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South America

$117+ Cheap flights from Panama City (PTY) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Panama City to South America

Cheapest flights from Panama City to South America
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/239:20 amPTY - CLO
Nonstop1h 41mCopa Airlines
Sun 11/303:12 pmCLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 10/30$202
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:54 amPTY - MDE
Nonstop1h 24mCopa Airlines
Fri 11/1410:46 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 10/29$202
This FlightHub deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:55 amPTY - MDE
1 stop4h 10mAvianca
Tue 12/239:00 pmMDE - PTY
1 stop4h 00mAvianca
Deal found 10/29$208
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:55 amPTY - MDE
1 stop4h 10mAvianca
Sun 12/149:50 amMDE - PTY
1 stop4h 10mAvianca
Deal found 10/28$213
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/55:50 pmPTY - MDE
1 stop4h 05mAvianca
Sat 11/84:45 amMDE - PTY
1 stop4h 05mAvianca
Deal found 10/28$215
This Gotogate deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:50 pmPTY - CLO
1 stop5h 20mAvianca
Fri 11/78:40 amCLO - PTY
1 stop5h 20mAvianca
Deal found 10/30$222
This Priceline deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:55 pmPTY - MDE
1 stop4h 00mAvianca
Thu 12/114:20 amMDE - PTY
1 stop4h 30mAvianca
Deal found 10/28$223
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:55 pmPTY - CLO
Nonstop1h 42mCopa Airlines
Fri 11/143:12 pmCLO - PTY
Nonstop1h 32mCopa Airlines
Deal found 10/29$224
This Copa Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:50 pmPTY - MDE
Nonstop1h 25mCopa Airlines
Tue 12/910:46 amMDE - PTY
Nonstop1h 28mCopa Airlines
Deal found 10/27$224
This Copa Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:23 pmPTY - BOG
Nonstop1h 40mCopa Airlines
Sun 12/72:24 pmBOG - PTY
Nonstop1h 48mCopa Airlines
Deal found 10/29$226
This Avianca deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/32:55 amPTY - CLO
1 stop4h 15mAvianca
Thu 12/118:15 pmCLO - PTY
1 stop4h 45mAvianca
Deal found 10/30$230
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:55 amPTY - MDE
1 stop4h 10mAvianca
Mon 12/18:10 pmMDE - PTY
1 stop4h 30mAvianca
Deal found 10/28$234

Cheap flight deals from Panama City to South America

Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated October 30, 2025.

Round-trip from

$202
(Copa Airlines)

One-way from

$117
(FlightHub)

Popular in

January

Cheapest in

September

Average price

$473

Good round-trip deal

$125 or less

Good one-way deal

$90 or less
From Panama City Tocumen Intl to South America
Search Deals
One-way flight from Panama City Tocumen Intl to South America
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($33 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 0% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from Panama City Tocumen Intl to South America.
Search Deals
Price to beat on a one-way flight from Panama City Tocumen Intl to South America.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.

Fly from

Panama City

Fly to

South America

Route

Depart

Return

Price

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Thu 11/27

9:20 am-11:01 am

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Sat 11/29

4:52 am-6:24 am

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sat 11/15

9:20 am-11:01 am

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Wed 12/10

3:11 pm-4:44 pm

Nonstop1h 33m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 11/10

12:29 pm-2:11 pm

Nonstop1h 42m

Cali Alfonso B. Aragon Intl

Fri 11/14

3:12 pm-4:44 pm

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 1/16

3:47 pm-5:37 pm

Nonstop1h 50m

Cali Alfonso B. Aragon Intl

Mon 1/19

8:48 am-10:20 am

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 3/23

9:25 am-11:04 am

Nonstop1h 39m

Cali Alfonso B. Aragon Intl

Mon 3/23

3:11 pm-4:44 pm

Nonstop1h 33m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 11/21

12:29 pm-2:11 pm

Nonstop1h 42m

Cali Alfonso B. Aragon Intl

Wed 11/26

4:52 am-6:24 am

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Mon 1/19

12:29 pm-2:10 pm

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Fri 1/23

8:48 am-10:20 am

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Tue 11/25

3:47 pm-5:29 pm

Nonstop1h 42m

Cali Alfonso B. Aragon Intl

Wed 11/26

4:52 am-6:24 am

Nonstop1h 32m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Sat 11/29

9:20 am-11:01 am

Nonstop1h 41m

Cali Alfonso B. Aragon Intl

Mon 12/8

3:11 pm-4:44 pm

Nonstop1h 33m

$202

Panama CityCali

PTY - CLO

PTYCLO

Panama City Tocumen Intl

Fri 1/2

9:20 am-11:00 am

Nonstop1h 40m

Cali Alfonso B. Aragon Intl

Mon 1/19

8:48 am-10:20 am

Nonstop1h 32m

$202

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 60 results
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Best time to book a flight from Panama City to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to South America

What is the cheapest month to book a flight from Panama City to South America?

Currently, August is the cheapest month in which you can book a flight from Panama City to South America (average of $65). Flying from Panama City to South America in February is currently the most expensive (average of $106). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to SA?

Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City to South America in the morning. If you’re flexible enough to do this you can expect to save up to 13% on your trip compared to booking a flight in the afternoon.

What is the cheapest day to fly from Panama City to South America?

Use this chart to determine the cheapest time to fly round-trip from Panama City to South America. Price data was last updated on October 26, 2025.

Travelers seeking maximum savings on their Panama City to South America flight should consider departing on Tuesday at noon when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Panama City to South America

Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated October 30, 2025.

The most flights from PTY to 0SA are scheduled on a Thursday (15 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 30, 2025.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,561 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,467 reviews
Copa Airlines
7.6
Good
1,561 reviews

Comfort

7.4

Entertainment

6.8

Food

6.9

Overall

7.6

Crew

8.1

Boarding

7.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Panama City to South America?

    If you book a flight to South America from Panama City, you will be flying from Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How popular is this Panama City to South America flight route?

    This flight path from Panama City Tocumen Intl to South America was viewed by 4 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Panama City to South America?

    A quick flight from Panama City to South America can take about 1h 41m. Copa Airlines provides one of the quickest options available for as low as $202. The distance from Panama City to South America is about 434 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Panama City to South America?

    While some choose either Panama City Tocumen Intl - Bogotá El Dorado or Panama City Tocumen Intl - Cartagena Rafael Nunez, Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl is the most popular route from Panama City to South America.

  • What are the most reliable airlines from Panama City to South America?

    The top 3 most reliable airlines when flying from Panama City to South America are Copa Airlines (91%), Turkish Airlines (85%) and Avianca (82%).

  • What are the cheapest flights from Panama City to South America?

    Looking for the cheapest flight from Panama City to South America? While on average our users pay $1,007, our data indicates the cheapest price to be $117. The most popular route (Panama City Tocumen Intl - Medellín Jose Maria Cordova Intl), is priced around $137.

  • Can I find deals for flights from Panama City to South America that include hotel bookings?

    Yes. In addition to deals on Panama City to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to South America.

  • Can I find deals for business class flights from Panama City to South America?

    Yes. Cheapflights offers flight deals from Panama City to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to South America?

    Currently, August is the cheapest month in which you can book a flight from Panama City to South America (average of $65). Flying from Panama City to South America in February is currently the most expensive (average of $106). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Panama City to South America

Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
WingoCheapest$73Average$164FlexibilityNo cancel feeOn-time83%
Copa AirlinesCheapest$117Average$460FlexibilityNo cancel feeOn-time70%
AviancaCheapest$164Average$406FlexibilityNo cancel feeOn-time71%

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