$393+ Cheap flights from Knoxville (TYS) to Guatemala City (GUA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GUA
Sep 16 — Sep 231
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Guatemala City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Guatemala City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to Guatemala CityExplore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
Explore the most affordable flight options available from Knoxville to Guatemala City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:00 pm -
1 stop12h 37m
Deal found 8/13![Avianca logo]()
$656
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:45 am -
2 stops10h 50m
Tue 11/1011:57 pm -
1 stop9h 47m
Deal found 8/15![United Airlines logo]()
$663
This Avianca deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:25 pm -
1 stop12h 25m
Tue 10/138:00 pm -
1 stop16h 42m
Deal found 8/14![Multiple Airlines logo]()
$665
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:15 pm -
2 stops12h 22m
Deal found 8/13![Multiple Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
1 stop7h 04m
Tue 11/106:00 am -
1 stop15h 01m
Deal found 8/13![American Airlines logo]()
$667
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop9h 05m
Fri 10/162:05 pm -
1 stop6h 54m
Deal found 8/15![American Airlines logo]()
$672
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop8h 45m
Wed 10/76:15 am -
1 stop9h 50m
Deal found 8/16![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop5h 46m
Tue 10/66:01 am -
1 stop14h 58m
Deal found 8/14![American Airlines logo]()
$689
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:05 am -
1 stop6h 41m
Thu 10/82:05 pm -
2 stops16h 27m
Deal found 8/17![American Airlines logo]()
$691
Best flights from Knoxville to Guatemala CityDiscover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
Discover carefully curated flight deals from Knoxville to Guatemala City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/187:00 am -
1 stop6h 26m
Thu 1/281:28 pm -
1 stop8h 51m
Deal found 8/15![United Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/217:45 am -
2 stops14h 20m
Thu 1/286:50 am -
2 stops13h 31m
Deal found 8/16![American Airlines logo]()
$629
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:00 pm -
1 stop12h 37m
Deal found 8/15![Avianca logo]()
$656
This Avianca deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:35 pm -
1 stop11h 25m
Tue 11/105:25 am -
2 stops11h 29m
Deal found 8/13![Multiple Airlines logo]()
$666
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:45 am -
2 stops10h 50m
Tue 11/1011:57 pm -
1 stop9h 47m
Deal found 8/15![United Airlines logo]()
$663
This Avianca deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:15 pm -
2 stops12h 22m
Deal found 8/12![Multiple Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
2 stops15h 23m
Tue 11/106:00 am -
2 stops15h 51m
Deal found 8/13![American Airlines logo]()
$671
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop9h 05m
Fri 10/162:05 pm -
1 stop6h 54m
Deal found 8/15![American Airlines logo]()
$672
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops12h 37m
Mon 10/51:30 am -
1 stop7h 47m
Deal found 8/14![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/126:00 am -
1 stop15h 16m
Mon 2/156:50 am -
1 stop8h 44m
Deal found 8/13![American Airlines logo]()
$736
Last-minute flights from Knoxville to Guatemala CityDiscover last-minute flight deals from Knoxville to Guatemala City. Data last updated August 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Guatemala City. Data last updated August 17, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:00 am -
2 stops11h 37m
Tue 8/2512:27 pm -
1 stop7h 18m
Deal found 8/14![United Airlines logo]()
$915
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2011:08 am -
2 stops10h 26m
Tue 8/252:23 pm -
2 stops18h 47m
Deal found 8/14![American Airlines logo]()
$919
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:03 am -
1 stop9h 19m
Mon 8/246:00 am -
1 stop15h 51m
Deal found 8/14![American Airlines logo]()
$988
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:45 am -
2 stops12h 52m
Mon 8/2412:27 pm -
1 stop7h 18m
Deal found 8/14![United Airlines logo]()
$989
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am -
1 stop9h 20m
Sat 9/196:01 am -
1 stop15h 06m
Deal found 8/16![American Airlines logo]()
$866
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am -
1 stop9h 20m
Sat 9/192:21 pm -
1 stop6h 46m
Deal found 8/13![American Airlines logo]()
$861
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop5h 46m
Tue 10/66:01 am -
1 stop14h 58m
Deal found 8/14![American Airlines logo]()
$689
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop8h 45m
Wed 10/76:15 am -
1 stop9h 50m
Deal found 8/16![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:18 pm -
2 stops17h 28m
Wed 10/76:01 am -
2 stops13h 32m
Deal found 8/16![American Airlines logo]()
$698
One-way flights from Knoxville to Guatemala CitySearch for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
Search for one-way flight options from Knoxville to Guatemala City. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:16 pm -
1 stop16h 06m
Deal found 8/13![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:40 pm -
2 stops22h 55m
Deal found 8/15![United Airlines logo]()
$419
Find flight deals from Knoxville to Guatemala City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Guatemala City (GUA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $625 (United Airlines) |
One-way from | $393 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Guatemala City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Knoxville to Guatemala City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Mon 1/18
7:00 am-12:26 pm
1 stop6h 26m
Guatemala City La Aurora
Thu 1/28
1:28 pm-11:19 pm
1 stop8h 51m
$625
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 1/21
7:45 am-9:05 pm
2 stops14h 20m
Guatemala City La Aurora
Thu 1/28
6:50 am-9:21 pm
2 stops13h 31m
$629
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-5:50 am
1 stop12h 25m
Guatemala City La Aurora
Mon 10/19
8:00 pm-10:37 am
1 stop12h 37m
$656
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Tue 10/27
5:45 am-2:35 pm
2 stops10h 50m
Guatemala City La Aurora
Tue 11/10
11:57 pm-10:44 am
1 stop9h 47m
$663
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Tue 10/27
7:35 pm-5:00 am
1 stop11h 25m
Guatemala City La Aurora
Tue 11/10
5:25 am-5:54 pm
2 stops11h 29m
$666
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-5:50 am
1 stop12h 25m
Guatemala City La Aurora
Mon 10/19
8:15 pm-10:37 am
2 stops12h 22m
$666
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Tue 10/27
6:00 am-7:23 pm
2 stops15h 23m
Guatemala City La Aurora
Tue 11/10
6:00 am-10:51 pm
2 stops15h 51m
$671
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Wed 10/7
6:00 am-1:05 pm
1 stop9h 05m
Guatemala City La Aurora
Fri 10/16
2:05 pm-10:59 pm
1 stop6h 54m
$672
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Tue 9/29
6:00 am-4:37 pm
2 stops12h 37m
Guatemala City La Aurora
Mon 10/5
1:30 am-11:17 am
1 stop7h 47m
$687
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Fri 2/12
6:00 am-8:16 pm
1 stop15h 16m
Guatemala City La Aurora
Mon 2/15
6:50 am-4:34 pm
1 stop8h 44m
$736
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Guatemala City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Guatemala City in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Knoxville-Guatemala City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Guatemala City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Guatemala City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Guatemala City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Guatemala City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Guatemala City
Have a flexible travel schedule? Discover the best time to fly to Guatemala City from Knoxville with our price prediction graph.
TYS-GUA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Guatemala City
Get insights into the airlines that provide service to Guatemala City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guatemala City. Reviews last updated August 17, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Guatemala City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Comfort
7.2
Boarding
7.5
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Comfort
7.2
Boarding
7.5
Entertainment
6.8
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Guatemala City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Guatemala City?
Book flights to Guatemala City if you plan to visit one of these locationsAntigua
Panajachel
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Guatemala City flight routes
Other flight options
Other flights from Knoxville
Popular flights
Alternative routes for Knoxville to Guatemala City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Guatemala City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Guatemala City by cabin class
Find flights from Knoxville to Guatemala City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Guatemala City
Explore flights to Guatemala City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 17, 2026.
Knoxville and Guatemala City flights
Browse other Knoxville and Guatemala City flight options. Last updated on August 17, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on August 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Guatemala City
Discover the top airline that operate flights from Knoxville to Guatemala City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$509 | Average$626 | FlexibilityNo cancel fee | On-time71% |