$203+ Cheap flights from Panama City (PTY) to South America
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to South America
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Cheapest flights from Panama City to South AmericaExplore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:10 pm -
Nonstop1h 40m
Fri 11/2010:40 am -
2 stops15h 30m
Deal found 11/2![Avianca logo]()
$255
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:30 am -
1 stop5h 15m
Mon 11/98:25 am -
1 stop6h 50m
Deal found 10/30![Avianca logo]()
$263
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:10 pm -
Nonstop1h 40m
Sat 11/143:00 pm -
2 stops11h 10m
Deal found 11/2![Avianca logo]()
$264
This Avianca deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:30 am -
1 stop5h 15m
Sun 11/159:20 am -
1 stop7h 55m
Deal found 10/31![Avianca logo]()
$264
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:45 pm -
Nonstop1h 15m
Sun 12/67:05 pm -
Nonstop1h 17m
Deal found 10/31![Copa Airlines logo]()
$272
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:30 am -
1 stop5h 15m
Sun 11/227:10 am -
1 stop8h 05m
Deal found 10/30![Avianca logo]()
$273
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:30 am -
1 stop13h 15m
Thu 11/57:15 am -
Nonstop1h 55m
Deal found 11/2![Avianca logo]()
$290
This Avianca deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:30 am -
1 stop13h 15m
Tue 11/1711:35 pm -
Nonstop1h 45m
Deal found 11/3![Avianca logo]()
$292
This Trip.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:30 am -
1 stop17h 45m
Sun 11/85:10 am -
1 stop12h 05m
Deal found 10/31![Avianca logo]()
$302
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/292:30 am -
1 stop7h 45m
Thu 12/1010:30 am -
1 stop4h 45m
Deal found 11/2![Avianca logo]()
$304
This Avianca deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:10 pm -
1 stop6h 55m
Wed 12/2312:05 pm -
1 stop5h 10m
Deal found 10/31![Avianca logo]()
$304
This Trip.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:30 am -
2 stops14h 55m
Tue 11/101:25 pm -
Nonstop1h 50m
Deal found 11/4![Avianca logo]()
$305
Best flights from Panama City to South AmericaDiscover carefully curated flight deals from Panama City to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Panama City to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:07 am -
Nonstop1h 08m
Sun 1/107:05 pm -
Nonstop1h 16m
Deal found 10/30![Copa Airlines logo]()
$271
This Avianca deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:05 am -
Nonstop1h 40m
Wed 11/1811:35 pm -
Nonstop1h 45m
Deal found 11/4![Avianca logo]()
$311
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/317:23 am -
Nonstop1h 12m
Sun 1/177:05 pm -
Nonstop1h 16m
Deal found 10/30![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:21 am -
Nonstop1h 14m
Mon 11/169:35 am -
Nonstop1h 18m
Deal found 10/31![Copa Airlines logo]()
$272
This GOL deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/236:10 pm -
2 stops27h 05m
Sat 1/308:30 am -
2 stops32h 45m
Deal found 11/4![GOL logo]()
$624
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:43 am -
Nonstop1h 17m
Mon 1/187:05 pm -
Nonstop1h 16m
Deal found 10/30![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/287:27 am -
Nonstop1h 08m
Sun 1/319:35 am -
Nonstop1h 15m
Deal found 10/31![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2912:50 pm -
Nonstop1h 15m
Thu 12/37:05 pm -
Nonstop1h 17m
Deal found 10/30![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:07 am -
Nonstop1h 08m
Sat 1/166:25 am -
Nonstop1h 17m
Deal found 10/31![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:53 pm -
Nonstop1h 12m
Mon 1/187:05 pm -
Nonstop1h 16m
Deal found 10/31![Copa Airlines logo]()
$282
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/143:55 pm -
Nonstop1h 38m
Sat 12/1912:02 pm -
Nonstop1h 41m
Deal found 11/2![Copa Airlines logo]()
$317
This GOL deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/62:30 am -
2 stops14h 45m
Fri 11/135:05 pm -
2 stops48h 10m
Deal found 10/31![GOL logo]()
$624
This Copa Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/303:27 pm -
Nonstop1h 37m
Thu 12/103:12 pm -
Nonstop1h 40m
Deal found 11/2![Copa Airlines logo]()
$317
This GOL deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:05 am -
2 stops18h 20m
Sun 2/74:50 pm -
1 stop24h 25m
Deal found 11/2![GOL logo]()
$625
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:29 pm -
Nonstop1h 37m
Tue 12/1512:02 pm -
Nonstop1h 41m
Deal found 11/4![Copa Airlines logo]()
$317
This GOL deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/164:10 pm -
1 stop11h 45m
Wed 3/1011:00 pm -
2 stops18h 15m
Deal found 10/31![GOL logo]()
$626
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:29 pm -
Nonstop1h 37m
Wed 12/168:40 am -
Nonstop1h 40m
Deal found 10/31![Copa Airlines logo]()
$317
This GOL deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/154:10 pm -
1 stop30h 20m
Thu 1/217:45 am -
1 stop9h 30m
Deal found 11/2![GOL logo]()
$627
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/412:29 pm -
Nonstop1h 37m
Sun 12/136:05 pm -
Nonstop1h 44m
Deal found 11/3![Copa Airlines logo]()
$317
This GOL deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:10 pm -
1 stop19h 35m
Tue 12/84:50 pm -
1 stop24h 25m
Deal found 10/30![GOL logo]()
$634
This Copa Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2912:29 pm -
Nonstop1h 37m
Sun 12/63:12 pm -
Nonstop1h 40m
Deal found 11/1![Copa Airlines logo]()
$317
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:20 am -
Nonstop1h 37m
Mon 11/308:42 am -
Nonstop1h 38m
Deal found 11/3![Copa Airlines logo]()
$317
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:29 pm -
Nonstop1h 37m
Mon 12/1412:02 pm -
Nonstop1h 41m
Deal found 11/4![Copa Airlines logo]()
$317
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:25 am -
Nonstop1h 42m
Fri 11/131:40 pm -
Nonstop1h 52m
Deal found 11/4![Copa Airlines logo]()
$330
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/129:25 am -
Nonstop1h 42m
Tue 11/1710:40 am -
Nonstop1h 51m
Deal found 11/4![Copa Airlines logo]()
$330
This Copa Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:53 am -
Nonstop1h 22m
Wed 12/166:20 pm -
Nonstop1h 34m
Deal found 11/4![Copa Airlines logo]()
$353
This Copa Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:57 am -
Nonstop1h 18m
Thu 11/1912:40 pm -
Nonstop1h 31m
Deal found 11/1![Copa Airlines logo]()
$354
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:57 am -
Nonstop1h 18m
Thu 11/2610:45 am -
Nonstop1h 29m
Deal found 10/31![Copa Airlines logo]()
$354
This Copa Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:53 am -
Nonstop1h 22m
Thu 1/710:45 am -
Nonstop1h 28m
Deal found 11/3![Copa Airlines logo]()
$354
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2212:55 pm -
Nonstop1h 20m
Tue 1/2610:45 am -
Nonstop1h 28m
Deal found 10/31![Copa Airlines logo]()
$354
Last-minute flights from Panama City to South AmericaDiscover last-minute flight deals from Panama City to South America. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to South America. Data last updated November 4, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/32:30 am -
1 stop17h 45m
Sun 11/85:10 am -
1 stop12h 05m
Deal found 10/31![Avianca logo]()
$302
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:30 am -
1 stop13h 15m
Thu 11/57:15 am -
Nonstop1h 55m
Deal found 11/2![Avianca logo]()
$290
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/52:30 am -
1 stop5h 15m
Mon 11/98:25 am -
1 stop6h 50m
Deal found 10/30![Avianca logo]()
$263
This Trip.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:30 am -
2 stops14h 55m
Tue 11/101:25 pm -
Nonstop1h 50m
Deal found 11/4![Avianca logo]()
$305
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/134:10 pm -
Nonstop1h 40m
Sat 11/143:00 pm -
2 stops11h 10m
Deal found 11/2![Avianca logo]()
$264
This Avianca deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/132:30 am -
1 stop5h 15m
Sun 11/159:20 am -
1 stop7h 55m
Deal found 10/31![Avianca logo]()
$264
This Avianca deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:30 am -
1 stop13h 15m
Tue 11/1711:35 pm -
Nonstop1h 45m
Deal found 11/3![Avianca logo]()
$292
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:30 am -
1 stop5h 15m
Sun 11/227:10 am -
1 stop8h 05m
Deal found 10/30![Avianca logo]()
$273
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:10 pm -
Nonstop1h 40m
Fri 11/2010:40 am -
2 stops15h 30m
Deal found 11/2![Avianca logo]()
$255
This Copa Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:45 pm -
Nonstop1h 15m
Sun 12/67:05 pm -
Nonstop1h 17m
Deal found 10/31![Copa Airlines logo]()
$272
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/292:30 am -
1 stop7h 45m
Thu 12/1010:30 am -
1 stop4h 45m
Deal found 11/2![Avianca logo]()
$304
This Avianca deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:10 pm -
1 stop6h 55m
Wed 12/2312:05 pm -
1 stop5h 10m
Deal found 10/31![Avianca logo]()
$304
One-way flights from Panama City to South AmericaSearch for one-way flight options from Panama City to South America. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Panama City to South America. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:10 pm -
1 stop6h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$203
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/234:10 pm -
1 stop5h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$204
This FlightHub deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:05 am -
1 stop6h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$207
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/52:30 am -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Avianca logo]()
$209
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/246:10 pm -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$210
This Avianca deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:10 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Avianca logo]()
$211
This Super.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1810:05 am -
1 stop10h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Avianca logo]()
$216
This Super.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:05 am -
1 stop5h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Avianca logo]()
$217
This Jetabroad deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Jetabroad is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:05 am -
1 stop10h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Avianca logo]()
$219
This Avianca deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:10 pm -
1 stop6h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/1![Avianca logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:10 pm -
2 stops22h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Multiple Airlines logo]()
$224
This Avianca deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/254:10 pm -
1 stop6h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Avianca logo]()
$225
Find flight deals from Panama City to South America
Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated November 4, 2026.
Round-trip from | $255 (Avianca) |
|---|---|
One-way from | $203 (Avianca) |
Popular in | December |
Cheapest in | March |
Average price | $548 |
Good round-trip deal | $113 or less |
Good one-way deal | $83 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Panama City to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityCali
PTY Panama City Tocumen Intl - CLO Cali Alfonso B. Aragon Intl
PTYCLO
Panama City Tocumen Intl
Wed 12/2
6:10 pm-11:35 pm
1 stop5h 25m
Cali Alfonso B. Aragon Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$203
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Fri 11/6
2:30 am-9:10 am
1 stop6h 40m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$204
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Wed 1/27
10:05 am-2:35 pm
1 stop4h 30m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$206
Panama CityBarranquilla
PTY Panama City Tocumen Intl - BAQ Barranquilla E Cortissoz
PTYBAQ
Panama City Tocumen Intl
Thu 12/24
2:30 am-9:35 am
1 stop7h 05m
Barranquilla E Cortissoz
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$224
Panama CityBarranquilla
PTY Panama City Tocumen Intl - BAQ Barranquilla E Cortissoz
PTYBAQ
Panama City Tocumen Intl
Tue 11/24
2:30 am-7:45 am
1 stop5h 15m
Barranquilla E Cortissoz
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$224
Panama CityCartagena
PTY Panama City Tocumen Intl - CTG Cartagena Rafael Nunez
PTYCTG
Panama City Tocumen Intl
Fri 1/15
4:10 pm-10:20 pm
1 stop6h 10m
Cartagena Rafael Nunez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$241
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Fri 11/20
12:54 pm-2:15 pm
Nonstop1h 21m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Fri 12/18
6:53 am-8:15 am
Nonstop1h 22m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Wed 11/18
12:54 pm-2:15 pm
Nonstop1h 21m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Sun 1/10
6:56 am-8:15 am
Nonstop1h 19m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$263
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Panama City to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
PTY-CLO
PTY-MDE
PTY-BAQ
PTY-BOG
PTY-CTG
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to South America
PTY-0SA
PTY-CLO
PTY-MDE
PTY-BAQ
PTY-BOG
What is the cheapest month to book a flight from Panama City to South America?
Currently, February is the cheapest month in which you can book a flight from Panama City to South America (average of $251). Flying from Panama City to South America in October is currently the most expensive (average of $340). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SA?
Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 4, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City to South America at noon. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the evening.
Weekly flight availability from Panama City to South America
Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated November 4, 2026.
The most flights from PTY to 0SA are scheduled on a Monday (19 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (13 on average).
How often are flights from Panama City to South America delayed?
About 6% of weekly flights between Panama City and South America have experienced delays in the past year, with the average delay time being 109 minutes.
What is the most punctual flight time for Panama City to South America flights?
Historically, flights departing in the morning are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Monday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Panama City to South America flights?
Over the last year, Copa Airlines have had the lowest number of delays on this route, with just 6% of flights being delayed.
How far ahead should I book a flight from Panama City to South America?
Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest day to fly from Panama City to South America?
Use this chart to determine the cheapest time to fly round-trip from Panama City to South America. Price data was last updated on October 31, 2026.
Travelers seeking maximum savings on their Panama City to South America flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 4, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Overall
7.6
Entertainment
6.9
Comfort
7.4
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Overall
7.6
Entertainment
6.9
Comfort
7.4
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Overall
7.6
Entertainment
6.9
Comfort
7.4
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Panama City to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama City to South America by cabin class
Find flights from Panama City to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and South America flights
Browse other Panama City and South America flight options. Last updated on November 4, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
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Panama City to South America flights
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Top 3 airlines flying from Panama City to South America
Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$68 | Average$156 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$122 | Average$499 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$151 | Average$470 | FlexibilityNo cancel fee | On-time71% |