What are the cheapest airlines flying from Knoxville to Santo Domingo round-trip?

Cheapflights users have booked flights from Knoxville to Santo Domingo round-trip from $435. Another airline that can offer you cheap pricing is American Airlines. Delta is currently priced 25% below the average price you’ll pay for this route.

In terms of precipitation, rainfall in Santo Domingo ranges from 1.6 - 6.7 inches per month. May is typically the wettest month, when rainfall can reach 6.7 in. February is typically the driest time to visit Santo Domingo when rainfall is around 1.6 in.

If weather is an important factor for your trip to Santo Domingo, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 75.2 F).

What is the cheapest time of day to fly from TYS to SDQ?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Santo Domingo as you normally would.

Most accurate provider : When it comes to deals on Knoxville-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santo Domingo flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Santo Domingo that include hotel bookings?

Yes. In addition to deals on Knoxville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Santo Domingo?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santo Domingo.

Can I find deals for business class flights from Knoxville to Santo Domingo?

Yes. Cheapflights offers flight deals from Knoxville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

Find Cheap Flights from Knoxville to Santo Domingo

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1. Tell us where you want to go

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Find flight deals from Knoxville to Santo Domingo

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Popular in	December
Cheapest in	June
Average price	$598

Provider with most accurate pricing for Knoxville McGhee Tyson-Santo Domingo Las Americas flight deals.

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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Santo Domingo Las Americas flights.

Search Deals

Highest demand for flights based on searches. 3% potential increase in price ($22 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).

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Average for round-trip flights in May 2026

Search Deals

Compare providers for flights from Knoxville to Santo Domingo

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santo Domingo in May.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
Ovago	Price Accuracy3 stars	Trust Score*3 stars
AranGrant	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Santo Domingo flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Knoxville with our price prediction graph.

TYS-SDQ

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santo Domingo

What is the cheapest month to book a flight from Knoxville to Santo Domingo?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Santo Domingo (average of $485). Flying from Knoxville to Santo Domingo in December is currently the most expensive (average of $702). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Santo Domingo

Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,457 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Delta

7.9

Good

8,457 reviews

Delta

7.9

Good

8,457 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

American Airlines

7.1

Good

11,669 reviews

Delta

7.9

Good

8,457 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

What are the cheapest airlines flying from Knoxville to Santo Domingo round-trip?
Cheapflights users have booked flights from Knoxville to Santo Domingo round-trip from $435. Another airline that can offer you cheap pricing is American Airlines. Delta is currently priced 25% below the average price you’ll pay for this route.
Can I find deals for flights from Knoxville to Santo Domingo that include hotel bookings?
Yes. In addition to deals on Knoxville to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Santo Domingo?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Santo Domingo.
Can I find deals for business class flights from Knoxville to Santo Domingo?
Yes. Cheapflights offers flight deals from Knoxville to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Santo Domingo?
Currently, June is the cheapest month in which you can book a flight from Knoxville to Santo Domingo (average of $485). Flying from Knoxville to Santo Domingo in December is currently the most expensive (average of $702). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 2 airlines flying from Knoxville to Santo Domingo

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$435	Average$664	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$467	Average$598	FlexibilityNo cancel fee	On-time71%

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Cheap flights from Knoxville (TYS) to Santo Domingo (SDQ)

Find cheap flights from Knoxville to Santo Domingo with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Find flight deals from Knoxville to Santo Domingo

Most accurate provider

Most trusted provider

Popular in

Cheapest in

Average price

Compare providers for flights from Knoxville to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Santo Domingo in May.

Best time to book a flight from Knoxville to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Santo Domingo

What is the cheapest month to book a flight from Knoxville to Santo Domingo?

Reviews of airlines servicing Santo Domingo

Peruse reviews from past customers who have flown with Delta and American Airlines from Knoxville to Santo Domingo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Santo Domingo round-trip?

Can I find deals for flights from Knoxville to Santo Domingo that include hotel bookings?

How can I find direct flights from Knoxville to Santo Domingo?

Can I find deals for business class flights from Knoxville to Santo Domingo?

What is the cheapest month to book a flight from Knoxville to Santo Domingo?

Traveling to a place near Santo Domingo?

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Alternative routes for Knoxville to Santo Domingo

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Complete your trip

Complete your trip to Santo Domingo by adding a car rental and/or hotel reservation to your travel itinerary.

Search flights from Knoxville to Santo Domingo by cabin class

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Knoxville and Santo Domingo flights

Browse other Knoxville and Santo Domingo flight options. Last updated on May 9, 2026.

Other flights from Knoxville

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Other flights to Santo Domingo

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Top 2 airlines flying from Knoxville to Santo Domingo

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