$621+ Cheap flights from Knoxville (TYS) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Oct 29 — Nov 51
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City
Cheapest
Best
Last-minute
Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:05 am -
1 stop7h 40m
Tue 1/194:41 pm -
1 stop18h 21m
Deal found 9/27![United Airlines logo]()
$621
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:52 pm -
2 stops17h 21m
Mon 11/233:34 pm -
1 stop9h 18m
Deal found 9/25![American Airlines logo]()
$699
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:22 pm -
1 stop18h 40m
Mon 11/233:29 pm -
1 stop19h 59m
Deal found 9/25![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 am -
2 stops12h 53m
Thu 11/198:55 am -
1 stop13h 02m
Deal found 9/27![United Airlines logo]()
$734
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:40 pm -
2 stops26h 22m
Mon 11/234:41 pm -
2 stops17h 12m
Deal found 9/25![United Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 9/28![United Airlines logo]()
$778
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:00 am -
1 stop12h 38m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 9/24![United Airlines logo]()
$785
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:05 am -
1 stop7h 40m
Tue 1/194:41 pm -
1 stop18h 21m
Deal found 9/27![United Airlines logo]()
$621
This Ovago deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/245:20 pm -
1 stop26h 18m
Thu 1/288:55 am -
1 stop9h 28m
Deal found 9/29![Copa Airlines logo]()
$682
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:22 pm -
1 stop18h 40m
Mon 11/233:29 pm -
1 stop19h 59m
Deal found 9/25![Delta logo]()
$716
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:45 am -
2 stops12h 53m
Thu 11/198:55 am -
1 stop13h 02m
Deal found 9/27![United Airlines logo]()
$734
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 9/28![United Airlines logo]()
$778
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated September 29, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:35 pm -
2 stops13h 20m
Wed 9/305:30 am -
2 stops13h 49m
Deal found 9/24![Avianca logo]()
$939
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop6h 26m
Wed 9/301:16 pm -
1 stop8h 51m
Deal found 9/24![American Airlines logo]()
$1,013
This Ovago deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:15 am -
1 stop7h 59m
Wed 9/303:30 pm -
2 stops17h 15m
Deal found 9/24![Copa Airlines logo]()
$1,015
This Kiwi.com deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:04 pm -
1 stop26h 15m
Sat 10/2412:03 pm -
1 stop19h 22m
Deal found 9/25![Multiple Airlines logo]()
$909
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:13 pm -
2 stops18h 49m
Sat 10/242:02 pm -
1 stop31h 57m
Deal found 9/25![American Airlines logo]()
$935
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:45 am -
2 stops14h 46m
Sat 10/249:45 am -
2 stops23h 08m
Deal found 9/25![United Airlines logo]()
$988
This United Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:00 am -
1 stop12h 38m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 9/24![United Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 9/28![United Airlines logo]()
$778
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $621 (United Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $916 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Tue 12/8
7:05 am-2:45 pm
1 stop7h 40m
Panama City Tocumen Intl
Tue 1/19
4:41 pm-11:02 am
1 stop18h 21m
$621
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sun 1/24
5:20 pm-7:38 pm
1 stop26h 18m
Panama City Tocumen Intl
Thu 1/28
8:55 am-6:23 pm
1 stop9h 28m
$682
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Mon 11/16
7:22 pm-2:02 pm
1 stop18h 40m
Panama City Tocumen Intl
Mon 11/23
3:29 pm-11:28 am
1 stop19h 59m
$716
Quickest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/12
6:45 am-7:38 pm
2 stops12h 53m
Panama City Tocumen Intl
Thu 11/19
8:55 am-9:57 pm
1 stop13h 02m
$734
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 10/28
11:19 am-7:02 pm
1 stop8h 43m
Panama City Tocumen Intl
Sun 11/1
4:41 pm-11:12 am
1 stop18h 31m
$778
Sorted by cheapest first
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 29, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Panama City flight routes
Popular flights
Alternative routes for Knoxville to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama City by cabin class
Find flights from Knoxville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on September 29, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Panama City
Discover the top airline that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$547 | Average$716 | FlexibilityNo cancel fee | On-timeN/A |