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$731+ Cheap flights from Knoxville (TYS) to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheap flight deals from Knoxville to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 1, 2025.

Round-trip from

$731
(Kiwi.com)
From Knoxville McGhee Tyson to Santiago Arturo Merino Benitez
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Find flight deals from Knoxville to Santiago

Cheapest flights from Knoxville to Santiago
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/146:00 amTYS - SCL
2 stops37h 24mMultiple Airlines
Sun 7/209:45 amSCL - TYS
1 stop24h 26mMultiple Airlines
Deal found 6/30$731
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:32 pmTYS - SCL
1 stop13h 18mAmerican Airlines
Sun 12/1411:15 pmSCL - TYS
1 stop20h 06mAmerican Airlines
Deal found 6/30$834
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:00 pmTYS - SCL
2 stops16h 25mDelta
Sun 12/148:50 pmSCL - TYS
2 stops16h 15mDelta
Deal found 6/30$854
This LATAM Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:00 pmTYS - SCL
3 stops20h 30mLATAM Airlines
Sun 12/146:30 pmSCL - TYS
2 stops16h 41mLATAM Airlines
Deal found 6/30$858
This deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:20 pmTYS - SCL
1 stop13h 30mUnited Airlines
Sun 12/1410:45 pmSCL - TYS
1 stop16h 33mUnited Airlines
Deal found 6/30$934
This Copa Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:45 amTYS - SCL
2 stops21h 01mCopa Airlines
Thu 8/212:26 amSCL - TYS
2 stops18h 30mCopa Airlines
Deal found 6/29$1,286
This FlightHub deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/267:00 amTYS - SCL
2 stops21h 15mAvianca
Tue 9/211:55 pmSCL - TYS
2 stops22h 50mAvianca
Deal found 6/30$2,830

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.

Fly from

Knoxville

Fly to

Santiago

Route

Depart

Return

Price

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 7/14

6:00 am-7:24 pm

2 stops37h 24m

Santiago Arturo Merino Benitez

Sun 7/20

9:45 am-10:11 am

1 stop24h 26m

$731

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 12/5

4:32 pm-7:50 am

1 stop13h 18m

Santiago Arturo Merino Benitez

Sun 12/14

11:15 pm-5:21 pm

1 stop20h 06m

$834

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 12/5

12:00 pm-6:25 am

2 stops16h 25m

Santiago Arturo Merino Benitez

Sun 12/14

8:50 pm-11:05 am

2 stops16h 15m

$854

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 12/5

4:00 pm-2:30 pm

3 stops20h 30m

Santiago Arturo Merino Benitez

Sun 12/14

6:30 pm-9:11 am

2 stops16h 41m

$858

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Fri 12/5

5:20 pm-8:50 am

1 stop13h 30m

Santiago Arturo Merino Benitez

Sun 12/14

10:45 pm-1:18 pm

1 stop16h 33m

$934

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Mon 8/18

5:45 am-2:46 am

2 stops21h 01m

Santiago Arturo Merino Benitez

Thu 8/21

2:26 am-8:56 pm

2 stops18h 30m

$1,286

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/26

7:00 am-4:15 am

2 stops21h 15m

Santiago Arturo Merino Benitez

Tue 9/2

11:55 pm-10:45 pm

2 stops22h 50m

$2,830

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Best time to book a flight from Knoxville to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santiago

What is the cheapest time of day to fly from TYS to SCL?

Find hourly flight availability from Knoxville to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

It’s optimal to fly from Knoxville to Santiago in the afternoon. By choosing this option you can save up to 27% on the cost of your flight, compared to a flight in the evening.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 1, 2025.
Get a feel of what it's like to fly with Delta, LATAM Airlines, and Copa Airlines from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,974 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,805 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,465 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,858 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,974 reviews

Food

7.3

Comfort

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Santiago round-trip?

    American Airlines, at $834, was found to be the cheapest airline from Knoxville to Santiago.Alternate airlines to your destination round-trip include Delta and LATAM Airlines.

  • Can I find deals for flights from Knoxville to Santiago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santiago.

  • Can I find deals for business class flights from Knoxville to Santiago?

    Yes. Cheapflights offers flight deals from Knoxville to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Knoxville to Santiago (average of $752). Flying from Knoxville to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Blountville to Santiago flights

Top airline flying from Knoxville to Santiago

Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$692Average$931FlexibilityNo cancel feeOn-time71%

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