$918+ Cheap flights from Santa Cruz de la Sierra (VVI) to San Francisco (SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/13. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — SFO
Oct 16 — Oct 231
Round-trip
1 adult, Economy
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Find cheap flights from Santa Cruz de la Sierra to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Santa Cruz de la Sierra to San Francisco
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Best
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One-way
Cheapest flights from Santa Cruz de la Sierra to San FranciscoExplore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Santa Cruz de la Sierra to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This United deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:35 am -
2 stops32h 00m
Wed 10/216:30 pm -
2 stops29h 00m
Deal found 9/14![Multiple Airlines logo]()
$918
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:47 am -
2 stops38h 05m
Sat 10/310:45 pm -
2 stops44h 59m
Deal found 9/13![United Airlines logo]()
$928
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:12 am -
1 stop25h 28m
Wed 10/218:21 pm -
1 stop23h 23m
Deal found 9/14![Copa Airlines logo]()
$983
This United deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:12 am -
2 stops36h 30m
Tue 9/2911:55 pm -
2 stops43h 49m
Deal found 9/15![Multiple Airlines logo]()
$987
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:12 am -
1 stop25h 28m
Sun 11/17:36 pm -
1 stop23h 02m
Deal found 9/14![Copa Airlines logo]()
$1,009
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/131:10 am -
1 stop20h 15m
Sun 1/37:36 pm -
1 stop28h 08m
Deal found 9/12![Copa Airlines logo]()
$1,052
This United deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:35 am -
2 stops23h 12m
Sun 11/111:20 pm -
2 stops24h 17m
Deal found 9/14![Multiple Airlines logo]()
$1,084
Best flights from Santa Cruz de la Sierra to San FranciscoDiscover carefully curated flight deals from Santa Cruz de la Sierra to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Santa Cruz de la Sierra to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:47 am -
2 stops38h 05m
Sat 10/310:45 pm -
2 stops44h 59m
Deal found 9/13![United Airlines logo]()
$928
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:12 am -
1 stop25h 28m
Wed 10/218:21 pm -
1 stop23h 23m
Deal found 9/14![Copa Airlines logo]()
$983
This United deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:35 am -
2 stops23h 12m
Sun 11/111:20 pm -
2 stops24h 17m
Deal found 9/14![Multiple Airlines logo]()
$1,084
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:05 am -
3 stops30h 45m
Tue 10/202:30 am -
3 stops29h 50m
Deal found 9/14![Multiple Airlines logo]()
$1,319
Last-minute flights from Santa Cruz de la Sierra to San FranciscoDiscover last-minute flight deals from Santa Cruz de la Sierra to San Francisco. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Cruz de la Sierra to San Francisco. Data last updated September 16, 2026 and is based on user searches.
This United deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:12 am -
2 stops36h 30m
Tue 9/2911:55 pm -
2 stops43h 49m
Deal found 9/15![Multiple Airlines logo]()
$987
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2911:47 am -
2 stops38h 05m
Sat 10/310:45 pm -
2 stops44h 59m
Deal found 9/13![United Airlines logo]()
$928
This United deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:35 am -
2 stops32h 00m
Wed 10/216:30 pm -
2 stops29h 00m
Deal found 9/14![Multiple Airlines logo]()
$918
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/131:12 am -
1 stop25h 28m
Wed 10/218:21 pm -
1 stop23h 23m
Deal found 9/14![Copa Airlines logo]()
$983
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/151:12 am -
1 stop25h 28m
Sun 11/17:36 pm -
1 stop23h 02m
Deal found 9/14![Copa Airlines logo]()
$1,009
This United deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:35 am -
2 stops23h 12m
Sun 11/111:20 pm -
2 stops24h 17m
Deal found 9/14![Multiple Airlines logo]()
$1,084
One-way flights from Santa Cruz de la Sierra to San FranciscoSearch for one-way flight options from Santa Cruz de la Sierra to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Santa Cruz de la Sierra to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:30 am -
3 stops43h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$1,047
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/38:00 pm -
3 stops49h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$1,090
This oojo deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/411:53 am -
1 stop33h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Copa Airlines logo]()
$1,293
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/21:14 am -
1 stop20h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Copa Airlines logo]()
$1,721
Find flight deals from Santa Cruz de la Sierra to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $918 (United) |
Popular in | June |
Cheapest in | October |
Average price | $900 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Cruz de la Sierra to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Tue 9/29
11:47 am-10:52 pm
2 stops38h 05m
San Francisco
Sat 10/3
10:45 pm-10:44 pm
2 stops44h 59m
$928
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Tue 10/13
1:12 am-11:40 pm
1 stop25h 28m
San Francisco
Wed 10/21
8:21 pm-10:44 pm
1 stop23h 23m
$983
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Thu 10/15
3:35 am-11:47 pm
2 stops23h 12m
San Francisco
Sun 11/1
11:20 pm-3:37 am
2 stops24h 17m
$1,084
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Sun 1/3
8:00 pm-5:01 pm
3 stops49h 01m
San Francisco
Wed 12/31
12:00 am-4:00 am
Nonstop0h 00m
$1,090
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Mon 1/4
11:35 pm-9:06 am
2 stops37h 31m
San Francisco
Wed 12/31
12:00 am-4:00 am
Nonstop0h 00m
$1,176
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Wed 10/14
9:05 am-12:50 pm
3 stops30h 45m
San Francisco
Tue 10/20
2:30 am-11:20 am
3 stops29h 50m
$1,319
Quickest round-trip
Santa Cruz de la SierraSan Francisco
VVI Santa Cruz de la Sierra Viru Viru Intl - SFO San Francisco
VVISFO
Santa Cruz de la Sierra Viru Viru Intl
Sat 1/2
1:14 am-5:25 pm
1 stop20h 11m
San Francisco
Wed 12/31
12:00 am-4:00 am
Nonstop0h 00m
$1,721
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Cruz de la Sierra-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Cruz de la Sierra to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santa Cruz de la Sierra with our price prediction graph.
VVI-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Cruz de la Sierra to San Francisco
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 16, 2026.
Read reviews from past customers who have flown Copa Airlines and United Airlines from Santa Cruz de la Sierra to San Francisco. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Comfort
7.4
Crew
8.1
Entertainment
6.9
Food
6.9
Overall
7.6
Reviews
1 / 20
4.0
OkayPaul,Jun 2025
PTY - MIA
Boarding
7.8
Comfort
7.4
Crew
8.1
Entertainment
6.9
Food
6.9
Overall
7.6
Reviews
1 / 20
4.0
OkayPaul,Jun 2025
PTY - MIA
Boarding
7.8
Comfort
7.4
Crew
8.1
Entertainment
6.9
Food
6.9
Overall
7.6
Reviews
1 / 20
4.0
OkayPaul,Jun 2025
PTY - MIA
Related info for your journey
Find useful and relevant information for your journey from Santa Cruz de la Sierra to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
San Bruno
Burlingame
Rancho Cordova
Roseville
Fairfield
Hayward
Cupertino
Newark
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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Alternative routes for Santa Cruz de la Sierra to San Francisco
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Complete your trip
Complete your trip to San Francisco by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Santa Cruz de la Sierra to San Francisco by cabin class
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Santa Cruz de la Sierra and San Francisco flights
Browse other Santa Cruz de la Sierra and San Francisco flight options. Last updated on September 16, 2026.
Popular flight searches
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Other flights to San Francisco
Explore flights to San Francisco departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Top 2 airlines flying from Santa Cruz de la Sierra to San Francisco
Discover the top 2 airlines that operate flights from Santa Cruz de la Sierra to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$299 | Average$837 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$455 | Average$1,205 | FlexibilityNo cancel fee | On-time70% |