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$320+ Cheap flights from San Francisco (SFO) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Cheapflights Tip: The best prices from San Francisco to Santiago Arturo Merino Benitez are usually found in August or May, booked 20 days in advance, depart on a Wednesday or Monday and return on a Saturday

Cheap flight deals from San Francisco to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 3, 2025.

Round-trip from

$581
(Justfly.com)

One-way from

$320
(Copa Airlines)

Popular in

December

Cheapest in

August

Average price

$892
From San Francisco to Santiago Arturo Merino Benitez
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One-way flight from San Francisco to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 14% potential increase in price ($136 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($45 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from San Francisco to Santiago

Cheapest flights from San Francisco to Santiago
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This Justfly.com deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:55 amSFO - SCL
2 stops20h 30mLATAM Airlines
Tue 9/2311:05 pmSCL - SFO
1 stop14h 53mLATAM Airlines
Deal found 7/3$581
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/85:55 amSFO - SCL
2 stops19h 50mDelta
Tue 9/239:40 pmSCL - SFO
1 stop20h 46mDelta
Deal found 7/3$615
This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/91:30 amSFO - SCL
1 stop14h 50mCopa Airlines
Wed 9/245:22 amSCL - SFO
1 stop22h 17mCopa Airlines
Deal found 7/2$629
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/101:30 amSFO - SCL
1 stop14h 54mMultiple Airlines
Thu 8/286:10 amSCL - SFO
2 stops19h 35mMultiple Airlines
Deal found 7/2$630
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/110:45 amSFO - SCL
2 stops17h 05mAmerican Airlines
Thu 11/1310:15 pmSCL - SFO
2 stops22h 10mAmerican Airlines
Deal found 7/2$653
This Priceline deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2112:05 amSFO - SCL
2 stops19h 25mAvianca
Fri 9/56:10 amSCL - SFO
2 stops19h 35mAvianca
Deal found 7/1$658

Cheapflights Fare Finder

Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.

Fly from

San Francisco

Fly to

Santiago

Route

Depart

Return

Price

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/15

5:55 am-6:25 am

2 stops20h 30m

Santiago Arturo Merino Benitez

Tue 9/23

11:05 pm-9:58 am

1 stop14h 53m

$581

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/8

5:55 am-6:00 am

1 stop20h 05m

Santiago Arturo Merino Benitez

Thu 9/25

9:40 pm-11:45 am

1 stop18h 05m

$615

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Tue 9/9

1:30 am-8:20 pm

1 stop14h 50m

Santiago Arturo Merino Benitez

Wed 9/24

5:22 am-11:39 pm

1 stop22h 17m

$629

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 8/10

1:30 am-7:24 pm

1 stop14h 54m

Santiago Arturo Merino Benitez

Thu 8/28

6:10 am-10:45 pm

2 stops19h 35m

$630

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sat 11/1

10:45 am-7:50 am

2 stops17h 05m

Santiago Arturo Merino Benitez

Thu 11/13

10:15 pm-3:25 pm

2 stops22h 10m

$653

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/21

12:05 am-10:30 pm

2 stops19h 25m

Santiago Arturo Merino Benitez

Fri 9/5

6:10 am-10:45 pm

2 stops19h 35m

$658

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Sun 8/17

1:30 am-11:08 pm

1 stop18h 38m

$320

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Wed 8/6

8:53 pm-1:25 pm

2 stops37h 32m

$328

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Mon 9/15

5:55 am-6:25 am

2 stops20h 30m

$341

San FranciscoSantiago

SFO - SCL

SFOSCL

San Francisco

Thu 8/14

2:20 pm-1:25 pm

2 stops20h 05m

$361

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/3

Showing 1-10 of 12 results
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Best time to book a flight from San Francisco to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Santiago

How far ahead should I book a flight from San Francisco to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Santiago. Price data was last updated on June 27, 2025.

Booking 20 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Francisco to Santiago?

Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SCL?

Find hourly flight availability from San Francisco to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 3, 2025.

One of the essential ways to save on airfare from San Francisco to Santiago is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 18% on airfare.

What is the cheapest day to fly from San Francisco to Santiago?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to Santiago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Francisco to Santiago flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from San Francisco to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 3, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,805 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,467 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Avianca
6.7
Okay
2,363 reviews
Delta
8.0
Very good
7,982 reviews

Boarding

8.2

Entertainment

7.9

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from San Francisco to Santiago round-trip?

    Currently priced at $581, LATAM Airlines will fly you from San Francisco to Santiago and back. In addition to LATAM Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and Copa Airlines - these airlines can fly you to your destination from $615 and $629, respectively. LATAM Airlines is currently priced 30% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from San Francisco to Santiago one-way?

    $320 is the cheapest one-way deal found within the past few days, from Copa Airlines. You may also be able to find cheap deals on LATAM Airlines and Avianca, with prices starting from $350 and $361, respectively.

  • Where are the most common layover locations when flying from San Francisco to Santiago?

    Of the flights from San Francisco to Santiago that have layovers, most of them stop in Los Angeles. San Francisco to Santiago flights stop in Panama City the next most. Houston comes next as the third most popular layover location for San Francisco to Santiago flights.

  • What are some popular things to do or see while on a layover in Los Angeles?

    Hollywood Bowl, Hollywood Walk of Fame, and L.A. Live are currently the most popular points of interest in Los Angeles at the moment. Hollywood Bowl, Hollywood Walk of Fame and L.A. Live are located about 12.5 mi, 11.7 mi, and 10.8 mi, respectively from Los Angeles if you are interested in checking them out. Travelers in need of a car in Los Angeles can rent one for about $41 per day.

  • What are some popular points of interest to see during a layover in Panama City?

    The majority of Panama City visitors spend their time at Panama Old Cathedral, Amador Causeway, and Panama Canal. Those on a layover in Panama City interested in visiting Panama Old Cathedral, Amador Causeway, or Panama Canal can do so by traveling 13.2 mi, 14.7 mi, and 15.1 mi, respectively from Panama City Tocumen Intl. Those looking to explore during their layover in Panama City can rent a car from Panama City Tocumen Intl for about $12 per day.

  • What are points of interest worth seeing during a layover in Houston?

    Most Houston visitors opt to spend their time at Space Center Houston, House of Blues Houston, and Revention Music Center. Space Center Houston, House of Blues Houston, and Revention Music Center can be accessed by traveling approximately 33.5 mi, 16.1 mi, and 15.5 mi, respectively from Houston George Bush Intcntl. Travelers can book a car rental at Houston George Bush Intcntl for about $37 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Francisco to Santiago flights?

    The least popular layover on flights from San Francisco to Santiago is Dallas. Atlanta is the second least popular location for layovers on flights from San Francisco to Santiago.

  • Can I find deals for flights from San Francisco to Santiago that include hotel bookings?

    Yes. In addition to deals on San Francisco to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Santiago.

  • Can I find deals for business class flights from San Francisco to Santiago?

    Yes. Cheapflights offers flight deals from San Francisco to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Santiago?

    Currently, April is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $752). Flying from San Francisco to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 7 airlines flying from San Francisco to Santiago

Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$508Average$659FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$534Average$732FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$622Average$848FlexibilityNo cancel feeOn-time69%
DeltaCheapest$642Average$824FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$655Average$889FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$657Average$922FlexibilityNo cancel feeOn-time71%
AeromexicoCheapest$758Average$992FlexibilityNo cancel feeOn-timeN/A

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