$604+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — VVI
Nov 25 — Dec 21
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santa Cruz de la Sierra
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Best
Last-minute
One-way
Cheapest flights from San Francisco to Santa Cruz de la SierraExplore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 26, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/251:31 am -
1 stop23h 09m
Thu 10/291:12 am -
1 stop25h 28m
Deal found 10/24![Copa Airlines logo]()
$840
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:33 am -
1 stop18h 05m
Sun 12/61:10 am -
1 stop26h 07m
Deal found 10/22![Copa Airlines logo]()
$844
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:15 pm -
2 stops43h 23m
Mon 12/711:42 am -
2 stops25h 40m
Deal found 10/21![United Airlines logo]()
$851
This United deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:53 am -
2 stops36h 47m
Thu 10/293:45 am -
2 stops21h 01m
Deal found 10/24![Multiple Airlines logo]()
$853
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:00 pm -
2 stops23h 40m
Wed 11/113:45 am -
2 stops21h 55m
Deal found 10/23![Avianca logo]()
$899
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:00 am -
2 stops18h 37m
Thu 11/1211:41 am -
2 stops16h 23m
Deal found 10/24![United Airlines logo]()
$921
This Avianca deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:00 pm -
2 stops23h 40m
Thu 11/193:45 am -
2 stops36h 10m
Deal found 10/21![Avianca logo]()
$935
This FlightHub deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/261:30 am -
2 stops21h 10m
Sun 12/63:45 am -
2 stops36h 10m
Deal found 10/22![Avianca logo]()
$1,082
Best flights from San Francisco to Santa Cruz de la SierraDiscover carefully curated flight deals from San Francisco to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
Discover carefully curated flight deals from San Francisco to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 26, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/17:55 pm -
1 stop29h 00m
Thu 4/159:56 am -
1 stop16h 44m
Deal found 10/22![Copa Airlines logo]()
$836
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/210:35 pm -
2 stops25h 08m
Mon 2/2211:55 am -
2 stops25h 27m
Deal found 10/26![United Airlines logo]()
$851
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/315:00 am -
2 stops18h 43m
Mon 2/2211:55 am -
2 stops27h 30m
Deal found 10/26![United Airlines logo]()
$851
This Copa Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:33 am -
1 stop18h 05m
Sun 12/61:10 am -
1 stop26h 07m
Deal found 10/23![Copa Airlines logo]()
$912
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:00 am -
2 stops37h 38m
Mon 12/711:34 am -
2 stops29h 06m
Deal found 10/23![United Airlines logo]()
$851
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:00 am -
2 stops18h 37m
Thu 11/1211:41 am -
2 stops16h 23m
Deal found 10/25![United Airlines logo]()
$851
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/810:50 pm -
2 stops43h 58m
Tue 12/1511:34 am -
2 stops26h 17m
Deal found 10/24![United Airlines logo]()
$921
Last-minute flights from San Francisco to Santa Cruz de la SierraDiscover last-minute flight deals from San Francisco to Santa Cruz de la Sierra. Data last updated October 26, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santa Cruz de la Sierra. Data last updated October 26, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/251:31 am -
1 stop23h 09m
Thu 10/291:12 am -
1 stop25h 28m
Deal found 10/24![Copa Airlines logo]()
$840
This United deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2610:53 am -
2 stops36h 47m
Thu 10/293:45 am -
2 stops21h 01m
Deal found 10/24![Multiple Airlines logo]()
$853
This Avianca deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:00 pm -
2 stops23h 40m
Wed 11/113:45 am -
2 stops21h 55m
Deal found 10/23![Avianca logo]()
$899
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:00 am -
2 stops18h 37m
Thu 11/1211:41 am -
2 stops16h 23m
Deal found 10/24![United Airlines logo]()
$921
This Avianca deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:00 pm -
2 stops23h 40m
Thu 11/193:45 am -
2 stops36h 10m
Deal found 10/21![Avianca logo]()
$935
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:33 am -
1 stop18h 05m
Sun 12/61:10 am -
1 stop26h 07m
Deal found 10/22![Copa Airlines logo]()
$844
This FlightHub deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/261:30 am -
2 stops21h 10m
Sun 12/63:45 am -
2 stops36h 10m
Deal found 10/22![Avianca logo]()
$1,082
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2711:15 pm -
2 stops43h 23m
Mon 12/711:42 am -
2 stops25h 40m
Deal found 10/21![United Airlines logo]()
$851
One-way flights from San Francisco to Santa Cruz de la SierraSearch for one-way flight options from San Francisco to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
Search for one-way flight options from San Francisco to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 26, 2026.
This BusinessClass deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:35 pm -
2 stops24h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Copa Airlines logo]()
$604
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:59 pm -
2 stops42h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![United Airlines logo]()
$660
This BusinessClass deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2312:45 am -
2 stops17h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Copa Airlines logo]()
$671
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/276:30 am -
3 stops42h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$762
This KAYAK deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/265:43 pm -
2 stops25h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$773
This FlightHub deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/241:15 pm -
2 stops35h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$1,099
This BusinessClass deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2511:59 pm -
2 stops18h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Copa Airlines logo]()
$1,133
This Copa Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2512:33 am -
1 stop18h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Copa Airlines logo]()
$1,323
Find flight deals from San Francisco to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $836 (Copa Airlines) |
One-way from | $604 (BusinessClass) |
Popular in | December |
Cheapest in | March |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Mon 11/23
6:35 pm-10:38 pm
2 stops24h 03m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$604
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Mon 11/23
11:59 pm-10:38 pm
2 stops42h 39m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$660
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Tue 11/24
5:00 am-10:38 pm
2 stops37h 38m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$660
Quickest round-trip
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Tue 11/24
7:15 am-3:37 am
2 stops16h 22m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$671
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Sun 12/27
6:30 am-4:30 am
3 stops42h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$762
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Sat 12/26
8:28 pm-4:35 am
3 stops28h 07m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-8:00 pm
Nonstop0h 00m
$826
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Thu 4/1
7:55 pm-3:55 am
1 stop29h 00m
Santa Cruz de la Sierra Viru Viru Intl
Thu 4/15
9:56 am-11:40 pm
1 stop16h 44m
$836
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Tue 2/2
10:35 pm-3:43 am
2 stops25h 08m
Santa Cruz de la Sierra Viru Viru Intl
Mon 2/22
11:55 am-9:22 am
2 stops25h 27m
$851
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Sun 1/31
5:00 am-3:43 am
2 stops18h 43m
Santa Cruz de la Sierra Viru Viru Intl
Mon 2/22
11:55 am-11:25 am
2 stops27h 30m
$851
San FranciscoSanta Cruz de la Sierra
SFO San Francisco - VVI Santa Cruz de la Sierra Viru Viru Intl
SFOVVI
San Francisco
Fri 11/27
5:00 am-10:38 pm
2 stops37h 38m
Santa Cruz de la Sierra Viru Viru Intl
Mon 12/7
11:34 am-12:40 pm
2 stops29h 06m
$851
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santa Cruz de la Sierra in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.
SFO-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated October 26, 2026.
Get a feel of what it's like to fly with Copa Airlines and United Airlines from San Francisco to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.5
Entertainment
6.9
Overall
7.6
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Boarding
7.8
Comfort
7.5
Entertainment
6.9
Overall
7.6
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Boarding
7.8
Comfort
7.5
Entertainment
6.9
Overall
7.6
Crew
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for San Francisco to Santa Cruz de la Sierra
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Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Francisco to Santa Cruz de la Sierra by cabin class
Find flights from San Francisco to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Francisco and Santa Cruz de la Sierra flights
Browse other San Francisco and Santa Cruz de la Sierra flight options. Last updated on October 26, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on October 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from San Francisco to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from San Francisco to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$374 | Average$1,058 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$664 | Average$1,067 | FlexibilityNo cancel fee | On-time70% |