$394+ Cheap flights from San Francisco (SFO) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — SCL
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Santiago
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Best
Last-minute
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Cheapest flights from San Francisco to SantiagoExplore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from San Francisco to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This Mytrip deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/210:17 pm -
3 stops24h 18m
Sat 11/79:25 am -
3 stops30h 52m
Deal found 9/20![Multiple Airlines logo]()
$790
This Justfly.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:59 am -
1 stop14h 36m
Sat 12/1211:55 pm -
1 stop15h 59m
Deal found 9/19![LATAM Airlines logo]()
$810
This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:59 am -
1 stop14h 36m
Thu 12/1011:55 pm -
1 stop19h 03m
Deal found 9/17![LATAM Airlines logo]()
$829
This FlightHub deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
2 stops19h 35m
Tue 10/1311:55 pm -
2 stops21h 07m
Deal found 9/18![LATAM Airlines logo]()
$841
This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:05 am -
2 stops17h 15m
Tue 12/88:25 pm -
2 stops19h 29m
Deal found 9/17![LATAM Airlines logo]()
$849
This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:00 am -
2 stops18h 00m
Tue 12/19:45 am -
2 stops19h 10m
Deal found 9/17![LATAM Airlines logo]()
$854
This Justfly.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:10 am -
1 stop18h 25m
Sat 11/77:40 am -
2 stops19h 35m
Deal found 9/22![LATAM Airlines logo]()
$856
This Justfly.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am -
2 stops19h 00m
Wed 11/411:55 pm -
1 stop18h 50m
Deal found 9/17![LATAM Airlines logo]()
$861
This LATAM Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/249:55 am -
1 stop14h 40m
Thu 12/311:55 pm -
1 stop15h 59m
Deal found 9/17![LATAM Airlines logo]()
$864
Best flights from San Francisco to SantiagoDiscover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from San Francisco to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/35:00 am -
1 stop22h 50m
Fri 2/1210:45 pm -
1 stop37h 35m
Deal found 9/17![United Airlines logo]()
$840
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/212:40 am -
1 stop22h 06m
Thu 2/111:17 am -
1 stop21h 08m
Deal found 9/21![Copa Airlines logo]()
$843
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/157:00 am -
1 stop18h 55m
Mon 3/19:50 pm -
1 stop19h 55m
Deal found 9/18![Delta logo]()
$855
This LATAM Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/210:30 pm -
3 stops32h 11m
Sun 3/141:40 pm -
2 stops25h 24m
Deal found 9/18![Multiple Airlines logo]()
$922
This Copa Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/412:40 am -
1 stop22h 06m
Wed 2/1012:26 pm -
1 stop33h 59m
Deal found 9/19![Copa Airlines logo]()
$843
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/95:00 am -
1 stop22h 50m
Sun 2/2110:45 pm -
1 stop25h 02m
Deal found 9/21![United Airlines logo]()
$855
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:00 am -
2 stops19h 40m
Wed 2/1011:10 pm -
2 stops19h 19m
Deal found 9/20![Delta logo]()
$860
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:36 pm -
1 stop23h 04m
Fri 1/151:32 am -
1 stop20h 53m
Deal found 9/21![Copa Airlines logo]()
$843
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
2 stops20h 30m
Tue 12/19:45 am -
2 stops19h 10m
Deal found 9/17![Delta logo]()
$930
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:33 am -
1 stop18h 45m
Mon 12/73:19 am -
1 stop19h 06m
Deal found 9/21![Copa Airlines logo]()
$913
Last-minute flights from San Francisco to SantiagoDiscover last-minute flight deals from San Francisco to Santiago. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Santiago. Data last updated September 22, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:00 am -
2 stops19h 35m
Tue 10/1311:55 pm -
2 stops21h 07m
Deal found 9/18![LATAM Airlines logo]()
$841
This Justfly.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:10 am -
1 stop18h 25m
Sat 11/77:40 am -
2 stops19h 35m
Deal found 9/22![LATAM Airlines logo]()
$856
This Mytrip deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
3 stops36h 36m
Sat 11/79:25 am -
3 stops30h 52m
Deal found 9/22![Multiple Airlines logo]()
$910
This Avianca deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:55 pm -
2 stops20h 25m
Sat 11/77:30 am -
2 stops20h 25m
Deal found 9/17![Avianca logo]()
$933
This Justfly.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2612:05 pm -
1 stop13h 30m
Wed 11/49:55 pm -
2 stops18h 01m
Deal found 9/21![LATAM Airlines logo]()
$868
This FlightHub deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:10 am -
2 stops19h 45m
Tue 11/108:40 am -
2 stops18h 47m
Deal found 9/21![LATAM Airlines logo]()
$876
This Despegar deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Despegar is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:10 am -
2 stops19h 45m
Mon 11/911:55 pm -
1 stop15h 54m
Deal found 9/18![LATAM Airlines logo]()
$908
This Justfly.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am -
2 stops19h 00m
Wed 11/411:55 pm -
1 stop18h 50m
Deal found 9/17![LATAM Airlines logo]()
$861
One-way flights from San Francisco to SantiagoSearch for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from San Francisco to Santiago. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:17 pm -
3 stops25h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$394
This Mytrip deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:17 pm -
3 stops24h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:14 pm -
3 stops46h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$419
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:52 pm -
3 stops49h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:02 am -
3 stops43h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1410:17 pm -
3 stops43h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$429
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1810:14 pm -
3 stops46h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Multiple Airlines logo]()
$435
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:02 am -
3 stops35h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$436
Find flight deals from San Francisco to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 22, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $786 (Justfly.com) |
One-way from | $394 (Kiwi.com) |
Popular in | May |
Cheapest in | January |
Average price | $802 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from San Francisco to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Mon 11/16
4:57 pm-5:35 am
2 stops31h 38m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$435
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 3/18
4:15 pm-9:50 pm
2 stops25h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$496
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 1/28
1:00 pm-3:00 pm
2 stops21h 00m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$496
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 2/4
4:15 pm-6:00 pm
2 stops20h 45m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$518
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Thu 12/31
6:25 am-5:20 am
2 stops17h 55m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$538
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Wed 2/24
11:27 am-9:15 pm
2 stops28h 48m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$538
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 10/4
8:21 pm-3:56 am
1 stop27h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$540
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 10/18
1:12 am-11:39 pm
1 stop18h 27m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$540
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Sun 10/18
8:21 pm-6:10 am
1 stop29h 49m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$540
Quickest round-trip
San FranciscoSantiago
SFO San Francisco - SCL Santiago Arturo Merino Benitez
SFOSCL
San Francisco
Wed 9/30
11:33 am-8:15 am
1 stop16h 42m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-7:00 pm
Nonstop0h 00m
$543
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Santiago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*1 star | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on San Francisco-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from San Francisco-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from San Francisco with our price prediction graph.
SFO-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Santiago
Prices
More
How far ahead should I book a flight from San Francisco to Santiago?
Booking 40 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Francisco to Santiago. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Francisco to Santiago?
Currently, January is the cheapest month in which you can book a flight from San Francisco to Santiago (average of $667). Flying from San Francisco to Santiago in May is currently the most expensive (average of $1,062). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Santiago?
Airfare is typical for this route at the moment.
San Francisco to Santiago flights typically cost between $652 and $930 in February.The cheapest round-trip price found within the last 5 days was $786 on LATAM Airlines (Feb 4-Feb 21).
What’s the top layover airport for flights from San Francisco to Santiago?
Share of 1-stop round-trip flights from San Francisco to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Los Angeles (LAX) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Francisco to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from San Francisco to Santiago?
Average round-trip fare for 1-stop flights from San Francisco to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $483.
What’s the fastest layover option from San Francisco to Santiago?
Shortest average travel time for 1-stop one-way flights from San Francisco to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Los Angeles (LAX) have the shortest average one-way travel time for 1-stop routes: 14h 50m.
Which airport typically offers the quickest layover for flights from San Francisco to Santiago?
Average layover duration for 1-stop one-way flights from San Francisco to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Dallas (DFW) offer the fastest connection on this route, with an average layover time of 2h 15m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 22, 2026.
Peruse reviews from past customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Francisco to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Food
7.2
Comfort
7.8
Entertainment
7.8
Crew
8.5
Overall
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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San Francisco and Santiago flights
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Top 8 airlines flying from San Francisco to Santiago
Discover the top 8 airlines that operate flights from San Francisco to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$290 | Average$582 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$482 | Average$2,124 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$482 | Average$977 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$494 | Average$927 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$494 | Average$749 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$593 | Average$973 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$594 | Average$830 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$919 | Average$1,298 | FlexibilityNo cancel fee | On-timeN/A |