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$311+ Cheap flights from Knoxville (TYS) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Aug 9 — Aug 161
Sun 8/9
Sun 8/16
1 adult, Economy
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Cheap flight deals from Knoxville to Panama

Cheapest flights from Knoxville to Panama
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 10, 2026.

This United Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:15 am
TYS
-
PTY
1 stop7h 59m
United Airlines
Thu 8/273:30 pm
PTY
-
TYS
2 stops20h 47m
United Airlines
Deal found 7/7$591
This Delta deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:50 am
TYS
-
PTY
1 stop6h 08m
Delta
Sun 9/132:23 pm
PTY
-
TYS
1 stop8h 32m
Delta
Deal found 7/9$617
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:16 pm
TYS
-
PTY
2 stops19h 00m
American Airlines
Sun 9/131:16 pm
PTY
-
TYS
2 stops21h 27m
American Airlines
Deal found 7/9$626
This American Airlines deal was found by Cheapflights users on 7/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:06 am
TYS
-
PTY
1 stop7h 33m
American Airlines
Thu 8/131:39 pm
PTY
-
TYS
1 stop9h 12m
American Airlines
Deal found 7/7$627
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:15 am
TYS
-
PTY
1 stop12h 22m
United Airlines
Sat 8/293:30 pm
PTY
-
TYS
2 stops20h 48m
United Airlines
Deal found 7/8$656
This Delta deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:30 am
TYS
-
PTY
1 stop6h 25m
Delta
Thu 8/132:20 pm
PTY
-
TYS
1 stop8h 32m
Delta
Deal found 7/10$657
This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:45 am
TYS
-
PTY
2 stops14h 46m
United Airlines
Thu 10/19:45 am
PTY
-
TYS
2 stops23h 00m
United Airlines
Deal found 7/9$752

Find flight deals from Knoxville to Panama

Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated July 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$591
(United Airlines)

One-way from

$311
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$677
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
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From Knoxville McGhee Tyson to Panama
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($83 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 10, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 8/26

7:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/27

3:30 pm-1:17 pm

2 stops20h 47m

$591
Quickest round-trip

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 9/9

7:50 am-12:58 pm

1 stop6h 08m

Panama City Tocumen Intl

Sun 9/13

2:23 pm-11:55 pm

1 stop8h 32m

$617

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 9/9

6:16 pm-12:16 pm

2 stops19h 00m

Panama City Tocumen Intl

Sun 9/13

1:16 pm-11:43 am

2 stops21h 27m

$626

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 8/7

6:06 am-12:39 pm

1 stop7h 33m

Panama City Tocumen Intl

Thu 8/13

1:39 pm-11:51 pm

1 stop9h 12m

$627

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/22

7:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Sat 8/29

3:30 pm-1:18 pm

2 stops20h 48m

$656

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 8/7

7:30 am-12:55 pm

1 stop6h 25m

Panama City Tocumen Intl

Thu 8/13

2:20 pm-11:52 pm

1 stop8h 32m

$657
Cheapest one-way

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/15

7:00 am-6:37 pm

2 stops12h 37m

$311
Quickest one-way

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/15

6:06 am-12:39 pm

1 stop7h 33m

$311

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Sat 8/15

7:20 pm-2:55 pm

3 stops20h 35m

$390

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/6

Sorted by cheapest first

Best time to book a flight from Knoxville to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama

What is the cheapest month to book a flight from Knoxville to Panama?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $261). Flying from Knoxville to Panama in June is currently the most expensive (average of $740). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated July 10, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,966 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Food

6.7

Boarding

7.7

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
9,966 reviews
United Airlines
7.4
Good
9,966 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Food

6.7

Boarding

7.7

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
American Airlines
7.1
Good
11,799 reviews
United Airlines
7.4
Good
9,966 reviews

Crew

8.1

Comfort

7.3

Overall

7.4

Entertainment

7.1

Food

6.7

Boarding

7.7

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Panama?

    For a flight from Knoxville to Panama, you will be flying from McGhee Tyson. Knoxville McGhee Tyson (TYS) is just 11.3 mi from the center of the city.

  • How long is the flight from Knoxville to Panama?

    Airlines like United Airlines fly from Knoxville to Panama in about 7h 59m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 1869 mi.

  • Can I find deals for flights from Knoxville to Panama that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama.

  • Can I find deals for business class flights from Knoxville to Panama?

    Yes. Cheapflights offers flight deals from Knoxville to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama (average of $261). Flying from Knoxville to Panama in June is currently the most expensive (average of $740). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Knoxville to Panama

Discover the top 2 airlines that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$261Average$529FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$504Average$624FlexibilityNo cancel feeOn-time71%

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