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$293+ Cheap flights from Santiago (SCL) to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — SFO
Dec 10 — Dec 171
Wed 12/10
Wed 12/17
1 adult, Economy
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Cheapflights Tip: The best prices from Santiago Arturo Merino Benitez to San Francisco are usually found in October or September, booked 76 days in advance, depart on a Saturday or Thursday and return on a Wednesday

Find flight deals from Santiago to San Francisco

Cheapest flights from Santiago to San Francisco
Explore the most affordable flight options available from Santiago to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2025.

This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2611:15 pmSCL - SFO
1 stop19h 05mAmerican Airlines
Wed 12/310:16 amSFO - SCL
1 stop16h 29mAmerican Airlines
Deal found 11/8$504
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1811:10 pmSCL - SFO
1 stop18h 20mDelta
Tue 1/276:00 amSFO - SCL
1 stop20h 40mDelta
Deal found 11/9$535
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:15 pmSCL - SFO
2 stops18h 05mAmerican Airlines
Mon 1/2610:11 amSFO - SCL
2 stops17h 49mAmerican Airlines
Deal found 11/9$538
This LATAM Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:40 amSCL - SFO
2 stops22h 40mLATAM Airlines
Wed 1/711:46 amSFO - SCL
1 stop14h 54mLATAM Airlines
Deal found 11/9$544
This LATAM Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:10 pmSCL - SFO
1 stop16h 33mLATAM Airlines
Wed 12/318:00 amSFO - SCL
3 stops25h 30mLATAM Airlines
Deal found 11/9$549
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:15 pmSCL - SFO
1 stop18h 58mAmerican Airlines
Sun 1/411:59 pmSFO - SCL
1 stop26h 46mAmerican Airlines
Deal found 11/8$553
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/610:45 pmSCL - SFO
1 stop27h 20mUnited Airlines
Thu 12/115:00 amSFO - SCL
1 stop22h 50mUnited Airlines
Deal found 11/9$555
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1011:15 pmSCL - SFO
1 stop17h 06mAmerican Airlines
Mon 1/1210:11 amSFO - SCL
1 stop17h 04mAmerican Airlines
Deal found 11/8$557
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/310:30 pmSCL - SFO
2 stops18h 51mAmerican Airlines
Wed 1/79:10 amSFO - SCL
2 stops18h 50mAmerican Airlines
Deal found 11/9$559
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1011:15 pmSCL - SFO
1 stop25h 07mAmerican Airlines
Mon 11/178:00 amSFO - SCL
1 stop20h 00mAmerican Airlines
Deal found 11/9$564

Cheap flight deals from Santiago to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 10, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$504
(American Airlines)

One-way from

$293
(Avianca)

Popular in

January

Cheapest in

October

Average price

$588
Provider with most accurate pricing for Santiago Arturo Merino Benitez-San Francisco flight deals.
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Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-San Francisco flights.
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From Santiago Arturo Merino Benitez to San Francisco
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One-way flight from Santiago Arturo Merino Benitez to San Francisco
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($106 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Santiago to San Francisco that are best for you.

Fly from

Santiago

Fly to

San Francisco

Route

Depart

Return

Price

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 12/1

10:45 pm-9:05 pm

1 stop27h 20m

San Francisco

Mon 12/29

11:59 pm-8:50 am

1 stop27h 51m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 1/28

11:10 pm-7:45 pm

1 stop25h 35m

San Francisco

Thu 3/5

6:00 am-12:50 pm

2 stops25h 50m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 12/24

10:45 pm-10:49 pm

1 stop29h 04m

San Francisco

Wed 12/31

11:15 am-8:50 am

1 stop16h 35m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 12/23

9:30 pm-12:50 pm

1 stop20h 20m

San Francisco

Tue 12/30

4:55 pm-5:25 pm

2 stops19h 30m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Wed 1/28

11:55 pm-12:39 pm

1 stop17h 44m

San Francisco

Tue 3/3

10:55 pm-7:00 am

2 stops27h 05m

$535

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 3/19

11:15 pm-5:25 pm

1 stop22h 10m

San Francisco

Mon 3/23

6:00 am-7:00 am

1 stop21h 00m

$544

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Thu 1/29

10:45 pm-5:50 pm

1 stop24h 05m

San Francisco

Sat 2/28

12:43 am-8:50 am

1 stop27h 07m

$570

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Fri 1/23

6:30 pm-10:38 am

2 stops21h 08m

San Francisco

Wed 3/11

6:00 am-5:35 am

2 stops19h 35m

$570

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Tue 1/20

9:30 pm-10:30 am

1 stop18h 00m

San Francisco

Fri 3/13

11:55 pm-5:35 am

2 stops25h 40m

$570

SantiagoSan Francisco

SCL - SFO

SCLSFO

Santiago Arturo Merino Benitez

Mon 1/26

11:10 pm-8:25 pm

1 stop26h 15m

San Francisco

Sun 3/1

7:00 am-6:55 am

1 stop18h 55m

$570

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/9

Showing 1-10 of 21 results
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Compare providers for flights from Santiago to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to San Francisco in November.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
AranGrantPrice Accuracy2 starsTrust Score*3 stars
Justfly.comPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to San Francisco

How far ahead should I book a flight from Santiago to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Santiago to San Francisco. Price data was last updated on November 7, 2025.

The price you pay for your flight from Santiago to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 76 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Santiago to San Francisco?

Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $417). Flying from Santiago to San Francisco in April is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SCL to SFO?

Find hourly flight availability from Santiago to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 10, 2025.

It’s typically best to fly out from Santiago to San Francisco in the afternoon. Doing so could potentially save you 31% on the flight price compared to flying in the evening, which is usually more expensive.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 10, 2025.
Peruse reviews from past customers who have flown with Delta, Copa Airlines, and LATAM Airlines from Santiago to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Copa Airlines
7.6
Good
1,562 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
LATAM Airlines
7.5
Good
1,872 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
American Airlines
7.2
Good
11,045 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception
Avianca
6.6
Okay
2,473 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Overall

7.9

Entertainment

7.9

Comfort

7.9

Boarding

8.1

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

TUS - LAX

Delta has consistently been the best U.S. airline for my travels and this flight was no exception

Related info for your journey

Find useful and relevant information for your journey from Santiago to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to San Francisco?

    Departing from Santiago to San Francisco will take you 25h 35m. The distance from Santiago to San Francisco is about 5918 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santiago to San Francisco round-trip?

    Currently priced at $408, Avianca will fly you from Santiago to San Francisco and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from American Airlines and Copa Airlines - these airlines can fly you to your destination from $481 and $511, respectively. Avianca is priced at 39% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Santiago to San Francisco that include hotel bookings?

    Yes. In addition to deals on Santiago to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to San Francisco.

  • Can I find deals for business class flights from Santiago to San Francisco?

    Yes. Cheapflights offers flight deals from Santiago to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Santiago to San Francisco?

    Currently, February is the cheapest month in which you can book a flight from Santiago to San Francisco (average of $417). Flying from Santiago to San Francisco in April is currently the most expensive (average of $555). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
Vallejo
Hollister
San Bruno
Foster City
Redwood City
Union City
Burlingame
Lodi
San Mateo
Vacaville
Lathrop

Browse thousands of different options on Cheapflights for your next trip

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Top 6 airlines flying from Santiago to San Francisco

Discover the top 6 airlines that operate flights from Santiago to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 10, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$408Average$714FlexibilityNo cancel feeOn-time71%
American AirlinesCheapest$481Average$891FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$511Average$626FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$518Average$711FlexibilityNo cancel feeOn-time81%
DeltaCheapest$547Average$745FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$603Average$838FlexibilityNo cancel feeOn-time69%

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