How popular is this Panama City to Madrid flight route?

This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

What are the cheapest airlines flying from Panama City to Madrid round-trip?

Turkish Airlines, at $742, was found to be the cheapest airline from Panama City to Madrid.Alternate airlines to your destination round-trip include Iberia and Air Europa. Turkish Airlines is 4% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Panama City to Madrid one-way?

One-way options have recently been found by users for as low as $435 on Turkish Airlines. Other airlines that offer cheap prices include KLM from $510 and Air France from $512 one-way.

In terms of precipitation, rainfall in Madrid ranges from 0.4 - 2.4 inches per month. November is typically the wettest month, when rainfall can reach 2.4 in. July is typically the driest time to visit Madrid when rainfall is around 0.4 in.

If weather is an important factor for your trip to Madrid, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

What are the cheapest flights from Panama City to Madrid?

Looking for the cheapest flight from Panama City to Madrid? While on average our users pay $1,600, our data indicates the cheapest price to be $526. The most popular route (Panama City Tocumen Intl - Madrid Barajas), is priced around $708.

What are the most reliable airlines from Panama City to Madrid?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (82%), Etihad Airways (82%), China Eastern (82%).

What are the most popular airlines that fly from Panama City to Madrid?

The most popular airlines flying from Panama City to Madrid are Air France, Avianca and Iberia. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from Panama City to Madrid?

Departing on a Monday is a good option for securing a great price. You can expect to save up to 7% when planning your travel around this day of the week.

How far in advance should I book a flight from Panama City to Madrid?

To save on the cost of your flight from Panama City to Madrid, book at least 59 days before your planned departure. Booking around this time can save you about 13% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $786 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $807.

What is the cheapest month to fly from Panama City to Madrid?

The best pricing can be found in the month of March. Prices to Madrid from Panama City average $773. You can even find prices in March for less than $773, as users have found deals to Madrid from as low as $574. The month of July appears to be one of the more expensive times to travel to Madrid from Panama City. Flying in the targeted month can save you up to 15%.

What airports do I use to fly from Panama City to Madrid?

Madrid Barajas is the airport most travelers will use when flying to Madrid from Panama City Tocumen Intl. Booking flights from Tocumen Intl (PTY) to Barajas (MAD) should be relatively easy as there are 5 daily flights to Madrid from 7 different airlines. 9h 35m is how long a flight from Panama City to Madrid Barajas will take if you book a nonstop flight.

Can I find deals for flights from Panama City to Madrid that include hotel bookings?

Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Panama City to Madrid?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.

Can I find deals for business class flights from Panama City to Madrid?

Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$435+ Flights from Panama City to Madrid, Spain

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Panama City to Madrid with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Tuesday or Wednesday and return on a Friday

Cheap flight deals from Panama City to Madrid

Round-trip from	$742 (Turkish Airlines)
One-way from	$435 (Turkish Airlines)
Popular in	July
Cheapest in	March
Average price	$892
Good round-trip deal	$823 or less
Good one-way deal	$632 or less

From Panama City Tocumen Intl to Madrid Barajas

Search Deals

One-way flight from Panama City Tocumen Intl to Madrid Barajas

Search Deals

Highest demand for flights based on searches. 9% potential increase in price ($79 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in July 2025

Search Deals

Price to beat on a round-trip flight from Panama City Tocumen Intl to Madrid Barajas.

Search Deals

Price to beat on a one-way flight from Panama City Tocumen Intl to Madrid Barajas.

Search Deals

Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

dom. 8/179:55 pmPTY - MAD

1 stop35h 55mTurkish Airlines

sáb. 8/302:45 pmMAD - PTY

1 stop36h 15mTurkish Airlines

Deal found 7/1

$742

sáb. 10/253:19 amPTY - MAD

1 stop13h 16mAvianca

mar. 11/118:30 amMAD - PTY

1 stop14h 00mAvianca

Deal found 6/30

$743

mié. 11/56:45 pmPTY - MAD

1 stop15h 20mMultiple Airlines

mié. 11/196:00 amMAD - PTY

1 stop20h 10mMultiple Airlines

Deal found 7/1

$753

lun. 9/225:10 pmPTY - MAD

Nonstop10h 05mIberia

mar. 10/712:00 pmMAD - PTY

Nonstop10h 40mIberia

Deal found 7/1

$755

mar. 8/58:25 pmPTY - MAD

Nonstop9h 50mAir Europa

vie. 9/193:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 6/30

$757

dom. 7/66:50 pmPTY - MAD

1 stop34h 15mKLM

dom. 7/137:05 amMAD - PTY

1 stop16h 45mKLM

Deal found 6/29

$778

vie. 9/192:14 pmPTY - MAD

1 stop36h 21mAir France

vie. 9/264:40 pmMAD - PTY

1 stop32h 05mAir France

Deal found 6/29

$784

Best flights from Panama City to Madrid
Discover carefully curated flight deals from Panama City to Madrid that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated julio 2, 2025.

dom. 8/179:55 pmPTY - MAD

1 stop35h 55mTurkish Airlines

sáb. 8/302:45 pmMAD - PTY

1 stop36h 15mTurkish Airlines

Deal found 7/1

$742

lun. 9/225:10 pmPTY - MAD

Nonstop10h 05mIberia

mar. 10/712:00 pmMAD - PTY

Nonstop10h 40mIberia

Deal found 7/1

$755

mar. 7/156:50 pmPTY - MAD

1 stop17h 40mMultiple Airlines

mar. 9/3010:05 amMAD - PTY

1 stop14h 40mMultiple Airlines

Deal found 6/30

$756

mar. 8/58:25 pmPTY - MAD

Nonstop9h 50mAir Europa

mar. 9/163:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 6/30

$757

dom. 7/66:50 pmPTY - MAD

1 stop34h 15mKLM

dom. 7/137:05 amMAD - PTY

1 stop16h 45mKLM

Deal found 6/29

$778

vie. 9/192:14 pmPTY - MAD

1 stop36h 21mAir France

vie. 9/264:40 pmMAD - PTY

1 stop32h 05mAir France

Deal found 6/29

$784

dom. 7/133:20 amPTY - MAD

1 stop13h 10mAvianca

dom. 8/311:10 pmMAD - PTY

1 stop15h 00mAvianca

Deal found 6/29

$799

Last-minute flights from Panama City to Madrid
Discover last-minute flight deals from Panama City to Madrid. Data last updated julio 2, 2025 and is based on user searches.

dom. 7/66:50 pmPTY - MAD

1 stop34h 15mKLM

dom. 7/137:05 amMAD - PTY

1 stop16h 45mKLM

Deal found 6/29

$778

lun. 7/76:50 pmPTY - MAD

1 stop17h 40mKLM

dom. 7/137:05 amMAD - PTY

1 stop16h 45mKLM

Deal found 6/30

$778

lun. 7/75:10 pmPTY - MAD

Nonstop10h 05mIberia

dom. 7/1312:00 pmMAD - PTY

Nonstop10h 40mIberia

Deal found 7/1

$843

lun. 7/73:25 amPTY - MAD

1 stop13h 05mAvianca

dom. 8/311:10 pmMAD - PTY

1 stop15h 00mAvianca

Deal found 6/29

$880

mar. 7/86:50 pmPTY - MAD

1 stop14h 35mMultiple Airlines

sáb. 7/1210:05 amMAD - PTY

1 stop15h 58mMultiple Airlines

Deal found 6/30

$784

mié. 7/99:45 amPTY - MAD

1 stop16h 15mUnited Airlines

mar. 7/2211:15 amMAD - PTY

2 stops35h 57mUnited Airlines

Deal found 7/2

$1,034

jue. 7/108:25 pmPTY - MAD

Nonstop9h 50mAir Europa

mar. 8/263:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 7/1

$757

dom. 7/133:20 amPTY - MAD

1 stop13h 10mAvianca

dom. 8/311:10 pmMAD - PTY

1 stop15h 00mAvianca

Deal found 6/29

$799

mar. 7/156:50 pmPTY - MAD

1 stop17h 40mMultiple Airlines

mar. 9/3010:05 amMAD - PTY

1 stop14h 40mMultiple Airlines

Deal found 6/30

$756

sáb. 8/25:10 pmPTY - MAD

Nonstop10h 05mIberia

dom. 8/1711:30 amMAD - PTY

1 stop15h 45mIberia

Deal found 6/30

$851

mar. 8/58:25 pmPTY - MAD

Nonstop9h 50mAir Europa

vie. 9/193:05 pmMAD - PTY

Nonstop10h 35mAir Europa

Deal found 6/30

$757

mié. 8/132:05 pmPTY - MAD

1 stop36h 30mAir France

vie. 2/206:00 amMAD - PTY

1 stop20h 10mAir France

Deal found 7/1

$795

One-way flights from Panama City to Madrid
Search for one-way flight options from Panama City to Madrid. Find affordable one-way fares based on user searches. Data last updated julio 2, 2025.

dom. 9/219:55 pmPTY - MAD

1 stop29h 30mTurkish Airlines

Deal found 6/30

$435

sáb. 8/25:25 pmPTY - MAD

3 stops42h 55mMultiple Airlines

Deal found 7/2

$459

mar. 7/156:50 pmPTY - MAD

1 stop31h 45mKLM

Deal found 7/1

$510

sáb. 7/127:55 pmPTY - MAD

1 stop16h 25mAir France

Deal found 7/1

$512

jue. 7/171:30 pmPTY - MAD

2 stops17h 35mAvianca

Deal found 7/2

$525

dom. 7/68:25 pmPTY - MAD

Nonstop9h 50mAir Europa

Deal found 7/1

$527

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 8/17

9:55 pm-4:50 pm

1 stop35h 55m

Madrid Barajas

sáb. 8/30

2:45 pm-8:00 pm

1 stop36h 15m

$742

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

lun. 9/22

5:10 pm-10:15 am

Nonstop10h 05m

Madrid Barajas

mar. 10/7

12:00 pm-3:40 pm

Nonstop10h 40m

$755

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mar. 7/15

6:50 pm-7:30 pm

1 stop17h 40m

Madrid Barajas

mar. 9/30

10:05 am-5:45 pm

1 stop14h 40m

$756

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mar. 8/5

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

mar. 9/16

3:05 pm-6:40 pm

Nonstop10h 35m

$757

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mar. 9/16

10:05 pm-11:30 pm

1 stop18h 25m

Madrid Barajas

lun. 9/29

1:30 am-4:30 pm

1 stop22h 00m

$768

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 7/6

6:50 pm-12:05 pm

1 stop34h 15m

Madrid Barajas

dom. 7/13

7:05 am-4:50 pm

1 stop16h 45m

$778

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

vie. 9/19

2:14 pm-9:35 am

1 stop36h 21m

Madrid Barajas

vie. 9/26

4:40 pm-5:45 pm

1 stop32h 05m

$784

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

dom. 9/21

9:55 pm-10:25 am

1 stop29h 30m

$435

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

sáb. 8/2

5:25 pm-7:20 pm

3 stops42h 55m

$459

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

mar. 7/15

6:50 pm-9:35 am

1 stop31h 45m

$510

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 13 results

The best insider tips for Panama City to Madrid flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip

Airports

PTY

For nighttime flights, bring snacks as most eateries close by 10 pm at PTY, ensuring you're not left hungry during your journey.

MAD

Upon arrival at MAD, rideshares like Uber and Cabify offer quick, affordable transport to the city center from dedicated pickup points.

Our travel experts

Lori Zaino

Expert on MAD

Taryn White

Expert on PTY

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

The price you pay for your flight from Panama City to Madrid may vary depending on when you book. For the best chance of a lower fare, look to book 58 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Madrid?

Currently, November is the cheapest month in which you can book a flight from Panama City to Madrid (average of $543). Flying from Panama City to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to MAD?

When flying from Panama City to Madrid, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 19% versus a flight at noon.

What is the cheapest day to fly from Panama City to Madrid?

Travelers seeking maximum savings on their Panama City to Madrid flight should consider departing on Sunday mornings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to Madrid

The most flights from PTY to MAD are scheduled on a Monday (5 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (5 on average).

How much does it cost to fly round-trip from Panama City to Madrid?

Reviews of airlines servicing Madrid

Get a feel of what it's like to fly with KLM, Air France, and Turkish Airlines from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

KLM

7.8

Good

1,366 reviews

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Air France

7.5

Good

1,472 reviews

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Turkish Airlines

7.3

Good

3,891 reviews

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Air Europa

7.0

Good

542 reviews

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Iberia

7.0

Good

2,817 reviews

KLM

7.8

Good

1,366 reviews

Reviews

1 / 20

4.0

Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Related info for your journey

What airports do I use to fly from Panama City to Madrid?
Madrid Barajas is the airport most travelers will use when flying to Madrid from Panama City Tocumen Intl. Booking flights from Tocumen Intl (PTY) to Barajas (MAD) should be relatively easy as there are 5 daily flights to Madrid from 7 different airlines. 9h 35m is how long a flight from Panama City to Madrid Barajas will take if you book a nonstop flight.
How popular is this Panama City to Madrid flight route?
This flight path from Panama City Tocumen Intl to Madrid Barajas was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
What are the cheapest airlines flying from Panama City to Madrid round-trip?
Turkish Airlines, at $742, was found to be the cheapest airline from Panama City to Madrid.Alternate airlines to your destination round-trip include Iberia and Air Europa. Turkish Airlines is 4% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Panama City to Madrid one-way?
One-way options have recently been found by users for as low as $435 on Turkish Airlines. Other airlines that offer cheap prices include KLM from $510 and Air France from $512 one-way.
What are the most reliable airlines from Panama City to Madrid?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Panama City to Madrid on time: Air Europa (82%), Etihad Airways (82%), China Eastern (82%).
What are the cheapest flights from Panama City to Madrid?
Looking for the cheapest flight from Panama City to Madrid? While on average our users pay $1,600, our data indicates the cheapest price to be $526. The most popular route (Panama City Tocumen Intl - Madrid Barajas), is priced around $708.
Can I find deals for flights from Panama City to Madrid that include hotel bookings?
Yes. In addition to deals on Panama City to Madrid flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Panama City to Madrid?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Madrid.
Can I find deals for business class flights from Panama City to Madrid?
Yes. Cheapflights offers flight deals from Panama City to Madrid by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Panama City to Madrid?
Currently, November is the cheapest month in which you can book a flight from Panama City to Madrid (average of $543). Flying from Panama City to Madrid in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Segovia

Fuenlabrada

Browse thousands of different options on Cheapflights for your next trip

Complete your trip

Madrid car rentals

Madrid Barajas Airport car rentals

Barajas car rentals

Centro car rentals

Gran Via car rentals

Chamartin car rentals

Salamanca car rentals

Other flights to Madrid

Top 7 airlines flying from Panama City to Madrid

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$543	Average$701	FlexibilityNo cancel fee	On-time71%
Air Europa	Cheapest$665	Average$784	FlexibilityNo cancel fee	On-time83%
KLM	Cheapest$670	Average$800	FlexibilityNo cancel fee	On-time75%
United Airlines	Cheapest$678	Average$793	FlexibilityNo cancel fee	On-time69%
Iberia	Cheapest$679	Average$830	FlexibilityNo cancel fee	On-time77%
Air France	Cheapest$695	Average$764	FlexibilityNo cancel fee	On-time77%
Turkish Airlines	Cheapest$729	Average$800	FlexibilityNo cancel fee	On-time77%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$435+ Cheap flights from Panama City (PTY) to Madrid, Spain (MAD)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Panama City to Madrid with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Panama City Tocumen Intl to Madrid Barajas are usually found in March or February, booked 58 days in advance, depart on a Tuesday or Wednesday and return on a Friday

Cheap flight deals from Panama City to Madrid

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Panama City to Madrid

Cheapest flights from Panama City to MadridExplore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Panama City to Madrid that are best for you.

The best insider tips for Panama City to Madrid flights

Cheapflights partnered with top experts to bring you the best recommendations for your Panama City to Madrid trip

Airports

PTY

MAD

Our travel experts

Best time to book a flight from Panama City to Madrid

Have a flexible travel schedule? Discover the best time to fly to Madrid from Panama City with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Madrid

How far ahead should I book a flight from Panama City to Madrid?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Madrid. Price data was last updated on June 27, 2025.

What is the cheapest month to book a flight from Panama City to Madrid?

What is the cheapest time of day to fly from PTY to MAD?

Find hourly flight availability from Panama City to Madrid. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 2, 2025.

What is the cheapest day to fly from Panama City to Madrid?

Use this chart to determine the cheapest time to fly round-trip from Panama City to Madrid. Price data was last updated on December 16, 2024.

Weekly flight availability from Panama City to Madrid

Explore weekly flight availability from Panama City to Madrid. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated julio 2, 2025.

How much does it cost to fly round-trip from Panama City to Madrid?

Reviews of airlines servicing Madrid

Get insights into the airlines that provide service to Madrid. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Madrid. Reviews last updated julio 2, 2025.

Get a feel of what it's like to fly with KLM, Air France, and Turkish Airlines from Panama City to Madrid by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Madrid. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airports do I use to fly from Panama City to Madrid?

How popular is this Panama City to Madrid flight route?

What are the cheapest airlines flying from Panama City to Madrid round-trip?

What are the cheapest airlines to fly from Panama City to Madrid one-way?

What are the most reliable airlines from Panama City to Madrid?

What are the cheapest flights from Panama City to Madrid?

Can I find deals for flights from Panama City to Madrid that include hotel bookings?

How can I find direct flights from Panama City to Madrid?

Can I find deals for business class flights from Panama City to Madrid?

What is the cheapest month to book a flight from Panama City to Madrid?

Traveling to a place near Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Madrid by adding a car rental and/or hotel reservation to your travel itinerary.

Top 7 airlines flying from Panama City to Madrid

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Panama City to Madrid
Explore the most affordable flight options available from Panama City to Madrid. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.