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South America

$101+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated November 5, 2025.

Most accurate provider

AranGrant
2 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$250
(Priceline)

One-way from

$101
(CheapOair)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From South Carolina to South America
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One-way flight from South Carolina to South America
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Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Priceline deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
Mon 12/152:05 amMDE - CLT
1 stop11h 58mSpirit Airlines
Deal found 11/4$250
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/122:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
Sat 12/132:05 amMDE - CLT
1 stop7h 34mSpirit Airlines
Deal found 11/4$259
This Orbitz deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:00 amCLT - CTG
1 stop6h 10mSpirit Airlines
Fri 12/122:15 pmCTG - CLT
1 stop9h 44mSpirit Airlines
Deal found 11/5$267
This KAYAK deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - CTG
1 stop22h 12mSpirit Airlines
Tue 12/162:15 pmCTG - CLT
1 stop9h 44mSpirit Airlines
Deal found 11/5$295
This Expedia deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/82:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
Fri 12/123:10 pmMDE - CLT
1 stop8h 49mSpirit Airlines
Deal found 11/4$298
This Expedia deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/68:55 pmCLT - MDE
1 stop14h 00mSpirit Airlines
Wed 12/102:05 amMDE - CLT
1 stop7h 34mSpirit Airlines
Deal found 11/5$300
This CheapOair deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/118:55 pmCLT - CTG
2 stops16h 15mSpirit Airlines
Mon 12/152:15 pmCTG - CLT
1 stop9h 44mSpirit Airlines
Deal found 11/4$304
This CheapOair deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:55 pmCLT - BOG
1 stop15h 57mSpirit Airlines
Mon 12/82:17 amBOG - CLT
1 stop11h 46mSpirit Airlines
Deal found 11/3$307
This Expedia deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:55 pmCLT - BOG
1 stop15h 57mSpirit Airlines
Thu 12/253:05 pmBOG - CLT
1 stop8h 24mSpirit Airlines
Deal found 11/3$311
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - MDE
1 stop10h 11mSpirit Airlines
Sun 12/142:05 amMDE - CLT
2 stops17h 55mSpirit Airlines
Deal found 11/4$313
This KAYAK deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/102:58 pmCLT - MDE
1 stop23h 16mSpirit Airlines
Mon 12/152:05 amMDE - CLT
1 stop11h 58mSpirit Airlines
Deal found 11/4$315
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:58 pmCLT - CTG
1 stop22h 12mSpirit Airlines
Sun 12/142:15 pmCTG - CLT
1 stop19h 24mSpirit Airlines
Deal found 11/5$316

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 12/11

2:58 pm-1:10 pm

1 stop22h 12m

Cartagena Rafael Nunez

Tue 12/16

2:15 pm-11:59 pm

1 stop9h 44m

$295

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 2/19

7:00 am-1:13 pm

1 stop6h 13m

Cartagena Rafael Nunez

Sun 2/22

2:21 pm-12:40 am

1 stop10h 19m

$297

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 1/8

7:00 am-12:21 am

1 stop17h 21m

Guayaquil Jose Joaquin de Olmedo

Tue 2/3

1:26 am-11:09 am

1 stop9h 43m

$307

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Fri 12/12

2:58 pm-1:09 am

1 stop10h 11m

Medellín Jose Maria Cordova Intl

Sun 12/14

3:10 pm-11:59 pm

1 stop8h 49m

$308

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 1/21

5:06 pm-12:56 am

1 stop7h 50m

Medellín Jose Maria Cordova Intl

Sat 1/24

3:11 pm-12:59 am

1 stop9h 48m

$311

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Mon 12/8

8:54 am-1:09 am

1 stop16h 15m

Medellín Jose Maria Cordova Intl

Sun 12/14

2:05 am-9:39 am

1 stop7h 34m

$313

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Fri 12/12

2:58 pm-1:10 pm

1 stop22h 12m

Cartagena Rafael Nunez

Mon 12/15

2:15 pm-11:59 pm

1 stop9h 44m

$316

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Mon 11/17

6:44 pm-9:40 pm

1 stop26h 56m

Medellín Jose Maria Cordova Intl

Thu 12/4

1:00 pm-11:59 pm

1 stop10h 59m

$321

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 12/10

2:58 pm-2:14 pm

1 stop23h 16m

Medellín Jose Maria Cordova Intl

Sat 12/13

2:05 am-9:39 am

1 stop7h 34m

$323

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 12/10

8:55 am-9:40 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

Tue 12/16

1:00 pm-11:59 pm

1 stop10h 59m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 16% on flights from South Carolina to South America by exploring options for tickets in the morning.

What is the cheapest day to fly from South Carolina to South America?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to South America. Price data was last updated on December 8, 2024.

Travelers seeking maximum savings on their South Carolina to South America flight should consider departing on Monday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to South America?

    A quick flight from South Carolina to South America can take about 11h 40m. Spirit Airlines provides one of the quickest options available for as low as $483. South Carolina and South America are separated by a distance of 2151 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$856FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$327Average$414FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$458Average$845FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$502Average$914FlexibilityNo cancel feeOn-time81%

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