$135+ Cheap flights from Knoxville (TYS) to Panama City Beach, FL
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PNS
Jul 13 — Jul 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Knoxville to Panama City Beach with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City Beach
Cheapest
Best
Last-minute
One-way
Cheapest flights from Knoxville to Panama City BeachExplore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
Explore the most affordable flight options available from Knoxville to Panama City Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:40 am
TYS
- ECP
1 stop3h 51m
Delta
Sat 8/155:02 pm
ECP
- TYS
1 stop4h 37m
Delta
Deal found 6/10![Delta logo]()
$236
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:38 pm
TYS
- ECP
1 stop4h 30m
Delta
Mon 8/249:27 am
ECP
- TYS
1 stop5h 03m
Delta
Deal found 6/9![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:00 am
TYS
- ECP
2 stops11h 10m
Southwest
Tue 9/157:45 am
ECP
- TYS
1 stop3h 20m
Southwest
Deal found 6/13![Southwest logo]()
$242
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:41 pm
TYS
- ECP
1 stop4h 49m
Delta
Tue 8/256:00 am
ECP
- TYS
1 stop4h 11m
Delta
Deal found 6/12![Delta logo]()
$248
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- ECP
2 stops11h 00m
Southwest
Sat 8/157:45 am
ECP
- TYS
1 stop3h 10m
Southwest
Deal found 6/10![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
TYS
- ECP
1 stop3h 40m
Southwest
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$258
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:20 pm
TYS
- ECP
1 stop8h 20m
Southwest
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:10 am
TYS
- ECP
2 stops11h 15m
Southwest
Tue 10/67:00 am
ECP
- TYS
2 stops8h 45m
Southwest
Deal found 6/11![Southwest logo]()
$265
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:38 pm
TYS
- ECP
1 stop4h 30m
Delta
Sun 8/236:00 am
ECP
- TYS
1 stop4h 11m
Delta
Deal found 6/9![Delta logo]()
$268
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- ECP
1 stop3h 14m
Delta
Wed 7/87:50 am
ECP
- TYS
1 stop5h 58m
Delta
Deal found 6/10![Delta logo]()
$269
Best flights from Knoxville to Panama City BeachDiscover carefully curated flight deals from Knoxville to Panama City Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
Discover carefully curated flight deals from Knoxville to Panama City Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 13, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:40 am
TYS
- ECP
1 stop3h 51m
Delta
Sat 8/155:02 pm
ECP
- TYS
1 stop4h 37m
Delta
Deal found 6/10![Delta logo]()
$236
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:00 am
TYS
- ECP
2 stops11h 10m
Southwest
Tue 9/157:45 am
ECP
- TYS
1 stop3h 20m
Southwest
Deal found 6/13![Southwest logo]()
$242
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
TYS
- ECP
1 stop3h 40m
Southwest
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$258
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:38 pm
TYS
- ECP
1 stop4h 30m
Delta
Sun 8/236:00 am
ECP
- TYS
1 stop4h 11m
Delta
Deal found 6/9![Delta logo]()
$268
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
- ECP
2 stops11h 00m
Southwest
Sat 8/158:15 am
ECP
- TYS
2 stops8h 25m
Southwest
Deal found 6/10![Southwest logo]()
$260
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- ECP
1 stop3h 14m
Delta
Tue 7/77:50 am
ECP
- TYS
1 stop4h 26m
Delta
Deal found 6/11![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:50 pm
TYS
- ECP
1 stop6h 45m
Southwest
Mon 9/146:00 am
ECP
- TYS
1 stop6h 25m
Southwest
Deal found 6/8![Southwest logo]()
$268
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:30 am
TYS
- ECP
1 stop3h 45m
Delta
Mon 9/149:23 am
ECP
- TYS
1 stop5h 02m
Delta
Deal found 6/12![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am
TYS
- ECP
2 stops9h 10m
Southwest
Sat 9/58:15 am
ECP
- TYS
2 stops8h 25m
Southwest
Deal found 6/12![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:50 pm
TYS
- ECP
1 stop6h 45m
Southwest
Fri 9/115:10 am
ECP
- TYS
2 stops7h 15m
Southwest
Deal found 6/9![Southwest logo]()
$292
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:10 am
TYS
- ECP
2 stops12h 35m
Southwest
Sun 7/261:05 pm
ECP
- TYS
2 stops8h 25m
Southwest
Deal found 6/9![Southwest logo]()
$300
Last-minute flights from Knoxville to Panama City BeachDiscover last-minute flight deals from Knoxville to Panama City Beach. Data last updated June 13, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City Beach. Data last updated June 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:08 pm
TYS
- ECP
1 stop4h 51m
Delta
Tue 7/79:12 am
ECP
- TYS
1 stop3h 04m
Delta
Deal found 6/13![Delta logo]()
$253
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:35 pm
TYS
- ECP
2 stops8h 35m
Southwest
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/47:00 am
TYS
- ECP
1 stop3h 40m
Southwest
Tue 7/77:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/11![Southwest logo]()
$258
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- ECP
1 stop3h 14m
Delta
Wed 7/87:50 am
ECP
- TYS
1 stop5h 58m
Delta
Deal found 6/10![Delta logo]()
$269
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:00 am
TYS
- ECP
1 stop3h 14m
Delta
Fri 7/109:12 am
ECP
- TYS
1 stop4h 36m
Delta
Deal found 6/10![Delta logo]()
$284
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:40 am
TYS
- ECP
1 stop3h 32m
Delta
Tue 7/147:50 am
ECP
- TYS
1 stop4h 26m
Delta
Deal found 6/13![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:35 am
TYS
- ECP
1 stop5h 56m
Delta
Mon 7/136:48 pm
ECP
- TYS
1 stop4h 04m
Delta
Deal found 6/13![Delta logo]()
$268
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
TYS
- ECP
1 stop3h 20m
Southwest
Wed 7/157:40 am
ECP
- TYS
2 stops8h 20m
Southwest
Deal found 6/8![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:10 am
TYS
- ECP
1 stop3h 20m
Southwest
Sun 7/197:20 am
ECP
- TYS
2 stops13h 00m
Southwest
Deal found 6/12![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:10 am
TYS
- ECP
1 stop3h 20m
Southwest
Sun 7/261:05 pm
ECP
- TYS
2 stops8h 25m
Southwest
Deal found 6/12![Southwest logo]()
$273
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:43 pm
TYS
- ECP
1 stop4h 54m
Delta
Sun 7/269:12 am
ECP
- TYS
1 stop4h 36m
Delta
Deal found 6/12![Delta logo]()
$288
One-way flights from Knoxville to Panama City BeachSearch for one-way flight options from Knoxville to Panama City Beach. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
Search for one-way flight options from Knoxville to Panama City Beach. Find affordable one-way fares based on user searches. Data last updated June 13, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:05 pm
TYS
- ECP
1 stop4h 32m
American Airlines
Deal found 6/10![American Airlines logo]()
$135
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:10 am
TYS
- ECP
2 stops10h 35m
Southwest
Deal found 6/9![Southwest logo]()
$146
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:55 pm
TYS
- ECP
1 stop4h 05m
Southwest
Deal found 6/11![Southwest logo]()
$150
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:54 pm
TYS
- ECP
1 stop3h 02m
Delta
Deal found 6/10![Delta logo]()
$189
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:40 am
TYS
- ECP
2 stops8h 35m
Southwest
Deal found 6/10![Southwest logo]()
$194
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:40 am
TYS
- ECP
1 stop3h 34m
Delta
Deal found 6/9![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:00 am
TYS
- ECP
2 stops9h 40m
Southwest
Deal found 6/10![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/2812:45 pm
TYS
- ECP
2 stops8h 55m
Southwest
Deal found 6/9![Southwest logo]()
$234
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:40 am
TYS
- ECP
2 stops7h 05m
Southwest
Deal found 6/10![Southwest logo]()
$243
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:40 am
TYS
- ECP
2 stops11h 35m
Southwest
Deal found 6/10![Southwest logo]()
$249
Find flight deals from Knoxville to Panama City Beach
Keep the following information in mind while searching for Knoxville to Panama City Beach flight deals. Data was last updated June 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $236 (Delta) |
One-way from | $135 (American Airlines) |
Popular in | December |
Cheapest in | January |
Average price | $405 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City Beach that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 8/12
5:40 am-8:31 am
1 stop3h 51m
Panama City NW Florida Beaches
Sat 8/15
5:02 pm-10:39 pm
1 stop4h 37m
$236
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 9/9
8:00 am-6:10 pm
2 stops11h 10m
Panama City NW Florida Beaches
Tue 9/15
7:45 am-12:05 pm
1 stop3h 20m
$242
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 7/4
7:00 am-9:40 am
1 stop3h 40m
Panama City NW Florida Beaches
Tue 7/7
7:40 am-5:00 pm
2 stops8h 20m
$258
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 8/12
7:00 am-5:00 pm
2 stops11h 00m
Panama City NW Florida Beaches
Sat 8/15
8:15 am-5:40 pm
2 stops8h 25m
$260
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Thu 8/20
4:38 pm-8:08 pm
1 stop4h 30m
Panama City NW Florida Beaches
Sun 8/23
6:00 am-11:11 am
1 stop4h 11m
$268
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sun 9/6
2:50 pm-8:35 pm
1 stop6h 45m
Panama City NW Florida Beaches
Mon 9/14
6:00 am-1:25 pm
1 stop6h 25m
$268
Quickest round-trip
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 7/4
6:00 am-8:14 am
1 stop3h 14m
Panama City NW Florida Beaches
Tue 7/7
7:50 am-1:16 pm
1 stop4h 26m
$269
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Fri 9/11
5:30 am-8:15 am
1 stop3h 45m
Panama City NW Florida Beaches
Mon 9/14
9:23 am-3:25 pm
1 stop5h 02m
$279
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Fri 8/28
7:10 am-3:20 pm
2 stops9h 10m
Panama City NW Florida Beaches
Sat 9/5
8:15 am-5:40 pm
2 stops8h 25m
$289
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sun 9/6
2:50 pm-8:35 pm
1 stop6h 45m
Panama City NW Florida Beaches
Fri 9/11
5:10 am-1:25 pm
2 stops7h 15m
$292
Showing 1-10 of 23 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Panama City Beach
Have a flexible travel schedule? Discover the best time to fly to Panama City Beach from Knoxville with our price prediction graph.
TYS-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama City Beach
TYS-PA9
TYS-ECP
What is the cheapest time of day to fly from TYS to PA9?
Find hourly flight availability from Knoxville to Panama City Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 13, 2026.
One of the essential ways to save on airfare from Knoxville to Panama City Beach is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the morning could potentially save you up to 17% on airfare.
How much does it cost to fly round-trip from Knoxville to Panama City Beach?
Reviews of airlines servicing Panama City Beach
Get insights into the airlines that provide service to Panama City Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City Beach. Reviews last updated June 13, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City Beach to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Entertainment
7.5
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Knoxville
Popular flights
Top destinations
Alternative routes for Knoxville to Panama City Beach
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City Beach by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to Panama City Beach by cabin class
Find flights from Knoxville to Panama City Beach, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama City Beach flights
Browse other Knoxville and Panama City Beach flight options. Last updated on June 13, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Panama City Beach flights
Consider these flights traveling from Knoxville to Panama City Beach.
Top 4 airlines flying from Knoxville to Panama City Beach
Discover the top 4 airlines that operate flights from Knoxville to Panama City Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$69 | Average$170 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$169 | Average$370 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$439 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$257 | Average$335 | FlexibilityNo cancel fee | On-time63% |