$144+ Cheap flights from Panama City (PTY) to South America
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BOG
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Panama City to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to South America
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Cheapest flights from Panama City to South AmericaExplore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:30 am -
2 stops13h 35m
Fri 9/43:20 pm -
Nonstop1h 40m
Deal found 9/1![Avianca logo]()
$242
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 am -
Nonstop1h 25m
Sat 11/78:35 am -
Nonstop1h 30m
Deal found 8/31![Copa Airlines logo]()
$272
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:50 pm -
2 stops13h 00m
Fri 9/2512:35 pm -
Nonstop1h 40m
Deal found 9/1![Avianca logo]()
$274
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:22 am -
Nonstop1h 23m
Fri 11/138:35 am -
Nonstop1h 30m
Deal found 8/31![Copa Airlines logo]()
$274
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:49 am -
Nonstop1h 40m
Tue 10/206:10 am -
Nonstop1h 51m
Deal found 9/3![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:20 am -
Nonstop1h 25m
Fri 10/3012:40 pm -
Nonstop1h 29m
Deal found 9/2![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:09 pm -
Nonstop1h 26m
Thu 11/58:35 am -
Nonstop1h 30m
Deal found 8/31![Copa Airlines logo]()
$282
This Trip.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:55 pm -
Nonstop1h 35m
Tue 9/222:05 pm -
2 stops20h 25m
Deal found 9/4![Avianca logo]()
$283
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:10 pm -
1 stop5h 10m
Thu 11/59:05 pm -
1 stop4h 15m
Deal found 8/31![Avianca logo]()
$285
This FlightHub deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:30 am -
2 stops23h 20m
Sun 9/1312:35 pm -
Nonstop1h 40m
Deal found 9/4![Avianca logo]()
$288
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/182:30 am -
1 stop4h 05m
Sun 11/2212:40 pm -
1 stop4h 35m
Deal found 8/31![Avianca logo]()
$288
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:30 am -
1 stop4h 05m
Fri 11/610:45 am -
1 stop4h 30m
Deal found 9/1![Avianca logo]()
$289
Best flights from Panama City to South AmericaDiscover carefully curated flight deals from Panama City to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Panama City to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 am -
Nonstop1h 25m
Sat 11/78:35 am -
Nonstop1h 30m
Deal found 8/31![Copa Airlines logo]()
$272
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:30 am -
1 stop4h 10m
Tue 11/39:30 am -
1 stop5h 45m
Deal found 9/1![Avianca logo]()
$471
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:29 am -
Nonstop1h 39m
Tue 10/274:45 am -
Nonstop1h 51m
Deal found 8/31![Copa Airlines logo]()
$276
This GOL deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:10 pm -
1 stop19h 35m
Wed 11/114:50 pm -
1 stop24h 25m
Deal found 9/3![GOL logo]()
$604
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/203:46 pm -
Nonstop1h 40m
Sun 9/276:17 pm -
Nonstop1h 50m
Deal found 9/1![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/189:26 am -
Nonstop1h 40m
Sun 9/276:17 pm -
Nonstop1h 50m
Deal found 8/31![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/188:29 am -
Nonstop1h 39m
Sun 9/206:10 am -
Nonstop1h 51m
Deal found 9/1![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/313:23 pm -
Nonstop1h 40m
Thu 11/510:40 am -
Nonstop1h 51m
Deal found 9/3![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:15 pm -
Nonstop1h 40m
Wed 10/212:24 pm -
Nonstop1h 50m
Deal found 9/2![Copa Airlines logo]()
$276
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2210:05 am -
1 stop5h 50m
Tue 1/56:25 pm -
1 stop6h 55m
Deal found 9/1![Avianca logo]()
$471
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:24 pm -
Nonstop1h 41m
Fri 11/62:30 pm -
Nonstop1h 52m
Deal found 9/3![Copa Airlines logo]()
$276
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/212:30 am -
1 stop5h 05m
Mon 1/46:25 pm -
1 stop6h 55m
Deal found 8/31![Avianca logo]()
$471
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/29:25 am -
Nonstop1h 42m
Fri 11/62:30 pm -
Nonstop1h 52m
Deal found 8/31![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:49 am -
Nonstop1h 40m
Mon 10/127:00 am -
Nonstop1h 51m
Deal found 9/2![Copa Airlines logo]()
$276
This Avianca deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:10 pm -
1 stop7h 45m
Sun 1/104:50 pm -
2 stops8h 30m
Deal found 9/4![Avianca logo]()
$501
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:50 pm -
Nonstop1h 25m
Sat 10/2410:35 am -
Nonstop1h 29m
Deal found 8/31![Copa Airlines logo]()
$276
This GOL deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:10 pm -
1 stop11h 45m
Mon 11/94:50 pm -
1 stop24h 25m
Deal found 9/4![GOL logo]()
$656
This Avianca deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:10 am -
2 stops7h 50m
Sat 10/244:40 pm -
2 stops7h 55m
Deal found 9/2![Avianca logo]()
$519
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 am -
Nonstop1h 25m
Wed 11/48:35 am -
Nonstop1h 30m
Deal found 9/4![Copa Airlines logo]()
$276
This GOL deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:55 pm -
1 stop28h 35m
Thu 10/154:40 pm -
1 stop18h 35m
Deal found 9/1![GOL logo]()
$656
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/298:20 am -
Nonstop1h 25m
Mon 11/212:40 pm -
Nonstop1h 31m
Deal found 9/3![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:50 pm -
Nonstop1h 25m
Tue 9/2212:40 pm -
Nonstop1h 29m
Deal found 9/3![Copa Airlines logo]()
$276
This GOL deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:10 pm -
2 stops29h 10m
Fri 11/64:50 pm -
1 stop24h 25m
Deal found 8/31![GOL logo]()
$725
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/21:25 pm -
Nonstop1h 20m
Wed 11/116:20 pm -
Nonstop1h 33m
Deal found 9/2![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/41:20 pm -
Nonstop1h 25m
Wed 10/74:30 pm -
Nonstop1h 29m
Deal found 9/4![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:57 am -
Nonstop1h 18m
Thu 11/2610:45 am -
Nonstop1h 29m
Deal found 9/3![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:20 am -
Nonstop1h 25m
Fri 10/3012:40 pm -
Nonstop1h 29m
Deal found 9/2![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:50 am -
Nonstop1h 25m
Tue 10/612:40 pm -
Nonstop1h 29m
Deal found 9/4![Copa Airlines logo]()
$276
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/184:40 pm -
Nonstop1h 15m
Fri 10/2312:00 pm -
Nonstop1h 22m
Deal found 9/3![Copa Airlines logo]()
$334
This Copa Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 am -
Nonstop1h 15m
Sun 10/186:20 am -
Nonstop1h 22m
Deal found 9/1![Copa Airlines logo]()
$334
Last-minute flights from Panama City to South AmericaDiscover last-minute flight deals from Panama City to South America. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Panama City to South America. Data last updated September 5, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:30 am -
2 stops13h 35m
Fri 9/43:20 pm -
Nonstop1h 40m
Deal found 9/1![Avianca logo]()
$242
This FlightHub deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:30 am -
2 stops23h 20m
Sun 9/1312:35 pm -
Nonstop1h 40m
Deal found 9/4![Avianca logo]()
$288
This Avianca deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/163:10 pm -
1 stop3h 45m
Sat 9/199:30 am -
1 stop4h 45m
Deal found 9/3![Avianca logo]()
$290
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:50 am -
Nonstop1h 25m
Mon 9/216:20 pm -
Nonstop1h 29m
Deal found 9/5![Copa Airlines logo]()
$287
This Trip.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:55 pm -
Nonstop1h 35m
Tue 9/222:05 pm -
2 stops20h 25m
Deal found 9/4![Avianca logo]()
$283
This Avianca deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:50 pm -
2 stops13h 00m
Fri 9/2512:35 pm -
Nonstop1h 40m
Deal found 9/1![Avianca logo]()
$274
This Avianca deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:10 pm -
1 stop5h 35m
Tue 10/611:55 am -
1 stop5h 05m
Deal found 9/2![Avianca logo]()
$289
This Copa Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1611:49 am -
Nonstop1h 40m
Tue 10/206:10 am -
Nonstop1h 51m
Deal found 9/3![Copa Airlines logo]()
$276
This Avianca deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:30 am -
1 stop13h 15m
Fri 10/303:30 pm -
Nonstop1h 45m
Deal found 9/2![Avianca logo]()
$290
This Copa Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 am -
Nonstop1h 25m
Sat 11/78:35 am -
Nonstop1h 30m
Deal found 8/31![Copa Airlines logo]()
$272
This Copa Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:30 am -
Nonstop1h 25m
Wed 11/48:35 am -
Nonstop1h 30m
Deal found 9/2![Copa Airlines logo]()
$276
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:10 pm -
1 stop5h 10m
Thu 11/59:05 pm -
1 stop4h 15m
Deal found 8/31![Avianca logo]()
$285
One-way flights from Panama City to South AmericaSearch for one-way flight options from Panama City to South America. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
Search for one-way flight options from Panama City to South America. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
This Super.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:50 am -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Copa Airlines logo]()
$144
This Super.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:50 am -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Copa Airlines logo]()
$145
This Copa Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:57 am -
Nonstop1h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Copa Airlines logo]()
$146
This FlightHub deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:10 pm -
1 stop6h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Avianca logo]()
$147
This Super.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:10 pm -
1 stop5h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Avianca logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:50 am -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Copa Airlines logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:50 am -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Copa Airlines logo]()
$152
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:10 pm -
1 stop5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Avianca logo]()
$153
This Super.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:10 pm -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Copa Airlines logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:30 am -
Nonstop1h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Copa Airlines logo]()
$158
This FlightHub deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1310:05 am -
1 stop4h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Avianca logo]()
$159
This Avianca deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:05 am -
Nonstop1h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Avianca logo]()
$168
Find flight deals from Panama City to South America
Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated September 5, 2026.
Round-trip from | $267 (Avianca) |
|---|---|
One-way from | $144 (Super.com) |
Popular in | June |
Cheapest in | March |
Average price | $210 |
Good round-trip deal | $138 or less |
Good one-way deal | $81 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Panama City to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Fri 9/18
6:50 am-8:15 am
Nonstop1h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Wed 10/14
1:20 pm-2:45 pm
Nonstop1h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Sun 11/15
6:57 am-8:15 am
Nonstop1h 18m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Mon 9/21
1:20 pm-2:45 pm
Nonstop1h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Sat 10/10
6:50 am-8:15 am
Nonstop1h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Mon 11/23
6:57 am-8:15 am
Nonstop1h 18m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Panama CityMedellín
PTY Panama City Tocumen Intl - MDE Medellín Jose Maria Cordova Intl
PTYMDE
Panama City Tocumen Intl
Tue 10/6
1:20 pm-2:45 pm
Nonstop1h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$146
Quickest round-trip
Panama CityCartagena
PTY Panama City Tocumen Intl - CTG Cartagena Rafael Nunez
PTYCTG
Panama City Tocumen Intl
Tue 9/29
7:25 am-8:40 am
Nonstop1h 15m
Cartagena Rafael Nunez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$174
Panama CityCartagena
PTY Panama City Tocumen Intl - CTG Cartagena Rafael Nunez
PTYCTG
Panama City Tocumen Intl
Tue 9/22
7:25 am-8:40 am
Nonstop1h 15m
Cartagena Rafael Nunez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$174
Panama CityCartagena
PTY Panama City Tocumen Intl - CTG Cartagena Rafael Nunez
PTYCTG
Panama City Tocumen Intl
Tue 10/20
7:25 am-8:40 am
Nonstop1h 15m
Cartagena Rafael Nunez
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$174
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Panama City to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
PTY-MDE
PTY-BGA
PTY-BOG
PTY-GIG
PTY-UIO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama City to South America
PTY-0SA
PTY-MDE
PTY-BGA
PTY-BOG
PTY-GIG
What is the cheapest month to book a flight from Panama City to South America?
Currently, February is the cheapest month in which you can book a flight from Panama City to South America (average of $254). Flying from Panama City to South America in August is currently the most expensive (average of $327). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SA?
Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 5, 2026.
A simple way to save on the total cost of your ticket is to fly from Panama City to South America in the morning. If you’re flexible enough to do this you can expect to save up to 12% on your trip compared to booking a flight at noon.
Weekly flight availability from Panama City to South America
Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated September 5, 2026.
The most flights from PTY to 0SA are scheduled on a Thursday (17 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).
How far ahead should I book a flight from Panama City to South America?
Booking 49 days in advance of your planned departure date is, on average, the best time to get cheap flights from Panama City to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest day to fly from Panama City to South America?
Use this chart to determine the cheapest time to fly round-trip from Panama City to South America. Price data was last updated on August 29, 2026.
Travelers seeking maximum savings on their Panama City to South America flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 5, 2026.
Peruse reviews from past customers who have flown with Copa Airlines and Avianca from Panama City to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Crew
8.1
Overall
7.6
Entertainment
6.9
Comfort
7.4
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Crew
8.1
Overall
7.6
Entertainment
6.9
Comfort
7.4
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Boarding
7.8
Crew
8.1
Overall
7.6
Entertainment
6.9
Comfort
7.4
Food
6.9
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Panama City to South America
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Complete your trip
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Find flights from Panama City to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama City and South America flights
Browse other Panama City and South America flight options. Last updated on September 5, 2026.
Popular flight searches
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Top 3 airlines flying from Panama City to South America
Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$69 | Average$160 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$117 | Average$487 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$151 | Average$458 | FlexibilityNo cancel fee | On-time71% |