$311+ Cheap flights from Knoxville (TYS) to Panama City (PTY)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Sep 13 — Sep 201
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City
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Best
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Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2026.
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:06 pm -
2 stops21h 07m
Tue 12/294:33 pm -
2 stops21h 32m
Deal found 8/10![American Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:05 pm -
1 stop7h 32m
Thu 10/13:30 pm -
1 stop29h 25m
Deal found 8/10![United Airlines logo]()
$673
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 pm -
2 stops26h 31m
Tue 9/153:30 pm -
2 stops17h 24m
Deal found 8/11![United Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am -
1 stop6h 26m
Tue 9/151:16 pm -
1 stop8h 51m
Deal found 8/11![American Airlines logo]()
$694
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am -
1 stop12h 22m
Sat 10/39:45 am -
1 stop10h 00m
Deal found 8/12![United Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:05 am -
1 stop7h 11m
Sun 9/131:16 pm -
1 stop8h 51m
Deal found 8/11![American Airlines logo]()
$724
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
1 stop7h 59m
Sat 9/129:45 am -
2 stops23h 52m
Deal found 8/13![United Airlines logo]()
$756
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2026.
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 pm -
2 stops26h 31m
Tue 9/153:30 pm -
2 stops17h 24m
Deal found 8/11![United Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:05 am -
1 stop7h 11m
Sun 9/131:16 pm -
1 stop8h 51m
Deal found 8/11![American Airlines logo]()
$724
This Ovago deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
1 stop7h 59m
Sat 9/123:30 pm -
1 stop25h 45m
Deal found 8/13![Copa Airlines logo]()
$813
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am -
1 stop12h 22m
Sat 10/39:45 am -
1 stop10h 00m
Deal found 8/12![United Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:22 pm -
2 stops19h 29m
Sun 1/104:46 pm -
2 stops18h 58m
Deal found 8/9![American Airlines logo]()
$786
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
1 stop7h 59m
Sat 9/129:45 am -
2 stops23h 52m
Deal found 8/13![United Airlines logo]()
$756
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:25 pm -
2 stops25h 06m
Thu 10/13:30 pm -
2 stops22h 12m
Deal found 8/10![United Airlines logo]()
$785
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated August 14, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated August 14, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
1 stop7h 59m
Sat 9/129:45 am -
2 stops23h 52m
Deal found 8/13![United Airlines logo]()
$756
This Ovago deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:15 am -
1 stop7h 59m
Sat 9/123:30 pm -
1 stop25h 45m
Deal found 8/13![Copa Airlines logo]()
$813
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:15 am -
1 stop7h 59m
Tue 9/153:30 pm -
2 stops17h 24m
Deal found 8/11![United Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am -
1 stop6h 26m
Tue 9/151:16 pm -
1 stop8h 51m
Deal found 8/11![American Airlines logo]()
$694
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:05 am -
1 stop7h 11m
Sun 9/131:16 pm -
1 stop8h 51m
Deal found 8/11![American Airlines logo]()
$724
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:05 pm -
1 stop7h 32m
Thu 10/13:30 pm -
1 stop29h 25m
Deal found 8/10![United Airlines logo]()
$673
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:15 am -
1 stop12h 22m
Sat 10/39:45 am -
1 stop10h 00m
Deal found 8/12![United Airlines logo]()
$697
One-way flights from Knoxville to Panama CitySearch for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated August 14, 2026.
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:15 am -
1 stop7h 59m
Deal found 8/10![United Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:25 pm -
2 stops18h 14m
Deal found 8/10![American Airlines logo]()
$312
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:20 pm -
2 stops25h 11m
Deal found 8/10![United Airlines logo]()
$331
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:06 am -
1 stop7h 33m
Deal found 8/12![American Airlines logo]()
$372
This FlightHub deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:20 pm -
3 stops20h 35m
Deal found 8/12![Avianca logo]()
$469
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:40 am -
3 stops25h 24m
Deal found 8/10![Multiple Airlines logo]()
$658
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/79:00 pm -
3 stops46h 35m
Deal found 8/10![Multiple Airlines logo]()
$728
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $635 (American Airlines) |
One-way from | $311 (United Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $602 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 9/9
6:00 pm-7:31 pm
2 stops26h 31m
Panama City Tocumen Intl
Tue 9/15
3:30 pm-9:54 am
2 stops17h 24m
$691
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sat 9/26
7:15 am-6:37 pm
1 stop12h 22m
Panama City Tocumen Intl
Sat 10/3
9:45 am-8:45 pm
1 stop10h 00m
$697
Quickest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Fri 9/11
6:05 am-12:16 pm
1 stop7h 11m
Panama City Tocumen Intl
Sun 9/13
1:16 pm-11:07 pm
1 stop8h 51m
$724
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sat 9/5
7:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Sat 9/12
9:45 am-10:37 am
2 stops23h 52m
$756
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 9/24
7:25 pm-7:31 pm
2 stops25h 06m
Panama City Tocumen Intl
Thu 10/1
3:30 pm-2:42 pm
2 stops22h 12m
$785
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sun 12/27
6:22 pm-1:51 pm
2 stops19h 29m
Panama City Tocumen Intl
Sun 1/10
4:46 pm-11:44 am
2 stops18h 58m
$786
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sat 9/5
7:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Sat 9/12
3:30 pm-6:15 pm
1 stop25h 45m
$813
Cheapest one-way
Quickest one-way
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Mon 9/7
7:15 am-2:14 pm
1 stop7h 59m
$311
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Mon 9/7
7:25 pm-12:39 pm
2 stops18h 14m
$312
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Tue 8/25
7:25 pm-12:39 pm
2 stops18h 14m
$372
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 14, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Overall
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Find flights from Knoxville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on August 14, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 14, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 14, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Panama City
Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$261 | Average$529 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$504 | Average$687 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$547 | Average$832 | FlexibilityNo cancel fee | On-timeN/A |