$326+ Cheap flights from San Francisco (SFO) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Sep 4 — Sep 111
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Santiago with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santiago
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Best
Last-minute
One-way
Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 5, 2026.
This FlightHub deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops18h 35m
Sat 11/218:40 am -
2 stops18h 44m
Deal found 8/4![LATAM Airlines logo]()
$695
This FlightHub deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:00 am -
2 stops17h 55m
Tue 12/18:30 pm -
2 stops19h 31m
Deal found 8/2![LATAM Airlines logo]()
$696
This Copa Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/87:36 pm -
1 stop29h 10m
Mon 11/163:48 am -
1 stop18h 37m
Deal found 8/5![Copa Airlines logo]()
$706
This Justfly.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:54 am -
1 stop14h 41m
Sat 11/79:50 pm -
2 stops18h 15m
Deal found 8/3![LATAM Airlines logo]()
$707
This FlightHub deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:55 am -
1 stop14h 40m
Sat 12/1211:55 pm -
1 stop16h 06m
Deal found 8/4![LATAM Airlines logo]()
$726
This Copa Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:36 pm -
1 stop23h 00m
Fri 11/203:19 am -
1 stop24h 53m
Deal found 8/4![Copa Airlines logo]()
$729
Best flights from San Francisco to SantiagoDiscover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 5, 2026.
This Copa Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:33 am -
1 stop18h 46m
Mon 11/303:19 am -
1 stop19h 06m
Deal found 8/1![Copa Airlines logo]()
$771
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:59 pm -
1 stop27h 51m
Sun 12/610:45 pm -
1 stop37h 35m
Deal found 7/31![United Airlines logo]()
$775
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:59 pm -
2 stops26h 56m
Wed 12/211:55 pm -
1 stop16h 06m
Deal found 8/5![Delta logo]()
$785
This Copa Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:36 pm -
1 stop23h 00m
Tue 12/112:20 pm -
1 stop34h 05m
Deal found 8/3![Copa Airlines logo]()
$773
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/311:59 pm -
1 stop27h 51m
Fri 2/1210:45 pm -
1 stop16h 57m
Deal found 8/2![United Airlines logo]()
$777
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/111:59 pm -
1 stop25h 41m
Tue 12/1511:10 pm -
1 stop23h 01m
Deal found 8/5![Delta logo]()
$785
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:00 pm -
1 stop26h 50m
Tue 12/111:10 pm -
1 stop18h 29m
Deal found 8/3![Delta logo]()
$785
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:35 pm -
1 stop33h 15m
Fri 11/2010:45 pm -
1 stop16h 05m
Deal found 8/4![United Airlines logo]()
$797
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/97:00 am -
2 stops19h 40m
Sat 1/237:30 am -
2 stops21h 27m
Deal found 8/4![Delta logo]()
$840
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/274:59 pm -
2 stops21h 26m
Sat 10/1011:55 pm -
1 stop15h 10m
Deal found 8/4![Delta logo]()
$846
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:30 am -
1 stop16h 05m
Thu 10/18:55 pm -
2 stops25h 22m
Deal found 8/1![Delta logo]()
$855
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:12 pm -
2 stops23h 43m
Wed 9/238:50 am -
2 stops17h 31m
Deal found 8/3![Delta logo]()
$885
Last-minute flights from San Francisco to SantiagoDiscover last-minute flight deals from San Francisco to Santiago. Data last updated August 5, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santiago. Data last updated August 5, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/229:30 am -
1 stop17h 05m
Sun 9/1311:55 pm -
1 stop17h 30m
Deal found 8/1![LATAM Airlines logo]()
$795
This FlightHub deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:30 am -
1 stop17h 05m
Sun 9/611:55 pm -
1 stop14h 57m
Deal found 7/31![LATAM Airlines logo]()
$777
This FlightHub deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:30 am -
1 stop17h 05m
Wed 9/1611:55 pm -
1 stop19h 59m
Deal found 8/5![LATAM Airlines logo]()
$794
This Justfly.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am -
2 stops19h 55m
Wed 9/306:40 am -
2 stops19h 41m
Deal found 7/31![LATAM Airlines logo]()
$800
This Justfly.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:00 am -
2 stops19h 55m
Mon 9/2111:55 pm -
1 stop14h 58m
Deal found 8/3![LATAM Airlines logo]()
$799
This FlightHub deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:20 am -
2 stops18h 15m
Mon 9/2811:55 pm -
2 stops19h 54m
Deal found 8/4![LATAM Airlines logo]()
$781
This Bravofly deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Bravofly is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am -
2 stops20h 55m
Wed 9/237:40 am -
2 stops33h 10m
Deal found 8/1![Multiple Airlines logo]()
$784
This FlightHub deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:30 am -
1 stop16h 05m
Fri 9/257:45 pm -
2 stops21h 40m
Deal found 8/1![LATAM Airlines logo]()
$787
This FlightHub deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:30 am -
1 stop16h 05m
Sun 9/276:40 am -
2 stops21h 00m
Deal found 8/1![LATAM Airlines logo]()
$751
This Justfly.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/259:30 am -
1 stop16h 05m
Thu 10/88:55 pm -
2 stops18h 10m
Deal found 8/2![LATAM Airlines logo]()
$765
One-way flights from San Francisco to SantiagoSearch for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated August 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:00 am -
3 stops44h 35m
Deal found 8/5![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2112:07 pm -
3 stops55h 32m
Deal found 8/1![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:17 pm -
3 stops28h 18m
Deal found 8/1![Multiple Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:56 pm -
3 stops49h 54m
Deal found 8/4![Multiple Airlines logo]()
$367
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:39 pm -
3 stops32h 35m
Deal found 8/3![Multiple Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2212:29 am -
3 stops43h 57m
Deal found 8/3![Multiple Airlines logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1711:05 pm -
3 stops41h 31m
Deal found 8/4![Multiple Airlines logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:00 am -
3 stops42h 00m
Deal found 8/3![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:35 pm -
3 stops29h 15m
Deal found 8/4![Multiple Airlines logo]()
$403
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:29 am -
3 stops23h 31m
Deal found 8/3![Multiple Airlines logo]()
$416
This Air Canada deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/288:25 am -
1 stop17h 25m
Deal found 8/2![Air Canada logo]()
$422
Find flight deals from San Francisco to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $695 (FlightHub) |
One-way from | $326 (Kiwi.com) |
Popular in | May |
Cheapest in | January |
Average price | $820 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 11/12
12:33 am-12:19 am
1 stop18h 46m
Santiago Arturo Merino Benitez
Mon 11/30
3:19 am-5:25 pm
1 stop19h 06m
$771
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Wed 11/25
7:36 pm-11:36 pm
1 stop23h 00m
Santiago Arturo Merino Benitez
Tue 12/1
12:20 pm-5:25 pm
1 stop34h 05m
$773
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Wed 12/2
11:59 pm-8:50 am
1 stop27h 51m
Santiago Arturo Merino Benitez
Sun 12/6
10:45 pm-7:20 am
1 stop37h 35m
$775
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 1/3
11:59 pm-8:50 am
1 stop27h 51m
Santiago Arturo Merino Benitez
Fri 2/12
10:45 pm-10:42 am
1 stop16h 57m
$777
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Mon 11/16
10:59 pm-6:55 am
2 stops26h 56m
Santiago Arturo Merino Benitez
Wed 12/2
11:55 pm-11:01 am
1 stop16h 06m
$785
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Tue 12/1
11:59 pm-6:40 am
1 stop25h 41m
Santiago Arturo Merino Benitez
Tue 12/15
11:10 pm-5:11 pm
1 stop23h 01m
$785
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Fri 11/13
11:00 pm-6:50 am
1 stop26h 50m
Santiago Arturo Merino Benitez
Tue 12/1
11:10 pm-12:39 pm
1 stop18h 29m
$785
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 11/5
6:35 pm-8:50 am
1 stop33h 15m
Santiago Arturo Merino Benitez
Fri 11/20
10:45 pm-9:50 am
1 stop16h 05m
$797
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sat 1/9
7:00 am-7:40 am
2 stops19h 40m
Santiago Arturo Merino Benitez
Sat 1/23
7:30 am-11:57 pm
2 stops21h 27m
$840
Quickest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 9/27
4:59 pm-6:25 pm
2 stops21h 26m
Santiago Arturo Merino Benitez
Sat 10/10
11:55 pm-11:05 am
1 stop15h 10m
$846
Showing 1-10 of 23 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
SFO-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Santiago
Prices
More
How far ahead should I book a flight from San Francisco to Santiago?
Booking 40 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $669). Flying from San Francisco to Santiago in May is currently the most expensive (average of $1,066). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Santiago?
Airfare is below average for this route at the moment.
San Francisco to Santiago flights typically cost between $718 and $920 in November.The cheapest round-trip price found within the last 5 days was $695 on LATAM Airlines (Nov 3-Nov 21).
What’s the top layover airport for flights from San Francisco to Santiago?
Share of 1-stop round-trip flights from San Francisco to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Los Angeles (LAX) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Francisco to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from San Francisco to Santiago?
Average round-trip fare for 1-stop flights from San Francisco to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $483.
What’s the fastest layover option from San Francisco to Santiago?
Shortest average travel time for 1-stop one-way flights from San Francisco to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Los Angeles (LAX) have the shortest average one-way travel time for 1-stop routes: 14h 50m.
Which airport typically offers the quickest layover for flights from San Francisco to Santiago?
Average layover duration for 1-stop one-way flights from San Francisco to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Dallas (DFW) offer the fastest connection on this route, with an average layover time of 2h 15m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated August 5, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Comfort
7.8
Crew
8.5
Food
7.2
Overall
7.8
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Related info for your journey
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San Francisco and Santiago flights
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Top 7 airlines flying from San Francisco to Santiago
Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$497 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$482 | Average$1,855 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$482 | Average$913 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$494 | Average$915 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$740 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$547 | Average$930 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$594 | Average$807 | FlexibilityNo cancel fee | On-time81% |