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$493+ Cheap flights from Panama City (PTY) to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/29. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — MAD
Jul 16 — Jul 231
Thu 7/16
Thu 7/23
1 adult, Economy
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Cheap flight deals from Panama City to Spain

Cheapest flights from Panama City to Spain
Explore the most affordable flight options available from Panama City to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2026.

This Gotogate deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:25 pm
PTY
-
AGP
1 stop12h 50m
Air Europa
Wed 9/3012:35 pm
AGP
-
PTY
1 stop13h 05m
Air Europa
Deal found 6/12$725
This Air Europa deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Europa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/248:25 pm
PTY
-
VLC
1 stop12h 50m
Air Europa
Mon 9/2812:30 pm
VLC
-
PTY
1 stop13h 10m
Air Europa
Deal found 6/14$733
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:45 am
PTY
-
AGP
1 stop14h 50m
United Airlines
Sat 9/59:35 am
AGP
-
PTY
2 stops59h 39m
United Airlines
Deal found 6/14$755
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:55 pm
PTY
-
MAD
1 stop27h 05m
United Airlines
Sun 9/1311:15 am
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 6/15$773
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:45 am
PTY
-
MAD
2 stops38h 05m
United Airlines
Mon 9/2811:15 am
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 6/15$774
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:30 pm
PTY
-
BIO
2 stops36h 15m
United Airlines
Thu 9/107:15 am
BIO
-
PTY
2 stops43h 16m
United Airlines
Deal found 6/14$775
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:45 am
PTY
-
MAD
2 stops38h 05m
United Airlines
Sat 10/1011:15 am
MAD
-
PTY
2 stops38h 22m
United Airlines
Deal found 6/13$775
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:45 am
PTY
-
MAD
2 stops38h 05m
United Airlines
Mon 10/1910:50 am
MAD
-
PTY
1 stop15h 41m
United Airlines
Deal found 6/11$776
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/239:45 am
PTY
-
MAD
1 stop16h 15m
United Airlines
Fri 11/611:00 am
MAD
-
PTY
2 stops33h 45m
United Airlines
Deal found 6/11$777
This Air Canada deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:45 am
PTY
-
MAD
2 stops38h 05m
Multiple Airlines
Thu 10/2912:35 pm
MAD
-
PTY
2 stops36h 27m
Multiple Airlines
Deal found 6/11$779
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:45 am
PTY
-
MAD
2 stops38h 05m
United Airlines
Tue 10/1311:15 am
MAD
-
PTY
2 stops33h 59m
United Airlines
Deal found 6/15$780
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:41 pm
PTY
-
MAD
2 stops34h 04m
United Airlines
Sat 11/711:00 am
MAD
-
PTY
2 stops33h 45m
United Airlines
Deal found 6/15$781

Find flight deals from Panama City to Spain

Keep the following information in mind while searching for Panama City to Spain flight deals. Data was last updated June 16, 2026.

Round-trip from

$725
(Gotogate)

One-way from

$493
(Kiwi.com)

Popular in

January

Cheapest in

May

Average price

$864

Good round-trip deal

$906 or less

Good one-way deal

$689 or less
From Panama City Tocumen Intl to Spain
Search Deals
One-way flight from Panama City Tocumen Intl to Spain
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to Spain.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to Spain.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Panama City to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Sun 8/16

9:45 am-7:35 am

1 stop14h 50m

Malaga

Sat 9/5

9:35 am-2:14 pm

2 stops59h 39m

$755

Panama CityMálaga

PTY - AGP

PTYAGP

Panama City Tocumen Intl

Thu 8/20

3:30 pm-7:35 am

2 stops33h 05m

Malaga

Tue 9/8

9:35 am-7:31 pm

1 stop16h 56m

$755

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 8/22

9:45 am-9:00 am

1 stop16h 15m

Madrid Barajas

Fri 9/4

12:45 pm-4:04 am

2 stops46h 19m

$776

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 8/4

10:55 pm-6:50 am

2 stops24h 55m

Madrid Barajas

Thu 9/3

10:50 am-4:04 am

1 stop24h 14m

$776

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 8/8

3:30 pm-9:00 am

2 stops34h 30m

Madrid Barajas

Fri 8/28

10:50 am-7:31 pm

1 stop15h 41m

$777

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 8/18

3:30 pm-9:00 am

2 stops34h 30m

Madrid Barajas

Wed 3/31

10:50 am-7:31 pm

1 stop15h 41m

$777

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 9/11

3:30 pm-8:05 am

2 stops33h 35m

Madrid Barajas

Wed 9/23

10:50 am-7:31 pm

1 stop15h 41m

$777

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 7/20

9:45 am-9:00 am

1 stop16h 15m

Madrid Barajas

Sun 8/9

11:15 am-4:12 pm

2 stops35h 57m

$777

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 9/8

3:30 pm-9:00 am

2 stops34h 30m

Madrid Barajas

Tue 9/22

11:15 am-2:14 pm

2 stops33h 59m

$781

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 8/14

3:30 pm-9:00 am

2 stops34h 30m

Madrid Barajas

Mon 8/31

11:15 am-2:14 pm

2 stops33h 59m

$781

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 56 resultsSorted by cheapest first
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Best time to book a flight from Panama City to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Spain

What is the cheapest month to book a flight from Panama City to Spain?

Currently, October is the cheapest month in which you can book a flight from Panama City to Spain (average of $718). Flying from Panama City to Spain in July is currently the most expensive (average of $1,225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to ES?

Find hourly flight availability from Panama City to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Spain as you normally would.

Weekly flight availability from Panama City to Spain

Explore weekly flight availability from Panama City to Spain. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 16, 2026.

The most flights from PTY to ES0 are scheduled on a Monday (5 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (4 on average).

How often are flights from Panama City to Spain delayed?

About 12% of weekly flights between Panama City and Spain have experienced delays in the past year, with the average delay time being 144 minutes.

What is the most punctual flight time for Panama City to Spain flights?

Historically, flights departing in the evening are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.

What day of the week experiences the fewest flight delays on this route?

Sunday tends to have the lowest number of delays on this route, whereas Friday has historically faced a higher average of delays compared to other days of the week.

Which airline has the best punctuality record on Panama City to Spain flights?

Over the last year, Air Europa have had the lowest number of delays on this route, with just 10% of flights being delayed.

How far ahead should I book a flight from Panama City to Spain?

Booking 90 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Spain. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated June 16, 2026.
Get a feel of what it's like to fly with Air France,Turkish Airlines, andAir Europa from Panama City to Spain by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Air France
7.4
Good
1,606 reviews
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Turkish Airlines
7.4
Good
4,409 reviews
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Air Europa
7.0
Good
618 reviews
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Iberia
7.0
Good
3,237 reviews
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.
Avianca
6.5
Okay
2,530 reviews
Air France
7.4
Good
1,606 reviews

Overall

7.4

Boarding

7.5

Entertainment

7.0

Food

7.0

Crew

8.2

Comfort

7.4

Reviews

1 / 20
2.0
Mediocre

Carolina,Apr 2026

CDG - BOG

The aircraft is old, uncomfortable, the seat so narrow you don’t even notice you are in business class. The food is the same they are offering since -at least- 2022. The liquors are so limited. So disappointed.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to Spain?

    Located just 11.4 mi from the city center, Panama City Tocumen Intl (PTY) is the airport most travelers will use when flying to Spain from Panama City.

  • How popular is this Panama City to Spain flight route?

    The Panama City Tocumen Intl to Spain flight path was viewed by 19 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to Spain?

    United Airlines, Air Europa, and Iberia can get you from Panama City to Spain in just under 14h 50m. Your travel time can differ by up to 16h 15m. Panama City and Spain are separated by a distance of 5006 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Panama City to Spain one-way?

    To fly one-way, consider booking your trip with Avianca, which is currently one of the cheapest options available, starting at $508. Air Europa flights start at $518 while deals on Copa Airlines start at $602 one-way.

  • What are the most popular routes from Panama City to Spain?

    Most travelers choose Panama City Tocumen Intl - Madrid Barajas, Panama City Tocumen Intl - Barcelona-El Prat or Panama City Tocumen Intl - Santander when deciding on the best route from Panama City to Spain.

  • What are the most reliable airlines from Panama City to Spain?

    Consider Air Europa (90%), Etihad Airways (90%) or China Eastern (90%) when booking your flight. These represent the most reliable airlines when flying from Panama City to Spain.

  • What are the cheapest flights from Panama City to Spain?

    On average you can expect to pay $1,455 for a flight from Panama City to Spain. The cheapest flight overall is $658 while the most popular route, (Panama City Tocumen Intl - Madrid Barajas) is currently priced at $717.

  • Can I find deals for flights from Panama City to Spain that include hotel bookings?

    Yes. In addition to deals on Panama City to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Spain.

  • Can I find deals for business class flights from Panama City to Spain?

    Yes. Cheapflights offers flight deals from Panama City to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Spain?

    Currently, October is the cheapest month in which you can book a flight from Panama City to Spain (average of $718). Flying from Panama City to Spain in July is currently the most expensive (average of $1,225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 8 airlines flying from Panama City to Spain

Discover the top 8 airlines that operate flights from Panama City to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$618Average$1,097FlexibilityNo cancel feeOn-time75%
AviancaCheapest$623Average$1,100FlexibilityNo cancel feeOn-time71%
Air FranceCheapest$644Average$889FlexibilityNo cancel feeOn-time77%
IberiaCheapest$666Average$908FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$672Average$910FlexibilityNo cancel feeOn-time83%
Turkish AirlinesCheapest$698Average$763FlexibilityNo cancel feeOn-time77%
Copa AirlinesCheapest$722Average$1,269FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$767Average$908FlexibilityNo cancel feeOn-time69%

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