Tyson to Panama City Tocumen Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

10:55 pm-11:59 pm

2 stops24h 04m

$591
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 8/4

5:45 am-4:12 pm

2 stops11h 27m

Panama City Tocumen Intl

Mon 9/28

10:00 am-9:55 pm

1 stop10h 55m

$611

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 8/3

7:15 am-4:12 pm

1 stop9h 57m

Panama City Tocumen Intl

Tue 9/29

3:30 pm-6:05 pm

1 stop25h 35m

$617

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 9/4

6:02 pm-2:14 pm

2 stops21h 12m

Panama City Tocumen Intl

Mon 9/7

3:30 pm-11:59 pm

2 stops31h 29m

$621
Cheapest one-way
Quickest one-way

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 7/2

7:15 am-4:12 pm

1 stop9h 57m

$386

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 7/2

5:25 pm-10:30 am

3 stops18h 05m

$1,164

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Sorted by cheapest first

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, April is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $496). Flying from Knoxville to Panama City in March is currently the most expensive (average of $997). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 30, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,894 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
9,894 reviews
United Airlines
7.4
Good
9,894 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
American Airlines
7.1
Good
11,768 reviews
United Airlines
7.4
Good
9,894 reviews

Boarding

7.7

Comfort

7.3

Entertainment

7.1

Crew

8.1

Food

6.6

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City?

    For as low as $591, United Airlines can have you in Panama City from Knoxville in 7h 59m. The distance between Knoxville and Panama City is about 1869 mi.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $261. Another option worth looking into is American Airlines, starting at $504 round trip. United Airlines is currently priced 62% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $496). Flying from Knoxville to Panama City in March is currently the most expensive (average of $997). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Panama City flights
Memphis to Panama City flights

Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$261Average$529FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$504Average$624FlexibilityNo cancel feeOn-time71%

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