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$92+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated October 22, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$241
(Spirit)

One-way from

$92
(CheapOair)
Provider with most accurate pricing for Myrtle Beach Intl-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Sao Paulo (SAO) flights.
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From South Carolina to South America
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One-way flight from South Carolina to South America
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Find flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This Spirit deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:59 pmCLT - MDE
1 stop6h 57mSpirit Airlines
Mon 12/82:15 amMDE - CLT
1 stop12h 05mSpirit Airlines
Deal found 10/21$241
This Cheapflightsfares deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:00 amCLT - MDE
1 stop16h 20mSpirit Airlines
Tue 12/92:15 amMDE - CLT
1 stop12h 05mSpirit Airlines
Deal found 10/20$255
This Priceline deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:00 amCLT - BOG
1 stop7h 09mSpirit Airlines
Thu 12/111:59 amBOG - CLT
1 stop7h 40mSpirit Airlines
Deal found 10/21$261
This Expedia deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:44 pmCLT - MDE
1 stop6h 13mSpirit Airlines
Wed 11/51:52 amMDE - CLT
1 stop15h 33mSpirit Airlines
Deal found 10/20$267
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/285:59 pmCLT - MDE
1 stop6h 57mSpirit Airlines
Sun 12/72:15 amMDE - CLT
1 stop7h 24mSpirit Airlines
Deal found 10/21$268
This Cheapflightsfares deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:11 pmCLT - MDE
1 stop9h 45mSpirit Airlines
Sun 12/72:15 amMDE - CLT
1 stop12h 05mSpirit Airlines
Deal found 10/20$269
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:59 pmCLT - MDE
1 stop6h 57mSpirit Airlines
Mon 12/82:15 amMDE - CLT
1 stop12h 05mSpirit Airlines
Deal found 10/21$271
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:15 pmCLT - MDE
1 stop10h 05mSpirit Airlines
Thu 1/291:51 amMDE - CLT
1 stop7h 36mSpirit Airlines
Deal found 10/21$281
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/257:30 amCLT - MDE
1 stop6h 33mSpirit Airlines
Sun 12/72:15 amMDE - CLT
1 stop7h 24mSpirit Airlines
Deal found 10/21$284
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/257:30 amCLT - MDE
1 stop6h 33mSpirit Airlines
Fri 12/52:15 amMDE - CLT
1 stop7h 24mSpirit Airlines
Deal found 10/21$287
This Cheapflightsfares deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:30 amCLT - MDE
1 stop6h 33mSpirit Airlines
Sun 12/72:15 amMDE - CLT
1 stop7h 24mSpirit Airlines
Deal found 10/21$289
This CheapOair deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:00 amCLT - CTG
1 stop6h 20mSpirit Airlines
Sun 12/72:25 pmCTG - CLT
1 stop7h 44mSpirit Airlines
Deal found 10/20$292

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sun 11/30

7:30 am-1:25 pm

1 stop5h 55m

Cartagena Rafael Nunez

Fri 12/5

2:25 pm-10:09 pm

1 stop7h 44m

$298

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Tue 11/25

7:30 am-9:40 pm

1 stop14h 10m

Medellín Jose Maria Cordova Intl

Sun 12/7

1:00 pm-10:09 pm

1 stop9h 09m

$310

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Tue 11/18

10:07 am-9:40 pm

1 stop11h 33m

Medellín Jose Maria Cordova Intl

Tue 11/25

1:00 pm-9:22 am

1 stop20h 22m

$319

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Thu 11/6

10:07 am-9:40 pm

1 stop11h 33m

Medellín Jose Maria Cordova Intl

Tue 11/11

1:00 pm-9:02 am

1 stop20h 02m

$319

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Mon 11/24

5:59 pm-9:40 pm

1 stop27h 41m

Medellín Jose Maria Cordova Intl

Mon 12/8

1:00 pm-10:09 pm

1 stop9h 09m

$319

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Thu 11/27

3:51 pm-1:25 pm

2 stops21h 34m

Cartagena Rafael Nunez

Tue 12/2

2:30 pm-9:22 am

1 stop18h 52m

$331

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 11/27

8:52 pm-9:15 am

2 stops12h 23m

Guayaquil Jose Joaquin de Olmedo

Sun 2/1

3:30 am-8:41 pm

2 stops17h 11m

$336

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Tue 11/18

7:59 pm-9:15 am

2 stops13h 16m

Guayaquil Jose Joaquin de Olmedo

Sun 2/1

3:30 am-8:41 pm

2 stops17h 11m

$336

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Mon 11/17

9:38 pm-2:30 pm

2 stops16h 52m

Guayaquil Jose Joaquin de Olmedo

Sun 2/1

4:40 am-8:41 pm

2 stops16h 01m

$336

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 11/13

9:38 pm-2:25 pm

2 stops16h 47m

Guayaquil Jose Joaquin de Olmedo

Sun 2/1

4:40 am-8:41 pm

2 stops16h 01m

$337

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/21

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 22, 2025.

Unlike at noon, when flights are generally more expensive, you can save up to 15% on flights from South Carolina to South America by exploring options for tickets in the morning.

What is the cheapest day to fly from South Carolina to South America?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to South America. Price data was last updated on December 8, 2024.

Travelers seeking maximum savings on their South Carolina to South America flight should consider departing on Monday mornings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to South America?

    A quick flight from South Carolina to South America can take about 5h 55m. Spirit Airlines provides one of the quickest options available for as low as $298. South Carolina and South America are separated by a distance of 1745 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from South Carolina to South America

Discover the top 4 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$862FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$327Average$414FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$458Average$821FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$491Average$911FlexibilityNo cancel feeOn-time81%

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