In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Can I find deals for flights from South Carolina to South America that include hotel bookings?

Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

Can I find deals for business class flights from South Carolina to South America?

Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$121+ Flights from South Carolina to South America

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from South Carolina to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to South America

Round-trip from	$264 (Cheapflightsfares)
One-way from	$121 (Flightnetwork)

From South Carolina to South America

Search Deals

One-way flight from South Carolina to South America

Search Deals

Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Wed 9/37:00 amCLT - MDE

1 stop17h 54mSpirit Airlines

Tue 9/91:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/13

$264

Mon 9/2210:10 amCHS - MDE

1 stop15h 18mSpirit Airlines

Wed 10/11:24 amMDE - CHS

1 stop8h 21mSpirit Airlines

Deal found 8/13

$277

Wed 9/34:48 pmCLT - MDE

1 stop8h 06mSpirit Airlines

Wed 9/101:24 amMDE - CLT

1 stop13h 08mSpirit Airlines

Deal found 8/13

$279

Fri 8/229:28 pmCLT - BOG

1 stop15h 32mSpirit Airlines

Fri 8/291:54 pmBOG - CLT

1 stop9h 01mSpirit Airlines

Deal found 8/13

$281

Wed 9/37:00 amCLT - MDE

1 stop17h 54mSpirit Airlines

Fri 9/51:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/13

$284

Wed 11/55:45 amCLT - BOG

1 stop8h 25mSpirit Airlines

Tue 11/113:05 pmBOG - CLT

1 stop9h 54mSpirit Airlines

Deal found 8/14

$289

Sun 10/266:00 amCLT - MDE

1 stop8h 14mSpirit Airlines

Fri 10/311:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/12

$292

Fri 9/55:36 pmCLT - MDE

1 stop7h 52mSpirit Airlines

Sat 9/61:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/13

$293

Sat 10/45:45 amCLT - BOG

1 stop8h 25mSpirit Airlines

Sat 10/182:10 pmBOG - CLT

1 stop18h 14mSpirit Airlines

Deal found 8/13

$294

Tue 9/27:00 amCLT - BOG

1 stop6h 59mSpirit Airlines

Tue 11/43:05 pmBOG - CLT

1 stop18h 22mSpirit Airlines

Deal found 8/13

$296

Tue 9/910:46 amCLT - MDE

1 stop14h 42mSpirit Airlines

Fri 9/192:09 pmMDE - CLT

1 stop7h 50mSpirit Airlines

Deal found 8/12

$297

Wed 12/35:45 amCLT - BOG

1 stop8h 25mSpirit Airlines

Mon 12/81:36 amBOG - CLT

1 stop7h 51mSpirit Airlines

Deal found 8/14

$298

Best flights from South Carolina to South America
Discover carefully curated flight deals from South Carolina to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 14, 2025.

Wed 9/37:00 amCLT - MDE

1 stop17h 54mSpirit Airlines

Tue 9/91:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/13

$264

Mon 10/610:19 amCLT - UIO

2 stops17h 26mMultiple Airlines

Mon 10/133:17 pmUIO - CLT

2 stops21h 18mMultiple Airlines

Deal found 8/14

$490

Mon 10/206:00 amGSP - MDE

1 stop15h 15mAmerican Airlines

Tue 10/281:35 pmMDE - GSP

1 stop8h 46mAmerican Airlines

Deal found 8/12

$506

Mon 10/207:00 amGSP - MDE

1 stop15h 10mUnited Airlines

Tue 10/289:45 amMDE - GSP

1 stop11h 14mUnited Airlines

Deal found 8/14

$506

Sat 9/610:46 amCLT - MDE

1 stop14h 42mSpirit Airlines

Fri 9/192:09 pmMDE - CLT

1 stop18h 13mSpirit Airlines

Deal found 8/12

$264

Fri 9/2610:10 amCHS - MDE

1 stop15h 18mSpirit Airlines

Wed 10/11:24 amMDE - CHS

1 stop8h 21mSpirit Airlines

Deal found 8/13

$277

Thu 9/42:30 pmCLT - GIG

2 stops18h 40mGOL

Mon 9/811:15 amGIG - CLT

2 stops35h 30mGOL

Deal found 8/12

$649

Mon 9/2210:10 amCHS - MDE

1 stop15h 18mSpirit Airlines

Thu 10/22:09 pmMDE - CHS

1 stop17h 56mSpirit Airlines

Deal found 8/13

$277

Wed 12/31:15 pmCLT - SCL

1 stop15h 40mLATAM Airlines

Tue 12/911:40 pmSCL - CLT

1 stop16h 12mLATAM Airlines

Deal found 8/12

$696

Thu 9/2512:08 pmCHS - MDE

1 stop13h 20mSpirit Airlines

Wed 10/11:24 amMDE - CHS

1 stop8h 21mSpirit Airlines

Deal found 8/13

$277

Wed 9/34:48 pmCLT - MDE

1 stop8h 06mSpirit Airlines

Wed 9/101:24 amMDE - CLT

1 stop13h 08mSpirit Airlines

Deal found 8/13

$279

Wed 9/1010:46 amCLT - MDE

1 stop14h 42mSpirit Airlines

Tue 9/161:24 amMDE - CLT

1 stop6h 58mSpirit Airlines

Deal found 8/12

$279

Last-minute flights from South Carolina to South America
Discover last-minute flight deals from South Carolina to South America. Data last updated August 14, 2025 and is based on user searches.

Tue 8/1911:00 amCLT - MDE

1 stop13h 54mSpirit Airlines

Sat 8/2312:49 amMDE - CLT

1 stop7h 27mSpirit Airlines

Deal found 8/13

$461

Tue 8/199:41 pmCLT - MDE

1 stop16h 23mMultiple Airlines

Sun 8/246:21 pmMDE - CLT

2 stops17h 17mMultiple Airlines

Deal found 8/13

$463

Wed 8/207:00 amCLT - GYE

2 stops17h 20mMultiple Airlines

Mon 9/154:15 amGYE - CLT

2 stops17h 44mMultiple Airlines

Deal found 8/12

$465

Thu 8/218:17 pmCHS - MDE

1 stop28h 37mSpirit Airlines

Wed 8/2712:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$369

Thu 8/218:17 pmCHS - MDE

1 stop28h 37mSpirit Airlines

Thu 8/2812:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$392

Thu 8/218:17 pmCHS - MDE

1 stop18h 05mSpirit Airlines

Tue 8/2612:49 amMDE - CHS

2 stops31h 44mSpirit Airlines

Deal found 8/13

$442

Thu 8/218:17 pmCHS - MDE

1 stop28h 37mSpirit Airlines

Sun 8/2412:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$447

Fri 8/229:28 pmCLT - BOG

1 stop15h 32mSpirit Airlines

Fri 8/291:54 pmBOG - CLT

1 stop9h 01mSpirit Airlines

Deal found 8/13

$281

Fri 8/228:17 pmCHS - MDE

1 stop18h 05mSpirit Airlines

Wed 8/2712:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$394

Fri 8/228:17 pmCHS - MDE

1 stop18h 05mSpirit Airlines

Thu 8/2812:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$417

Fri 8/226:00 amCLT - BOG

1 stop7h 00mMultiple Airlines

Thu 8/281:35 amBOG - CLT

1 stop10h 03mMultiple Airlines

Deal found 8/13

$466

Fri 8/228:17 pmCHS - MDE

1 stop18h 05mSpirit Airlines

Sun 8/2412:49 amMDE - CHS

1 stop17h 23mSpirit Airlines

Deal found 8/13

$472

One-way flights from South Carolina to South America
Search for one-way flight options from South Carolina to South America. Find affordable one-way fares based on user searches. Data last updated August 14, 2025.

Sat 9/275:45 amCLT - BOG

1 stop8h 25mSpirit Airlines

Deal found 8/13

$121

Wed 10/110:46 amCLT - MDE

1 stop14h 42mSpirit Airlines

Deal found 8/14

$121

Mon 8/257:00 amCLT - BOG

1 stop6h 59mSpirit Airlines

Deal found 8/12

$124

Fri 9/1210:17 amCLT - MDE

1 stop15h 11mSpirit Airlines

Deal found 8/14

$124

Tue 8/267:00 amCLT - MDE

1 stop7h 22mSpirit Airlines

Deal found 8/12

$132

Sat 9/610:46 amCLT - BOG

1 stop27h 24mSpirit Airlines

Deal found 8/12

$133

Mon 8/257:00 amCLT - MDE

1 stop17h 54mSpirit Airlines

Deal found 8/12

$147

Sat 8/236:00 amCLT - BOG

1 stop7h 00mSpirit Airlines

Deal found 8/12

$148

Sat 9/610:46 amCLT - BOG

2 stops22h 19mMultiple Airlines

Deal found 8/12

$153

Sat 9/2710:46 amCLT - BOG

2 stops22h 19mMultiple Airlines

Deal found 8/13

$155

Wed 10/15:45 amCLT - MDE

3 stops14h 04mMultiple Airlines

Deal found 8/14

$157

Tue 8/267:00 amCLT - BOG

1 stop6h 59mSpirit Airlines

Deal found 8/12

$159

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 9/3

7:00 am-11:54 pm

1 stop17h 54m

Medellín Jose Maria Cordova Intl

Tue 9/9

1:24 am-9:22 am

1 stop6h 58m

$264

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sat 9/6

10:46 am-12:28 am

1 stop14h 42m

Medellín Jose Maria Cordova Intl

Fri 9/19

2:09 pm-9:22 am

1 stop18h 13m

$264

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 9/26

10:10 am-12:28 am

1 stop15h 18m

Medellín Jose Maria Cordova Intl

Wed 10/1

1:24 am-10:45 am

1 stop8h 21m

$277

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Mon 9/22

10:10 am-12:28 am

1 stop15h 18m

Medellín Jose Maria Cordova Intl

Thu 10/2

2:09 pm-9:05 am

1 stop17h 56m

$277

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 9/25

12:08 pm-12:28 am

1 stop13h 20m

Medellín Jose Maria Cordova Intl

Wed 10/1

1:24 am-10:45 am

1 stop8h 21m

$277

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 9/3

4:48 pm-11:54 pm

1 stop8h 06m

Medellín Jose Maria Cordova Intl

Wed 9/10

1:24 am-3:32 pm

1 stop13h 08m

$279

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 9/10

10:46 am-12:28 am

1 stop14h 42m

Medellín Jose Maria Cordova Intl

Tue 9/16

1:24 am-9:22 am

1 stop6h 58m

$279

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Fri 8/22

9:28 pm-12:00 pm

1 stop15h 32m

Bogotá El Dorado

Fri 8/29

1:54 pm-11:55 pm

1 stop9h 01m

$281

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 9/3

7:00 am-11:54 pm

1 stop17h 54m

Medellín Jose Maria Cordova Intl

Fri 9/5

1:24 am-9:22 am

1 stop6h 58m

$284

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 10/8

10:19 am-12:17 am

1 stop14h 58m

Medellín Jose Maria Cordova Intl

Tue 10/14

2:22 pm-9:24 am

1 stop18h 02m

$284

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to South America as you normally would.

Related info for your journey

Can I find deals for flights from South Carolina to South America that include hotel bookings?
Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.
Can I find deals for business class flights from South Carolina to South America?
Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to South America?
Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from South Carolina to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$333	Average$414	FlexibilityNo cancel fee	On-time65%
Delta	Cheapest$436	Average$838	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$458	Average$824	FlexibilityNo cancel fee	On-time71%
LATAM Airlines	Cheapest$502	Average$877	FlexibilityNo cancel fee	On-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$121+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to South America with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated August 14, 2025.

Round-trip from

One-way from

Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South AmericaExplore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

Can I find deals for flights from South Carolina to South America that include hotel bookings?

How can I find direct flights from South Carolina to South America?

Can I find deals for business class flights from South Carolina to South America?

What is the cheapest month to book a flight from South Carolina to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from South Carolina to South America

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.