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South America

$142+ Cheap flights from Panama City (PTY) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
Aug 5 — Aug 121
Wed 8/5
Wed 8/12
1 adult, Economy
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Cheap flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 6, 2026.

This Avianca deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:25 am
PTY
-
BOG
1 stop8h 05m
Avianca
Fri 10/303:00 pm
BOG
-
PTY
Nonstop1h 55m
Avianca
Deal found 7/2$267
This Copa Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:49 am
PTY
-
MDE
Nonstop1h 26m
Copa Airlines
Tue 7/214:30 pm
MDE
-
PTY
Nonstop1h 26m
Copa Airlines
Deal found 7/6$276
This Avianca deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1211:25 am
PTY
-
BOG
1 stop7h 40m
Avianca
Tue 10/1312:35 pm
BOG
-
PTY
Nonstop1h 40m
Avianca
Deal found 7/2$277
This Gotogate deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/293:50 pm
PTY
-
BOG
2 stops21h 05m
Avianca
Mon 11/3010:45 pm
BOG
-
PTY
Nonstop1h 55m
Avianca
Deal found 7/2$286
This Copa Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/143:29 pm
PTY
-
MDE
Nonstop1h 26m
Copa Airlines
Tue 8/186:20 pm
MDE
-
PTY
Nonstop1h 27m
Copa Airlines
Deal found 7/5$287
This FlightHub deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:50 pm
PTY
-
BOG
2 stops27h 40m
Avianca
Sun 12/612:15 pm
BOG
-
PTY
Nonstop1h 45m
Avianca
Deal found 7/2$288
This Avianca deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/164:25 am
PTY
-
MDE
1 stop4h 45m
Avianca
Sun 8/309:30 am
MDE
-
PTY
1 stop4h 45m
Avianca
Deal found 7/1$288
This Avianca deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/174:25 am
PTY
-
MDE
1 stop4h 20m
Avianca
Tue 7/214:50 am
MDE
-
PTY
1 stop4h 25m
Avianca
Deal found 7/3$289
This Avianca deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2110:10 am
PTY
-
MDE
1 stop5h 50m
Avianca
Sat 7/2510:40 am
MDE
-
PTY
1 stop6h 20m
Avianca
Deal found 7/5$290
This Avianca deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/195:30 am
PTY
-
BOG
1 stop6h 30m
Avianca
Mon 7/207:30 am
BOG
-
PTY
Nonstop1h 45m
Avianca
Deal found 7/5$291
This Copa Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/19:46 pm
PTY
-
CTG
Nonstop1h 14m
Copa Airlines
Sat 8/812:00 pm
CTG
-
PTY
Nonstop1h 20m
Copa Airlines
Deal found 7/3$291
This Copa Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/313:29 pm
PTY
-
MDE
Nonstop1h 26m
Copa Airlines
Mon 8/36:20 pm
MDE
-
PTY
Nonstop1h 27m
Copa Airlines
Deal found 7/3$297

Find flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated July 6, 2026.

Round-trip from

$267
(Avianca)

One-way from

$142
(Super.com)

Popular in

June

Cheapest in

March

Average price

$188

Good round-trip deal

$78 or less

Good one-way deal

$71 or less
From Panama City Tocumen Intl to South America
Search Deals
One-way flight from Panama City Tocumen Intl to South America
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($16 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to South America.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to South America.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 8/16

6:49 am-8:15 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Sat 8/22

10:35 am-12:02 pm

Nonstop1h 27m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 7/22

6:49 am-8:15 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Sat 7/25

4:30 pm-5:56 pm

Nonstop1h 26m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 9/30

7:10 pm-8:35 pm

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Mon 10/5

4:30 pm-5:59 pm

Nonstop1h 29m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 8/1

12:49 pm-2:15 pm

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Tue 8/4

10:35 am-12:02 pm

Nonstop1h 27m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sat 7/18

6:49 am-8:15 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Mon 7/20

8:35 am-10:01 am

Nonstop1h 26m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 7/13

6:49 am-8:15 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Fri 7/17

6:20 pm-7:46 pm

Nonstop1h 26m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Mon 9/21

8:15 am-9:40 am

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Mon 9/28

10:35 am-12:04 pm

Nonstop1h 29m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Thu 7/23

8:14 am-9:40 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Sat 7/25

4:30 pm-5:56 pm

Nonstop1h 26m

$276

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Fri 7/17

6:49 am-8:15 am

Nonstop1h 26m

Medellín Jose Maria Cordova Intl

Tue 7/21

4:30 pm-5:56 pm

Nonstop1h 26m

$276

Panama CityBogotá

PTY - BOG

PTYBOG

Panama City Tocumen Intl

Sun 7/19

5:30 am-12:00 pm

1 stop6h 30m

Bogotá El Dorado

Mon 7/20

7:30 am-9:15 am

Nonstop1h 45m

$291

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City to South America?

Currently, September is the cheapest month in which you can book a flight from Panama City to South America (average of $240). Flying from Panama City to South America in June is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 6, 2026.

A simple way to save on the total cost of your ticket is to fly from Panama City to South America in the morning. If you’re flexible enough to do this you can expect to save up to 13% on your trip compared to booking a flight in the afternoon.

Weekly flight availability from Panama City to South America

Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 6, 2026.

The most flights from PTY to 0SA are scheduled on a Friday (18 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (12 on average).

How far ahead should I book a flight from Panama City to South America?

Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest day to fly from Panama City to South America?

Use this chart to determine the cheapest time to fly round-trip from Panama City to South America. Price data was last updated on July 4, 2026.

Travelers seeking maximum savings on their Panama City to South America flight should consider departing on Saturday evenings when fares are most often at their lowest. Wednesday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 6, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,568 reviews

Boarding

7.8

Crew

8.1

Food

6.9

Overall

7.6

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Copa Airlines
7.6
Good
1,568 reviews
Copa Airlines
7.6
Good
1,568 reviews

Boarding

7.8

Crew

8.1

Food

6.9

Overall

7.6

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it
Avianca
6.5
Okay
2,520 reviews
Copa Airlines
7.6
Good
1,568 reviews

Boarding

7.8

Crew

8.1

Food

6.9

Overall

7.6

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Maria,Dec 2025

PTY - SLA

Old plain no entertainment , no outlet for cell or computer! And online they said you have all that! Almost 6 hrs looking to the floor..terrible expirencw and I pay a lot of money for it

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    If you book a flight to South America from Panama City, you will be flying from Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How popular is this Panama City to South America flight route?

    This flight path from Panama City Tocumen Intl to South America was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to South America?

    A quick flight from Panama City to South America can take about 1h 26m. Copa Airlines provides one of the quickest options available for as low as $276. The distance from Panama City to South America is about 337 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Panama City to South America one-way?

    One-way options have recently been found by users for as low as $66 on Wingo. Other airlines that offer cheap prices include Avianca from $111 and Copa Airlines from $120 one-way.

  • What are the most popular routes from Panama City to South America?

    While some choose either Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl or Panama City Tocumen Intl - Buenos Aires Ministro Pistarini, Panama City Tocumen Intl - Bogotá El Dorado is the most popular route from Panama City to South America.

  • What are the most reliable airlines from Panama City to South America?

    The top 3 most reliable airlines when flying from Panama City to South America are Lufthansa (95%), Turkish Airlines (93%) and Copa Airlines (93%).

  • What are the cheapest flights from Panama City to South America?

    Looking for the cheapest flight from Panama City to South America? While on average our users pay $896, our data indicates the cheapest price to be $154. The most popular route (Panama City Tocumen Intl - Bogotá El Dorado), is priced around $136.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South America?

    Currently, September is the cheapest month in which you can book a flight from Panama City to South America (average of $240). Flying from Panama City to South America in June is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Panama City to South America

Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 6, 2026.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$70Average$164FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$108Average$481FlexibilityNo cancel feeOn-time70%
AviancaCheapest$153Average$459FlexibilityNo cancel feeOn-time71%

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