$577+ Cheap flights from Panama City (PTY) to Madrid, Spain (MAD)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Madrid with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or May, booked 35 days in advance, depart on a Thursday or Wednesday and return on a Wednesday
Cheap flight deals from Panama City to Madrid
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to MadridExplore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:30 pm -
Nonstop9h 35m
Fri 11/203:10 pm -
Nonstop10h 35m
Deal found 9/11![Air Europa logo]()
$727
This Air Europa deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:25 pm -
Nonstop9h 50m
Sun 10/253:10 pm -
Nonstop10h 35m
Deal found 9/15![Air Europa logo]()
$728
This Air Europa deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:30 pm -
Nonstop9h 35m
Wed 11/253:10 pm -
Nonstop10h 35m
Deal found 9/10![Air Europa logo]()
$729
This Air France deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:23 pm -
1 stop14h 52m
Thu 9/2412:20 pm -
1 stop14h 25m
Deal found 9/10![Air France logo]()
$730
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:35 pm -
Nonstop10h 05m
Fri 1/2212:00 pm -
Nonstop11h 05m
Deal found 9/11![Iberia logo]()
$732
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/112:30 am -
1 stop23h 40m
Tue 1/198:10 am -
1 stop23h 10m
Deal found 9/14![Avianca logo]()
$743
This Avianca deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2010:05 am -
1 stop16h 05m
Tue 1/198:10 am -
1 stop15h 05m
Deal found 9/13![Avianca logo]()
$749
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:05 am -
1 stop14h 05m
Thu 11/128:10 am -
1 stop15h 05m
Deal found 9/10![Avianca logo]()
$750
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:35 pm -
Nonstop10h 05m
Fri 11/2012:00 pm -
Nonstop11h 05m
Deal found 9/10![Iberia logo]()
$753
This Iberia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:35 pm -
Nonstop10h 05m
Sun 11/2212:00 pm -
Nonstop11h 05m
Deal found 9/10![Iberia logo]()
$754
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:30 pm -
Nonstop9h 35m
Sat 11/213:10 pm -
Nonstop10h 35m
Deal found 9/11![Air Europa logo]()
$758
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/99:30 pm -
Nonstop9h 35m
Mon 11/163:10 pm -
Nonstop10h 35m
Deal found 9/11![Air Europa logo]()
$759
Best flights from Panama City to MadridDiscover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/910:00 am -
1 stop17h 30m
Fri 2/1911:15 am -
2 stops33h 30m
Deal found 9/11![United Airlines logo]()
$773
This Air Europa deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/299:30 pm -
Nonstop9h 35m
Sat 2/273:10 pm -
Nonstop10h 35m
Deal found 9/14![Air Europa logo]()
$793
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1810:00 am -
1 stop17h 30m
Sat 1/3011:15 am -
2 stops33h 30m
Deal found 9/12![United Airlines logo]()
$773
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:41 pm -
2 stops34h 49m
Sun 11/221:25 pm -
2 stops36h 37m
Deal found 9/14![United Airlines logo]()
$780
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/304:41 pm -
2 stops33h 04m
Sat 1/161:25 pm -
2 stops36h 37m
Deal found 9/14![United Airlines logo]()
$780
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:41 pm -
2 stops34h 49m
Fri 11/2011:15 am -
2 stops33h 30m
Deal found 9/13![United Airlines logo]()
$781
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/34:41 pm -
2 stops34h 49m
Fri 3/511:15 am -
1 stop23h 55m
Deal found 9/11![United Airlines logo]()
$782
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2910:00 am -
1 stop17h 30m
Mon 3/111:15 am -
2 stops33h 30m
Deal found 9/11![United Airlines logo]()
$782
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/204:41 pm -
2 stops34h 49m
Thu 1/281:25 pm -
2 stops36h 37m
Deal found 9/14![United Airlines logo]()
$786
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/264:41 pm -
2 stops34h 49m
Wed 2/1011:15 am -
2 stops33h 30m
Deal found 9/14![United Airlines logo]()
$787
Last-minute flights from Panama City to MadridDiscover last-minute flight deals from Panama City to Madrid. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Madrid. Data last updated September 15, 2026 and is based on user searches.
This Air France deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:23 pm -
1 stop14h 52m
Tue 9/226:00 am -
1 stop17h 50m
Deal found 9/13![Multiple Airlines logo]()
$758
This Air France deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:23 pm -
1 stop14h 52m
Thu 9/2412:20 pm -
1 stop14h 25m
Deal found 9/10![Air France logo]()
$730
This Air France deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:23 pm -
1 stop14h 52m
Fri 9/256:00 am -
2 stops20h 45m
Deal found 9/10![Multiple Airlines logo]()
$762
This Booking.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:25 pm -
Nonstop9h 50m
Mon 10/193:05 pm -
Nonstop10h 35m
Deal found 9/14![Air Europa logo]()
$770
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/189:45 am -
1 stop16h 15m
Mon 11/211:00 am -
2 stops39h 02m
Deal found 9/12![United Airlines logo]()
$767
This Air Europa deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:25 pm -
Nonstop9h 50m
Sun 10/253:10 pm -
Nonstop10h 35m
Deal found 9/15![Air Europa logo]()
$728
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:25 pm -
Nonstop9h 50m
Wed 11/43:10 pm -
Nonstop10h 35m
Deal found 9/11![Air Europa logo]()
$729
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:05 am -
1 stop14h 05m
Thu 11/128:10 am -
1 stop15h 05m
Deal found 9/10![Avianca logo]()
$750
This Air Europa deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:30 pm -
Nonstop9h 35m
Fri 11/63:10 pm -
Nonstop10h 35m
Deal found 9/12![Air Europa logo]()
$759
This Air Europa deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:30 pm -
Nonstop9h 35m
Sat 11/73:10 pm -
Nonstop10h 35m
Deal found 9/11![Air Europa logo]()
$761
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 pm -
Nonstop9h 35m
Thu 11/53:10 pm -
Nonstop10h 35m
Deal found 9/10![Air Europa logo]()
$760
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:30 am -
1 stop18h 00m
Sat 11/711:00 am -
2 stops33h 45m
Deal found 9/14![United Airlines logo]()
$768
One-way flights from Panama City to MadridSearch for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This Air Europa deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 pm -
Nonstop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Air Europa logo]()
$577
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/232:50 pm -
1 stop32h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Aeromexico logo]()
$603
This KLM deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:45 pm -
1 stop15h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![KLM logo]()
$606
This KLM deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/19:55 pm -
1 stop15h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![KLM logo]()
$608
This Air France deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/129:55 pm -
1 stop14h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Air France logo]()
$609
This FlightHub deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:39 pm -
2 stops20h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$625
This KLM deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:46 am -
2 stops26h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![KLM logo]()
$629
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2710:25 am -
3 stops41h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$631
This KLM deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 pm -
1 stop21h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![KLM logo]()
$635
This KLM deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/910:30 pm -
2 stops19h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![KLM logo]()
$639
This KLM deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:30 pm -
2 stops19h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![KLM logo]()
$641
This KLM deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/129:55 pm -
2 stops18h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![KLM logo]()
$643
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $727 (Air Europa) |
One-way from | $577 (Air Europa) |
Popular in | December |
Cheapest in | February |
Average price | $892 |
Good round-trip deal | $885 or less |
Good one-way deal | $777 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 10/6
6:46 am-4:25 pm
2 stops26h 39m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$629
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 12/9
10:30 pm-11:35 pm
2 stops19h 05m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$639
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 10/12
9:55 pm-11:25 pm
2 stops18h 30m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$643
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 11/4
10:30 pm-11:35 pm
2 stops19h 05m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$648
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 1/22
4:00 pm-6:05 pm
2 stops20h 05m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$670
Quickest round-trip
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sat 2/6
9:30 pm-1:05 pm
Nonstop9h 35m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$671
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 1/22
9:30 pm-1:05 pm
Nonstop9h 35m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$673
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 9/30
8:25 pm-1:15 pm
Nonstop9h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$673
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 2/9
10:00 am-9:30 am
1 stop17h 30m
Madrid Barajas
Fri 2/19
11:15 am-2:45 pm
2 stops33h 30m
$773
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 1/18
10:00 am-9:30 am
1 stop17h 30m
Madrid Barajas
Sat 1/30
11:15 am-2:45 pm
2 stops33h 30m
$773
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Panama City to Madrid
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Madrid in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Madrid flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Madrid flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Madrid flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Madrid flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Madrid flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
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How far ahead should I book a flight from Panama City to Madrid?
The price you pay for your flight from Panama City to Madrid may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of $749). Flying from Panama City to Madrid in December is currently the most expensive (average of $973). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Panama City to Madrid delayed?
About 13% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 152 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the last year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.
What’s the top layover airport for flights from Panama City to Madrid?
Share of 1-stop round-trip flights from Panama City to Madrid chosen by Cheapflights users in the past 12 months, using the same layover each way.
Paris (CDG) – chosen by Cheapflights users on 40% of 1-stop itineraries from Panama City to Madrid on Cheapflights.
What’s the cheapest layover airport for flights from Panama City to Madrid?
Average round-trip fare for 1-stop flights from Panama City to Madrid, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Paris (CDG) is the most affordable 1-stop option, with an average round-trip price of $685.
What’s the fastest layover option from Panama City to Madrid?
Shortest average travel time for 1-stop one-way flights from Panama City to Madrid, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for 1-stop routes: 12h 50m.
Which airport typically offers the quickest layover for flights from Panama City to Madrid?
Average layover duration for 1-stop one-way flights from Panama City to Madrid, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average layover time of 1h 55m.
The best insider tips for Panama City to Madrid flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip
Our travel experts
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated September 15, 2026.
Get a feel of what it's like to fly with Air France,United Airlines, andIberia from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Crew
8.2
Comfort
7.4
Overall
7.5
Food
7.1
Boarding
7.5
Entertainment
7.0
Reviews
1 / 20
2.0
MediocreMichael,Aug 2026
CDG - AMS
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Madrid?
Book flights to Madrid if you plan to visit one of these locationsGetafe
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Top 8 airlines flying from Panama City to Madrid
Discover the top 8 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$567 | Average$775 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$618 | Average$902 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$644 | Average$778 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$658 | Average$749 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$660 | Average$900 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$676 | Average$900 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$728 | Average$1,347 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$767 | Average$848 | FlexibilityNo cancel fee | On-time69% |