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South America

$123+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated July 3, 2025.

Round-trip from

$298
(FlightHub)

One-way from

$123
(SmartFares)
From South Carolina to South America
Search Deals
One-way flight from South Carolina to South America
Search Deals

Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This FlightHub deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/187:00 amCLT - BOG
1 stop6h 59mSpirit Airlines
Tue 8/191:54 pmBOG - CLT
1 stop8h 04mSpirit Airlines
Deal found 7/2$298
This FlightHub deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/178:21 pmCLT - CTG
1 stop16h 54mSpirit Airlines
Wed 7/231:28 pmCTG - CLT
1 stop7h 48mSpirit Airlines
Deal found 7/2$299
This Cheapflightsfares deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/810:06 pmCLT - MDE
1 stop15h 54mSpirit Airlines
Thu 9/111:21 amMDE - CLT
1 stop10h 02mSpirit Airlines
Deal found 7/2$333
This FlightHub deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/218:17 pmCHS - MDE
1 stop18h 05mSpirit Airlines
Wed 8/272:20 pmMDE - CHS
1 stop27h 52mSpirit Airlines
Deal found 7/2$340
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/151:43 pmCLT - MDE
1 stop8h 32mMultiple Airlines
Fri 8/2211:50 pmMDE - CLT
1 stop11h 48mMultiple Airlines
Deal found 7/2$372
This Kiwi.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/3110:06 pmGSP - MDE
1 stop15h 58mMultiple Airlines
Thu 8/71:59 pmMDE - GSP
1 stop17h 49mMultiple Airlines
Deal found 7/3$380
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/212:50 pmCHS - MDE
1 stop23h 14mMultiple Airlines
Tue 8/262:00 pmMDE - CHS
2 stops28h 36mMultiple Airlines
Deal found 7/2$393
This Avianca Connect deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/66:00 amCLT - GYE
2 stops21h 05mMultiple Airlines
Wed 9/33:35 amGYE - CLT
2 stops16h 14mMultiple Airlines
Deal found 7/1$443
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/277:25 pmCLT - PEI
2 stops23h 37mMultiple Airlines
Tue 8/127:20 amPEI - CLT
3 stops29h 45mMultiple Airlines
Deal found 7/2$459
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:00 amGSP - MDE
1 stop15h 15mAmerican Airlines
Tue 10/286:00 amMDE - GSP
1 stop16h 21mAmerican Airlines
Deal found 7/3$506
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2411:41 amCLT - GYE
2 stops27h 05mUnited Airlines
Tue 10/148:28 amGYE - CLT
2 stops35h 44mUnited Airlines
Deal found 7/3$517
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:00 amCHS - MDE
1 stop15h 15mAmerican Airlines
Tue 11/43:45 pmMDE - CHS
1 stop8h 34mAmerican Airlines
Deal found 7/1$523

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Mon 8/18

7:00 am-12:59 pm

1 stop6h 59m

Bogotá El Dorado

Tue 8/19

1:54 pm-10:58 pm

1 stop8h 04m

$298

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 7/17

8:21 pm-12:15 pm

1 stop16h 54m

Cartagena Rafael Nunez

Wed 7/23

1:28 pm-10:16 pm

1 stop7h 48m

$299

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Fri 8/22

4:48 pm-11:54 pm

1 stop8h 06m

Medellín Jose Maria Cordova Intl

Sun 8/24

12:49 am-9:16 am

1 stop7h 27m

$327

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 8/21

8:17 pm-1:22 pm

1 stop18h 05m

Medellín Jose Maria Cordova Intl

Wed 8/27

2:20 pm-7:12 pm

1 stop27h 52m

$340

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Fri 8/15

1:43 pm-9:15 pm

1 stop8h 32m

Medellín Jose Maria Cordova Intl

Fri 8/22

11:50 pm-12:38 pm

1 stop11h 48m

$372

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Thu 7/31

10:06 pm-1:04 pm

1 stop15h 58m

Medellín Jose Maria Cordova Intl

Thu 8/7

1:59 pm-8:48 am

1 stop17h 49m

$380

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 8/21

2:50 pm-1:04 pm

1 stop23h 14m

Medellín Jose Maria Cordova Intl

Tue 8/26

2:00 pm-7:36 pm

2 stops28h 36m

$393

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 8/6

6:00 am-2:05 am

2 stops21h 05m

Guayaquil Jose Joaquin de Olmedo

Wed 9/3

3:35 am-8:49 pm

2 stops16h 14m

$443

CharlottePereira

CLT - PEI

CLTPEI

Charlotte Douglas

Sun 7/27

7:25 pm-6:02 pm

2 stops23h 37m

Pereira Matecana

Tue 8/12

7:20 am-2:05 pm

3 stops29h 45m

$459

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 10/20

6:00 am-8:15 pm

1 stop15h 15m

Medellín Jose Maria Cordova Intl

Tue 10/28

6:00 am-11:21 pm

1 stop16h 21m

$506

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 3, 2025.
Read through reviews of airlines operating flights from South Carolina to South America, such as Delta, LATAM Airlines, and Copa Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,805 reviews
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,467 reviews
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,861 reviews
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
GOL
7.3
Good
1,086 reviews
Delta
8.0
Very good
7,982 reviews

Entertainment

7.9

Crew

8.5

Food

7.3

Comfort

7.9

Boarding

8.2

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $123 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Avianca and American Airlines, with prices starting from $282 and $310, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$333Average$439FlexibilityNo cancel feeOn-time65%
DeltaCheapest$436Average$822FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$796FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$871FlexibilityNo cancel feeOn-time81%

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