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$170+ Cheap flights from San Francisco (SFO) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — BOG
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from San Francisco to South America

Keep the following information in mind while searching for San Francisco to South America flight deals. Data was last updated September 11, 2025.

Round-trip from

$400
(JetBlue)

One-way from

$170
(Kiwi.com)

Popular in

December

Cheapest in

October

Average price

$655
From San Francisco to South America
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One-way flight from San Francisco to South America
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Highest demand for flights based on searches. 11% potential increase in price ($98 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Francisco to South America

Cheapest flights from San Francisco to South America
Explore the most affordable flight options available from San Francisco to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:20 pmSFO - MDE
1 stop12h 12mJetBlue
Sat 11/11:10 pmMDE - SFO
1 stop12h 21mJetBlue
Deal found 9/10$400
This JetBlue deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1411:20 pmSFO - MDE
1 stop12h 45mJetBlue
Sat 10/181:30 pmMDE - SFO
1 stop11h 46mJetBlue
Deal found 9/10$410
This JetBlue deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:43 pmSFO - MDE
1 stop14h 49mJetBlue
Sat 11/82:10 pmMDE - SFO
1 stop12h 21mJetBlue
Deal found 9/9$419
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:43 pmSFO - MDE
1 stop14h 49mJetBlue
Tue 11/182:10 pmMDE - SFO
1 stop22h 15mJetBlue
Deal found 9/10$420
This lastminute.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:20 pmSFO - MDE
1 stop12h 12mJetBlue
Sat 11/82:10 pmMDE - SFO
1 stop12h 21mJetBlue
Deal found 9/11$423
This Cheapflightsfares deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/912:05 amSFO - BOG
1 stop12h 04mAvianca
Sat 9/133:59 amBOG - SFO
1 stop10h 36mAvianca
Deal found 9/10$423
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/112:10 amSFO - BOG
1 stop14h 00mAvianca
Thu 11/134:00 amBOG - SFO
1 stop11h 00mAvianca
Deal found 9/10$427
This SmartFares deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:45 pmSFO - MDE
1 stop13h 47mJetBlue
Sat 11/152:10 pmMDE - SFO
1 stop22h 15mJetBlue
Deal found 9/10$428
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:20 pmSFO - BOG
1 stop9h 35mAvianca
Sat 11/11:30 pmBOG - SFO
1 stop12h 50mAvianca
Deal found 9/10$428
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/19:43 pmSFO - MDE
1 stop14h 49mJetBlue
Tue 11/112:10 pmMDE - SFO
1 stop22h 15mJetBlue
Deal found 9/10$429
This Avianca deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/232:30 amSFO - BOG
1 stop9h 39mAvianca
Fri 10/314:00 amBOG - SFO
1 stop11h 00mAvianca
Deal found 9/9$429
This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/288:00 amSFO - MDE
1 stop27h 32mJetBlue
Fri 10/311:10 pmMDE - SFO
1 stop12h 21mJetBlue
Deal found 9/9$430

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.

Fly from

San Francisco

Fly to

South America

Route

Depart

Return

Price

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Sat 11/1

9:43 pm-2:32 pm

1 stop14h 49m

Medellín Jose Maria Cordova Intl

Sat 11/8

2:10 pm-11:31 pm

1 stop12h 21m

$419

San FranciscoMedellín

SFO - MDE

SFOMDE

San Francisco

Sun 11/2

9:44 pm-2:32 pm

1 stop13h 48m

Medellín Jose Maria Cordova Intl

Sat 11/8

2:10 pm-11:31 pm

1 stop12h 21m

$429

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Fri 10/24

2:20 pm-1:55 am

1 stop9h 35m

Bogotá El Dorado

Fri 10/31

1:30 pm-10:50 pm

1 stop11h 20m

$436

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Fri 11/28

7:10 pm-10:35 pm

1 stop24h 25m

Bogotá El Dorado

Sun 12/14

8:15 am-7:47 am

1 stop26h 32m

$450

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Mon 2/9

2:41 pm-5:10 am

1 stop11h 29m

Bogotá El Dorado

Wed 2/11

8:15 am-4:50 pm

1 stop11h 35m

$459

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Fri 2/6

2:41 pm-5:10 am

1 stop11h 29m

Bogotá El Dorado

Sun 4/26

8:30 am-11:55 pm

1 stop17h 25m

$459

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Tue 2/24

3:00 pm-5:10 am

1 stop11h 10m

Bogotá El Dorado

Thu 3/12

8:15 am-12:25 am

1 stop18h 10m

$459

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Wed 12/3

5:00 am-10:35 pm

1 stop14h 35m

Bogotá El Dorado

Thu 12/11

8:15 am-4:46 pm

1 stop11h 31m

$459

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Fri 2/6

2:41 pm-5:10 am

1 stop11h 29m

Bogotá El Dorado

Wed 4/29

8:30 am-8:50 pm

1 stop14h 20m

$459

San FranciscoBogotá

SFO - BOG

SFOBOG

San Francisco

Mon 12/1

11:59 pm-10:35 pm

1 stop19h 36m

Bogotá El Dorado

Fri 12/12

8:15 am-4:46 pm

1 stop11h 31m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 60 results
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Best time to book a flight from San Francisco to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to South America

What is the cheapest month to book a flight from San Francisco to South America?

Currently, May is the cheapest month in which you can book a flight from San Francisco to South America (average of $359). Flying from San Francisco to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SA?

Find hourly flight availability from San Francisco to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from San Francisco to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Copa Airlines, LATAM Airlines, and United Airlines from San Francisco to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
LATAM Airlines
7.5
Good
1,847 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
United Airlines
7.4
Good
8,937 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Boarding

7.8

Entertainment

6.8

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.6

Reviews

1 / 20
6.0
Good

Paul,May 2025

PTY - AUA

Had to use my phone for entertainment? Once we landed people were already out their seats and standing in the isles while the plane was still taxiing to the gate. This is unsafe and flight crew had a responsibility to ensure that people remain seated until the pilots turn off the seatbelt sign.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Francisco to South America?

    Most people fly from San Francisco (SFO) if they book a flight from San Francisco to South America. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from San Francisco to South America?

    Airlines like JetBlue, Avianca, and United Airlines fly from San Francisco to South America in about 9h 35m. The time it takes to get you to your destination can typically vary by up to 14h 50m. The distance from San Francisco to South America is about 3786 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from San Francisco to South America one-way?

    $172 is the cheapest one-way deal found within the past few days, from JetBlue. You may also be able to find cheap deals on Avianca and LATAM Airlines, with prices starting from $203 and $205, respectively.

  • What are the most popular routes from San Francisco to South America?

    While some choose either San Francisco - Sao Paulo Guarulhos Intl or San Francisco - Lima J Chavez Intl, San Francisco - Buenos Aires Ministro Pistarini is the most popular route from San Francisco to South America.

  • Can I find deals for flights from San Francisco to South America that include hotel bookings?

    Yes. In addition to deals on San Francisco to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to South America.

  • Can I find deals for business class flights from San Francisco to South America?

    Yes. Cheapflights offers flight deals from San Francisco to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to South America?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to South America (average of $359). Flying from San Francisco to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 10 airlines flying from San Francisco to South America

Discover the top 10 airlines that operate flights from San Francisco to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
VolarisCheapest$242Average$466FlexibilityNo cancel feeOn-time79%
AviancaCheapest$381Average$674FlexibilityNo cancel feeOn-time71%
DeltaCheapest$389Average$927FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$389Average$863FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$389Average$835FlexibilityNo cancel feeOn-time69%
Copa AirlinesCheapest$391Average$770FlexibilityNo cancel feeOn-time70%
JetBlueCheapest$409Average$665FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$463Average$905FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$531Average$848FlexibilityNo cancel feeOn-time67%
AeromexicoCheapest$652Average$1,030FlexibilityNo cancel feeOn-timeN/A

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