$233+ Cheap flights from Panama City (PTY) to Guayaquil (GYE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — GYE
Oct 9 — Oct 161
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to Guayaquil with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Panama City Tocumen Intl to Guayaquil Jose Joaquin de Olmedo are usually found in February or October, booked 79 days in advance, depart on a Sunday or Monday and return on a Thursday
Cheap flight deals from Panama City to Guayaquil
Cheapest
Best
Last-minute
One-way
Cheapest flights from Panama City to GuayaquilExplore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Panama City to Guayaquil. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:08 am -
Nonstop2h 13m
Tue 9/222:59 pm -
Nonstop2h 12m
Deal found 9/6![Copa Airlines logo]()
$424
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:39 pm -
Nonstop2h 16m
Tue 11/172:47 pm -
Nonstop2h 14m
Deal found 9/7![Copa Airlines logo]()
$434
This Avianca deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:10 pm -
1 stop14h 50m
Wed 11/47:35 pm -
1 stop13h 35m
Deal found 9/4![Avianca logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:08 am -
Nonstop2h 13m
Tue 9/226:00 am -
Nonstop2h 12m
Deal found 9/4![Copa Airlines logo]()
$438
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3011:27 am -
Nonstop2h 15m
Sun 1/176:34 pm -
Nonstop2h 16m
Deal found 9/7![Copa Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:21 am -
Nonstop2h 13m
Wed 10/76:30 pm -
Nonstop2h 10m
Deal found 9/7![Copa Airlines logo]()
$449
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:40 pm -
Nonstop2h 17m
Sat 1/168:25 am -
Nonstop2h 16m
Deal found 9/6![Copa Airlines logo]()
$452
This Avianca deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:25 am -
2 stops11h 30m
Sun 9/133:30 am -
1 stop13h 30m
Deal found 9/4![Avianca logo]()
$472
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:30 am -
2 stops9h 55m
Sat 11/283:30 am -
1 stop11h 45m
Deal found 9/6![Avianca logo]()
$473
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:19 pm -
Nonstop2h 13m
Wed 11/412:24 pm -
Nonstop2h 15m
Deal found 9/4![Copa Airlines logo]()
$481
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:08 am -
Nonstop2h 13m
Mon 9/146:28 pm -
Nonstop2h 12m
Deal found 9/6![Copa Airlines logo]()
$493
Best flights from Panama City to GuayaquilDiscover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Panama City to Guayaquil that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:27 am -
Nonstop2h 13m
Tue 11/34:22 am -
Nonstop2h 12m
Deal found 9/6![Copa Airlines logo]()
$434
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:40 pm -
Nonstop2h 17m
Sat 1/168:25 am -
Nonstop2h 16m
Deal found 9/6![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/296:40 pm -
Nonstop2h 19m
Thu 2/114:22 am -
Nonstop2h 12m
Deal found 9/5![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1711:27 am -
Nonstop2h 15m
Sat 11/2112:24 pm -
Nonstop2h 15m
Deal found 9/7![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:48 pm -
Nonstop2h 13m
Sun 9/2711:48 am -
Nonstop2h 12m
Deal found 9/4![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:39 pm -
Nonstop2h 13m
Sat 10/106:30 pm -
Nonstop2h 10m
Deal found 9/6![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/319:39 pm -
Nonstop2h 19m
Sun 1/178:25 am -
Nonstop2h 16m
Deal found 9/8![Copa Airlines logo]()
$452
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:40 pm -
Nonstop2h 17m
Fri 1/84:21 am -
Nonstop2h 13m
Deal found 9/7![Copa Airlines logo]()
$452
Last-minute flights from Panama City to GuayaquilDiscover last-minute flight deals from Panama City to Guayaquil. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to Guayaquil. Data last updated September 9, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:08 am -
Nonstop2h 13m
Mon 9/146:28 pm -
Nonstop2h 12m
Deal found 9/4![Copa Airlines logo]()
$452
This Avianca deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:25 am -
2 stops11h 30m
Sun 9/133:30 am -
1 stop13h 30m
Deal found 9/4![Avianca logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:08 am -
Nonstop2h 13m
Tue 9/222:59 pm -
Nonstop2h 12m
Deal found 9/6![Copa Airlines logo]()
$424
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1410:10 am -
1 stop13h 20m
Tue 9/221:50 pm -
2 stops10h 45m
Deal found 9/6![Avianca logo]()
$501
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/169:08 am -
Nonstop2h 13m
Tue 9/226:00 am -
Nonstop2h 12m
Deal found 9/4![Copa Airlines logo]()
$438
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:21 am -
Nonstop2h 13m
Wed 10/76:30 pm -
Nonstop2h 10m
Deal found 9/7![Copa Airlines logo]()
$449
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/49:48 pm -
Nonstop2h 13m
Sun 10/1112:18 pm -
Nonstop2h 16m
Deal found 9/6![Copa Airlines logo]()
$498
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:48 pm -
Nonstop2h 13m
Wed 11/42:47 pm -
Nonstop2h 14m
Deal found 9/7![Copa Airlines logo]()
$434
This Avianca deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:10 pm -
1 stop14h 50m
Wed 11/47:35 pm -
1 stop13h 35m
Deal found 9/4![Avianca logo]()
$435
One-way flights from Panama City to GuayaquilSearch for one-way flight options from Panama City to Guayaquil. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Panama City to Guayaquil. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Copa Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/279:08 am -
Nonstop2h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Copa Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2911:27 am -
Nonstop2h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Copa Airlines logo]()
$242
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:08 am -
Nonstop2h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Copa Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2910:31 pm -
1 stop12h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:31 pm -
1 stop10h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$381
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:31 pm -
1 stop4h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:33 pm -
2 stops13h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$466
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:25 am -
2 stops14h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$467
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/39:02 am -
Nonstop2h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Copa Airlines logo]()
$491
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:46 am -
1 stop16h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$510
Find flight deals from Panama City to Guayaquil
Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Guayaquil (GYE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $434 (Copa Airlines) |
One-way from | $233 (Copa Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $380 |
Good round-trip deal | $451 or less |
Good one-way deal | $252 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to Guayaquil that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Panama City to Guayaquil that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 2/21
6:40 pm-8:58 pm
Nonstop2h 18m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Quickest round-trip
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Thu 9/17
9:48 pm-12:01 am
Nonstop2h 13m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 9/20
11:21 am-1:34 pm
Nonstop2h 13m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 3/7
9:57 pm-12:14 am
Nonstop2h 17m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Mon 10/19
9:08 am-11:21 am
Nonstop2h 13m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Wed 12/2
11:27 am-1:42 pm
Nonstop2h 15m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Mon 9/14
11:21 am-1:34 pm
Nonstop2h 13m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Thu 2/25
9:39 pm-11:59 pm
Nonstop2h 20m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sat 10/10
9:08 am-11:21 am
Nonstop2h 13m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Panama CityGuayaquil
PTY Panama City Tocumen Intl - GYE Guayaquil Jose Joaquin de Olmedo
PTYGYE
Panama City Tocumen Intl
Sun 1/17
6:40 pm-8:59 pm
Nonstop2h 19m
Guayaquil Jose Joaquin de Olmedo
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$233
Showing 1-10 of 18 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Panama City-Guayaquil flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City-Guayaquil flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City-Guayaquil flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Panama City-Guayaquil flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City-Guayaquil flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Panama City to Guayaquil
Have a flexible travel schedule? Discover the best time to fly to Guayaquil from Panama City with our price prediction graph.
PTY-GYE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to Guayaquil
Prices
Airlines
Delays
How far ahead should I book a flight from Panama City to Guayaquil?
Booking 78 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to Guayaquil. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Panama City to Guayaquil?
Currently, February is the cheapest month in which you can book a flight from Panama City to Guayaquil (average of $330). Flying from Panama City to Guayaquil in June is currently the most expensive (average of $396). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to GYE?
Find hourly flight availability from Panama City to Guayaquil. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 9, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to Guayaquil as you normally would.
How often are flights from Panama City to Guayaquil delayed?
About 7% of weekly flights between Panama City and Guayaquil have experienced delays in the past year, with the average delay time being 101 minutes.
What is the most punctual flight time for Panama City to Guayaquil flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving at night tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Tuesday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to Guayaquil flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 7% of flights being delayed.
Reviews of airlines servicing Guayaquil
Get insights into the airlines that provide service to Guayaquil. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Guayaquil. Reviews last updated September 9, 2026.
See what other customers who have flown with Copa Airlines and Avianca from Panama City to Guayaquil have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Comfort
7.4
Food
6.9
Entertainment
6.9
Crew
8.1
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Comfort
7.4
Food
6.9
Entertainment
6.9
Crew
8.1
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Overall
7.6
Comfort
7.4
Food
6.9
Entertainment
6.9
Crew
8.1
Boarding
7.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
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Top 2 airlines flying from Panama City to Guayaquil
Discover the top 2 airlines that operate flights from Panama City to Guayaquil. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$382 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$257 | Average$396 | FlexibilityNo cancel fee | On-time70% |