$358+ Cheap flights from Panama City (PTY) to Cusco (CUZ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CUZ
Nov 28 — Dec 51
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Cuzco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to Cuzco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to CuzcoExplore the most affordable flight options available from Panama City to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
Explore the most affordable flight options available from Panama City to Cuzco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2026.
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:30 am -
1 stop8h 55m
Wed 12/235:10 pm -
1 stop16h 00m
Deal found 10/28![Avianca logo]()
$432
This Trip.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:30 am -
2 stops14h 25m
Thu 12/248:10 pm -
2 stops29h 10m
Deal found 10/28![Multiple Airlines logo]()
$627
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:30 am -
2 stops19h 05m
Fri 11/612:10 pm -
2 stops27h 05m
Deal found 10/25![Multiple Airlines logo]()
$703
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:10 pm -
1 stop17h 15m
Thu 12/245:10 pm -
1 stop8h 10m
Deal found 10/28![Avianca logo]()
$728
Best flights from Panama City to CuzcoDiscover carefully curated flight deals from Panama City to Cuzco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
Discover carefully curated flight deals from Panama City to Cuzco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 29, 2026.
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:30 am -
1 stop8h 55m
Wed 12/235:10 pm -
1 stop16h 00m
Deal found 10/28![Avianca logo]()
$432
This Trip.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/142:30 am -
2 stops16h 45m
Sat 3/209:05 pm -
2 stops28h 15m
Deal found 10/27![Multiple Airlines logo]()
$618
This Avianca deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/112:30 am -
1 stop8h 55m
Wed 2/175:10 pm -
1 stop16h 00m
Deal found 10/28![Avianca logo]()
$433
This Trip.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:30 am -
2 stops12h 00m
Thu 12/2412:10 pm -
2 stops13h 10m
Deal found 10/25![Multiple Airlines logo]()
$633
This Avianca deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/156:10 pm -
1 stop17h 15m
Sat 3/205:10 pm -
1 stop16h 00m
Deal found 10/27![Avianca logo]()
$645
This Avianca deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:30 am -
1 stop8h 55m
Thu 12/245:10 pm -
1 stop8h 10m
Deal found 10/25![Avianca logo]()
$728
Last-minute flights from Panama City to CuzcoDiscover last-minute flight deals from Panama City to Cuzco. Data last updated October 29, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Cuzco. Data last updated October 29, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:30 am -
2 stops19h 05m
Fri 11/612:10 pm -
2 stops27h 05m
Deal found 10/25![Multiple Airlines logo]()
$703
This Avianca deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:30 am -
1 stop8h 55m
Wed 11/45:10 pm -
1 stop16h 00m
Deal found 10/25![Avianca logo]()
$1,417
One-way flights from Panama City to CuzcoSearch for one-way flight options from Panama City to Cuzco. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
Search for one-way flight options from Panama City to Cuzco. Find affordable one-way fares based on user searches. Data last updated October 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:13 pm -
1 stop10h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:44 pm -
1 stop8h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Multiple Airlines logo]()
$375
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:30 am -
2 stops14h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$412
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/54:25 am -
2 stops11h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Multiple Airlines logo]()
$429
This Avianca deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/44:25 am -
1 stop6h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Avianca logo]()
$460
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/46:38 pm -
1 stop11h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$503
Find flight deals from Panama City to Cuzco
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Cuzco (CUZ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $432 (Avianca) |
One-way from | $358 (Kiwi.com) |
Popular in | August |
Cheapest in | September |
Average price | $524 |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Cuzco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
Use the filters below to find and compare flights from Panama City to Cusco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Mon 11/9
8:13 pm-6:15 am
1 stop10h 02m
Cusco Velazco Astete
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$358
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Thu 12/17
2:30 am-4:55 pm
2 stops14h 25m
Cusco Velazco Astete
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$412
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Mon 4/5
4:25 am-3:40 pm
2 stops11h 15m
Cusco Velazco Astete
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$429
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Wed 12/16
2:30 am-11:25 am
1 stop8h 55m
Cusco Velazco Astete
Wed 12/23
5:10 pm-9:10 am
1 stop16h 00m
$432
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Thu 2/11
2:30 am-11:25 am
1 stop8h 55m
Cusco Velazco Astete
Wed 2/17
5:10 pm-9:10 am
1 stop16h 00m
$433
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Sun 4/4
6:38 pm-6:25 am
1 stop11h 47m
Cusco Velazco Astete
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$503
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Sun 3/14
2:30 am-7:15 pm
2 stops16h 45m
Cusco Velazco Astete
Sat 3/20
9:05 pm-1:20 am
2 stops28h 15m
$618
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Thu 12/17
2:30 am-2:30 pm
2 stops12h 00m
Cusco Velazco Astete
Thu 12/24
12:10 pm-1:20 am
2 stops13h 10m
$633
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Mon 3/15
6:10 pm-11:25 am
1 stop17h 15m
Cusco Velazco Astete
Sat 3/20
5:10 pm-9:10 am
1 stop16h 00m
$645
Panama CityCusco
PTY Panama City Tocumen Intl - CUZ Cusco Velazco Astete
PTYCUZ
Panama City Tocumen Intl
Thu 12/17
2:30 am-11:25 am
1 stop8h 55m
Cusco Velazco Astete
Thu 12/24
5:10 pm-1:20 am
1 stop8h 10m
$728
Sorted by cheapest first
Compare providers for flights from Panama City to Cuzco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Cuzco in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Cusco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Cusco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Cusco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Cusco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Cusco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Cuzco
Have a flexible travel schedule? Discover the best time to fly to Cuzco from Panama City with our price prediction graph.
PTY-CUZ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Cusco
What is the cheapest month to book a flight from Panama City to Cusco?
Currently, September is the cheapest month in which you can book a flight from Panama City to Cusco (average of $410). Flying from Panama City to Cusco in August is currently the most expensive (average of $648). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Panama City to Cusco?
Airfare is typical for this route at the moment.
Panama City to Cusco flights typically cost between $418 and $475 in December.The cheapest round-trip price found within the last 5 days was $432 on Avianca (Dec 16-Dec 23).
Reviews of airlines servicing Cuzco
Get insights into the airlines that provide service to Cuzco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cuzco. Reviews last updated October 29, 2026.
Read through reviews of airlines operating flights from Panama City to Cusco, such as Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
6.9
Overall
6.5
Food
5.0
Comfort
6.1
Crew
7.2
Entertainment
5.3
Reviews
1 / 20
10.0
ExcellentAna Victoria,Jun 2026
BOG - SJO
Boarding
6.9
Overall
6.5
Food
5.0
Comfort
6.1
Crew
7.2
Entertainment
5.3
Reviews
1 / 20
10.0
ExcellentAna Victoria,Jun 2026
BOG - SJO
Related info for your journey
Find useful and relevant information for your journey from Panama City to Cuzco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Popular flights
Alternative routes for Panama City to Cuzco
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Complete your trip
Complete your trip to Cuzco by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Cuzco
Explore flights to Cuzco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 29, 2026.
Search flights from Panama City to Cuzco by cabin class
Find flights from Panama City to Cuzco, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and Cuzco flights
Browse other Panama City and Cuzco flight options. Last updated on October 29, 2026.
Other flights from Panama City
Browse through other flights departing from Panama City. Flights are based on user searches made on Cheapflights and were last updated on October 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Panama City to Cuzco
Discover the top airline that operate flights from Panama City to Cuzco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$394 | Average$556 | FlexibilityNo cancel fee | On-time71% |