$178+ Cheap flights from San Francisco (SFO) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — BOG
Feb 26 — Mar 51
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Francisco to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to South America
Cheapest flights from San Francisco to South AmericaExplore the most affordable flight options available from San Francisco to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.
Explore the most affordable flight options available from San Francisco to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:20 pm
SFO
- MDE
2 stops13h 45m
Avianca
Wed 3/42:10 pm
MDE
- SFO
1 stop10h 40m
Avianca
Deal found 1/27![Avianca logo]()
$378
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/97:10 pm
SFO
- MDE
1 stop23h 55m
United Airlines
Thu 2/1910:45 am
MDE
- SFO
1 stop16h 14m
United Airlines
Deal found 1/26![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/97:10 pm
SFO
- MDE
1 stop23h 55m
United Airlines
Wed 2/1810:45 am
MDE
- SFO
1 stop23h 46m
United Airlines
Deal found 1/26![United Airlines logo]()
$388
This Priceline deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:10 pm
SFO
- MDE
1 stop10h 45m
Avianca
Mon 3/210:15 pm
MDE
- SFO
2 stops16h 45m
Avianca
Deal found 1/24![Avianca logo]()
$397
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:10 pm
SFO
- MDE
2 stops13h 20m
Avianca
Sat 2/282:10 pm
MDE
- SFO
1 stop12h 10m
Avianca
Deal found 1/26![Avianca logo]()
$398
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/31:35 am
SFO
- MDE
2 stops14h 35m
Avianca
Sun 3/810:15 pm
MDE
- SFO
2 stops16h 45m
Avianca
Deal found 1/27![Avianca logo]()
$404
This Avianca deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:15 pm
SFO
- MDE
1 stop9h 50m
Avianca
Sun 4/193:15 am
MDE
- SFO
1 stop11h 35m
Avianca
Deal found 1/24![Avianca logo]()
$405
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:15 pm
SFO
- MDE
1 stop9h 50m
Avianca
Tue 4/2111:54 am
MDE
- SFO
2 stops14h 01m
Avianca
Deal found 1/27![Avianca logo]()
$410
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/41:20 pm
SFO
- MDE
1 stop20h 35m
Avianca
Wed 3/189:00 pm
MDE
- SFO
2 stops27h 50m
Avianca
Deal found 1/27![Avianca logo]()
$415
This Avianca deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:35 am
SFO
- MDE
2 stops13h 40m
Avianca
Mon 3/1610:40 am
MDE
- SFO
2 stops14h 10m
Avianca
Deal found 1/26![Avianca logo]()
$417
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:43 am
SFO
- BOG
1 stop18h 52m
United Airlines
Fri 2/131:30 am
BOG
- SFO
1 stop13h 41m
United Airlines
Deal found 1/27![United Airlines logo]()
$430
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:55 pm
SFO
- BOG
1 stop10h 05m
Avianca
Fri 5/14:25 am
BOG
- SFO
1 stop10h 25m
Avianca
Deal found 1/27![Avianca logo]()
$431
Find flight deals from San Francisco to South America
Keep the following information in mind while searching for San Francisco to South America flight deals. Data was last updated January 27, 2026.
Round-trip from | $378 (Avianca) |
|---|---|
One-way from | $178 (Kiwi.com) |
Popular in | December |
Cheapest in | August |
Average price | $607 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from San Francisco to South America that are best for you.
Fly from
San Francisco
Fly to
South America
Route
Depart
Return
Price
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Wed 2/25
1:20 pm-6:05 am
2 stops13h 45m
Medellín Jose Maria Cordova Intl
Wed 3/4
2:10 pm-9:50 pm
1 stop10h 40m
$378
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Wed 4/8
12:45 am-9:10 pm
1 stop18h 25m
Medellín Jose Maria Cordova Intl
Fri 4/17
9:45 am-7:16 am
1 stop23h 31m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Fri 4/10
12:45 am-9:10 pm
1 stop18h 25m
Medellín Jose Maria Cordova Intl
Fri 4/17
9:45 am-10:40 am
1 stop26h 55m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Sun 4/12
5:00 am-9:10 pm
1 stop14h 10m
Medellín Jose Maria Cordova Intl
Fri 4/17
9:45 am-7:16 am
1 stop23h 31m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Tue 4/7
6:55 pm-9:10 pm
1 stop24h 15m
Medellín Jose Maria Cordova Intl
Tue 4/21
9:45 am-6:58 pm
1 stop11h 13m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Wed 2/25
11:59 pm-10:05 pm
1 stop19h 06m
Medellín Jose Maria Cordova Intl
Mon 3/2
10:45 am-5:08 pm
1 stop33h 23m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Tue 4/7
12:45 am-9:10 pm
1 stop18h 25m
Medellín Jose Maria Cordova Intl
Fri 4/17
9:45 am-10:40 am
1 stop26h 55m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Wed 3/4
12:43 am-10:05 pm
1 stop18h 22m
Medellín Jose Maria Cordova Intl
Mon 3/9
9:45 am-7:36 am
1 stop23h 51m
$379
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Wed 3/4
1:20 pm-6:05 am
2 stops13h 45m
Medellín Jose Maria Cordova Intl
Sun 3/8
2:10 pm-10:50 pm
1 stop10h 40m
$411
San FranciscoMedellín
SFO - MDE
SFOMDE
San Francisco
Sat 3/7
12:54 am-2:15 pm
1 stop10h 21m
Medellín Jose Maria Cordova Intl
Sat 3/14
12:42 pm-11:40 pm
1 stop12h 58m
$429
Showing 1-10 of 60 results
Best time to book a flight from San Francisco to South America
Have a flexible travel schedule? Discover the best time to fly to South America from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to South America
What is the cheapest month to book a flight from San Francisco to South America?
Currently, October is the cheapest month in which you can book a flight from San Francisco to South America (average of $220). Flying from San Francisco to South America in January is currently the most expensive (average of $379). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with Copa Airlines, LATAM Airlines, and United Airlines from San Francisco to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Crew
8.1
Comfort
7.4
Entertainment
6.8
Overall
7.6
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreJuan,Dec 2025
EZE - PTY
Related info for your journey
Find useful and relevant information for your journey from San Francisco to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for San Francisco to South America
See prices for flight routes from nearby airports that may be better suited for you.
Top 10 airlines flying from San Francisco to South America
Discover the top 10 airlines that operate flights from San Francisco to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$214 | Average$799 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$224 | Average$753 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$258 | Average$778 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$293 | Average$754 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$304 | Average$887 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$309 | Average$648 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$453 | Average$1,066 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$463 | Average$884 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$531 | Average$752 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$668 | Average$1,546 | FlexibilityNo cancel fee | On-time74% |