HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$128+ Cheap flights from Panama City (PTY) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated May 1, 2025.

Round-trip from

$232
(Copa Airlines)

One-way from

$128
(Priceline)

Popular in

January

Cheapest in

February

Average price

$508

Good round-trip deal

$99 or less

Good one-way deal

$68 or less
From Panama City Tocumen Intl to South America
Search Deals
One-way flight from Panama City Tocumen Intl to South America
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($12 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to South America.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to South America.
Search Deals

Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Priceline deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/63:20 amPTY - BOG
Nonstop1h 34mAvianca
Wed 5/78:00 amBOG - PTY
1 stop4h 35mAvianca
Deal found 4/29$216
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/811:50 amPTY - BOG
Nonstop1h 39mCopa Airlines
Sun 5/1112:08 pmBOG - PTY
Nonstop1h 46mCopa Airlines
Deal found 4/30$232
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/97:20 amPTY - MDE
Nonstop1h 25mCopa Airlines
Sun 5/1111:29 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 4/30$232
This Priceline deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/111:20 amPTY - MDE
Nonstop1h 10mAvianca
Mon 5/55:08 amMDE - PTY
1 stop5h 02mAvianca
Deal found 4/30$242
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1612:43 pmPTY - CLO
Nonstop1h 39mCopa Airlines
Thu 5/228:47 amCLO - PTY
Nonstop1h 33mCopa Airlines
Deal found 4/30$246
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/177:26 amPTY - CTG
Nonstop1h 15mCopa Airlines
Thu 7/316:20 amCTG - PTY
Nonstop1h 19mCopa Airlines
Deal found 4/30$250
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/183:49 pmPTY - BAQ
Nonstop1h 20mCopa Airlines
Thu 7/36:24 pmBAQ - PTY
Nonstop1h 25mCopa Airlines
Deal found 4/30$255
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/43:20 amPTY - CLO
1 stop4h 15mAvianca
Sat 5/104:56 pmCLO - PTY
1 stop4h 14mAvianca
Deal found 4/29$260
This Trip.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/183:20 amPTY - CTG
1 stop7h 33mAvianca
Wed 5/217:01 pmCTG - PTY
1 stop5h 09mAvianca
Deal found 4/29$275
This Avianca deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/173:40 pmPTY - BAQ
2 stops6h 51mAvianca
Wed 5/218:20 amBAQ - PTY
2 stops6h 20mAvianca
Deal found 4/30$279
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/195:25 pmPTY - CLO
1 stop4h 17mMultiple Airlines
Fri 5/233:02 pmCLO - PTY
1 stop6h 08mMultiple Airlines
Deal found 4/30$317
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/53:20 amPTY - CTG
1 stop6h 19mMultiple Airlines
Sun 6/86:20 amCTG - PTY
Nonstop1h 19mMultiple Airlines
Deal found 4/30$334

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityBogotá

PTY - BOG

PTYBOG

Panama City Tocumen Intl

Sat 5/17

3:47 pm-5:26 pm

Nonstop1h 39m

Bogotá El Dorado

Wed 5/21

8:35 am-10:21 am

Nonstop1h 46m

$232

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Sun 5/18

7:20 am-8:45 am

Nonstop1h 25m

Medellín Jose Maria Cordova Intl

Sat 5/24

11:29 am-12:57 pm

Nonstop1h 28m

$232

Panama CityBogotá

PTY - BOG

PTYBOG

Panama City Tocumen Intl

Wed 5/14

3:20 am-4:54 am

Nonstop1h 34m

Bogotá El Dorado

Mon 5/19

11:06 am-2:40 pm

1 stop3h 34m

$242

Panama CityMedellín

PTY - MDE

PTYMDE

Panama City Tocumen Intl

Wed 5/14

11:05 am-3:48 pm

1 stop4h 43m

Medellín Jose Maria Cordova Intl

Sun 5/18

1:25 pm-2:40 pm

Nonstop1h 15m

$242

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 5/16

12:43 pm-2:22 pm

Nonstop1h 39m

Cali Alfonso B. Aragon Intl

Thu 5/22

8:47 am-10:20 am

Nonstop1h 33m

$246

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Thu 7/17

9:44 pm-10:59 pm

Nonstop1h 15m

Cartagena Rafael Nunez

Thu 7/31

6:20 am-7:39 am

Nonstop1h 19m

$250

Panama CityBarranquilla

PTY - BAQ

PTYBAQ

Panama City Tocumen Intl

Wed 6/18

3:49 pm-5:09 pm

Nonstop1h 20m

Barranquilla E Cortissoz

Thu 7/3

6:24 pm-7:49 pm

Nonstop1h 25m

$255

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sun 5/4

3:20 am-7:35 am

1 stop4h 15m

Cali Alfonso B. Aragon Intl

Sat 5/10

4:56 pm-9:10 pm

1 stop4h 14m

$260

Panama CityCartagena

PTY - CTG

PTYCTG

Panama City Tocumen Intl

Sun 5/18

3:20 am-10:53 am

1 stop7h 33m

Cartagena Rafael Nunez

Wed 5/21

7:01 pm-12:10 am

1 stop5h 09m

$275

Panama CityBarranquilla

PTY - BAQ

PTYBAQ

Panama City Tocumen Intl

Sat 5/17

3:40 pm-10:31 pm

2 stops6h 51m

Barranquilla E Cortissoz

Wed 5/21

8:20 am-2:40 pm

2 stops6h 20m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City to South America?

Currently, May is the cheapest month in which you can book a flight from Panama City to South America (average of $359). Flying from Panama City to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to South America as you normally would.

Weekly flight availability from Panama City to South America

Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 1, 2025.

The most flights from PTY to 0SA are scheduled on a Monday (15 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (9 on average).

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 1, 2025.
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Azul
8.0
Very good
777 reviews
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Emirates
8.0
Very good
3,215 reviews
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
Copa Airlines
7.5
Good
1,415 reviews
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
United Airlines
7.4
Good
8,696 reviews
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.
American Airlines
7.2
Good
10,000 reviews
Azul
8.0
Very good
777 reviews

Boarding

8.1

Comfort

8.0

Food

7.1

Entertainment

7.5

Crew

8.6

Overall

8.0

Reviews

1 / 14
2.0
Mediocre

Mike,Feb 2025

NVT - LIS

Experience was terrible. Flight cancelled. Missed connection. Replace service with EuroAtlantic airlines. Awful seats, awful food.

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    If you book a flight to South America from Panama City, you will be flying from Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How popular is this Panama City to South America flight route?

    This flight path from Panama City Tocumen Intl to South America was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Panama City to South America one-way?

    One-way options have recently been found by users for as low as $128 on Avianca. Other airlines that offer cheap prices include Copa Airlines from $134 and British Airways from $7,851 one-way.

  • What are the most popular routes from Panama City to South America?

    While some choose either Panama City Tocumen Intl - Rio de Janeiro–Galeão Intl or Panama City Tocumen Intl - Buenos Aires Ministro Pistarini, Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl is the most popular route from Panama City to South America.

  • What are the most reliable airlines from Panama City to South America?

    The top 3 most reliable airlines when flying from Panama City to South America are Avianca Ecuador (96%), Turkish Airlines (93%) and Copa Airlines (88%).

  • What are the cheapest flights from Panama City to South America?

    Looking for the cheapest flight from Panama City to South America? While on average our users pay $944, our data indicates the cheapest price to be $129. The most popular route (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl), is priced around $139.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South America?

    Currently, May is the cheapest month in which you can book a flight from Panama City to South America (average of $359). Flying from Panama City to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to South America

See prices for flight routes from nearby airports that may be better suited for you.
Panama City to Miami flights
Panama City to John F Kennedy Intl flights
Panama City to Newark flights
Panama City to Orlando flights
Panama City to Madrid flights
Panama City to Los Angeles flights
Panama City to LaGuardia flights
Panama City to Tampa flights
Panama City to Jose Maria Cordova Intl flights
Panama City to Rio de Janeiro–Galeão Intl flights
Panama City to Cancún flights
Panama City to Mexico City flights
Panama City to Atlanta flights
Panama City to O'Hare Intl flights
Panama City to Boston flights
Panama City to Ministro Pistarini flights
Panama City to Lima flights
Panama City to Hobby flights
Panama City to Fort Lauderdale flights
Panama City to San José flights
Panama City to Bogotá flights
Panama City to San Francisco flights
Panama City to Charles de Gaulle flights
Panama City to George Bush Intcntl flights
Panama City to Dulles Intl flights
Panama City to Punta Cana flights
Panama City to Dallas/Fort Worth flights
Panama City to Santiago flights
Panama City to Barranquilla flights
Panama City to Santo Domingo flights
Panama City to Las Vegas flights
Panama City to Leonardo da Vinci/Fiumicino flights
Panama City to Ontario flights
Panama City to Cartagena flights
Panama City to Austin flights
Panama City to Barcelona-El Prat flights
Panama City to Baltimore flights
Panama City to Hartford flights
Panama City to San Salvador flights
Panama City to Pearson Intl flights
Panama City to Honolulu flights
Panama City to Guarulhos Intl flights
Panama City to Amsterdam flights
Panama City to Raleigh flights
Panama City to Indianapolis flights
Panama City to Cleveland flights
Panama City to Luis Munoz Marin Intl flights
Panama City to Heathrow flights
Panama City to Berlin flights

Top 3 airlines flying from Panama City to South America

Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$72Average$153FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$113Average$500FlexibilityNo cancel feeOn-time70%
AviancaCheapest$159Average$411FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.