$389+ Cheap flights from San Francisco (SFO) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Jul 24 — Jul 311
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Francisco to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
This FlightHub deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:00 am
SFO
- SCL
2 stops17h 00m
LATAM Airlines
Wed 11/48:50 pm
SCL
- SFO
2 stops20h 04m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$645
This LATAM Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/274:15 pm
SFO
- SCL
2 stops17h 50m
LATAM Airlines
Tue 11/108:50 pm
SCL
- SFO
2 stops20h 04m
LATAM Airlines
Deal found 6/22![LATAM Airlines logo]()
$673
This FlightHub deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/77:00 am
SFO
- SCL
2 stops16h 20m
LATAM Airlines
Sat 12/1211:25 pm
SCL
- SFO
1 stop17h 29m
LATAM Airlines
Deal found 6/24![LATAM Airlines logo]()
$675
This Copa Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:31 am
SFO
- SCL
1 stop14h 48m
Copa Airlines
Mon 11/91:22 am
SCL
- SFO
1 stop21h 03m
Copa Airlines
Deal found 6/22![Copa Airlines logo]()
$692
This Copa Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:36 pm
SFO
- SCL
1 stop23h 00m
Copa Airlines
Sat 11/75:07 am
SCL
- SFO
1 stop23h 05m
Copa Airlines
Deal found 6/22![Copa Airlines logo]()
$715
This Justfly.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 am
SFO
- SCL
2 stops16h 00m
LATAM Airlines
Tue 12/16:30 am
SCL
- SFO
2 stops21h 41m
LATAM Airlines
Deal found 6/23![LATAM Airlines logo]()
$718
This FlightHub deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:13 am
SFO
- SCL
1 stop19h 22m
LATAM Airlines
Fri 9/46:45 pm
SCL
- SFO
2 stops21h 41m
LATAM Airlines
Deal found 6/23![LATAM Airlines logo]()
$721
This Copa Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/251:31 am
SFO
- SCL
1 stop18h 08m
Copa Airlines
Tue 11/31:22 am
SCL
- SFO
1 stop21h 03m
Copa Airlines
Deal found 6/23![Copa Airlines logo]()
$723
This FlightHub deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/811:05 am
SFO
- SCL
2 stops22h 40m
LATAM Airlines
Mon 10/127:15 am
SCL
- SFO
2 stops19h 56m
LATAM Airlines
Deal found 6/23![LATAM Airlines logo]()
$726
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/812:12 pm
SFO
- SCL
1 stop15h 38m
American Airlines
Mon 10/129:30 pm
SCL
- SFO
1 stop25h 11m
American Airlines
Deal found 6/20![American Airlines logo]()
$727
Best flights from San Francisco to SantiagoDiscover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
This Copa Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/261:31 am
SFO
- SCL
1 stop14h 48m
Copa Airlines
Mon 11/91:22 am
SCL
- SFO
1 stop21h 03m
Copa Airlines
Deal found 6/22![Copa Airlines logo]()
$692
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 am
SFO
- SCL
2 stops18h 50m
Delta
Tue 12/111:10 pm
SCL
- SFO
1 stop16h 22m
Delta
Deal found 6/20![Delta logo]()
$740
This Avianca deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:15 pm
SFO
- SCL
2 stops21h 00m
Avianca
Mon 8/246:40 am
SCL
- SFO
2 stops18h 55m
Avianca
Deal found 6/19![Avianca logo]()
$754
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:30 am
SFO
- SCL
2 stops18h 25m
Delta
Tue 11/2411:10 pm
SCL
- SFO
1 stop17h 49m
Delta
Deal found 6/23![Delta logo]()
$740
This Copa Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:33 am
SFO
- SCL
1 stop18h 46m
Copa Airlines
Mon 11/303:19 am
SCL
- SFO
1 stop19h 06m
Copa Airlines
Deal found 6/22![Copa Airlines logo]()
$746
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am
SFO
- SCL
2 stops19h 55m
Delta
Mon 11/1611:05 pm
SCL
- SFO
2 stops23h 06m
Delta
Deal found 6/23![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:54 am
SFO
- SCL
1 stop14h 41m
Delta
Mon 8/2411:00 pm
SCL
- SFO
2 stops23h 39m
Delta
Deal found 6/19![Delta logo]()
$790
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/169:30 am
SFO
- SCL
1 stop17h 05m
Delta
Sun 8/238:40 pm
SCL
- SFO
1 stop16h 37m
Delta
Deal found 6/19![Delta logo]()
$805
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/192:36 pm
SFO
- SCL
2 stops20h 29m
Delta
Tue 9/158:40 pm
SCL
- SFO
2 stops22h 12m
Delta
Deal found 6/23![Delta logo]()
$810
Last-minute flights from San Francisco to SantiagoDiscover last-minute flight deals from San Francisco to Santiago. Data last updated June 24, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santiago. Data last updated June 24, 2026 and is based on user searches.
This oojo deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:58 pm
SFO
- SCL
1 stop33h 37m
LATAM Airlines
Tue 6/309:30 pm
SCL
- SFO
2 stops28h 55m
LATAM Airlines
Deal found 6/22![LATAM Airlines logo]()
$844
This Expedia deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3011:59 pm
SFO
- SCL
3 stops34h 26m
Multiple Airlines
Tue 8/183:20 pm
SCL
- SFO
2 stops24h 30m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$843
This Expedia deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:00 pm
SFO
- SCL
2 stops36h 35m
Multiple Airlines
Tue 8/256:40 am
SCL
- SFO
2 stops18h 55m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$845
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/128:16 pm
SFO
- SCL
1 stop23h 27m
Multiple Airlines
Thu 7/306:40 am
SCL
- SFO
2 stops20h 15m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$807
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:55 am
SFO
- SCL
2 stops30h 50m
Delta
Tue 7/2811:00 pm
SCL
- SFO
2 stops24h 06m
Delta
Deal found 6/22![Delta logo]()
$840
This FlightHub deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 am
SFO
- SCL
1 stop19h 35m
LATAM Airlines
Thu 7/307:55 pm
SCL
- SFO
2 stops20h 31m
LATAM Airlines
Deal found 6/22![LATAM Airlines logo]()
$799
This CheapOair deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 am
SFO
- SCL
1 stop19h 35m
Multiple Airlines
Wed 7/2912:30 am
SCL
- SFO
2 stops26h 25m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$808
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 am
SFO
- SCL
1 stop19h 35m
Delta
Thu 7/308:40 pm
SCL
- SFO
1 stop16h 40m
Delta
Deal found 6/22![Delta logo]()
$835
This Justfly.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2111:55 pm
SFO
- SCL
2 stops35h 20m
Avianca
Mon 7/273:20 pm
SCL
- SFO
2 stops24h 30m
Avianca
Deal found 6/19![Avianca logo]()
$794
This Avianca deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/212:30 am
SFO
- SCL
2 stops32h 45m
Avianca
Mon 8/33:20 pm
SCL
- SFO
2 stops24h 30m
Avianca
Deal found 6/23![Avianca logo]()
$832
This Avianca deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/212:15 pm
SFO
- SCL
2 stops45h 00m
Avianca
Mon 8/36:40 am
SCL
- SFO
2 stops44h 15m
Avianca
Deal found 6/23![Avianca logo]()
$842
One-way flights from San Francisco to SantiagoSearch for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:42 am
SFO
- SCL
3 stops36h 14m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:40 pm
SFO
- SCL
3 stops30h 36m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:05 pm
SFO
- SCL
3 stops51h 09m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:00 pm
SFO
- SCL
3 stops49h 50m
Multiple Airlines
Deal found 6/20![Multiple Airlines logo]()
$416
This FlightHub deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:15 pm
SFO
- SCL
2 stops19h 45m
LATAM Airlines
Deal found 6/23![LATAM Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:30 pm
SFO
- SCL
3 stops30h 40m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$423
This Orbitz deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/278:30 am
SFO
- SCL
1 stop21h 45m
Air Canada
Deal found 6/20![Air Canada logo]()
$427
This Justfly.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:50 am
SFO
- SCL
2 stops18h 00m
LATAM Airlines
Deal found 6/19![LATAM Airlines logo]()
$435
This oojo deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
SFO
- SCL
1 stop20h 35m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$452
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:17 pm
SFO
- SCL
3 stops46h 48m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$453
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/259:39 pm
SFO
- SCL
3 stops46h 04m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$456
This Atrapalo deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Atrapalo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:00 am
SFO
- SCL
2 stops18h 50m
LATAM Airlines
Deal found 6/21![LATAM Airlines logo]()
$457
Find flight deals from San Francisco to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $735 (LATAM Airlines) |
One-way from | $389 (Kiwi.com) |
Popular in | May |
Cheapest in | January |
Average price | $837 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 10/26
1:31 am-8:19 pm
1 stop14h 48m
Santiago Arturo Merino Benitez
Mon 11/9
1:22 am-5:25 pm
1 stop21h 03m
$692
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Fri 11/13
7:00 am-6:50 am
2 stops18h 50m
Santiago Arturo Merino Benitez
Tue 12/1
11:10 pm-10:32 am
1 stop16h 22m
$740
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Thu 11/12
7:30 am-6:55 am
2 stops18h 25m
Santiago Arturo Merino Benitez
Tue 11/24
11:10 pm-11:59 am
1 stop17h 49m
$740
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Fri 10/23
7:00 am-6:55 am
2 stops19h 55m
Santiago Arturo Merino Benitez
Mon 11/16
11:05 pm-5:11 pm
2 stops23h 06m
$740
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Thu 11/12
12:33 am-12:19 am
1 stop18h 46m
Santiago Arturo Merino Benitez
Mon 11/30
3:19 am-5:25 pm
1 stop19h 06m
$746
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 8/10
2:15 pm-2:15 pm
2 stops21h 00m
Santiago Arturo Merino Benitez
Mon 8/24
6:40 am-10:35 pm
2 stops18h 55m
$754
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 8/10
11:54 am-5:35 am
1 stop14h 41m
Santiago Arturo Merino Benitez
Mon 8/24
11:00 pm-7:39 pm
2 stops23h 39m
$790
Quickest round-trip
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sun 8/16
9:30 am-5:35 am
1 stop17h 05m
Santiago Arturo Merino Benitez
Sun 8/23
8:40 pm-10:17 am
1 stop16h 37m
$805
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Wed 8/19
2:36 pm-2:05 pm
2 stops20h 29m
Santiago Arturo Merino Benitez
Tue 9/15
8:40 pm-2:52 pm
2 stops22h 12m
$810
Cheapest one-way
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 7/14
6:00 am-5:35 am
1 stop20h 35m
$452
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
SFO-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Santiago
Prices
More
How far ahead should I book a flight from San Francisco to Santiago?
Booking 22 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $665). Flying from San Francisco to Santiago in May is currently the most expensive (average of $1,065). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Santiago?
What’s the top layover airport for flights from San Francisco to Santiago?
Share of 1-stop round-trip flights from San Francisco to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Los Angeles (LAX) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Francisco to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from San Francisco to Santiago?
Average round-trip fare for 1-stop flights from San Francisco to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $483.
What’s the fastest layover option from San Francisco to Santiago?
Shortest average travel time for 1-stop one-way flights from San Francisco to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Los Angeles (LAX) have the shortest average one-way travel time for 1-stop routes: 14h 50m.
Which airport typically offers the quickest layover for flights from San Francisco to Santiago?
Average layover duration for 1-stop one-way flights from San Francisco to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Dallas (DFW) offer the fastest connection on this route, with an average layover time of 2h 15m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 24, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Entertainment
7.8
Comfort
7.8
Overall
7.8
Crew
8.5
Boarding
8.1
Food
7.2
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from San Francisco
Popular flights
Santiago flight routes
Alternative routes for San Francisco to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Francisco to Santiago by cabin class
Find flights from San Francisco to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Francisco and Santiago flights
Browse other San Francisco and Santiago flight options. Last updated on June 24, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on June 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 24, 2026.
Top 7 airlines flying from San Francisco to Santiago
Discover the top 7 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$556 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$470 | Average$856 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$494 | Average$736 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$494 | Average$910 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$583 | Average$821 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$593 | Average$901 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$782 | Average$1,266 | FlexibilityNo cancel fee | On-timeN/A |