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$472+ Cheap flights from Santiago (SCL) to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — TYS
Jul 13 — Jul 201
Mon 7/13
Mon 7/20
1 adult, Economy
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Cheap flight deals from Santiago to Knoxville

Cheapest flights from Santiago to Knoxville
Explore the most affordable flight options available from Santiago to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 13, 2026.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:50 pm
SCL
-
TYS
1 stop27h 01m
American Airlines
Tue 9/16:00 am
TYS
-
SCL
1 stop24h 25m
American Airlines
Deal found 6/10$874
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:55 pm
SCL
-
TYS
2 stops22h 49m
Delta
Thu 7/167:49 pm
TYS
-
SCL
1 stop11h 26m
Delta
Deal found 6/10$916
This Travelocity deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:50 pm
SCL
-
TYS
2 stops31h 02m
LATAM Airlines
Thu 7/167:49 pm
TYS
-
SCL
1 stop11h 26m
LATAM Airlines
Deal found 6/10$951
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:45 pm
SCL
-
TYS
2 stops38h 59m
Delta
Wed 9/26:12 pm
TYS
-
SCL
1 stop13h 03m
Delta
Deal found 6/10$953
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/99:30 pm
SCL
-
TYS
2 stops26h 22m
LATAM Airlines
Tue 7/143:54 pm
TYS
-
SCL
3 stops21h 31m
LATAM Airlines
Deal found 6/10$961
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:05 pm
SCL
-
TYS
2 stops21h 33m
Delta
Sun 11/293:55 pm
TYS
-
SCL
1 stop13h 45m
Delta
Deal found 6/11$982
This Expedia deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2612:10 am
SCL
-
TYS
1 stop12h 56m
LATAM Airlines
Sun 11/292:30 pm
TYS
-
SCL
1 stop15h 10m
LATAM Airlines
Deal found 6/11$1,016

Find flight deals from Santiago to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$874
(American Airlines)

One-way from

$472
(eDestinos)
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Knoxville McGhee Tyson flights.
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From Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
Search Deals
One-way flight from Santiago Arturo Merino Benitez to Knoxville McGhee Tyson
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 13, 2026.
Use the filters below to find and compare flights from Santiago to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

8:50 pm-11:51 pm

1 stop27h 01m

Knoxville McGhee Tyson

Tue 9/1

6:00 am-6:25 am

1 stop24h 25m

$874

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

7:55 pm-6:44 pm

2 stops22h 49m

Knoxville McGhee Tyson

Tue 7/14

11:57 am-7:15 am

1 stop19h 18m

$916

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Thu 7/9

7:55 pm-6:44 pm

2 stops22h 49m

Knoxville McGhee Tyson

Thu 7/16

7:49 pm-7:15 am

1 stop11h 26m

$916

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

6:45 pm-9:44 am

2 stops38h 59m

Knoxville McGhee Tyson

Wed 9/2

6:12 pm-7:15 am

1 stop13h 03m

$953

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Wed 11/25

12:40 am-5:18 pm

2 stops18h 38m

Knoxville McGhee Tyson

Sun 11/29

12:00 pm-6:00 am

2 stops16h 00m

$982
Quickest round-trip

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

8:40 pm-9:33 am

1 stop12h 53m

Knoxville McGhee Tyson

Mon 8/31

4:38 pm-7:15 am

1 stop14h 37m

$1,021

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Tue 8/4

8:40 pm-3:30 pm

1 stop18h 50m

Knoxville McGhee Tyson

Thu 8/6

7:41 pm-7:15 am

1 stop11h 34m

$1,292
Cheapest one-way

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

11:22 am-4:02 pm

2 stops52h 40m

$472
Quickest one-way

SantiagoKnoxville

SCL - TYS

SCLTYS

Santiago Arturo Merino Benitez

Fri 8/21

8:50 pm-7:10 pm

1 stop22h 20m

$669

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Sorted by cheapest first

Compare providers for flights from Santiago to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to Knoxville in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Santiago-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Santiago to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to Knoxville?

    There are many flights that can get you from Santiago to Knoxville in 22h 49m. Fly via American Airlines or Delta to get the fastest option. The distance between Santiago and Knoxville is about 4853 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Santiago to Knoxville that include hotel bookings?

    Yes. In addition to deals on Santiago to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to Knoxville.

  • Can I find deals for business class flights from Santiago to Knoxville?

    Yes. Cheapflights offers flight deals from Santiago to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Alternative routes for Santiago to Knoxville

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