$395+ Cheap flights from Knoxville (TYS) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Nov 11 — Nov 181
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to PanamaExplore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
Explore the most affordable flight options available from Knoxville to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
1 stop8h 34m
Thu 12/33:13 pm -
1 stop8h 52m
Deal found 10/9![American Airlines logo]()
$703
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 10/7![United Airlines logo]()
$798
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:38 pm -
2 stops19h 03m
Sun 1/104:55 pm -
2 stops19h 06m
Deal found 10/8![American Airlines logo]()
$1,099
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/277:35 pm -
2 stops21h 37m
Sun 1/1011:35 am -
3 stops24h 10m
Deal found 10/8![United Airlines logo]()
$1,623
This BusinessClass deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:35 am -
1 stop22h 35m
Sun 1/104:41 pm -
1 stop29h 18m
Deal found 10/9![Copa Airlines logo]()
$1,904
Best flights from Knoxville to PanamaDiscover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
Discover carefully curated flight deals from Knoxville to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
1 stop8h 34m
Thu 12/33:13 pm -
1 stop8h 52m
Deal found 10/9![American Airlines logo]()
$703
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 10/11![United Airlines logo]()
$798
Last-minute flights from Knoxville to PanamaDiscover last-minute flight deals from Knoxville to Panama. Data last updated October 12, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama. Data last updated October 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:19 am -
1 stop8h 43m
Sun 11/14:41 pm -
1 stop18h 31m
Deal found 10/7![United Airlines logo]()
$798
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:00 am -
1 stop8h 34m
Thu 12/33:13 pm -
1 stop8h 52m
Deal found 10/9![American Airlines logo]()
$703
One-way flights from Knoxville to PanamaSearch for one-way flight options from Knoxville to Panama. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
Search for one-way flight options from Knoxville to Panama. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
This Avianca deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:45 am -
2 stops16h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Avianca logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:14 pm -
2 stops28h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
1 stop9h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$426
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:36 am -
1 stop8h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$439
Find flight deals from Knoxville to Panama
Keep the following information in mind while searching for Knoxville to Panama flight deals. Data was last updated October 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $703 (American Airlines) |
One-way from | $395 (Avianca) |
Popular in | March |
Cheapest in | April |
Average price | $556 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
Use the filters below to find and compare flights from Knoxville to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 11/4
9:45 am-2:10 am
2 stops16h 25m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$395
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/19
9:45 am-2:10 am
2 stops16h 25m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$395
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 10/28
4:14 pm-8:13 pm
2 stops28h 59m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$415
Quickest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 11/4
10:55 am-8:19 pm
1 stop9h 24m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$426
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Thu 11/19
3:42 pm-7:45 pm
3 stops28h 03m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$663
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Fri 11/27
6:00 am-2:34 pm
1 stop8h 34m
Panama City Tocumen Intl
Thu 12/3
3:13 pm-12:05 am
1 stop8h 52m
$703
KnoxvillePanama City
TYS Knoxville McGhee Tyson - PTY Panama City Tocumen Intl
TYSPTY
Knoxville McGhee Tyson
Wed 10/28
11:19 am-7:02 pm
1 stop8h 43m
Panama City Tocumen Intl
Sun 11/1
4:41 pm-11:12 am
1 stop18h 31m
$798
Sorted by cheapest first
Best time to book a flight from Knoxville to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Knoxville with our price prediction graph.
TYS-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama
TYS-PA0
TYS-PTY
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 12, 2026.
Read through reviews of airlines operating flights from Knoxville to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Food
7.2
Comfort
7.8
Entertainment
7.8
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Panama
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Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama by cabin class
Find flights from Knoxville to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama flights
Browse other Knoxville and Panama flight options. Last updated on October 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Panama
Discover the top airline that operate flights from Knoxville to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$586 | Average$724 | FlexibilityNo cancel fee | On-timeN/A |