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South America

$201+ Cheap flights from San Francisco (SFO) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — BOG
ago. 3 — ago. 101
dom. 8/3
dom. 8/10
1 adult, Economy
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Cheap flight deals from San Francisco to South America

Keep the following information in mind while searching for San Francisco to South America flight deals. Data was last updated julio 29, 2025.

Round-trip from

$425
(FlightHub)

One-way from

$201
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$851
From San Francisco to South America
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One-way flight from San Francisco to South America
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Highest demand for flights based on searches. 11% potential increase in price ($95 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($27 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Francisco to South America

Cheapest flights from San Francisco to South America
Explore the most affordable flight options available from San Francisco to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 29, 2025.

This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/203:45 pmSFO - BOG
2 stops22h 50mLATAM Airlines
mié. 8/277:00 amBOG - SFO
2 stops17h 09mLATAM Airlines
Deal found 7/27$425
This Avianca deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/312:05 amSFO - BOG
1 stop11h 15mAvianca
jue. 9/112:20 pmBOG - SFO
1 stop10h 25mAvianca
Deal found 7/27$427
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/31:20 pmSFO - MDE
1 stop9h 35mAvianca
sáb. 11/83:20 amMDE - SFO
1 stop11h 40mAvianca
Deal found 7/29$437
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/912:43 amSFO - BOG
1 stop18h 52mUnited Airlines
jue. 11/278:15 amBOG - SFO
1 stop14h 10mUnited Airlines
Deal found 7/27$446
This Copa Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/111:30 amSFO - BOG
1 stop19h 10mCopa Airlines
mar. 9/2312:08 pmBOG - SFO
1 stop13h 17mCopa Airlines
Deal found 7/28$447
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/1112:45 amSFO - BOG
2 stops17h 13mDelta
lun. 9/152:55 pmBOG - SFO
1 stop21h 35mDelta
Deal found 7/29$463
This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/93:45 pmSFO - SCL
2 stops19h 15mLATAM Airlines
mié. 9/176:35 amSCL - SFO
2 stops20h 34mLATAM Airlines
Deal found 7/28$467
This Flysmarter deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/1311:20 pmSFO - MDE
1 stop12h 45mJetBlue
sáb. 9/201:30 pmMDE - SFO
1 stop11h 40mJetBlue
Deal found 7/27$473
This Copa Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/211:30 amSFO - MDE
1 stop11h 15mCopa Airlines
mié. 8/279:15 amMDE - SFO
1 stop16h 24mCopa Airlines
Deal found 7/27$491
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/205:09 amSFO - MDE
2 stops13h 06mAmerican Airlines
jue. 11/131:30 amMDE - SFO
2 stops15h 08mAmerican Airlines
Deal found 7/28$497
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/314:15 pmSFO - MDE
1 stop10h 27mUnited Airlines
mar. 8/512:15 amMDE - SFO
1 stop14h 01mUnited Airlines
Deal found 7/28$501
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/2310:45 pmSFO - SCL
1 stop27h 10mDelta
mié. 12/311:55 pmSCL - SFO
1 stop15h 05mDelta
Deal found 7/28$502

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 29, 2025.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

San Francisco

Fly to

South America

Route

Depart

Return

Price

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

mié. 8/20

3:45 pm-4:35 pm

2 stops22h 50m

Bogotá El Dorado

mié. 8/27

7:00 am-10:09 pm

2 stops17h 09m

$425

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

mié. 9/3

12:05 am-1:20 pm

1 stop11h 15m

Bogotá El Dorado

jue. 9/11

2:20 pm-10:45 pm

1 stop10h 25m

$427

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

dom. 11/9

12:43 am-10:35 pm

1 stop18h 52m

Bogotá El Dorado

jue. 11/27

8:15 am-7:25 pm

1 stop14h 10m

$446

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

jue. 9/11

1:30 am-10:40 pm

1 stop19h 10m

Bogotá El Dorado

lun. 9/15

6:10 am-11:25 pm

1 stop19h 15m

$447

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

jue. 9/11

9:38 pm-7:15 pm

1 stop19h 37m

Bogotá El Dorado

mié. 9/17

1:35 am-5:47 pm

2 stops18h 12m

$463

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

vie. 10/3

2:20 pm-2:05 am

1 stop9h 45m

Medellín Jose Maria Cordova Intl

jue. 10/9

1:25 pm-12:35 pm

2 stops25h 10m

$467

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

mar. 9/9

3:45 pm-3:00 pm

2 stops19h 15m

Santiago Arturo Merino Benitez

mié. 9/17

6:35 am-11:09 pm

2 stops20h 34m

$467

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

sáb. 9/13

11:20 pm-2:05 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

sáb. 9/20

1:30 pm-11:10 pm

1 stop11h 40m

$473

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

jue. 8/21

1:30 am-2:45 pm

1 stop11h 15m

Medellín Jose Maria Cordova Intl

mié. 8/27

9:15 am-11:39 pm

1 stop16h 24m

$491

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

vie. 8/1

11:59 pm-9:10 pm

1 stop19h 11m

Medellín Jose Maria Cordova Intl

dom. 8/10

9:45 am-11:59 pm

1 stop16h 14m

$501

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 60 results
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Best time to book a flight from San Francisco to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to South America

What is the cheapest month to book a flight from San Francisco to South America?

Currently, May is the cheapest month in which you can book a flight from San Francisco to South America (average of $359). Flying from San Francisco to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SA?

Find hourly flight availability from San Francisco to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 29, 2025.

When flying from San Francisco to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated julio 29, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from San Francisco to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,821 reviews
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Aeromexico
7.5
Good
1,720 reviews
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,899 reviews
Delta
8.0
Very good
7,977 reviews

Crew

8.5

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Francisco to South America?

    Most people fly from San Francisco (SFO) if they book a flight from San Francisco to South America. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • What are the cheapest airlines to fly from San Francisco to South America one-way?

    $201 is the cheapest one-way deal found within the past few days, from Avianca. You may also be able to find cheap deals on LATAM Airlines and United Airlines, with prices starting from $204 and $206, respectively.

  • What are the most popular routes from San Francisco to South America?

    While some choose either San Francisco - Quito Mariscal Sucr or San Francisco - Lima J Chavez Intl, San Francisco - Buenos Aires Ministro Pistarini is the most popular route from San Francisco to South America.

  • Can I find deals for flights from San Francisco to South America that include hotel bookings?

    Yes. In addition to deals on San Francisco to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to South America.

  • Can I find deals for business class flights from San Francisco to South America?

    Yes. Cheapflights offers flight deals from San Francisco to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to South America?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to South America (average of $359). Flying from San Francisco to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 10 airlines flying from San Francisco to South America

Discover the top 10 airlines that operate flights from San Francisco to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
VolarisCheapest$242Average$466FlexibilityNo cancel feeOn-time79%
Copa AirlinesCheapest$381Average$742FlexibilityNo cancel feeOn-time70%
AviancaCheapest$382Average$763FlexibilityNo cancel feeOn-time71%
DeltaCheapest$389Average$916FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$389Average$832FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$389Average$871FlexibilityNo cancel feeOn-time81%
JetBlueCheapest$438Average$646FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$446Average$901FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$539Average$810FlexibilityNo cancel feeOn-time67%
AeromexicoCheapest$652Average$1,031FlexibilityNo cancel feeOn-timeN/A

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