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$435+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated July 3, 2025.

Round-trip from

$741
(KLM)

One-way from

$435
(Turkish Airlines)

Popular in

July

Cheapest in

March

Average price

$897

Good round-trip deal

$823 or less

Good one-way deal

$632 or less
From Panama City Tocumen Intl to Spain
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One-way flight from Panama City Tocumen Intl to Spain
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Highest demand for flights based on searches. 6% potential increase in price ($59 potential increase over avg. RT price).
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Cheapest flight prices on average. 0% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
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Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
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Find flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This KLM deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:50 pmPTY - VLC
1 stop17h 15mMultiple Airlines
Tue 9/306:40 amVLC - PTY
1 stop18h 05mMultiple Airlines
Deal found 7/2$741
This KLM deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/66:50 pmPTY - AGP
1 stop31h 55mKLM
Thu 8/211:20 pmAGP - PTY
1 stop34h 30mKLM
Deal found 7/2$742
This Turkish Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/179:55 pmPTY - MAD
1 stop35h 55mTurkish Airlines
Sat 8/302:45 pmMAD - PTY
1 stop36h 15mTurkish Airlines
Deal found 7/1$742
This Turkish Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/319:55 pmPTY - AGP
1 stop29h 55mTurkish Airlines
Thu 9/116:00 pmAGP - PTY
1 stop33h 00mTurkish Airlines
Deal found 7/3$751
This KLM deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:45 pmPTY - MAD
1 stop15h 20mMultiple Airlines
Wed 11/196:00 amMAD - PTY
1 stop20h 10mMultiple Airlines
Deal found 7/1$753
This Iberia deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/225:10 pmPTY - MAD
Nonstop10h 05mIberia
Tue 10/712:00 pmMAD - PTY
Nonstop10h 40mIberia
Deal found 7/1$755
This Air Europa deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/228:25 pmPTY - MAD
Nonstop9h 50mAir Europa
Wed 10/153:05 pmMAD - PTY
Nonstop10h 35mAir Europa
Deal found 7/3$756
This Priceline deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1610:05 pmPTY - MAD
1 stop18h 25mAvianca
Mon 9/291:30 amMAD - PTY
1 stop22h 00mAvianca
Deal found 7/2$768
This Air Europa deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:25 pmPTY - VLC
1 stop12h 50mAir Europa
Sun 10/1212:35 pmVLC - PTY
1 stop13h 05mAir Europa
Deal found 7/2$774
This KLM deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/56:50 pmPTY - BCN
1 stop34h 45mMultiple Airlines
Sun 9/286:10 amBCN - PTY
1 stop18h 35mMultiple Airlines
Deal found 7/1$779
This Trip.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:25 pmPTY - BCN
1 stop13h 10mAir Europa
Mon 11/38:30 pmBCN - PTY
1 stop29h 15mAir Europa
Deal found 7/2$781
This Turkish Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/318:00 pmPTY - BCN
1 stop20h 10mTurkish Airlines
Sun 8/107:50 amBCN - PTY
1 stop19h 10mTurkish Airlines
Deal found 7/2$783

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Panama City

Fly to

Spain

Route

Depart

Return

Price

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Mon 9/22

6:50 pm-7:05 pm

1 stop17h 15m

Valencia

Tue 9/30

6:40 am-5:45 pm

1 stop18h 05m

$741

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Wed 8/6

6:50 pm-9:45 am

1 stop31h 55m

Malaga

Thu 8/21

1:20 pm-4:50 pm

1 stop34h 30m

$742

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 8/17

9:55 pm-4:50 pm

1 stop35h 55m

Madrid Barajas

Sat 8/30

2:45 pm-8:00 pm

1 stop36h 15m

$742

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 8/31

9:55 pm-10:50 am

1 stop29h 55m

Malaga

Thu 9/11

6:00 pm-8:00 pm

1 stop33h 00m

$751

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 11/5

6:45 pm-4:05 pm

1 stop15h 20m

Madrid Barajas

Wed 11/19

6:00 am-8:10 pm

1 stop20h 10m

$753

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 9/22

5:10 pm-10:15 am

Nonstop10h 05m

Madrid Barajas

Tue 10/7

12:00 pm-3:40 pm

Nonstop10h 40m

$755

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 9/22

8:25 pm-1:15 pm

Nonstop9h 50m

Madrid Barajas

Wed 10/15

3:05 pm-6:40 pm

Nonstop10h 35m

$756

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/16

10:05 pm-11:30 pm

1 stop18h 25m

Madrid Barajas

Mon 9/29

1:30 am-4:30 pm

1 stop22h 00m

$768

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 9/6

2:05 pm-9:35 am

1 stop36h 30m

Madrid Barajas

Sat 9/20

6:00 am-5:45 pm

1 stop18h 45m

$771

Panama CityValencia

PTY - VLC

PTYVLC

Panama City Tocumen Intl

Sun 10/5

8:25 pm-4:15 pm

1 stop12h 50m

Valencia

Sun 10/12

12:35 pm-6:40 pm

1 stop13h 05m

$774

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/2

Showing 1-10 of 50 results
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 3, 2025.

The most flights from PTY to ES0 are scheduled on a Monday (10 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (4 on average).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated July 3, 2025.
Get a feel of what it's like to fly with KLM, Air France, and United Airlines from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
KLM
7.8
Good
1,367 reviews
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Air France
7.5
Good
1,465 reviews
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
United Airlines
7.4
Good
8,861 reviews
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
Turkish Airlines
7.3
Good
3,895 reviews
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.
American Airlines
7.2
Good
10,000 reviews
KLM
7.8
Good
1,367 reviews

Boarding

7.8

Food

7.2

Crew

8.4

Comfort

7.7

Entertainment

7.1

Overall

7.8

Reviews

1 / 20
4.0
Okay

Anonymous,Jun 2025

AMS - BOS

A two and half hour delay caused havoc with all connections. Otherwise on board service was great.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 16 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Turkish Airlines, which is currently one of the cheapest options available, starting at $435. KLM flights start at $510 while deals on Air France start at $512 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Santa Cruz de Tenerife Tenerife-Norte when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (87%), Etihad Airways (87%) or China Eastern (87%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,600 for a flight from Panama City to Spain. The cheapest flight overall is $526 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $708.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, November is the cheapest month in which you can book a flight from Panama City to Spain (average of $543). Flying from Panama City to Spain in June is currently the most expensive (average of $1,054). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama City to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Panama City to Spain

Discover the top 7 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$543Average$862FlexibilityNo cancel feeOn-time71%
Air EuropaCheapest$665Average$816FlexibilityNo cancel feeOn-time83%
KLMCheapest$670Average$885FlexibilityNo cancel feeOn-time75%
Air FranceCheapest$674Average$801FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$678Average$807FlexibilityNo cancel feeOn-time69%
IberiaCheapest$679Average$954FlexibilityNo cancel feeOn-time77%
Turkish AirlinesCheapest$729Average$804FlexibilityNo cancel feeOn-time77%

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