$375+ Cheap flights from Knoxville (TYS) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — SCL
Oct 12 — Oct 191
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Santiago
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Cheapest flights from Knoxville to SantiagoExplore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
Explore the most affordable flight options available from Knoxville to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:11 pm -
2 stops22h 08m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$889
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
2 stops24h 58m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$957
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop17h 06m
Sun 11/2911:10 pm -
1 stop16h 45m
Deal found 9/8![Delta logo]()
$1,065
This LATAM Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
2 stops16h 56m
Sun 11/2911:10 pm -
1 stop14h 18m
Deal found 9/11![LATAM Airlines logo]()
$1,085
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
2 stops19h 35m
Fri 10/3010:15 pm -
1 stop15h 54m
Deal found 9/8![American Airlines logo]()
$1,096
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop18h 51m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,097
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:35 am -
2 stops20h 00m
Tue 11/310:30 pm -
2 stops20h 12m
Deal found 9/8![American Airlines logo]()
$1,102
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop25h 35m
Wed 11/410:30 pm -
2 stops19h 59m
Deal found 9/8![American Airlines logo]()
$1,113
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:45 pm -
1 stop15h 05m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,127
This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/214:42 pm -
3 stops20h 18m
Thu 12/3111:00 pm -
1 stop16h 38m
Deal found 9/11![LATAM Airlines logo]()
$1,154
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:16 pm -
2 stops17h 14m
Thu 12/3111:00 pm -
1 stop13h 11m
Deal found 9/11![Delta logo]()
$1,159
Best flights from Knoxville to SantiagoDiscover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
Discover carefully curated flight deals from Knoxville to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
2 stops24h 58m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$957
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:10 am -
2 stops22h 20m
Sun 11/298:13 am -
2 stops17h 44m
Deal found 9/9![LATAM Airlines logo]()
$1,065
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
1 stop17h 06m
Sun 11/2911:10 pm -
1 stop16h 45m
Deal found 9/8![Delta logo]()
$1,065
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:34 am -
2 stops20h 01m
Tue 11/310:30 pm -
2 stops17h 35m
Deal found 9/8![American Airlines logo]()
$1,102
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:45 pm -
1 stop15h 05m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,127
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:55 pm -
1 stop33h 45m
Mon 12/288:13 am -
2 stops17h 37m
Deal found 9/11![Delta logo]()
$1,264
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
1 stop24h 00m
Fri 10/99:30 pm -
1 stop16h 39m
Deal found 9/8![American Airlines logo]()
$1,414
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/219:00 am -
2 stops20h 30m
Tue 12/299:50 pm -
1 stop13h 41m
Deal found 9/11![Delta logo]()
$1,321
Last-minute flights from Knoxville to SantiagoDiscover last-minute flight deals from Knoxville to Santiago. Data last updated September 12, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Santiago. Data last updated September 12, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am -
2 stops22h 10m
Fri 10/98:20 am -
2 stops16h 39m
Deal found 9/10![LATAM Airlines logo]()
$1,167
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
1 stop24h 00m
Fri 10/99:30 pm -
2 stops21h 03m
Deal found 9/8![American Airlines logo]()
$1,314
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
2 stops19h 35m
Fri 10/3010:15 pm -
1 stop15h 54m
Deal found 9/8![American Airlines logo]()
$1,096
This Expedia deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:06 pm -
2 stops17h 49m
Fri 10/308:15 am -
3 stops30h 16m
Deal found 9/8![LATAM Airlines logo]()
$1,233
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:11 pm -
2 stops22h 08m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$889
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop18h 51m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,097
This Expedia deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:38 pm -
3 stops30h 02m
Tue 11/37:30 am -
2 stops16h 32m
Deal found 9/8![LATAM Airlines logo]()
$1,203
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
2 stops24h 58m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$957
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:35 am -
2 stops20h 00m
Tue 11/310:30 pm -
2 stops20h 12m
Deal found 9/8![American Airlines logo]()
$1,102
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop25h 35m
Wed 11/410:30 pm -
2 stops19h 59m
Deal found 9/8![American Airlines logo]()
$1,113
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:45 pm -
1 stop15h 05m
Wed 11/410:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,127
One-way flights from Knoxville to SantiagoSearch for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
Search for one-way flight options from Knoxville to Santiago. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:13 pm -
2 stops37h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:04 pm -
3 stops46h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:00 pm -
3 stops45h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$432
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/289:52 pm -
2 stops29h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:32 pm -
3 stops36h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$471
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:10 am -
3 stops56h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$517
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:10 am -
3 stops50h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$561
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2911:38 am -
3 stops41h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$618
Find flight deals from Knoxville to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 12, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $889 (Kiwi.com) |
One-way from | $375 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
Use the filters below to find and compare flights from Knoxville to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 10/30
1:04 pm-12:40 pm
3 stops46h 36m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$410
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Tue 12/1
11:49 am-8:50 am
1 stop19h 01m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$716
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sun 11/29
7:22 pm-7:40 am
1 stop34h 18m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$749
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Sat 11/28
7:00 am-8:50 am
1 stop23h 50m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$764
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/27
11:59 am-8:50 am
1 stop18h 51m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$764
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
12:32 pm-7:30 am
2 stops16h 58m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$786
Quickest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Thu 12/17
6:25 pm-9:00 am
1 stop12h 35m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$940
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 10/30
9:41 pm-11:39 pm
2 stops24h 58m
Santiago Arturo Merino Benitez
Tue 11/3
11:50 pm-1:58 pm
1 stop16h 08m
$957
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
7:10 am-7:30 am
2 stops22h 20m
Santiago Arturo Merino Benitez
Sun 11/29
8:13 am-11:57 pm
2 stops17h 44m
$1,065
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 11/20
12:34 pm-7:40 am
1 stop17h 06m
Santiago Arturo Merino Benitez
Sun 11/29
11:10 pm-1:55 pm
1 stop16h 45m
$1,065
Showing 1-10 of 15 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Knoxville-Santiago flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Knoxville-Santiago flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Knoxville-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Santiago flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Knoxville with our price prediction graph.
TYS-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 12, 2026.
Get a feel of what it's like to fly with Delta from Knoxville to Santiago by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Boarding
8.1
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Knoxville to Santiago
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Complete your trip
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Knoxville and Santiago flights
Browse other Knoxville and Santiago flight options. Last updated on September 12, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 12, 2026.
Top airline flying from Knoxville to Santiago
Discover the top airline that operate flights from Knoxville to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$714 | Average$1,128 | FlexibilityNo cancel fee | On-timeN/A |