$261+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
mag 17 — mag 241
Round-trip
1 adult, Economy
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on aprile 17, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on aprile 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/149:40 pm
TYS
- CTG
1 stop15h 46m
Multiple Airlines
gio 5/211:31 pm
CTG
- TYS
1 stop28h 03m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$395
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/911:56 am
TYS
- CTG
1 stop25h 30m
Multiple Airlines
lun 5/111:31 pm
CTG
- TYS
2 stops19h 09m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$450
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 5/181:15 pm
TYS
- CTG
2 stops10h 45m
Multiple Airlines
mer 5/271:31 pm
CTG
- TYS
1 stop21h 42m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/36:00 am
TYS
- CTG
1 stop7h 35m
American Airlines
lun 9/142:05 pm
CTG
- TYS
1 stop8h 26m
American Airlines
Deal found 4/14![American Airlines logo]()
$582
This KAYAK deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/35:30 am
TYS
- CTG
2 stops16h 40m
LATAM Airlines
lun 9/1410:10 am
CTG
- TYS
2 stops12h 37m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$604
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 6/116:00 am
TYS
- CTG
1 stop7h 35m
American Airlines
mar 6/163:13 pm
CTG
- TYS
1 stop7h 46m
American Airlines
Deal found 4/12![American Airlines logo]()
$606
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/35:30 am
TYS
- CTG
2 stops15h 05m
Delta
lun 9/1410:10 am
CTG
- TYS
2 stops12h 37m
Delta
Deal found 4/13![Delta logo]()
$616
This BusinessClass deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/305:40 am
TYS
- CTG
2 stops18h 55m
LATAM Airlines
mar 8/410:10 am
CTG
- TYS
2 stops12h 42m
LATAM Airlines
Deal found 4/14![LATAM Airlines logo]()
$618
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/289:19 pm
TYS
- AXM
2 stops18h 31m
Multiple Airlines
gio 6/41:56 pm
AXM
- TYS
1 stop27h 41m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$654
This LATAM Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 8/117:07 am
TYS
- LIM
2 stops14h 48m
LATAM Airlines
gio 8/201:30 pm
LIM
- TYS
2 stops20h 35m
LATAM Airlines
Deal found 4/13![LATAM Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 8/510:26 am
TYS
- LIM
2 stops22h 39m
Delta
mar 8/1812:10 am
LIM
- TYS
2 stops22h 40m
Delta
Deal found 4/16![Delta logo]()
$665
This KAYAK deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 8/57:33 am
TYS
- LIM
2 stops15h 02m
LATAM Airlines
gio 8/208:55 am
LIM
- TYS
2 stops13h 52m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$690
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated aprile 17, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated aprile 17, 2026.
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/36:00 am
TYS
- CTG
1 stop9h 15m
American Airlines
lun 9/142:05 pm
CTG
- TYS
1 stop8h 26m
American Airlines
Deal found 4/16![American Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/35:30 am
TYS
- CTG
2 stops15h 05m
Delta
lun 9/1410:10 am
CTG
- TYS
2 stops12h 37m
Delta
Deal found 4/12![Delta logo]()
$616
This LATAM Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 8/255:57 pm
TYS
- LIM
1 stop12h 03m
LATAM Airlines
ven 8/2812:05 pm
LIM
- TYS
1 stop10h 42m
LATAM Airlines
Deal found 4/12![LATAM Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/77:05 am
TYS
- PEI
2 stops14h 15m
United Airlines
dom 5/105:15 am
PEI
- TYS
2 stops17h 29m
United Airlines
Deal found 4/14![United Airlines logo]()
$924
This Avianca deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/77:18 pm
TYS
- PEI
2 stops38h 52m
Avianca
dom 5/107:00 am
PEI
- TYS
2 stops26h 49m
Avianca
Deal found 4/15![Avianca logo]()
$944
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 6/116:00 am
TYS
- CTG
1 stop9h 13m
American Airlines
mar 6/163:13 pm
CTG
- TYS
2 stops18h 35m
American Airlines
Deal found 4/12![American Airlines logo]()
$611
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 7/33:54 pm
TYS
- CTG
1 stop22h 14m
Delta
mar 7/79:25 am
CTG
- TYS
2 stops13h 27m
Delta
Deal found 4/14![Delta logo]()
$634
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/236:07 pm
TYS
- CTG
2 stops19h 28m
American Airlines
sab 5/301:35 pm
CTG
- TYS
2 stops20h 13m
American Airlines
Deal found 4/12![American Airlines logo]()
$625
This KAYAK deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 9/65:57 pm
TYS
- LIM
2 stops29h 03m
LATAM Airlines
dom 9/1312:15 pm
LIM
- TYS
2 stops29h 02m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$713
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 8/57:00 am
TYS
- CTG
1 stop6h 35m
American Airlines
dom 8/93:17 pm
CTG
- TYS
1 stop27h 06m
American Airlines
Deal found 4/13![American Airlines logo]()
$639
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 9/67:07 am
TYS
- LIM
2 stops15h 28m
Delta
dom 9/1312:05 pm
LIM
- TYS
1 stop20h 06m
Delta
Deal found 4/12![Delta logo]()
$725
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/287:15 am
TYS
- PEI
2 stops41h 20m
United Airlines
gio 6/45:15 am
PEI
- TYS
2 stops16h 57m
United Airlines
Deal found 4/13![United Airlines logo]()
$998
This Gotogate deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/285:45 am
TYS
- AXM
2 stops26h 45m
Avianca
gio 6/410:15 pm
AXM
- TYS
2 stops45h 41m
Avianca
Deal found 4/13![Avianca logo]()
$1,068
This KAYAK deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 9/305:57 pm
TYS
- SCL
2 stops19h 08m
LATAM Airlines
ven 10/97:45 am
SCL
- TYS
2 stops17h 01m
LATAM Airlines
Deal found 4/12![LATAM Airlines logo]()
$997
This Delta deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 9/3010:05 am
TYS
- SCL
1 stop21h 10m
Delta
ven 10/98:40 pm
SCL
- TYS
1 stop13h 32m
Delta
Deal found 4/12![Delta logo]()
$1,005
This Expedia deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 9/305:57 pm
TYS
- SCL
2 stops22h 28m
LATAM Airlines
ven 10/912:05 am
SCL
- TYS
2 stops24h 41m
LATAM Airlines
Deal found 4/12![LATAM Airlines logo]()
$1,036
This Avianca deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/149:50 am
TYS
- IBE
2 stops30h 30m
Avianca
lun 5/187:40 am
IBE
- TYS
2 stops26h 09m
Avianca
Deal found 4/14![Avianca logo]()
$1,149
This Ovago deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 6/193:54 pm
TYS
- LPB
3 stops60h 01m
Multiple Airlines
dom 6/287:15 pm
LPB
- TYS
3 stops28h 39m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$2,590
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 5/127:00 am
TYS
- EZE
2 stops24h 00m
United Airlines
mar 5/199:00 pm
EZE
- TYS
2 stops24h 45m
United Airlines
Deal found 4/12![United Airlines logo]()
$1,251
This KAYAK deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 6/311:56 am
TYS
- GRU
2 stops16h 34m
LATAM Airlines
mer 6/108:15 am
GRU
- TYS
2 stops16h 39m
LATAM Airlines
Deal found 4/14![LATAM Airlines logo]()
$1,155
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/177:15 am
TYS
- CWB
2 stops30h 10m
United Airlines
lun 9/216:45 pm
CWB
- TYS
2 stops23h 14m
United Airlines
Deal found 4/15![United Airlines logo]()
$1,280
This KAYAK deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 5/1211:56 am
TYS
- EZE
1 stop20h 49m
LATAM Airlines
mar 5/197:35 am
EZE
- TYS
2 stops17h 21m
LATAM Airlines
Deal found 4/12![LATAM Airlines logo]()
$1,227
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 6/87:19 pm
TYS
- GRU
1 stop13h 11m
United Airlines
gio 6/119:50 pm
GRU
- TYS
2 stops24h 06m
United Airlines
Deal found 4/15![United Airlines logo]()
$1,358
This LATAM Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/174:00 pm
TYS
- CWB
2 stops24h 40m
LATAM Airlines
lun 9/2111:45 am
CWB
- TYS
2 stops31h 32m
LATAM Airlines
Deal found 4/16![LATAM Airlines logo]()
$1,242
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 8/143:25 pm
TYS
- EZE
1 stop15h 35m
United Airlines
mar 8/189:00 pm
EZE
- TYS
2 stops18h 37m
United Airlines
Deal found 4/12![United Airlines logo]()
$1,441
This Avianca deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 6/197:19 pm
TYS
- LPB
2 stops31h 01m
Avianca
sab 6/273:25 am
LPB
- TYS
2 stops31h 17m
Avianca
Deal found 4/15![Avianca logo]()
$1,870
This Ovago deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 8/107:20 pm
TYS
- GRU
1 stop33h 20m
LATAM Airlines
dom 8/1610:50 pm
GRU
- TYS
1 stop13h 15m
LATAM Airlines
Deal found 4/12![LATAM Airlines logo]()
$1,292
This United Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 5/17:18 pm
TYS
- GRU
1 stop13h 12m
United Airlines
sab 5/309:30 pm
GRU
- TYS
1 stop17h 57m
United Airlines
Deal found 4/12![United Airlines logo]()
$1,546
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 5/316:30 am
TYS
- EZE
2 stops48h 30m
United Airlines
gio 6/49:00 pm
EZE
- TYS
2 stops28h 30m
United Airlines
Deal found 4/14![United Airlines logo]()
$1,652
This Booking.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 6/2010:00 am
TYS
- LPB
3 stops28h 45m
Avianca
sab 7/43:50 pm
LPB
- TYS
3 stops18h 52m
Avianca
Deal found 4/13![Avianca logo]()
$2,300
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated aprile 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated aprile 17, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/77:05 am
TYS
- PEI
2 stops14h 15m
United Airlines
dom 5/105:15 am
PEI
- TYS
2 stops17h 29m
United Airlines
Deal found 4/14![United Airlines logo]()
$924
This Avianca deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/77:18 pm
TYS
- PEI
2 stops38h 52m
Avianca
dom 5/107:00 am
PEI
- TYS
2 stops26h 49m
Avianca
Deal found 4/15![Avianca logo]()
$944
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/911:56 am
TYS
- CTG
1 stop25h 30m
Multiple Airlines
lun 5/111:31 pm
CTG
- TYS
2 stops19h 09m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/96:30 am
TYS
- CTG
1 stop8h 34m
American Airlines
lun 5/113:10 pm
CTG
- TYS
1 stop7h 49m
American Airlines
Deal found 4/14![American Airlines logo]()
$707
This LATAM Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 5/107:27 am
TYS
- LIM
2 stops13h 53m
LATAM Airlines
dom 5/1712:05 pm
LIM
- TYS
1 stop10h 51m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$860
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/149:40 pm
TYS
- CTG
1 stop15h 46m
Multiple Airlines
gio 5/211:31 pm
CTG
- TYS
1 stop28h 03m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$395
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/146:38 pm
TYS
- CTG
2 stops18h 31m
American Airlines
gio 5/213:15 pm
CTG
- TYS
2 stops16h 19m
American Airlines
Deal found 4/14![American Airlines logo]()
$645
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 5/181:15 pm
TYS
- CTG
2 stops10h 45m
Multiple Airlines
mer 5/271:31 pm
CTG
- TYS
1 stop21h 42m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 5/186:30 am
TYS
- CTG
1 stop6h 39m
American Airlines
mer 5/271:35 pm
CTG
- TYS
1 stop9h 24m
American Airlines
Deal found 4/13![American Airlines logo]()
$725
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/236:07 pm
TYS
- CTG
2 stops21h 06m
American Airlines
sab 5/303:15 pm
CTG
- TYS
2 stops20h 27m
American Airlines
Deal found 4/14![American Airlines logo]()
$625
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/289:19 pm
TYS
- AXM
2 stops18h 31m
Multiple Airlines
gio 6/41:56 pm
AXM
- TYS
1 stop27h 41m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$654
This Ovago deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 5/2911:56 am
TYS
- LIM
1 stop10h 59m
LATAM Airlines
ven 6/512:05 pm
LIM
- TYS
1 stop10h 51m
LATAM Airlines
Deal found 4/14![LATAM Airlines logo]()
$757
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated aprile 17, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated aprile 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 7/285:00 pm
TYS
- PEI
3 stops30h 30m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 8/155:04 pm
TYS
- LPB
2 stops33h 16m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 7/258:40 pm
TYS
- PEI
3 stops26h 40m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 7/247:20 pm
TYS
- PEI
3 stops25h 45m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/309:11 pm
TYS
- PEI
3 stops33h 44m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 7/277:20 pm
TYS
- PEI
2 stops28h 00m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 7/291:05 pm
TYS
- PEI
3 stops21h 05m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 6/135:56 pm
TYS
- LIM
2 stops31h 14m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 6/208:47 pm
TYS
- LPB
2 stops29h 33m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 7/269:11 pm
TYS
- PEI
3 stops26h 09m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 6/205:56 pm
TYS
- LIM
2 stops31h 14m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 6/196:34 pm
TYS
- LPB
3 stops31h 46m
Multiple Airlines
Deal found 4/12![Multiple Airlines logo]()
$361
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated aprile 17, 2026.
Round-trip from | $395 (Kiwi.com) |
|---|---|
One-way from | $261 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated aprile 17, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
gio 9/3
6:00 am-2:15 pm
1 stop9h 15m
Cartagena Rafael Nunez
lun 9/14
2:05 pm-11:31 pm
1 stop8h 26m
$582
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
gio 6/11
6:00 am-2:13 pm
1 stop9h 13m
Cartagena Rafael Nunez
mar 6/16
3:13 pm-10:48 am
2 stops18h 35m
$611
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
gio 9/3
5:30 am-7:35 pm
2 stops15h 05m
Cartagena Rafael Nunez
lun 9/14
10:10 am-11:47 pm
2 stops12h 37m
$616
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
sab 5/23
6:07 pm-12:35 pm
2 stops19h 28m
Cartagena Rafael Nunez
sab 5/30
1:35 pm-10:48 am
2 stops20h 13m
$625
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
ven 7/3
3:54 pm-1:08 pm
1 stop22h 14m
Cartagena Rafael Nunez
mar 7/7
9:25 am-11:52 pm
2 stops13h 27m
$634
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
mer 8/5
7:00 am-12:35 pm
1 stop6h 35m
Cartagena Rafael Nunez
dom 8/9
3:17 pm-7:23 pm
1 stop27h 06m
$639
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
mar 8/25
5:57 pm-5:00 am
1 stop12h 03m
Lima J Chavez Intl
ven 8/28
12:05 pm-11:47 pm
1 stop10h 42m
$695
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
dom 9/6
5:57 pm-10:00 pm
2 stops29h 03m
Lima J Chavez Intl
dom 9/13
12:15 pm-6:17 pm
2 stops29h 02m
$713
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
dom 9/6
7:07 am-9:35 pm
2 stops15h 28m
Lima J Chavez Intl
dom 9/13
12:05 pm-9:11 am
1 stop20h 06m
$725
KnoxvillePereira
TYS - PEI
TYSPEI
Knoxville McGhee Tyson
gio 5/7
7:05 am-8:20 pm
2 stops14h 15m
Pereira Matecana
dom 5/10
5:15 am-11:44 pm
2 stops17h 29m
$924
Showing 1-10 of 47 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-LPB
TYS-LIM
TYS-PEI
TYS-GRU
TYS-CTG
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-LPB
TYS-LIM
TYS-PEI
TYS-GRU
What is the cheapest month to book a flight from Knoxville to South America?
Currently, August is the cheapest month in which you can book a flight from Knoxville to South America (average of $488). Flying from Knoxville to South America in November is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated aprile 17, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Entertainment
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Comfort
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on aprile 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated aprile 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$488 | Average$876 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$599 | Average$880 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$622 | Average$830 | FlexibilityNo cancel fee | On-time81% |