$375+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Oct 11 — Oct 181
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to South America
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/144:12 pm -
2 stops21h 23m
Sat 11/212:35 pm -
2 stops20h 39m
Deal found 9/10![American Airlines logo]()
$516
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/254:49 pm -
2 stops20h 46m
Sun 11/12:35 pm -
2 stops20h 37m
Deal found 9/10![American Airlines logo]()
$592
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
2 stops15h 40m
Wed 10/2811:40 pm -
1 stop10h 14m
Deal found 9/10![Delta logo]()
$717
This LATAM Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:09 am -
2 stops12h 16m
Sun 11/158:40 pm -
2 stops20h 42m
Deal found 9/6![LATAM Airlines logo]()
$725
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:09 am -
2 stops15h 26m
Tue 10/2712:15 am -
2 stops16h 13m
Deal found 9/10![LATAM Airlines logo]()
$726
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:23 pm -
2 stops11h 37m
Sun 11/112:10 pm -
1 stop9h 58m
Deal found 9/10![LATAM Airlines logo]()
$739
This LATAM Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:09 am -
2 stops12h 16m
Sat 11/1412:10 pm -
1 stop10h 02m
Deal found 9/8![LATAM Airlines logo]()
$743
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:09 am -
1 stop15h 46m
Sat 10/248:15 am -
2 stops13h 07m
Deal found 9/10![LATAM Airlines logo]()
$755
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:09 am -
2 stops12h 16m
Mon 11/912:10 pm -
1 stop11h 49m
Deal found 9/10![LATAM Airlines logo]()
$759
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop15h 30m
Wed 10/287:00 am -
1 stop14h 59m
Deal found 9/7![American Airlines logo]()
$764
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:46 pm -
2 stops20h 49m
Thu 10/11:35 pm -
1 stop8h 32m
Deal found 9/8![American Airlines logo]()
$796
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:19 am -
2 stops12h 41m
Wed 11/46:25 am -
2 stops11h 29m
Deal found 9/9![United Airlines logo]()
$869
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 11, 2026.
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:00 am -
1 stop7h 35m
Sat 11/214:34 pm -
1 stop7h 23m
Deal found 9/10![American Airlines logo]()
$551
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2112:06 pm -
1 stop10h 49m
Wed 10/2812:10 pm -
1 stop20h 24m
Deal found 9/10![Delta logo]()
$717
This LATAM Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:50 am -
1 stop17h 10m
Sun 11/158:40 pm -
2 stops20h 42m
Deal found 9/6![LATAM Airlines logo]()
$725
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/812:20 pm -
2 stops35h 10m
Fri 2/128:35 pm -
2 stops21h 02m
Deal found 9/9![United Airlines logo]()
$773
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:11 pm -
2 stops22h 08m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$889
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:35 pm -
2 stops22h 30m
Thu 11/1210:05 pm -
2 stops37h 25m
Deal found 9/6![Avianca logo]()
$974
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:06 pm -
2 stops19h 29m
Sun 11/12:35 pm -
1 stop9h 24m
Deal found 9/10![American Airlines logo]()
$592
This BusinessClass deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:35 pm -
2 stops23h 50m
Fri 11/2010:10 am -
2 stops30h 38m
Deal found 9/8![Copa Airlines logo]()
$1,296
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/137:54 pm -
2 stops19h 36m
Sun 2/214:30 pm -
1 stop26h 06m
Deal found 9/10![American Airlines logo]()
$604
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/710:05 am -
1 stop18h 55m
Mon 3/1512:10 pm -
1 stop20h 02m
Deal found 9/9![Delta logo]()
$750
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:09 am -
2 stops12h 16m
Mon 11/912:10 pm -
1 stop11h 49m
Deal found 9/9![LATAM Airlines logo]()
$759
This KAYAK deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:42 pm -
3 stops20h 43m
Thu 11/191:15 pm -
2 stops36h 17m
Deal found 9/10![GOL logo]()
$1,663
This Expedia deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:45 pm -
2 stops27h 45m
Sun 11/18:40 pm -
2 stops20h 58m
Deal found 9/10![LATAM Airlines logo]()
$761
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
2 stops13h 45m
Sun 11/812:15 am -
2 stops18h 12m
Deal found 9/9![Delta logo]()
$780
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:19 am -
2 stops12h 41m
Wed 11/46:25 am -
2 stops11h 29m
Deal found 9/9![United Airlines logo]()
$869
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:16 pm -
1 stop9h 59m
Sun 11/812:46 am -
1 stop19h 31m
Deal found 9/9![American Airlines logo]()
$765
This LATAM Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:09 am -
2 stops12h 16m
Sat 11/148:40 pm -
2 stops27h 19m
Deal found 9/6![LATAM Airlines logo]()
$775
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:46 pm -
2 stops20h 49m
Thu 10/11:35 pm -
1 stop8h 32m
Deal found 9/8![American Airlines logo]()
$796
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:09 am -
2 stops14h 41m
Thu 11/511:40 pm -
1 stop11h 05m
Deal found 9/9![LATAM Airlines logo]()
$800
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/68:25 am -
1 stop22h 25m
Sat 11/144:13 am -
2 stops34h 35m
Deal found 9/6![Multiple Airlines logo]()
$1,165
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop18h 51m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,097
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/204:00 pm -
1 stop13h 40m
Sun 11/2911:10 pm -
1 stop16h 45m
Deal found 9/6![Delta logo]()
$1,065
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:10 am -
1 stop35h 35m
Sun 11/83:10 am -
2 stops18h 49m
Deal found 9/7![Multiple Airlines logo]()
$1,184
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:45 pm -
1 stop15h 05m
Wed 11/410:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,127
This Avianca deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:45 am -
2 stops26h 00m
Wed 11/47:25 am -
2 stops40h 34m
Deal found 9/6![Avianca logo]()
$1,391
This LATAM Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:10 am -
2 stops22h 20m
Sat 11/2812:48 am -
2 stops25h 09m
Deal found 9/6![LATAM Airlines logo]()
$1,065
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:55 pm -
1 stop18h 25m
Mon 11/1610:25 pm -
1 stop15h 05m
Deal found 9/7![United Airlines logo]()
$1,204
This Ovago deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:43 pm -
3 stops18h 42m
Fri 11/201:15 pm -
2 stops36h 17m
Deal found 9/9![GOL logo]()
$1,742
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/223:00 pm -
1 stop17h 00m
Thu 10/2910:35 pm -
1 stop21h 53m
Deal found 9/6![American Airlines logo]()
$1,204
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/510:45 am -
2 stops18h 25m
Tue 2/910:15 pm -
1 stop14h 47m
Deal found 9/8![United Airlines logo]()
$1,234
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated September 11, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated September 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/254:46 pm -
2 stops20h 49m
Thu 10/11:35 pm -
1 stop8h 32m
Deal found 9/8![American Airlines logo]()
$796
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:09 am -
1 stop15h 46m
Sat 10/248:15 am -
2 stops13h 07m
Deal found 9/10![LATAM Airlines logo]()
$755
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
2 stops15h 40m
Wed 10/2811:40 pm -
1 stop10h 14m
Deal found 9/10![Delta logo]()
$717
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:09 am -
2 stops15h 26m
Tue 10/2712:15 am -
2 stops16h 13m
Deal found 9/10![LATAM Airlines logo]()
$726
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop15h 30m
Wed 10/287:00 am -
1 stop14h 59m
Deal found 9/7![American Airlines logo]()
$764
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:35 am -
2 stops19h 35m
Fri 10/3010:15 pm -
1 stop15h 54m
Deal found 9/8![American Airlines logo]()
$1,096
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/254:49 pm -
2 stops20h 46m
Sun 11/12:35 pm -
2 stops20h 37m
Deal found 9/10![American Airlines logo]()
$592
This LATAM Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:23 pm -
2 stops11h 37m
Sun 11/112:10 pm -
1 stop9h 58m
Deal found 9/10![LATAM Airlines logo]()
$739
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:11 pm -
2 stops22h 08m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$889
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:59 am -
1 stop18h 51m
Tue 11/310:45 pm -
1 stop21h 09m
Deal found 9/8![United Airlines logo]()
$1,097
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:41 pm -
2 stops24h 58m
Tue 11/311:50 pm -
1 stop16h 08m
Deal found 9/8![Multiple Airlines logo]()
$957
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:19 am -
2 stops12h 41m
Wed 11/46:25 am -
2 stops11h 29m
Deal found 9/9![United Airlines logo]()
$869
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated September 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3012:13 pm -
2 stops37h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:04 pm -
3 stops46h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$410
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:00 pm -
3 stops45h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$432
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/289:52 pm -
2 stops29h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:32 pm -
3 stops36h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$471
This eDestinos deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:10 am -
2 stops39h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$484
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:10 am -
3 stops56h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$517
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/214:00 pm -
1 stop13h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$521
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:01 pm -
2 stops12h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![American Airlines logo]()
$524
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:10 am -
3 stops50h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$561
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/172:55 pm -
3 stops47h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$566
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2911:38 am -
3 stops41h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/9![Multiple Airlines logo]()
$618
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated September 11, 2026.
Round-trip from | $516 (American Airlines) |
|---|---|
One-way from | $375 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Fri 10/30
1:04 pm-12:40 pm
3 stops46h 36m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$410
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 11/21
9:10 am-12:10 am
2 stops39h 00m
Lima J Chavez Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$484
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 11/21
4:00 pm-5:00 am
1 stop13h 00m
Lima J Chavez Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$521
Quickest round-trip
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 11/21
5:01 pm-5:14 am
2 stops12h 13m
Lima J Chavez Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$524
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Sat 11/14
6:00 am-1:35 pm
1 stop7h 35m
Cartagena Rafael Nunez
Sat 11/21
4:34 pm-11:57 pm
1 stop7h 23m
$551
KnoxvilleMontevideo
TYS Knoxville McGhee Tyson - MVD Montevideo Carrasco
TYSMVD
Knoxville McGhee Tyson
Wed 2/17
2:55 pm-4:25 pm
3 stops47h 30m
Montevideo Carrasco
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$566
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Sun 10/25
6:06 pm-12:35 pm
2 stops19h 29m
Cartagena Rafael Nunez
Sun 11/1
2:35 pm-11:59 pm
1 stop9h 24m
$592
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Sat 2/13
7:54 pm-3:30 pm
2 stops19h 36m
Cartagena Rafael Nunez
Sun 2/21
4:30 pm-6:36 pm
1 stop26h 06m
$604
KnoxvilleMontevideo
TYS Knoxville McGhee Tyson - MVD Montevideo Carrasco
TYSMVD
Knoxville McGhee Tyson
Wed 2/17
9:13 am-10:10 am
2 stops22h 57m
Montevideo Carrasco
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$649
KnoxvilleSantiago
TYS Knoxville McGhee Tyson - SCL Santiago Arturo Merino Benitez
TYSSCL
Knoxville McGhee Tyson
Wed 12/2
4:45 pm-8:50 am
1 stop14h 05m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$716
Showing 1-10 of 41 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-SCL
TYS-LIM
TYS-MVD
TYS-CTG
TYS-PEI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-SCL
TYS-LIM
TYS-MVD
TYS-CTG
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 11, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Overall
7.8
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on September 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$1,029 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$488 | Average$812 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$622 | Average$715 | FlexibilityNo cancel fee | On-time81% |