$256+ Cheap flights from Knoxville (TYS) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Jun 16 — Jun 231
Round-trip
1 adult, Economy
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Best
Last-minute
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Cheapest flights from Knoxville to PanamaExplore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 17, 2026.
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 17, 2026.
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
TYS
- PTY
2 stops23h 04m
United Airlines
Mon 7/1310:00 am
PTY
- TYS
1 stop12h 12m
United Airlines
Deal found 5/14![United Airlines logo]()
$531
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Thu 8/273:30 pm
PTY
- TYS
1 stop25h 47m
United Airlines
Deal found 5/13![United Airlines logo]()
$536
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
TYS
- PTY
2 stops12h 37m
United Airlines
Wed 8/2610:55 pm
PTY
- TYS
2 stops17h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$541
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:53 pm
TYS
- PTY
1 stop17h 31m
American Airlines
Wed 9/93:40 pm
PTY
- TYS
1 stop6h 51m
American Airlines
Deal found 5/14![American Airlines logo]()
$548
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Fri 8/213:30 pm
PTY
- TYS
2 stops17h 18m
United Airlines
Deal found 5/12![United Airlines logo]()
$561
This American Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/307:01 pm
TYS
- PTY
1 stop18h 52m
American Airlines
Tue 1/54:56 pm
PTY
- TYS
1 stop24h 10m
American Airlines
Deal found 5/16![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:40 am
TYS
- PTY
1 stop9h 30m
American Airlines
Sat 9/193:40 pm
PTY
- TYS
1 stop6h 51m
American Airlines
Deal found 5/15![American Airlines logo]()
$597
This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:02 pm
TYS
- PTY
2 stops21h 12m
United Airlines
Sat 9/193:30 pm
PTY
- TYS
2 stops20h 47m
United Airlines
Deal found 5/15![United Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:00 am
TYS
- PTY
1 stop7h 14m
American Airlines
Mon 8/31:14 pm
PTY
- TYS
2 stops22h 56m
American Airlines
Deal found 5/15![American Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:45 am
TYS
- PTY
2 stops14h 46m
United Airlines
Tue 6/93:30 pm
PTY
- TYS
2 stops28h 26m
United Airlines
Deal found 5/17![United Airlines logo]()
$621
Best flights from Knoxville to PanamaDiscover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 17, 2026.
Discover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 17, 2026.
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
TYS
- PTY
2 stops23h 04m
United Airlines
Mon 7/1310:00 am
PTY
- TYS
1 stop12h 12m
United Airlines
Deal found 5/14![United Airlines logo]()
$531
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:37 pm
TYS
- PTY
2 stops18h 47m
American Airlines
Thu 8/271:24 pm
PTY
- TYS
2 stops19h 19m
American Airlines
Deal found 5/14![American Airlines logo]()
$541
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:15 am
TYS
- PTY
1 stop12h 22m
United Airlines
Thu 8/273:30 pm
PTY
- TYS
1 stop29h 15m
United Airlines
Deal found 5/14![United Airlines logo]()
$536
This United Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Wed 8/263:30 pm
PTY
- TYS
2 stops17h 18m
United Airlines
Deal found 5/15![United Airlines logo]()
$541
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:20 pm
TYS
- PTY
2 stops25h 11m
United Airlines
Fri 8/213:30 pm
PTY
- TYS
2 stops17h 18m
United Airlines
Deal found 5/12![United Airlines logo]()
$561
Last-minute flights from Knoxville to PanamaDiscover last-minute flight deals from Knoxville to Panama. Data last updated May 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama. Data last updated May 17, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:41 pm
TYS
- PTY
2 stops23h 31m
United Airlines
Fri 5/2910:55 pm
PTY
- TYS
2 stops14h 32m
United Airlines
Deal found 5/13![United Airlines logo]()
$681
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:45 am
TYS
- PTY
2 stops14h 46m
United Airlines
Tue 6/93:30 pm
PTY
- TYS
2 stops28h 26m
United Airlines
Deal found 5/17![United Airlines logo]()
$621
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:00 am
TYS
- PTY
1 stop7h 13m
American Airlines
Sun 6/71:15 pm
PTY
- TYS
1 stop9h 44m
American Airlines
Deal found 5/15![American Airlines logo]()
$752
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
TYS
- PTY
1 stop7h 13m
American Airlines
Tue 6/161:15 pm
PTY
- TYS
1 stop9h 44m
American Airlines
Deal found 5/14![American Airlines logo]()
$697
This United Airlines deal was found by Cheapflights users on 5/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/257:15 am
TYS
- PTY
1 stop9h 57m
United Airlines
Tue 7/77:55 am
PTY
- TYS
1 stop9h 12m
United Airlines
Deal found 5/16![United Airlines logo]()
$738
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:35 pm
TYS
- PTY
2 stops25h 39m
United Airlines
Sat 7/47:55 am
PTY
- TYS
2 stops24h 48m
United Airlines
Deal found 5/13![United Airlines logo]()
$671
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:15 am
TYS
- PTY
1 stop7h 59m
United Airlines
Sun 7/510:00 am
PTY
- TYS
1 stop12h 12m
United Airlines
Deal found 5/14![United Airlines logo]()
$747
One-way flights from Knoxville to PanamaSearch for one-way flight options from Knoxville to Panama. Find affordable one-way fares based on user searches. Data last updated May 17, 2026.
Search for one-way flight options from Knoxville to Panama. Find affordable one-way fares based on user searches. Data last updated May 17, 2026.
This Delta deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/277:35 am
TYS
- PTY
1 stop6h 30m
Delta
Deal found 5/15![Delta logo]()
$256
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:07 pm
TYS
- PTY
2 stops19h 07m
American Airlines
Deal found 5/15![American Airlines logo]()
$260
This Delta deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:40 am
TYS
- PTY
1 stop8h 10m
Delta
Deal found 5/12![Delta logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2712:40 pm
TYS
- PTY
3 stops31h 40m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$278
This Delta deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:40 am
TYS
- PTY
1 stop8h 10m
Delta
Deal found 5/15![Delta logo]()
$316
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:59 pm
TYS
- PTY
2 stops17h 15m
American Airlines
Deal found 5/15![American Airlines logo]()
$322
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:07 pm
TYS
- PTY
2 stops19h 07m
American Airlines
Deal found 5/15![American Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
TYS
- PTY
1 stop7h 13m
American Airlines
Deal found 5/13![American Airlines logo]()
$386
This Kiwi.com deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:22 pm
TYS
- PTY
3 stops42h 26m
Multiple Airlines
Deal found 5/12![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:00 am
TYS
- PTY
3 stops33h 55m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$535
This Kiwi.com deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:20 pm
TYS
- PTY
3 stops30h 59m
Multiple Airlines
Deal found 5/15![Multiple Airlines logo]()
$635
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:45 am
TYS
- PTY
3 stops15h 42m
United Airlines
Deal found 5/13![United Airlines logo]()
$2,674
Find flight deals from Knoxville to Panama
Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated May 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $531 (United Airlines) |
One-way from | $256 (Delta) |
Popular in | March |
Cheapest in | September |
Average price | $550 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 17, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 7/9
6:00 am-4:04 am
2 stops23h 04m
Panama City Tocumen Intl
Mon 7/13
10:00 am-11:12 pm
1 stop12h 12m
$531
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 8/24
7:15 am-6:37 pm
1 stop12h 22m
Panama City Tocumen Intl
Thu 8/27
3:30 pm-9:45 pm
1 stop29h 15m
$536
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 8/24
6:37 pm-12:24 pm
2 stops18h 47m
Panama City Tocumen Intl
Thu 8/27
1:24 pm-9:43 am
2 stops19h 19m
$541
Quickest round-trip
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Tue 8/25
7:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Wed 8/26
3:30 pm-9:48 am
2 stops17h 18m
$541
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 8/17
7:20 pm-7:31 pm
2 stops25h 11m
Panama City Tocumen Intl
Fri 8/21
3:30 pm-9:48 am
2 stops17h 18m
$561
Cheapest one-way
Quickest one-way
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 7/27
7:35 am-1:05 pm
1 stop6h 30m
$256
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 5/28
1:53 pm-12:14 pm
2 stops23h 21m
$271
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Thu 5/28
5:40 am-12:50 pm
1 stop8h 10m
$271
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Mon 7/27
12:40 pm-7:20 pm
3 stops31h 40m
$278
KnoxvillePanama City
TYS - PTY
TYSPTY
Knoxville McGhee Tyson
Wed 5/27
12:10 pm-6:37 pm
1 stop7h 27m
$316
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama
TYS-PA0
TYS-PTY
What is the cheapest month to book a flight from Knoxville to Panama?
Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $261). Flying from Knoxville to Panama in July is currently the most expensive (average of $677). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated May 17, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Overall
7.4
Entertainment
7.1
Boarding
7.7
Crew
8.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Comfort
7.3
Overall
7.4
Entertainment
7.1
Boarding
7.7
Crew
8.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Comfort
7.3
Overall
7.4
Entertainment
7.1
Boarding
7.7
Crew
8.1
Food
6.6
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Knoxville to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama by cabin class
Find flights from Knoxville to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama flights
Browse other Knoxville and Panama flight options. Last updated on May 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Panama
Discover the top 2 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$261 | Average$507 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$507 | Average$617 | FlexibilityNo cancel fee | On-time71% |