$515+ Cheap flights from Panama City (PTY) to Madrid, Spain (MAD)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Madrid with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in February or May, booked 55 days in advance, depart on a Thursday or Wednesday and return on a Saturday
Cheap flight deals from Panama City to Madrid
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to MadridExplore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2811:55 pm -
1 stop27h 35m
Sun 2/711:15 am -
2 stops35h 57m
Deal found 11/10![United Airlines logo]()
$767
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/308:55 am -
2 stops40h 50m
Sun 1/2411:15 am -
2 stops35h 57m
Deal found 11/9![United Airlines logo]()
$768
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:55 pm -
1 stop27h 35m
Tue 1/191:25 pm -
2 stops33h 47m
Deal found 11/6![United Airlines logo]()
$771
This KLM deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/259:55 pm -
1 stop15h 40m
Thu 8/268:30 pm -
1 stop27h 20m
Deal found 11/9![KLM logo]()
$779
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/304:41 pm -
2 stops33h 04m
Sat 1/161:25 pm -
2 stops36h 37m
Deal found 11/8![United Airlines logo]()
$780
This KLM deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:45 pm -
1 stop22h 50m
Sun 1/2410:00 am -
1 stop16h 20m
Deal found 11/7![Multiple Airlines logo]()
$786
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/134:41 pm -
2 stops34h 49m
Mon 1/186:05 am -
2 stops38h 40m
Deal found 11/9![United Airlines logo]()
$793
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:00 am -
2 stops19h 45m
Fri 12/1111:00 am -
2 stops38h 38m
Deal found 11/5![United Airlines logo]()
$794
This Avianca deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:10 pm -
1 stop23h 15m
Thu 2/48:10 am -
1 stop15h 05m
Deal found 11/5![Avianca logo]()
$804
This KLM deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
1 stop22h 50m
Wed 11/256:00 am -
1 stop20h 20m
Deal found 11/5![Multiple Airlines logo]()
$805
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:55 am -
2 stops25h 25m
Sat 12/1211:00 am -
2 stops39h 02m
Deal found 11/5![United Airlines logo]()
$811
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2711:55 pm -
1 stop27h 35m
Thu 8/2610:50 am -
2 stops34h 24m
Deal found 11/9![United Airlines logo]()
$814
Best flights from Panama City to MadridDiscover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/210:00 am -
1 stop17h 30m
Wed 3/1011:00 am -
2 stops39h 02m
Deal found 11/5![United Airlines logo]()
$773
This Air Europa deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/108:25 pm -
Nonstop9h 50m
Mon 5/33:05 pm -
Nonstop10h 35m
Deal found 11/6![Air Europa logo]()
$906
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/198:55 am -
2 stops18h 35m
Sun 1/3111:15 am -
2 stops33h 30m
Deal found 11/5![United Airlines logo]()
$773
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/304:41 pm -
2 stops33h 04m
Sat 1/161:25 pm -
2 stops36h 37m
Deal found 11/8![United Airlines logo]()
$780
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/174:41 pm -
2 stops34h 49m
Wed 3/31:25 pm -
2 stops36h 37m
Deal found 11/9![United Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/198:55 am -
2 stops18h 35m
Tue 2/21:25 pm -
2 stops36h 37m
Deal found 11/8![United Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/204:41 pm -
2 stops34h 49m
Thu 1/281:25 pm -
2 stops31h 20m
Deal found 11/6![United Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/3110:55 pm -
2 stops27h 05m
Tue 4/2011:15 am -
2 stops33h 59m
Deal found 11/9![United Airlines logo]()
$830
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2410:00 am -
1 stop17h 30m
Thu 12/1011:15 am -
2 stops33h 30m
Deal found 11/6![United Airlines logo]()
$884
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:00 am -
1 stop17h 30m
Sat 12/2611:00 am -
2 stops33h 45m
Deal found 11/7![United Airlines logo]()
$884
Last-minute flights from Panama City to MadridDiscover last-minute flight deals from Panama City to Madrid. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Madrid. Data last updated November 10, 2026 and is based on user searches.
This KLM deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
1 stop22h 50m
Wed 11/256:00 am -
1 stop20h 20m
Deal found 11/5![Multiple Airlines logo]()
$805
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:00 am -
2 stops19h 45m
Fri 12/1111:00 am -
2 stops38h 38m
Deal found 11/5![United Airlines logo]()
$794
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:55 am -
2 stops25h 25m
Sat 12/1211:00 am -
2 stops39h 02m
Deal found 11/5![United Airlines logo]()
$811
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/134:41 pm -
2 stops34h 49m
Mon 1/186:05 am -
2 stops38h 40m
Deal found 11/9![United Airlines logo]()
$793
This KLM deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:45 pm -
1 stop22h 50m
Sun 1/2410:00 am -
1 stop16h 20m
Deal found 11/7![Multiple Airlines logo]()
$786
This KLM deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/259:55 pm -
1 stop15h 40m
Thu 8/268:30 pm -
1 stop27h 20m
Deal found 11/9![KLM logo]()
$779
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2711:55 pm -
1 stop27h 35m
Thu 8/2610:50 am -
2 stops34h 24m
Deal found 11/9![United Airlines logo]()
$814
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2811:55 pm -
1 stop27h 35m
Sun 2/711:15 am -
2 stops35h 57m
Deal found 11/10![United Airlines logo]()
$767
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:55 pm -
1 stop27h 35m
Sun 1/2411:15 am -
2 stops33h 30m
Deal found 11/9![United Airlines logo]()
$768
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:55 pm -
1 stop27h 35m
Tue 1/191:25 pm -
2 stops33h 47m
Deal found 11/6![United Airlines logo]()
$771
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/304:41 pm -
2 stops33h 04m
Sat 1/161:25 pm -
2 stops36h 37m
Deal found 11/8![United Airlines logo]()
$780
This Avianca deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:10 pm -
1 stop23h 15m
Thu 2/48:10 am -
1 stop15h 05m
Deal found 11/5![Avianca logo]()
$804
One-way flights from Panama City to MadridSearch for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:30 pm -
Nonstop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Air Europa logo]()
$515
This Cheapflightsfares deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/139:30 pm -
Nonstop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Air Europa logo]()
$524
This KLM deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:45 pm -
1 stop22h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![KLM logo]()
$612
This KLM deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
1 stop18h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![KLM logo]()
$617
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/299:30 pm -
Nonstop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Air Europa logo]()
$623
This KLM deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/299:55 pm -
1 stop19h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![KLM logo]()
$625
This Air France deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:34 pm -
2 stops17h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Air France logo]()
$626
This FlightHub deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:44 pm -
2 stops27h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$638
This Cheapflightsfares deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/229:30 pm -
Nonstop9h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Air Europa logo]()
$644
This Avianca deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/62:30 am -
1 stop23h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Avianca logo]()
$647
Find flight deals from Panama City to Madrid
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Madrid (MAD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $768 (United Airlines) |
One-way from | $515 (Kiwi.com) |
Popular in | December |
Cheapest in | February |
Average price | $821 |
Good round-trip deal | $944 or less |
Good one-way deal | $645 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Madrid that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from Panama City to Madrid that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Mon 11/16
6:45 pm-7:35 pm
1 stop18h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sun 11/22
6:45 pm-11:35 pm
1 stop22h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Thu 12/24
6:45 pm-11:35 pm
1 stop22h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 11/25
6:45 pm-7:35 pm
1 stop18h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Tue 12/1
6:45 pm-4:05 pm
1 stop15h 20m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Thu 11/19
6:45 pm-11:35 pm
1 stop22h 50m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$617
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Wed 11/25
12:44 pm-9:45 pm
2 stops27h 01m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$638
Quickest round-trip
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Sun 12/27
9:30 pm-1:05 pm
Nonstop9h 35m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$644
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Fri 12/11
10:05 am-6:10 am
1 stop14h 05m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$649
Panama CityMadrid
PTY Panama City Tocumen Intl - MAD Madrid Barajas
PTYMAD
Panama City Tocumen Intl
Thu 12/17
10:05 am-8:10 am
1 stop16h 05m
Madrid Barajas
Wed 12/31
12:00 am-6:00 pm
Nonstop0h 00m
$649
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Panama City to Madrid
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Madrid in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Panama City-Madrid flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Madrid flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Madrid flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Madrid flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Madrid flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Madrid
Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.
PTY-MAD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Madrid
Prices
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How far ahead should I book a flight from Panama City to Madrid?
The price you pay for your flight from Panama City to Madrid may vary depending on when you book. For the best chance of a lower fare, look to book 90 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, February is the cheapest month in which you can book a flight from Panama City to Madrid (average of $763). Flying from Panama City to Madrid in December is currently the most expensive (average of $974). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to MAD?
Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 10, 2026.
When flying from Panama City to Madrid, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How often are flights from Panama City to Madrid delayed?
About 13% of weekly flights between Panama City and Madrid have experienced delays in the past year, with the average delay time being 153 minutes.
What is the most punctual flight time for Panama City to Madrid flights?
Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Tuesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Madrid flights?
Over the last year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.
What’s the top layover airport for flights from Panama City to Madrid?
Share of 1-stop round-trip flights from Panama City to Madrid chosen by Cheapflights users in the past 12 months, using the same layover each way.
Paris (CDG) – chosen by Cheapflights users on 40% of 1-stop itineraries from Panama City to Madrid on Cheapflights.
What’s the cheapest layover airport for flights from Panama City to Madrid?
Average round-trip fare for 1-stop flights from Panama City to Madrid, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Paris (CDG) is the most affordable 1-stop option, with an average round-trip price of $685.
What’s the fastest layover option from Panama City to Madrid?
Shortest average travel time for 1-stop one-way flights from Panama City to Madrid, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Bogotá (BOG) have the shortest average one-way travel time for 1-stop routes: 12h 50m.
Which airport typically offers the quickest layover for flights from Panama City to Madrid?
Average layover duration for 1-stop one-way flights from Panama City to Madrid, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Bogotá (BOG) offer the fastest connection on this route, with an average layover time of 1h 55m.
The best insider tips for Panama City to Madrid flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip
Our travel experts
Reviews of airlines servicing Madrid
Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated November 10, 2026.
Get a feel of what it's like to fly with Air France,United Airlines, andAir Europa from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Crew
8.2
Food
7.1
Comfort
7.4
Entertainment
7.0
Overall
7.5
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentPatrick,Jun 2026
CDG - BER
Related info for your journey
Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Madrid?
Book flights to Madrid if you plan to visit one of these locationsGetafe
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Top 8 airlines flying from Panama City to Madrid
Discover the top 8 airlines that operate flights from Panama City to Madrid. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$567 | Average$964 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$603 | Average$951 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$658 | Average$750 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$673 | Average$910 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$681 | Average$761 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$696 | Average$905 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$767 | Average$838 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$1,292 | Average$1,347 | FlexibilityNo cancel fee | On-time70% |