How long is the flight from Santiago to Knoxville?

There are many flights that can get you from Santiago to Knoxville in 14h 17m. Fly via United Airlines to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

What is the cheapest time of day to fly from SCL to TYS?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to Knoxville as you normally would.

Most accurate provider : When it comes to deals on Santiago-Knoxville flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Santiago-Knoxville flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Santiago-Knoxville flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

Can I find deals for business class flights from Santiago to Knoxville?

Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$1,506+ Cheap Flights from Santiago to Knoxville

Q: E

Most trusted provider : When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Q: Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

Q: How can I find direct flights from Santiago to Knoxville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

Q: Can I find deals for business class flights from Santiago to Knoxville?

Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.

Tue 10/279:45 pm -

1 stop14h 27m

Fri 10/303:45 pm -

1 stop15h 05m

Deal found 9/6

$1,506

Find flight deals from Santiago to Knoxville

Most accurate provider	Expedia 1 star
Most trusted provider	Expedia 3 stars
Round-trip from	$986 (United Airlines)

Provider with most accurate pricing for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flight deals.

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SCL Santiago Arturo Merino Benitez - TYS Knoxville McGhee Tyson

SCLTYS

Santiago Arturo Merino Benitez

Tue 10/27

9:45 pm-11:12 am

1 stop14h 27m

Knoxville McGhee Tyson

Fri 10/30

3:45 pm-7:50 am

1 stop15h 05m

$1,506

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Most accurate provider: When it comes to deals on Santiago-Knoxville flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Santiago-Knoxville flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Santiago-Knoxville flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.

SCL-TYS

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Related info for your journey

How long is the flight from Santiago to Knoxville?
There are many flights that can get you from Santiago to Knoxville in 14h 17m. Fly via United Airlines to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi.
Can I find deals for flights from Santiago to Knoxville that include hotel bookings?
Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to Knoxville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.
Can I find deals for business class flights from Santiago to Knoxville?
Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

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$1,506+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to Knoxville with Cheapflights

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Cheapest flights from Santiago to KnoxvilleExplore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.

Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.

Best flights from Santiago to KnoxvilleDiscover carefully curated flight deals from Santiago to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.

Discover carefully curated flight deals from Santiago to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.

Last-minute flights from Santiago to KnoxvilleDiscover last-minute flight deals from Santiago to Knoxville. Data last updated September 8, 2026 and is based on user searches.

Discover last-minute flight deals from Santiago to Knoxville. Data last updated September 8, 2026 and is based on user searches.

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Best time to book a flight from Santiago to Knoxville

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Related info for your journey

How long is the flight from Santiago to Knoxville?

Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

How can I find direct flights from Santiago to Knoxville?

Can I find deals for business class flights from Santiago to Knoxville?

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Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 8, 2026.

Best flights from Santiago to Knoxville
Discover carefully curated flight deals from Santiago to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 8, 2026.

Last-minute flights from Santiago to Knoxville
Discover last-minute flight deals from Santiago to Knoxville. Data last updated September 8, 2026 and is based on user searches.