$381+ Cheap flights from San Francisco (SFO) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — VVI
May 28 — Jun 41
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santa Cruz de la Sierra
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Best
Last-minute
One-way
Cheapest flights from San Francisco to Santa Cruz de la SierraExplore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
Explore the most affordable flight options available from San Francisco to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2026.
This Ovago deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:59 pm
SFO
- VVI
2 stops19h 41m
Copa Airlines
Thu 9/311:47 am
VVI
- SFO
2 stops33h 42m
Copa Airlines
Deal found 4/27![Copa Airlines logo]()
$851
This Copa Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:16 pm
SFO
- VVI
1 stop23h 24m
Copa Airlines
Sat 8/291:12 am
VVI
- SFO
1 stop19h 47m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$857
This KAYAK deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:35 pm
SFO
- VVI
2 stops21h 03m
Multiple Airlines
Sun 6/1412:45 pm
VVI
- SFO
2 stops45h 37m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$876
This Copa Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:12 am
SFO
- VVI
1 stop23h 19m
Copa Airlines
Sat 6/61:12 am
VVI
- SFO
1 stop20h 02m
Copa Airlines
Deal found 4/25![Copa Airlines logo]()
$882
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:30 pm
SFO
- VVI
2 stops20h 14m
United Airlines
Thu 10/2211:47 am
VVI
- SFO
2 stops25h 44m
United Airlines
Deal found 4/26![United Airlines logo]()
$883
This Copa Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:12 am
SFO
- VVI
1 stop23h 26m
Copa Airlines
Sat 10/1711:47 am
VVI
- SFO
1 stop14h 53m
Copa Airlines
Deal found 4/27![Copa Airlines logo]()
$965
This Cheapflightsfares deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:55 pm
SFO
- VVI
2 stops23h 35m
Avianca
Thu 5/283:35 am
VVI
- SFO
2 stops22h 00m
Avianca
Deal found 4/24![Avianca logo]()
$966
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2111:55 pm
SFO
- VVI
2 stops23h 35m
Avianca
Sat 5/303:35 am
VVI
- SFO
2 stops36h 15m
Avianca
Deal found 4/23![Avianca logo]()
$973
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:15 pm
SFO
- VVI
2 stops33h 15m
Avianca
Sat 5/303:35 am
VVI
- SFO
2 stops46h 00m
Avianca
Deal found 4/23![Avianca logo]()
$983
This Cheapflightsfares deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/112:30 am
SFO
- VVI
2 stops21h 00m
Avianca
Sat 6/133:35 am
VVI
- SFO
2 stops22h 00m
Avianca
Deal found 4/24![Avianca logo]()
$984
Best flights from San Francisco to Santa Cruz de la SierraDiscover carefully curated flight deals from San Francisco to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
Discover carefully curated flight deals from San Francisco to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2026.
This Ovago deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:59 pm
SFO
- VVI
2 stops19h 41m
Copa Airlines
Thu 9/311:47 am
VVI
- SFO
2 stops33h 42m
Copa Airlines
Deal found 4/27![Copa Airlines logo]()
$851
This KAYAK deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:35 pm
SFO
- VVI
2 stops21h 03m
Multiple Airlines
Sun 6/1412:45 pm
VVI
- SFO
2 stops45h 37m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$876
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/94:48 pm
SFO
- VVI
2 stops26h 56m
United Airlines
Sat 10/1711:47 am
VVI
- SFO
2 stops22h 37m
United Airlines
Deal found 4/27![United Airlines logo]()
$883
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:15 pm
SFO
- VVI
2 stops33h 15m
Avianca
Sat 5/303:35 am
VVI
- SFO
2 stops46h 00m
Avianca
Deal found 4/23![Avianca logo]()
$983
This Copa Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:16 pm
SFO
- VVI
1 stop23h 24m
Copa Airlines
Sat 8/291:12 am
VVI
- SFO
1 stop19h 47m
Copa Airlines
Deal found 4/27![Copa Airlines logo]()
$857
This Copa Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:12 am
SFO
- VVI
1 stop23h 19m
Copa Airlines
Sat 6/131:12 am
VVI
- SFO
1 stop20h 02m
Copa Airlines
Deal found 4/28![Copa Airlines logo]()
$965
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1812:45 am
SFO
- VVI
2 stops23h 53m
United Airlines
Thu 10/2211:47 am
VVI
- SFO
1 stop14h 53m
United Airlines
Deal found 4/27![United Airlines logo]()
$1,106
This Copa Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/81:12 am
SFO
- VVI
1 stop23h 26m
Copa Airlines
Sat 10/1711:47 am
VVI
- SFO
1 stop14h 53m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$965
Last-minute flights from San Francisco to Santa Cruz de la SierraDiscover last-minute flight deals from San Francisco to Santa Cruz de la Sierra. Data last updated April 28, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santa Cruz de la Sierra. Data last updated April 28, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/181:12 am
SFO
- VVI
1 stop18h 26m
Copa Airlines
Sat 5/301:12 am
VVI
- SFO
1 stop25h 28m
Copa Airlines
Deal found 4/23![Copa Airlines logo]()
$1,027
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:15 pm
SFO
- VVI
2 stops33h 15m
Avianca
Sat 5/303:35 am
VVI
- SFO
2 stops46h 00m
Avianca
Deal found 4/23![Avianca logo]()
$983
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:55 pm
SFO
- VVI
2 stops23h 35m
Multiple Airlines
Sat 5/303:35 am
VVI
- SFO
3 stops33h 40m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$1,149
This Mytrip deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:55 pm
SFO
- VVI
2 stops23h 35m
Multiple Airlines
Sat 5/303:35 am
VVI
- SFO
3 stops33h 40m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$1,150
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2111:55 pm
SFO
- VVI
2 stops23h 35m
Avianca
Sat 5/303:35 am
VVI
- SFO
2 stops36h 15m
Avianca
Deal found 4/23![Avianca logo]()
$973
This Cheapflightsfares deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:55 pm
SFO
- VVI
2 stops23h 35m
Avianca
Thu 5/283:35 am
VVI
- SFO
2 stops22h 00m
Avianca
Deal found 4/24![Avianca logo]()
$966
This Copa Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:12 am
SFO
- VVI
1 stop23h 19m
Copa Airlines
Sat 6/131:12 am
VVI
- SFO
1 stop20h 02m
Copa Airlines
Deal found 4/28![Copa Airlines logo]()
$965
This KAYAK deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2710:35 pm
SFO
- VVI
2 stops21h 03m
Multiple Airlines
Sun 6/1412:45 pm
VVI
- SFO
2 stops45h 37m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$876
This Copa Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:12 am
SFO
- VVI
1 stop23h 19m
Copa Airlines
Sat 6/61:12 am
VVI
- SFO
1 stop20h 02m
Copa Airlines
Deal found 4/25![Copa Airlines logo]()
$882
One-way flights from San Francisco to Santa Cruz de la SierraSearch for one-way flight options from San Francisco to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
Search for one-way flight options from San Francisco to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated April 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:48 pm
SFO
- VVI
2 stops27h 43m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$381
This KAYAK deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2610:37 pm
SFO
- VVI
2 stops21h 01m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:37 pm
SFO
- VVI
2 stops21h 01m
United Airlines
Deal found 4/23![United Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
SFO
- VVI
2 stops37h 38m
United Airlines
Deal found 4/27![United Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
SFO
- VVI
3 stops37h 38m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:19 am
SFO
- VVI
2 stops33h 19m
United Airlines
Deal found 4/27![United Airlines logo]()
$415
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:38 pm
SFO
- VVI
3 stops31h 00m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$436
This KAYAK deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:12 am
SFO
- VVI
1 stop18h 26m
Copa Airlines
Deal found 4/27![Copa Airlines logo]()
$441
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:59 pm
SFO
- VVI
3 stops19h 39m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$455
This KAYAK deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/711:59 pm
SFO
- VVI
2 stops43h 41m
Copa Airlines
Deal found 4/25![Copa Airlines logo]()
$461
This Copa Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:16 pm
SFO
- VVI
1 stop23h 24m
Copa Airlines
Deal found 4/23![Copa Airlines logo]()
$464
Find flight deals from San Francisco to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $851 (Ovago) |
One-way from | $381 (Kiwi.com) |
Popular in | December |
Cheapest in | March |
Average price | $783 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
Use the filters below to find and compare flights from San Francisco to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Tue 8/18
11:59 pm-10:40 pm
2 stops19h 41m
Santa Cruz de la Sierra Viru Viru Intl
Thu 9/3
11:47 am-6:29 pm
2 stops33h 42m
$851
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Thu 7/30
8:16 pm-10:40 pm
1 stop23h 24m
Santa Cruz de la Sierra Viru Viru Intl
Sat 8/29
1:12 am-5:59 pm
1 stop19h 47m
$857
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Wed 5/27
10:35 pm-10:38 pm
2 stops21h 03m
Santa Cruz de la Sierra Viru Viru Intl
Sun 6/14
12:45 pm-7:22 am
2 stops45h 37m
$876
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Fri 10/9
4:48 pm-10:44 pm
2 stops26h 56m
Santa Cruz de la Sierra Viru Viru Intl
Sat 10/17
11:47 am-7:24 am
2 stops22h 37m
$883
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Tue 5/26
1:12 am-3:31 am
1 stop23h 19m
Santa Cruz de la Sierra Viru Viru Intl
Sat 6/13
1:12 am-6:14 pm
1 stop20h 02m
$965
Quickest round-trip
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Thu 10/8
1:12 am-3:38 am
1 stop23h 26m
Santa Cruz de la Sierra Viru Viru Intl
Sat 10/17
11:47 am-11:40 pm
1 stop14h 53m
$965
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Tue 5/19
2:15 pm-2:30 am
2 stops33h 15m
Santa Cruz de la Sierra Viru Viru Intl
Sat 5/30
3:35 am-10:35 pm
2 stops46h 00m
$983
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Sun 10/18
12:45 am-3:38 am
2 stops23h 53m
Santa Cruz de la Sierra Viru Viru Intl
Thu 10/22
11:47 am-11:40 pm
1 stop14h 53m
$1,106
Cheapest one-way
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Tue 5/12
10:28 am-3:31 am
2 stops38h 03m
$385
San FranciscoSanta Cruz de la Sierra
SFO - VVI
SFOVVI
San Francisco
Sat 5/16
12:45 am-3:31 am
2 stops23h 46m
$385
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santa Cruz de la Sierra in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from San Francisco with our price prediction graph.
SFO-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Santa Cruz de la Sierra
What is the cheapest month to book a flight from San Francisco to Santa Cruz de la Sierra?
Currently, March is the cheapest month in which you can book a flight from San Francisco to Santa Cruz de la Sierra (average of $356). Flying from San Francisco to Santa Cruz de la Sierra in December is currently the most expensive (average of $1,667). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Santa Cruz de la Sierra?
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated April 28, 2026.
Get a feel of what it's like to fly with Copa Airlines,United Airlines, andAvianca from San Francisco to Santa Cruz de la Sierra by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Entertainment
6.8
Food
6.8
Overall
7.5
Comfort
7.4
Boarding
7.8
Crew
8.1
Reviews
1 / 20
2.0
MediocreKaterine,Mar 2026
LAX - PTY
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for San Francisco to Santa Cruz de la Sierra
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Francisco to Santa Cruz de la Sierra by cabin class
Find flights from San Francisco to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Francisco and Santa Cruz de la Sierra flights
Browse other San Francisco and Santa Cruz de la Sierra flight options. Last updated on April 28, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on April 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from San Francisco to Santa Cruz de la Sierra
Discover the top 3 airlines that operate flights from San Francisco to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$374 | Average$1,022 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$622 | Average$839 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$633 | Average$921 | FlexibilityNo cancel fee | On-time71% |