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South America

$99+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
ene. 3 — ene. 101
sáb. 1/3
sáb. 1/10
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 4, 2025.

This FlightHub deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/162:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
sáb. 12/202:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/2$268
This Expedia deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/138:55 pmCLT - MDE
1 stop14h 00mSpirit Airlines
sáb. 12/202:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/1$314
This Cheapflightsfares deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/102:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
sáb. 12/132:05 amMDE - CLT
1 stop7h 34mSpirit Airlines
Deal found 12/2$315
This CheapOair deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/88:55 pmCLT - CTG
2 stops16h 15mSpirit Airlines
jue. 12/112:15 pmCTG - CLT
1 stop9h 44mSpirit Airlines
Deal found 12/2$336
This Cheapflightsfares deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/289:34 pmCLT - MDE
1 stop13h 21mSpirit Airlines
lun. 12/292:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/2$343
This Expedia deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/148:55 pmCLT - MDE
1 stop14h 00mSpirit Airlines
mié. 12/172:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/2$347
This Expedia deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/289:34 pmCLT - BOG
1 stop15h 18mSpirit Airlines
mar. 1/273:06 pmBOG - CLT
2 stops25h 48mSpirit Airlines
Deal found 12/2$351
This Cheapflightsfares deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/148:55 pmCLT - MDE
1 stop14h 00mSpirit Airlines
dom. 12/212:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/2$362
This KAYAK deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/247:00 amCLT - BOG
1 stop18h 12mSpirit Airlines
mar. 12/302:17 amBOG - CLT
1 stop7h 22mSpirit Airlines
Deal found 12/1$364
This Orbitz deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/229:34 pmCLT - BOG
1 stop15h 18mSpirit Airlines
mié. 1/143:06 pmBOG - CLT
2 stops19h 11mSpirit Airlines
Deal found 12/1$381
This Orbitz deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/317:00 amCLT - BOG
1 stop7h 09mSpirit Airlines
mié. 1/71:47 pmBOG - CLT
2 stops18h 24mSpirit Airlines
Deal found 12/3$389
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/249:34 pmCLT - MDE
1 stop13h 21mSpirit Airlines
jue. 12/252:25 amMDE - CLT
1 stop7h 14mSpirit Airlines
Deal found 12/3$390

Find flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated diciembre 4, 2025.

Most accurate provider

AranGrant
2 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$224
(Cheapflightsfares)

One-way from

$99
(Cheapflightsfares)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
Search Deals
From South Carolina to South America
Search Deals
One-way flight from South Carolina to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

dom. 2/8

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

mié. 2/11

2:21 pm-12:40 am

1 stop10h 19m

$279

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

mar. 2/17

1:24 pm-12:47 pm

2 stops23h 23m

Bogotá El Dorado

mar. 2/24

3:05 pm-12:40 am

1 stop9h 35m

$280

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

lun. 1/26

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

jue. 1/29

2:21 pm-12:40 am

1 stop10h 19m

$280

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

sáb. 1/24

6:00 am-2:07 pm

1 stop8h 07m

Bogotá El Dorado

mar. 1/27

3:06 pm-12:40 am

1 stop9h 34m

$285

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

sáb. 1/17

7:43 pm-12:50 pm

2 stops17h 07m

Bogotá El Dorado

dom. 1/25

3:06 pm-12:40 am

1 stop9h 34m

$313

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

jue. 2/5

6:01 pm-1:15 pm

2 stops19h 14m

Cartagena Rafael Nunez

dom. 2/8

2:21 pm-12:40 am

1 stop10h 19m

$326

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

lun. 2/2

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

dom. 2/8

2:21 pm-10:17 am

2 stops19h 56m

$326

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

jue. 1/22

6:00 am-1:15 pm

1 stop7h 15m

Cartagena Rafael Nunez

mié. 1/28

2:21 pm-12:40 am

1 stop10h 19m

$331

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

vie. 2/6

8:20 pm-1:15 pm

2 stops40h 55m

Cartagena Rafael Nunez

mar. 2/10

2:21 pm-12:40 am

1 stop10h 19m

$334

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

lun. 12/8

8:55 pm-1:10 pm

2 stops16h 15m

Cartagena Rafael Nunez

jue. 12/11

2:15 pm-11:59 pm

1 stop9h 44m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/4

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 4, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 15% on flights from South Carolina to South America by exploring options for tickets in the evening.

What is the cheapest day to fly from South Carolina to South America?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to South America. Price data was last updated on December 8, 2024.

Travelers seeking maximum savings on their South Carolina to South America flight should consider departing on Monday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to South America?

    A quick flight from South Carolina to South America can take about 7h 15m. Spirit Airlines provides one of the quickest options available for as low as $279. South Carolina and South America are separated by a distance of 1745 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $103 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $278 and $314, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$907FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$327Average$395FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$435Average$823FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$837FlexibilityNo cancel feeOn-time81%

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