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$105+ Cheap flights from North Carolina to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — BOG
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from North Carolina to South America

Keep the following information in mind while searching for North Carolina to South America flight deals. Data was last updated September 15, 2025.

Round-trip from

$245
(Cheapflightsfares)

One-way from

$105
(CheapOair)

Popular in

January

Cheapest in

November

Average price

$559
From North Carolina to South America
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One-way flight from North Carolina to South America
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Highest demand for flights based on searches. 17% potential increase in price ($127 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from North Carolina to South America

Cheapest flights from North Carolina to South America
Explore the most affordable flight options available from North Carolina to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/63:09 pmCLT - MDE
1 stop10h 12mSpirit Airlines
Wed 10/291:16 amMDE - CLT
1 stop7h 08mSpirit Airlines
Deal found 9/14$245
This Expedia deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/303:09 pmCLT - MDE
1 stop10h 12mSpirit Airlines
Thu 11/63:11 pmMDE - CLT
1 stop9h 48mSpirit Airlines
Deal found 9/15$248
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:19 pmRDU - MDE
1 stop16h 58mCopa Airlines
Mon 10/276:24 amMDE - RDU
1 stop7h 03mCopa Airlines
Deal found 9/14$253
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/183:09 pmCLT - MDE
1 stop10h 12mSpirit Airlines
Thu 10/302:22 pmMDE - CLT
1 stop8h 06mSpirit Airlines
Deal found 9/14$259
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:49 pmCLT - MDE
1 stop7h 32mSpirit Airlines
Wed 10/291:16 amMDE - CLT
1 stop7h 08mSpirit Airlines
Deal found 9/14$260
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/183:09 pmCLT - MDE
1 stop10h 12mSpirit Airlines
Wed 10/292:22 pmMDE - CLT
1 stop8h 06mSpirit Airlines
Deal found 9/14$263
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/217:15 amRDU - MDE
1 stop7h 50mJetBlue
Wed 10/291:10 pmMDE - RDU
1 stop7h 56mJetBlue
Deal found 9/15$263
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/75:45 amCLT - MDE
1 stop12h 19mSpirit Airlines
Tue 11/116:59 pmMDE - CLT
1 stop14h 28mSpirit Airlines
Deal found 9/14$264
This JetBlue deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/288:00 amRDU - MDE
1 stop7h 05mJetBlue
Wed 10/81:30 pmMDE - RDU
1 stop7h 40mJetBlue
Deal found 9/14$265
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/35:45 amCLT - BOG
1 stop8h 25mSpirit Airlines
Mon 10/132:10 pmBOG - CLT
1 stop8h 18mSpirit Airlines
Deal found 9/15$266
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/34:19 pmRDU - MDE
1 stop16h 58mCopa Airlines
Sat 10/119:42 amMDE - RDU
1 stop27h 45mCopa Airlines
Deal found 9/14$268
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/264:21 pmRDU - MDE
1 stop19h 34mCopa Airlines
Thu 10/24:15 pmMDE - RDU
1 stop21h 12mCopa Airlines
Deal found 9/14$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from North Carolina to South America that are best for you.

Fly from

North Carolina

Fly to

South America

Route

Depart

Return

Price

CharlotteMedellín

CLT - MDE

CLTMDE

Charlotte Douglas

Wed 11/5

5:45 am-6:04 pm

1 stop12h 19m

Medellín Jose Maria Cordova Intl

Mon 11/10

6:59 pm-9:27 am

1 stop14h 28m

$245

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 9/30

8:00 am-2:05 pm

1 stop7h 05m

Medellín Jose Maria Cordova Intl

Wed 10/8

1:30 pm-10:10 pm

1 stop7h 40m

$265

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sun 9/28

8:00 am-2:05 pm

1 stop7h 05m

Medellín Jose Maria Cordova Intl

Wed 10/8

1:30 pm-10:10 pm

1 stop7h 40m

$265

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 10/21

7:15 am-2:05 pm

1 stop7h 50m

Medellín Jose Maria Cordova Intl

Wed 10/29

1:10 pm-10:06 pm

1 stop7h 56m

$265

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sat 10/18

5:24 am-8:15 pm

2 stops15h 51m

Medellín Jose Maria Cordova Intl

Tue 10/21

6:00 am-11:06 pm

2 stops16h 06m

$287

CharlotteBogotá

CLT - BOG

CLTBOG

Charlotte Douglas

Sat 11/1

5:45 am-1:15 pm

1 stop8h 30m

Bogotá El Dorado

Sun 11/2

3:10 pm-11:28 pm

1 stop8h 18m

$292

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sat 10/18

7:15 am-2:05 pm

1 stop7h 50m

Medellín Jose Maria Cordova Intl

Tue 10/21

1:30 pm-10:10 pm

1 stop7h 40m

$297

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Fri 10/24

7:45 pm-9:05 pm

2 stops26h 20m

Medellín Jose Maria Cordova Intl

Wed 10/29

9:45 am-9:54 pm

1 stop11h 09m

$307

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Sat 9/27

6:15 am-9:10 pm

2 stops15h 55m

Medellín Jose Maria Cordova Intl

Thu 10/2

9:45 am-10:14 pm

1 stop11h 29m

$307

RaleighMedellín

RDU - MDE

RDUMDE

Raleigh-Durham

Tue 9/30

6:00 am-9:10 pm

2 stops16h 10m

Medellín Jose Maria Cordova Intl

Wed 10/8

9:45 am-10:14 pm

1 stop11h 29m

$307

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results
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Best time to book a flight from North Carolina to South America

Have a flexible travel schedule? Discover the best time to fly to South America from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to South America

What is the cheapest month to book a flight from North Carolina to South America?

Currently, May is the cheapest month in which you can book a flight from North Carolina to South America (average of $359). Flying from North Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to SA?

Find hourly flight availability from North Carolina to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to South America as you normally would.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from North Carolina to South America?

    A quick flight from North Carolina to South America can take about 7h 05m. Spirit Airlines provides one of the quickest options available for as low as $265. The distance from North Carolina to South America is about 2063 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from North Carolina to South America one-way?

    The cheapest airlines for a one-way flight from North Carolina to South America are JetBlue ($105), Copa Airlines ($106), and Spirit Airlines ($116).

  • Can I find deals for flights from North Carolina to South America that include hotel bookings?

    Yes. In addition to deals on North Carolina to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to South America.

  • Can I find deals for business class flights from North Carolina to South America?

    Yes. Cheapflights offers flight deals from North Carolina to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to South America?

    Currently, May is the cheapest month in which you can book a flight from North Carolina to South America (average of $359). Flying from North Carolina to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for North Carolina to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 8 airlines flying from North Carolina to South America

Discover the top 8 airlines that operate flights from North Carolina to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$189Average$862FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$222Average$596FlexibilityNo cancel feeOn-time65%
LATAM AirlinesCheapest$225Average$720FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$246Average$527FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$288Average$891FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$311Average$774FlexibilityNo cancel feeOn-time69%
JetBlueCheapest$374Average$491FlexibilityNo cancel feeOn-time62%
GOLCheapest$481Average$774FlexibilityNo cancel feeOn-time74%

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