HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$131+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/13. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$278
(FlightHub)

One-way from

$131
(FlightHub)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
Search Deals
From South Carolina to South America
Search Deals
One-way flight from South Carolina to South America
Search Deals

Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/149:02 pmCLT - CTG
1 stop16h 08mSpirit Airlines
Thu 6/191:15 pmCTG - CLT
2 stops18h 30mSpirit Airlines
Deal found 4/30$293
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/139:02 pmCLT - BOG
1 stop17h 03mSpirit Airlines
Fri 6/272:00 pmBOG - CLT
1 stop17h 06mSpirit Airlines
Deal found 4/30$355
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/239:02 pmCLT - CTG
2 stops26h 58mMultiple Airlines
Wed 5/286:55 amCTG - CLT
2 stops30h 03mMultiple Airlines
Deal found 4/29$400
This Avianca Connect deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/311:23 amCLT - BOG
1 stop7h 51mMultiple Airlines
Wed 6/49:20 amBOG - CLT
1 stop10h 20mMultiple Airlines
Deal found 4/30$406
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/199:02 pmCLT - MDE
1 stop17h 10mSpirit Airlines
Mon 6/232:13 pmMDE - CLT
1 stop25h 10mSpirit Airlines
Deal found 4/29$409
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/129:02 pmCLT - MDE
2 stops27h 40mMultiple Airlines
Mon 6/1610:20 amMDE - CLT
1 stop29h 03mMultiple Airlines
Deal found 4/29$417
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/77:00 amCLT - MDE
1 stop15h 10mUnited Airlines
Sun 7/1312:15 amMDE - CLT
1 stop14h 45mUnited Airlines
Deal found 4/29$425
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2411:22 amCLT - BAQ
2 stops13h 18mMultiple Airlines
Mon 9/154:41 amBAQ - CLT
2 stops16h 16mMultiple Airlines
Deal found 4/30$459
This Priceline deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/198:50 amCLT - BAQ
1 stop5h 56mSpirit Airlines
Fri 5/232:46 pmBAQ - CLT
2 stops24h 05mSpirit Airlines
Deal found 4/29$464
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2211:07 amCLT - MDE
1 stop13h 38mAmerican Airlines
Fri 7/2512:45 amMDE - CLT
2 stops10h 41mAmerican Airlines
Deal found 4/30$467
This eDestinos deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/238:19 pmCLT - BOG
2 stops15h 36mLATAM Airlines
Mon 7/141:35 amBOG - CLT
2 stops15h 50mLATAM Airlines
Deal found 4/29$471
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2011:22 amCLT - CLO
2 stops13h 02mMultiple Airlines
Tue 9/168:27 pmCLO - CLT
2 stops13h 27mMultiple Airlines
Deal found 4/29$480

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sat 6/14

9:02 pm-12:10 pm

1 stop16h 08m

Cartagena Rafael Nunez

Wed 6/18

1:15 pm-8:45 am

2 stops18h 30m

$278

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Fri 6/13

9:02 pm-1:05 pm

1 stop17h 03m

Bogotá El Dorado

Fri 6/27

2:00 pm-8:06 am

1 stop17h 06m

$355

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Tue 6/3

11:23 am-6:14 pm

1 stop7h 51m

Bogotá El Dorado

Wed 6/4

9:20 am-8:40 pm

1 stop10h 20m

$406

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Thu 6/19

9:02 pm-1:12 pm

1 stop17h 10m

Medellín Jose Maria Cordova Intl

Mon 6/23

2:13 pm-4:23 pm

1 stop25h 10m

$409

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Thu 6/12

9:02 pm-11:42 pm

2 stops27h 40m

Medellín Jose Maria Cordova Intl

Mon 6/16

10:20 am-4:23 pm

1 stop29h 03m

$417

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Mon 7/7

7:00 am-9:10 pm

1 stop15h 10m

Medellín Jose Maria Cordova Intl

Sun 7/13

12:15 am-4:00 pm

1 stop14h 45m

$425

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Mon 6/2

9:02 pm-12:10 pm

1 stop16h 08m

Cartagena Rafael Nunez

Mon 6/23

7:55 am-5:58 pm

3 stops33h 03m

$461

CharlotteBarranquilla

CLT - BAQ

CLTBAQ

Charlotte Douglas

Mon 5/19

8:50 am-1:46 pm

1 stop5h 56m

Barranquilla E Cortissoz

Fri 5/23

2:46 pm-3:51 pm

2 stops24h 05m

$464

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Tue 7/22

11:07 am-11:45 pm

1 stop13h 38m

Medellín Jose Maria Cordova Intl

Fri 7/25

12:45 am-12:26 pm

2 stops10h 41m

$467

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Mon 6/23

8:19 pm-10:55 am

2 stops15h 36m

Bogotá El Dorado

Mon 7/14

1:35 am-6:25 pm

2 stops15h 50m

$471

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,414 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
GOL
7.3
Good
1,068 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $131 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Avianca and Copa Airlines, with prices starting from $300 and $327, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to South America (average of $359). Flying from South Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
LaGuardia to Fort Lauderdale flights
John F Kennedy Intl to Los Angeles flights
Newark to Fort Lauderdale flights
John F Kennedy Intl to Miami flights
Dallas/Fort Worth to LaGuardia flights
LaGuardia to Miami flights
Newark to Miami flights
Newark to Las Vegas flights
Los Angeles to Seattle flights
John F Kennedy Intl to Heathrow flights
LaGuardia to Dallas/Fort Worth flights
LaGuardia to O'Hare Intl flights
San Francisco to John F Kennedy Intl flights
Newark to Orlando flights
Dallas/Fort Worth to Seattle flights
Los Angeles to Newark flights
Newark to Cancún flights
Los Angeles to Haneda flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Heathrow flights
Dallas/Fort Worth to Los Angeles flights
Dallas/Fort Worth to O'Hare Intl flights
Dallas/Fort Worth to John F Kennedy Intl flights
O'Hare Intl to Dallas/Fort Worth flights
John F Kennedy Intl to Seattle flights
O'Hare Intl to LaGuardia flights
Seattle to Los Angeles flights
George Bush Intcntl to Cancún flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Los Angeles to Dallas/Fort Worth flights
John F Kennedy Intl to Las Vegas flights
John F Kennedy Intl to O'Hare Intl flights
Dallas/Fort Worth to Cancún flights
Newark to Dallas/Fort Worth flights
John F Kennedy Intl to Cancún flights
John F Kennedy Intl to Fort Lauderdale flights
Newark to Seattle flights
Dallas/Fort Worth to Newark flights
John F Kennedy Intl to Orlando flights
O'Hare Intl to Cancún flights
Newark to San Francisco flights
Newark to Charles de Gaulle flights
Los Angeles to Narita flights
LaGuardia to Atlanta flights
Newark to Los Angeles flights
Los Angeles to LaGuardia flights
Newark to Luis Munoz Marin Intl flights
LaGuardia to Orlando flights
Newark to O'Hare Intl flights

Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$272Average$416FlexibilityNo cancel feeOn-time65%
DeltaCheapest$379Average$859FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$405Average$822FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$872FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.