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South America

$96+ Cheap flights from South Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from South Carolina to South America

Cheapest flights from South Carolina to South America
Explore the most affordable flight options available from South Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This CheapOair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
CLT
-
GYE
1 stop18h 01m
Spirit Airlines
Tue 5/511:59 pm
GYE
-
CLT
1 stop13h 14m
Spirit Airlines
Deal found 1/21$221
This CheapOair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
CLT
-
GYE
1 stop18h 01m
Spirit Airlines
Wed 5/611:59 pm
GYE
-
CLT
1 stop13h 14m
Spirit Airlines
Deal found 1/21$233
This CheapOair deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:55 am
CLT
-
MDE
1 stop8h 18m
Spirit Airlines
Thu 3/53:15 pm
MDE
-
CLT
1 stop8h 41m
Spirit Airlines
Deal found 1/20$234
This Expedia deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/36:00 am
CLT
-
CTG
1 stop7h 10m
Spirit Airlines
Fri 2/62:21 pm
CTG
-
CLT
1 stop10h 19m
Spirit Airlines
Deal found 1/20$243
This CheapOair deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/86:00 am
CLT
-
CTG
1 stop7h 10m
Spirit Airlines
Wed 2/112:21 pm
CTG
-
CLT
1 stop10h 19m
Spirit Airlines
Deal found 1/21$250
This Cheapflightsfares deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:55 am
CLT
-
MDE
1 stop8h 18m
Spirit Airlines
Tue 3/102:15 pm
MDE
-
CLT
1 stop17h 11m
Spirit Airlines
Deal found 1/20$271
This Expedia deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:00 am
CLT
-
MDE
1 stop8h 22m
Spirit Airlines
Fri 3/202:17 pm
MDE
-
CLT
1 stop9h 21m
Spirit Airlines
Deal found 1/20$272
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/86:00 am
CLT
-
MDE
1 stop8h 15m
Spirit Airlines
Fri 2/273:15 pm
MDE
-
CLT
1 stop8h 41m
Spirit Airlines
Deal found 1/20$281
This Cheapflightsfares deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/86:00 am
CLT
-
MDE
1 stop8h 15m
Spirit Airlines
Fri 2/203:15 pm
MDE
-
CLT
1 stop8h 41m
Spirit Airlines
Deal found 1/19$285
This Expedia deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:55 am
CLT
-
CTG
1 stop7h 15m
Spirit Airlines
Fri 3/131:24 pm
CTG
-
CLT
1 stop10h 14m
Spirit Airlines
Deal found 1/20$288
This Kiwi.com deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:55 am
CLT
-
MDE
1 stop8h 18m
Spirit Airlines
Thu 3/53:15 pm
MDE
-
CLT
1 stop8h 41m
Spirit Airlines
Deal found 1/20$289
This Cheapflightsfares deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:55 am
CLT
-
MDE
1 stop8h 18m
Spirit Airlines
Sat 3/142:17 pm
MDE
-
CLT
1 stop17h 04m
Spirit Airlines
Deal found 1/20$291

Find flight deals from South Carolina to South America

Keep the following information in mind while searching for South Carolina to South America flight deals. Data was last updated January 21, 2026.

Round-trip from

$221
(Priceline)

One-way from

$96
(Cheapflightsfares)
From South Carolina to South America
Search Deals
One-way flight from South Carolina to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from South Carolina to South America that are best for you.

Fly from

South Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Mon 3/2

5:55 am-2:13 pm

1 stop8h 18m

Medellín Jose Maria Cordova Intl

Thu 3/5

3:15 pm-11:56 pm

1 stop8h 41m

$234

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Thu 3/5

5:55 am-2:13 pm

1 stop8h 18m

Medellín Jose Maria Cordova Intl

Sun 3/8

2:15 pm-8:26 am

1 stop17h 11m

$234

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Sun 2/8

6:00 am-1:10 pm

1 stop7h 10m

Cartagena Rafael Nunez

Wed 2/11

2:21 pm-12:40 am

1 stop10h 19m

$250

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Fri 3/6

5:55 am-2:13 pm

1 stop8h 18m

Medellín Jose Maria Cordova Intl

Wed 3/11

2:15 pm-11:56 pm

1 stop8h 41m

$272

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Fri 3/6

5:55 am-1:10 pm

1 stop7h 15m

Cartagena Rafael Nunez

Fri 3/13

1:24 pm-12:38 am

1 stop10h 14m

$288

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Sun 3/1

5:55 am-2:13 pm

1 stop8h 18m

Medellín Jose Maria Cordova Intl

Thu 3/5

3:15 pm-11:56 pm

1 stop8h 41m

$289

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 3/5

1:24 pm-12:04 am

1 stop10h 40m

Guayaquil Jose Joaquin de Olmedo

Fri 3/13

11:59 pm-10:11 am

2 stops9h 12m

$292

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Thu 2/19

5:55 am-12:04 am

1 stop18h 09m

Guayaquil Jose Joaquin de Olmedo

Mon 3/16

11:59 pm-10:11 am

2 stops9h 12m

$293

CharlotteCartagena

CLT - CTG

CLTCTG

Charlotte Douglas

Wed 2/4

6:00 am-1:10 pm

1 stop7h 10m

Cartagena Rafael Nunez

Sun 2/8

2:21 pm-12:40 am

1 stop10h 19m

$298

CharlotteGuayaquil

CLT - GYE

CLTGYE

Charlotte Douglas

Wed 3/11

1:24 pm-11:04 pm

1 stop10h 40m

Guayaquil Jose Joaquin de Olmedo

Mon 3/23

11:59 pm-2:17 pm

1 stop13h 18m

$303

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/21

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to South America

What is the cheapest month to book a flight from South Carolina to South America?

Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SA?

Find hourly flight availability from South Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 21, 2026.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 31% on flights from South Carolina to South America by exploring options for tickets in the evening.

What is the cheapest day to fly from South Carolina to South America?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to South America. Price data was last updated on March 23, 2025.

Travelers seeking maximum savings on their South Carolina to South America flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to South America?

    A quick flight from South Carolina to South America can take about 8h 18m. Spirit Airlines provides one of the quickest options available for as low as $234. South Carolina and South America are separated by a distance of 2037 mi.

  • What are the cheapest airlines to fly from South Carolina to South America one-way?

    $103 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $296 and $313, respectively.

  • Can I find deals for flights from South Carolina to South America that include hotel bookings?

    Yes. In addition to deals on South Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to South America.

  • Can I find deals for business class flights from South Carolina to South America?

    Yes. Cheapflights offers flight deals from South Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to South America?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to South America (average of $176). Flying from South Carolina to South America in October is currently the most expensive (average of $486). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from South Carolina to South America

Discover the top 5 airlines that operate flights from South Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$881FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$327Average$395FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$435Average$818FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$494Average$784FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$505Average$598FlexibilityNo cancel feeOn-time69%

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