Panama City Beach

$135+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Jun 6 — Jun 131
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Cheap flight deals from Knoxville to Panama City Beach

Cheapest flights from Knoxville to Panama City Beach
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.

This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2311:55 am
TYS
-
ECP
1 stop5h 28m
Delta
Tue 6/307:41 am
ECP
-
TYS
1 stop4h 38m
Delta
Deal found 5/4$249
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:10 am
TYS
-
ECP
2 stops12h 30m
Southwest
Tue 6/307:00 am
ECP
-
TYS
1 stop6h 05m
Southwest
Deal found 5/4$260
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/275:59 pm
TYS
-
ECP
1 stop6h 02m
Delta
Fri 5/299:19 am
ECP
-
TYS
1 stop2h 51m
Delta
Deal found 5/4$274
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:25 am
TYS
-
ECP
1 stop3h 25m
Delta
Mon 6/89:19 am
ECP
-
TYS
1 stop3h 00m
Delta
Deal found 5/4$277
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:05 pm
TYS
-
ECP
1 stop7h 55m
Southwest
Tue 8/1111:30 am
ECP
-
TYS
2 stops7h 20m
Southwest
Deal found 5/4$279
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:59 pm
TYS
-
ECP
1 stop4h 41m
American Airlines
Fri 6/126:45 pm
ECP
-
TYS
1 stop4h 02m
American Airlines
Deal found 5/6$284
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/178:10 am
TYS
-
ECP
2 stops12h 30m
Southwest
Tue 6/237:40 am
ECP
-
TYS
2 stops8h 20m
Southwest
Deal found 5/6$285
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/87:35 am
TYS
-
ECP
1 stop4h 19m
Delta
Fri 6/126:45 pm
ECP
-
TYS
1 stop4h 09m
Delta
Deal found 5/5$288
This Southwest deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:00 am
TYS
-
ECP
2 stops11h 10m
Southwest
Sun 8/307:00 am
ECP
-
TYS
1 stop6h 00m
Southwest
Deal found 5/6$289

Find flight deals from Knoxville to Panama City Beach

Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated May 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$135
(Delta)

Popular in

June

Cheapest in

August

Average price

$366
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
From Knoxville McGhee Tyson to Panama City Beach
One-way flight from Knoxville McGhee Tyson to Panama City Beach
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 8/6

2:05 pm-9:00 pm

1 stop7h 55m

Panama City NW Florida Beaches

Tue 8/11

11:30 am-7:50 pm

2 stops7h 20m

$279

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 8/26

7:00 am-9:40 am

1 stop3h 40m

Panama City NW Florida Beaches

Sun 8/30

7:00 am-2:00 pm

1 stop6h 00m

$284

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 7/1

2:45 pm-10:05 pm

1 stop8h 20m

Panama City NW Florida Beaches

Wed 7/8

7:40 am-5:00 pm

2 stops8h 20m

$285
Quickest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 5/30

5:40 am-8:30 am

1 stop3h 50m

Panama City NW Florida Beaches

Fri 6/5

6:00 am-11:09 am

1 stop4h 09m

$288

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 7/18

6:55 pm-9:55 pm

1 stop4h 00m

Panama City NW Florida Beaches

Thu 7/23

10:15 am-9:10 pm

2 stops9h 55m

$304

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 7/6

5:40 am-8:14 am

1 stop3h 34m

Panama City NW Florida Beaches

Fri 7/10

7:50 am-1:16 pm

1 stop4h 26m

$309

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 5/23

7:45 am-3:45 pm

2 stops9h 00m

Panama City NW Florida Beaches

Sat 5/30

12:40 pm-6:30 pm

1 stop4h 50m

$323

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 9/28

12:30 pm-7:00 pm

2 stops7h 30m

Panama City NW Florida Beaches

Sat 10/3

5:55 am-5:40 pm

2 stops10h 45m

$327

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 7/6

6:40 am-2:15 pm

2 stops8h 35m

Panama City NW Florida Beaches

Fri 7/10

1:25 pm-9:10 pm

2 stops6h 45m

$348
Cheapest one-way

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 6/24

5:40 am-8:14 am

1 stop3h 34m

$135

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/5

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Knoxville to Panama City Beach

Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City Beach

What is the cheapest time of day to fly from TYS to PA9?

Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 7, 2026.

One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the morning could potentially save you up to 20% on airfare.

How much does it cost to fly round-trip from Knoxville to Panama City Beach?

Reviews of airlines servicing Panama City Beach

Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated May 7, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Entertainment

7.5

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Entertainment

7.5

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Entertainment

7.5

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Boarding

8.1

Entertainment

7.5

Overall

7.9

Comfort

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to Panama City Beach?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Panama City Beach. On average, McGhee Tyson has 0 outbound flights to Panama City Beach per day from 4 airlines. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Panama City Beach?

    Southwest and Delta can get you from Knoxville to Panama City Beach in just under 3h 50m. Your travel time can differ by up to 4h 05m. The distance between Knoxville and Panama City Beach is about 390 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Knoxville to Panama City Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City Beach.

  • Can I find deals for business class flights from Knoxville to Panama City Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Alternative routes for Knoxville to Panama City Beach

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Knoxville to Panama City Beach

Discover the top 4 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$133FlexibilityNo cancel feeOn-time88%
DeltaCheapest$124Average$384FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$422FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$256Average$333FlexibilityNo cancel feeOn-time63%

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