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Panama City

$238+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Apr 9 — Apr 161
Thu 4/9
Thu 4/16
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.

This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:30 pm
TYS
-
PTY
2 stops20h 50m
American Airlines
Fri 9/113:40 pm
PTY
-
TYS
1 stop6h 51m
American Airlines
Deal found 3/8$511
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:25 am
TYS
-
PTY
1 stop8h 12m
United Airlines
Tue 4/287:55 am
PTY
-
TYS
1 stop9h 20m
United Airlines
Deal found 3/7$527
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:15 am
TYS
-
PTY
1 stop12h 22m
United Airlines
Wed 8/263:30 pm
PTY
-
TYS
1 stop29h 00m
United Airlines
Deal found 3/5$536
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:15 pm
TYS
-
PTY
1 stop26h 22m
United Airlines
Mon 4/277:55 am
PTY
-
TYS
1 stop14h 46m
United Airlines
Deal found 3/6$537
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/205:11 pm
TYS
-
PTY
2 stops20h 35m
American Airlines
Mon 4/271:49 pm
PTY
-
TYS
2 stops21h 41m
American Airlines
Deal found 3/6$551
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:57 pm
TYS
-
PTY
2 stops19h 49m
American Airlines
Sun 5/171:49 pm
PTY
-
TYS
2 stops20h 29m
American Airlines
Deal found 3/5$556
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:05 am
TYS
-
PTY
1 stop10h 07m
United Airlines
Wed 4/227:55 am
PTY
-
TYS
1 stop11h 01m
United Airlines
Deal found 3/7$567
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:38 pm
TYS
-
PTY
2 stops19h 08m
American Airlines
Wed 4/221:49 pm
PTY
-
TYS
2 stops20h 29m
American Airlines
Deal found 3/7$571
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/236:21 pm
TYS
-
PTY
2 stops20h 59m
American Airlines
Thu 3/261:40 pm
PTY
-
TYS
1 stop9h 19m
American Airlines
Deal found 3/9$591
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:05 am
TYS
-
PTY
1 stop12h 32m
United Airlines
Sat 5/167:55 am
PTY
-
TYS
1 stop9h 16m
United Airlines
Deal found 3/8$605
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/257:15 am
TYS
-
PTY
1 stop12h 22m
United Airlines
Thu 5/287:55 am
PTY
-
TYS
1 stop14h 17m
United Airlines
Deal found 3/8$617

Find flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$527
(United Airlines)

One-way from

$238
(Kiwi.com)

Popular in

December

Cheapest in

September

Average price

$521
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
Search Deals
From Knoxville McGhee Tyson to Panama City Tocumen Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($93 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Tue 4/21

11:25 am-6:37 pm

1 stop8h 12m

Panama City Tocumen Intl

Tue 4/28

7:55 am-6:15 pm

1 stop9h 20m

$527

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 4/20

5:15 pm-6:37 pm

1 stop26h 22m

Panama City Tocumen Intl

Mon 4/27

7:55 am-11:41 pm

1 stop14h 46m

$537

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/17

5:11 pm-12:46 pm

2 stops20h 35m

Panama City Tocumen Intl

Wed 4/22

1:49 pm-11:59 pm

1 stop9h 10m

$571

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 3/23

6:21 pm-12:40 pm

2 stops19h 19m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-11:20 am

2 stops20h 40m

$591

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 5/25

12:10 pm-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Thu 5/28

7:55 am-11:12 pm

1 stop14h 17m

$617

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 4/2

5:02 pm-12:45 pm

2 stops20h 43m

Panama City Tocumen Intl

Thu 4/9

1:49 pm-12:30 pm

2 stops21h 41m

$641

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 4/2

7:05 am-6:37 pm

1 stop12h 32m

Panama City Tocumen Intl

Thu 4/9

3:30 pm-7:56 pm

1 stop27h 26m

$647

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-8:19 pm

1 stop23h 47m

Panama City Tocumen Intl

Sun 4/26

12:03 pm-8:42 pm

1 stop7h 39m

$650

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sun 3/22

5:00 am-2:20 pm

2 stops10h 20m

Panama City Tocumen Intl

Wed 3/25

1:40 pm-11:59 pm

1 stop9h 19m

$651
Cheapest one-way
Quickest one-way

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 4/22

7:05 am-2:14 pm

1 stop8h 09m

$241

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/9

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $385). Flying from Knoxville to Panama City in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 10, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,409 reviews

Crew

8.1

Overall

7.4

Boarding

7.7

Food

6.6

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
United Airlines
7.4
Good
9,409 reviews
United Airlines
7.4
Good
9,409 reviews

Crew

8.1

Overall

7.4

Boarding

7.7

Food

6.6

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family
American Airlines
7.1
Good
11,414 reviews
United Airlines
7.4
Good
9,409 reviews

Crew

8.1

Overall

7.4

Boarding

7.7

Food

6.6

Entertainment

7.1

Comfort

7.3

Reviews

1 / 20
10.0
Excellent

Dane,Jan 2026

TYS - IAD

It was a short flight, so no time for amenities. Just glad everything was quick and easy from boarding to arriving at my destination with my family

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City?

    For as low as $527, United Airlines can have you in Panama City from Knoxville in 8h 12m. The distance between Knoxville and Panama City is about 1869 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $387. Another option worth looking into is American Airlines, starting at $475 round trip. United Airlines is currently priced 35% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $385). Flying from Knoxville to Panama City in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Memphis to Panama City flights
Nashville to Panama City flights

Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$496FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$475Average$617FlexibilityNo cancel feeOn-time71%

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