$393+ Cheap flights from Knoxville (TYS) to Guatemala
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GUA
Sep 19 — Sep 261
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to GuatemalaExplore the most affordable flight options available from Knoxville to Guatemala. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
Explore the most affordable flight options available from Knoxville to Guatemala. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2026.
This Avianca deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:00 pm -
1 stop12h 37m
Deal found 8/16![Avianca logo]()
$656
This Avianca deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:15 pm -
2 stops12h 22m
Deal found 8/18![Multiple Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:11 pm -
2 stops18h 53m
Tue 11/106:00 am -
2 stops14h 44m
Deal found 8/19![American Airlines logo]()
$667
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop8h 45m
Wed 10/76:15 am -
1 stop9h 50m
Deal found 8/16![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:05 am -
1 stop6h 41m
Thu 10/82:05 pm -
2 stops16h 27m
Deal found 8/17![American Airlines logo]()
$691
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:18 pm -
2 stops17h 28m
Wed 10/76:01 am -
2 stops13h 32m
Deal found 8/16![American Airlines logo]()
$698
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:05 pm -
1 stop8h 44m
Sat 10/101:30 am -
2 stops11h 12m
Deal found 8/18![United Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:16 pm -
2 stops18h 30m
Mon 10/123:06 pm -
2 stops17h 27m
Deal found 8/18![American Airlines logo]()
$743
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:16 pm -
2 stops18h 30m
Sun 10/116:01 am -
2 stops15h 54m
Deal found 8/18![American Airlines logo]()
$748
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:40 am -
1 stop7h 52m
Sun 10/41:02 pm -
1 stop8h 53m
Deal found 8/19![Delta logo]()
$760
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops12h 37m
Mon 10/1912:27 pm -
1 stop7h 28m
Deal found 8/17![United Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:15 am -
1 stop6h 09m
Sat 10/31:30 am -
2 stops13h 38m
Deal found 8/19![United Airlines logo]()
$764
Best flights from Knoxville to GuatemalaDiscover carefully curated flight deals from Knoxville to Guatemala that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
Discover carefully curated flight deals from Knoxville to Guatemala that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 20, 2026.
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/187:00 am -
1 stop6h 26m
Thu 1/281:28 pm -
1 stop8h 51m
Deal found 8/15![United Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/217:45 am -
2 stops14h 20m
Thu 1/286:50 am -
2 stops13h 31m
Deal found 8/16![American Airlines logo]()
$629
This Avianca deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:25 pm -
1 stop12h 25m
Mon 10/198:00 pm -
1 stop12h 37m
Deal found 8/15![Avianca logo]()
$656
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:40 am -
1 stop7h 52m
Sun 10/41:02 pm -
1 stop8h 53m
Deal found 8/19![Delta logo]()
$760
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:05 pm -
1 stop6h 32m
Sat 10/101:30 am -
2 stops11h 12m
Deal found 8/19![United Airlines logo]()
$741
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:00 am -
1 stop7h 06m
Thu 11/126:00 am -
2 stops9h 07m
Deal found 8/15![American Airlines logo]()
$825
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops12h 37m
Mon 10/1912:27 pm -
1 stop7h 28m
Deal found 8/17![United Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:45 am -
2 stops17h 55m
Mon 10/1210:50 pm -
1 stop14h 45m
Deal found 8/19![United Airlines logo]()
$811
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:00 am -
2 stops15h 25m
Mon 2/157:00 am -
2 stops29h 18m
Deal found 8/15![United Airlines logo]()
$835
Last-minute flights from Knoxville to GuatemalaDiscover last-minute flight deals from Knoxville to Guatemala. Data last updated August 20, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Guatemala. Data last updated August 20, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/135:40 am -
1 stop7h 52m
Sun 10/41:02 pm -
1 stop8h 53m
Deal found 8/19![Delta logo]()
$760
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:15 am -
1 stop6h 09m
Sat 10/31:30 am -
2 stops13h 38m
Deal found 8/19![United Airlines logo]()
$764
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:13 pm -
2 stops16h 33m
Sun 10/46:01 am -
2 stops13h 52m
Deal found 8/19![American Airlines logo]()
$769
This Avianca deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:15 am -
2 stops13h 15m
Sat 9/198:00 pm -
1 stop12h 37m
Deal found 8/18![Multiple Airlines logo]()
$770
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am -
1 stop9h 20m
Sat 9/196:01 am -
1 stop15h 06m
Deal found 8/16![American Airlines logo]()
$866
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am -
1 stop9h 20m
Sat 9/192:21 pm -
1 stop6h 46m
Deal found 8/17![American Airlines logo]()
$861
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:00 am -
2 stops12h 37m
Fri 9/181:30 am -
2 stops13h 28m
Deal found 8/18![United Airlines logo]()
$1,097
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
1 stop8h 45m
Wed 10/76:15 am -
1 stop9h 50m
Deal found 8/16![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:18 pm -
2 stops17h 28m
Wed 10/76:01 am -
2 stops13h 32m
Deal found 8/16![American Airlines logo]()
$698
One-way flights from Knoxville to GuatemalaSearch for one-way flight options from Knoxville to Guatemala. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
Search for one-way flight options from Knoxville to Guatemala. Find affordable one-way fares based on user searches. Data last updated August 20, 2026.
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:16 pm -
1 stop16h 06m
Deal found 8/17![American Airlines logo]()
$393
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:40 pm -
2 stops22h 55m
Deal found 8/16![United Airlines logo]()
$419
Find flight deals from Knoxville to Guatemala
Keep the following information in mind while searching for Knoxville to Guatemala flight deals. Data was last updated August 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $625 (United Airlines) |
One-way from | $393 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Guatemala that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
Use the filters below to find and compare flights from Knoxville to Guatemala that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Mon 1/18
7:00 am-12:26 pm
1 stop6h 26m
Guatemala City La Aurora
Thu 1/28
1:28 pm-11:19 pm
1 stop8h 51m
$625
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 1/21
7:45 am-9:05 pm
2 stops14h 20m
Guatemala City La Aurora
Thu 1/28
6:50 am-9:21 pm
2 stops13h 31m
$629
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 10/15
7:25 pm-5:50 am
1 stop12h 25m
Guatemala City La Aurora
Mon 10/19
8:00 pm-10:37 am
1 stop12h 37m
$656
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Fri 10/2
12:05 pm-4:37 pm
1 stop6h 32m
Guatemala City La Aurora
Sat 10/10
1:30 am-2:42 pm
2 stops11h 12m
$741
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Sun 9/13
5:40 am-11:32 am
1 stop7h 52m
Guatemala City La Aurora
Sun 10/4
1:02 pm-11:55 pm
1 stop8h 53m
$760
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 10/15
6:00 am-4:37 pm
2 stops12h 37m
Guatemala City La Aurora
Mon 10/19
12:27 pm-9:55 pm
1 stop7h 28m
$763
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Thu 10/1
5:45 am-9:40 pm
2 stops17h 55m
Guatemala City La Aurora
Mon 10/12
10:50 pm-3:35 pm
1 stop14h 45m
$811
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Sun 11/8
6:00 am-12:06 pm
1 stop7h 06m
Guatemala City La Aurora
Thu 11/12
6:00 am-4:07 pm
2 stops9h 07m
$825
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Mon 2/1
7:00 am-9:25 pm
2 stops15h 25m
Guatemala City La Aurora
Mon 2/15
7:00 am-1:18 pm
2 stops29h 18m
$835
Cheapest one-way
Quickest one-way
KnoxvilleGuatemala City
TYS Knoxville McGhee Tyson - GUA Guatemala City La Aurora
TYSGUA
Knoxville McGhee Tyson
Mon 11/2
7:16 pm-10:22 am
1 stop16h 06m
$393
Showing 1-10 of 11 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Guatemala
Have a flexible travel schedule? Discover the best time to fly to Guatemala from Knoxville with our price prediction graph.
TYS-GUA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Guatemala
TYS-GT0
TYS-GUA
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Guatemala
Get insights into the airlines that provide service to Guatemala. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guatemala. Reviews last updated August 20, 2026.
Read through reviews of airlines operating flights from Knoxville to Guatemala, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Comfort
7.2
Crew
7.9
Food
6.4
Overall
7.1
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Entertainment
6.8
Comfort
7.2
Crew
7.9
Food
6.4
Overall
7.1
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Guatemala. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Guatemala
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Complete your trip
Complete your trip to Guatemala by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Guatemala flights
Browse other Knoxville and Guatemala flight options. Last updated on August 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Knoxville to Guatemala
Discover the top airline that operate flights from Knoxville to Guatemala. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$509 | Average$626 | FlexibilityNo cancel fee | On-time71% |