$653+ Cheap flights from Knoxville (TYS) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Sep 24 — Oct 11
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama
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Best
Last-minute
Cheapest flights from Knoxville to PanamaExplore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 25, 2026.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:15 am -
1 stop7h 59m
Wed 10/149:45 am -
1 stop10h 00m
Deal found 8/23![United Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:30 pm -
1 stop27h 32m
Wed 11/118:55 am -
1 stop13h 02m
Deal found 8/24![United Airlines logo]()
$658
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am -
2 stops13h 37m
Sat 9/263:30 pm -
2 stops28h 19m
Deal found 8/20![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:15 am -
1 stop12h 22m
Thu 10/153:30 pm -
1 stop29h 25m
Deal found 8/24![United Airlines logo]()
$664
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:20 am -
1 stop8h 42m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 8/24![United Airlines logo]()
$679
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 pm -
2 stops19h 07m
Thu 10/152:02 pm -
2 stops25h 16m
Deal found 8/24![American Airlines logo]()
$692
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:05 am -
1 stop7h 11m
Fri 9/251:16 pm -
1 stop8h 51m
Deal found 8/23![American Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:15 pm -
2 stops17h 47m
Sun 10/112:02 pm -
1 stop7h 57m
Deal found 8/20![American Airlines logo]()
$738
Best flights from Knoxville to PanamaDiscover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
Discover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 25, 2026.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:15 am -
1 stop7h 59m
Wed 10/149:45 am -
1 stop10h 00m
Deal found 8/23![United Airlines logo]()
$653
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:35 pm -
2 stops24h 27m
Wed 11/118:55 am -
1 stop8h 59m
Deal found 8/24![United Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop12h 22m
Sat 9/269:45 am -
2 stops23h 52m
Deal found 8/20![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:45 am -
2 stops14h 46m
Sun 10/1110:00 am -
2 stops23h 37m
Deal found 8/20![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:15 am -
1 stop12h 22m
Thu 10/153:30 pm -
1 stop29h 25m
Deal found 8/24![United Airlines logo]()
$664
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:20 am -
1 stop8h 42m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 8/24![United Airlines logo]()
$679
Last-minute flights from Knoxville to PanamaDiscover last-minute flight deals from Knoxville to Panama. Data last updated August 25, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama. Data last updated August 25, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:00 am -
2 stops22h 04m
Sun 9/63:30 pm -
1 stop29h 15m
Deal found 8/23![United Airlines logo]()
$846
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:25 pm -
2 stops18h 14m
Sun 9/61:39 pm -
2 stops20h 06m
Deal found 8/23![American Airlines logo]()
$938
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:15 am -
1 stop12h 22m
Sat 9/269:45 am -
2 stops23h 52m
Deal found 8/20![United Airlines logo]()
$661
This Gotogate deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:20 pm -
2 stops31h 35m
Sat 9/2611:25 am -
3 stops22h 12m
Deal found 8/20![Avianca logo]()
$885
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:05 am -
1 stop7h 11m
Fri 9/251:16 pm -
1 stop8h 51m
Deal found 8/23![American Airlines logo]()
$719
Find flight deals from Knoxville to Panama
Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated August 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $653 (United Airlines) |
Popular in | March |
Cheapest in | April |
Average price | $586 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 10/7
7:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Wed 10/14
9:45 am-8:45 pm
1 stop10h 00m
$653
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 11/4
7:35 pm-8:02 pm
2 stops24h 27m
Panama City Tocumen Intl
Wed 11/11
8:55 am-5:54 pm
1 stop8h 59m
$657
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sat 9/19
7:15 am-6:37 pm
1 stop12h 22m
Panama City Tocumen Intl
Sat 9/26
9:45 am-10:37 am
2 stops23h 52m
$661
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Sun 10/4
5:45 am-7:31 pm
2 stops14h 46m
Panama City Tocumen Intl
Sun 10/11
10:00 am-10:37 am
2 stops23h 37m
$661
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 10/8
7:15 am-6:37 pm
1 stop12h 22m
Panama City Tocumen Intl
Thu 10/15
3:30 pm-9:55 pm
1 stop29h 25m
$664
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 10/28
11:20 am-7:02 pm
1 stop8h 42m
Panama City Tocumen Intl
Sun 11/1
4:41 pm-11:12 am
1 stop18h 31m
$679
Sorted by cheapest first
Best time to book a flight from Knoxville to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama
TYS-PA0
TYS-PTY
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 25, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Crew
8.5
Overall
7.8
Boarding
8.1
Food
7.2
Entertainment
7.8
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama by cabin class
Find flights from Knoxville to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama flights
Browse other Knoxville and Panama flight options. Last updated on August 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Panama
Discover the top 3 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$261 | Average$507 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$504 | Average$747 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$547 | Average$716 | FlexibilityNo cancel fee | On-timeN/A |