$310+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Aug 16 — Aug 231
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/136:05 am
TYS
- CTG
1 stop7h 30m
American Airlines
Fri 9/181:35 pm
CTG
- TYS
1 stop8h 32m
American Airlines
Deal found 7/14![American Airlines logo]()
$616
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:25 pm
TYS
- CTG
2 stops19h 50m
American Airlines
Mon 9/141:35 pm
CTG
- TYS
2 stops22h 32m
American Airlines
Deal found 7/13![American Airlines logo]()
$617
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:50 am
TYS
- CTG
1 stop6h 25m
Delta
Thu 9/172:30 pm
CTG
- TYS
1 stop8h 25m
Delta
Deal found 7/14![Delta logo]()
$622
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:06 am
TYS
- CTG
1 stop7h 29m
American Airlines
Wed 8/193:15 pm
CTG
- TYS
1 stop7h 36m
American Airlines
Deal found 7/13![American Airlines logo]()
$630
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:28 am
TYS
- CTG
2 stops14h 07m
Delta
Mon 9/145:35 am
CTG
- TYS
2 stops17h 20m
Delta
Deal found 7/14![Delta logo]()
$633
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:35 am
TYS
- CTG
1 stop8h 40m
Delta
Thu 10/12:30 pm
CTG
- TYS
1 stop8h 25m
Delta
Deal found 7/14![Delta logo]()
$634
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:00 pm
TYS
- CTG
2 stops26h 45m
Delta
Mon 9/149:35 am
CTG
- TYS
2 stops13h 20m
Delta
Deal found 7/14![Delta logo]()
$639
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:12 pm
TYS
- CTG
1 stop20h 03m
Delta
Thu 9/102:30 pm
CTG
- TYS
1 stop6h 57m
Delta
Deal found 7/14![Delta logo]()
$641
This oojo deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:55 pm
TYS
- LIM
1 stop13h 05m
LATAM Airlines
Mon 11/301:30 pm
LIM
- TYS
2 stops21h 36m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$688
This LATAM Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:06 pm
TYS
- LIM
1 stop17h 54m
LATAM Airlines
Thu 10/291:00 am
LIM
- TYS
2 stops15h 36m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$723
This LATAM Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:57 pm
TYS
- LIM
2 stops12h 03m
LATAM Airlines
Wed 11/1812:15 am
LIM
- TYS
2 stops21h 30m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$740
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:57 pm
TYS
- LIM
2 stops33h 13m
Multiple Airlines
Sat 9/512:05 pm
LIM
- TYS
1 stop20h 39m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$742
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 17, 2026.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:25 pm
TYS
- CTG
2 stops19h 50m
American Airlines
Mon 9/141:35 pm
CTG
- TYS
2 stops22h 32m
American Airlines
Deal found 7/13![American Airlines logo]()
$617
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:28 am
TYS
- CTG
2 stops14h 07m
Delta
Mon 9/144:30 am
CTG
- TYS
2 stops18h 25m
Delta
Deal found 7/15![Delta logo]()
$633
This oojo deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:55 pm
TYS
- LIM
1 stop13h 05m
LATAM Airlines
Mon 11/301:30 pm
LIM
- TYS
2 stops21h 36m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$688
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:57 pm
TYS
- LIM
2 stops33h 13m
Multiple Airlines
Sat 9/512:05 pm
LIM
- TYS
1 stop20h 39m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$742
This Avianca deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:20 pm
TYS
- PEI
2 stops21h 05m
Avianca
Fri 9/186:35 am
PEI
- TYS
2 stops26h 23m
Avianca
Deal found 7/14![Avianca logo]()
$892
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:53 am
TYS
- SCL
1 stop18h 57m
United Airlines
Mon 11/210:45 pm
SCL
- TYS
1 stop21h 03m
United Airlines
Deal found 7/16![United Airlines logo]()
$997
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:06 am
TYS
- CTG
1 stop7h 29m
American Airlines
Wed 8/193:15 pm
CTG
- TYS
1 stop7h 36m
American Airlines
Deal found 7/15![American Airlines logo]()
$630
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/287:50 am
TYS
- CTG
2 stops11h 55m
Delta
Tue 10/64:25 am
CTG
- TYS
2 stops12h 11m
Delta
Deal found 7/14![Delta logo]()
$645
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:35 am
TYS
- CTG
1 stop8h 40m
Delta
Tue 9/2210:10 am
CTG
- TYS
2 stops12h 45m
Delta
Deal found 7/14![Delta logo]()
$650
This LATAM Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:06 pm
TYS
- LIM
1 stop17h 54m
LATAM Airlines
Thu 10/291:00 am
LIM
- TYS
2 stops15h 36m
LATAM Airlines
Deal found 7/17![LATAM Airlines logo]()
$723
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/258:20 am
TYS
- GRU
1 stop19h 40m
Multiple Airlines
Tue 9/2911:10 am
GRU
- TYS
2 stops26h 51m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$758
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:45 pm
TYS
- CTG
1 stop20h 30m
Delta
Fri 9/1811:50 am
CTG
- TYS
2 stops11h 05m
Delta
Deal found 7/14![Delta logo]()
$653
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am
TYS
- LIM
1 stop17h 25m
American Airlines
Fri 11/1312:45 am
LIM
- TYS
1 stop15h 52m
American Airlines
Deal found 7/16![American Airlines logo]()
$765
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:30 am
TYS
- LIM
2 stops14h 35m
LATAM Airlines
Sat 9/51:30 pm
LIM
- TYS
2 stops19h 14m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$765
This Booking.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:45 am
TYS
- PEI
2 stops31h 20m
Avianca
Sat 10/174:20 pm
PEI
- TYS
2 stops41h 17m
Avianca
Deal found 7/14![Avianca logo]()
$925
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:30 am
TYS
- GRU
1 stop34h 10m
Multiple Airlines
Sat 9/55:00 am
GRU
- TYS
2 stops30h 04m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$971
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3110:40 am
TYS
- GRU
2 stops18h 50m
United Airlines
Mon 9/79:30 pm
GRU
- TYS
2 stops20h 28m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,108
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:40 pm
TYS
- SCL
1 stop11h 25m
American Airlines
Sun 8/308:50 pm
SCL
- TYS
2 stops19h 07m
American Airlines
Deal found 7/14![American Airlines logo]()
$1,002
This United Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:21 pm
TYS
- GRU
2 stops18h 19m
United Airlines
Tue 9/810:20 pm
GRU
- TYS
1 stop19h 38m
United Airlines
Deal found 7/17![United Airlines logo]()
$1,108
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:30 am
TYS
- GRU
1 stop34h 10m
Multiple Airlines
Thu 9/311:50 am
GRU
- TYS
2 stops35h 55m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$1,025
This oojo deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:50 am
TYS
- SCL
2 stops22h 05m
LATAM Airlines
Fri 10/98:15 am
SCL
- TYS
2 stops16h 44m
LATAM Airlines
Deal found 7/13![LATAM Airlines logo]()
$1,047
This United Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:45 am
TYS
- EZE
2 stops21h 15m
United Airlines
Wed 10/149:00 pm
EZE
- TYS
2 stops27h 59m
United Airlines
Deal found 7/16![United Airlines logo]()
$1,127
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/271:56 pm
TYS
- GRU
2 stops16h 19m
American Airlines
Thu 9/311:15 pm
GRU
- TYS
2 stops19h 19m
American Airlines
Deal found 7/13![American Airlines logo]()
$1,087
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:38 pm
TYS
- SCL
1 stop14h 37m
Delta
Mon 8/106:45 pm
SCL
- TYS
2 stops18h 49m
Delta
Deal found 7/15![Delta logo]()
$1,087
This LATAM Airlines deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:25 pm
TYS
- EZE
2 stops21h 56m
Multiple Airlines
Fri 10/237:35 am
EZE
- TYS
2 stops17h 24m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$1,188
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:38 pm
TYS
- SCL
1 stop14h 37m
Delta
Tue 8/118:40 pm
SCL
- TYS
1 stop14h 31m
Delta
Deal found 7/15![Delta logo]()
$1,087
This American Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:08 pm
TYS
- EZE
1 stop18h 22m
American Airlines
Wed 12/910:50 pm
EZE
- TYS
1 stop19h 43m
American Airlines
Deal found 7/15![American Airlines logo]()
$1,148
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:15 am
TYS
- PEI
2 stops14h 09m
United Airlines
Fri 9/185:15 am
PEI
- TYS
2 stops32h 22m
United Airlines
Deal found 7/13![United Airlines logo]()
$1,278
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:12 pm
TYS
- SCL
1 stop13h 03m
Delta
Tue 8/118:40 pm
SCL
- TYS
1 stop16h 54m
Delta
Deal found 7/15![Delta logo]()
$1,087
This Viajes Falabella deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Viajes Falabella is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:31 pm
TYS
- PEI
2 stops9h 59m
LATAM Airlines
Sat 10/173:30 pm
PEI
- TYS
3 stops31h 29m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$1,411
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated July 17, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated July 17, 2026 and is based on user searches.
This eDestinos deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:19 pm
TYS
- LIM
3 stops33h 42m
Multiple Airlines
Wed 7/2912:05 pm
LIM
- TYS
1 stop10h 47m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:00 am
TYS
- LIM
1 stop17h 25m
American Airlines
Wed 7/296:30 am
LIM
- TYS
1 stop16h 29m
American Airlines
Deal found 7/14![American Airlines logo]()
$983
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:40 am
TYS
- LIM
1 stop17h 15m
Delta
Wed 7/2912:05 pm
LIM
- TYS
1 stop10h 47m
Delta
Deal found 7/13![Delta logo]()
$1,001
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:06 am
TYS
- CTG
1 stop7h 29m
American Airlines
Wed 8/193:15 pm
CTG
- TYS
1 stop7h 36m
American Airlines
Deal found 7/13![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:15 am
TYS
- SCL
2 stops19h 50m
American Airlines
Sun 8/308:50 pm
SCL
- TYS
2 stops16h 41m
American Airlines
Deal found 7/14![American Airlines logo]()
$1,002
This oojo deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:30 am
TYS
- LIM
1 stop22h 30m
LATAM Airlines
Mon 8/3112:05 pm
LIM
- TYS
1 stop10h 47m
LATAM Airlines
Deal found 7/12![LATAM Airlines logo]()
$802
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:56 pm
TYS
- LIM
2 stops15h 14m
American Airlines
Mon 8/3111:45 pm
LIM
- TYS
2 stops18h 16m
American Airlines
Deal found 7/12![American Airlines logo]()
$824
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/279:30 am
TYS
- GRU
1 stop34h 10m
Multiple Airlines
Thu 9/311:50 am
GRU
- TYS
2 stops35h 55m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$1,025
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:57 pm
TYS
- LIM
2 stops33h 13m
Multiple Airlines
Sat 9/512:05 pm
LIM
- TYS
1 stop20h 39m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$742
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:30 am
TYS
- LIM
2 stops14h 35m
LATAM Airlines
Sat 9/51:30 pm
LIM
- TYS
2 stops19h 14m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$765
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/299:30 am
TYS
- GRU
1 stop34h 10m
Multiple Airlines
Sat 9/55:00 am
GRU
- TYS
2 stops30h 04m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$971
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:49 pm
TYS
- GRU
1 stop15h 51m
Multiple Airlines
Mon 9/711:10 am
GRU
- TYS
2 stops47h 54m
Multiple Airlines
Deal found 7/17![Multiple Airlines logo]()
$880
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated July 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:34 am
TYS
- LIM
3 stops38h 46m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:15 am
TYS
- LIM
3 stops60h 00m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:49 pm
TYS
- SCL
2 stops47h 46m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:05 am
TYS
- LIM
1 stop15h 25m
American Airlines
Deal found 7/13![American Airlines logo]()
$426
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1312:01 pm
TYS
- LIM
1 stop10h 54m
Delta
Deal found 7/14![Delta logo]()
$431
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:11 pm
TYS
- EZE
3 stops46h 09m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/412:06 pm
TYS
- SCL
1 stop17h 39m
American Airlines
Deal found 7/16![American Airlines logo]()
$666
This LATAM Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:00 pm
TYS
- SCL
3 stops24h 25m
LATAM Airlines
Deal found 7/15![LATAM Airlines logo]()
$761
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:00 am
TYS
- EZE
3 stops41h 20m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$776
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:18 pm
TYS
- SCL
1 stop17h 27m
American Airlines
Deal found 7/14![American Airlines logo]()
$880
This Travelocity deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/23:54 pm
TYS
- EZE
2 stops57h 51m
LATAM Airlines
Deal found 7/14![LATAM Airlines logo]()
$987
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:10 pm
TYS
- EZE
1 stop18h 50m
United Airlines
Deal found 7/14![United Airlines logo]()
$993
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated July 17, 2026.
Round-trip from | $616 (American Airlines) |
|---|---|
One-way from | $310 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Thu 9/3
7:25 pm-2:15 pm
2 stops19h 50m
Cartagena Rafael Nunez
Mon 9/14
1:35 pm-1:07 pm
2 stops22h 32m
$617
Quickest round-trip
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Wed 8/12
6:06 am-12:35 pm
1 stop7h 29m
Cartagena Rafael Nunez
Wed 8/19
3:15 pm-11:51 pm
1 stop7h 36m
$630
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Thu 9/3
10:28 am-11:35 pm
2 stops14h 07m
Cartagena Rafael Nunez
Mon 9/14
4:30 am-11:55 pm
2 stops18h 25m
$633
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Mon 9/28
7:50 am-6:45 pm
2 stops11h 55m
Cartagena Rafael Nunez
Tue 10/6
4:25 am-5:36 pm
2 stops12h 11m
$645
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Thu 9/17
5:35 am-1:15 pm
1 stop8h 40m
Cartagena Rafael Nunez
Tue 9/22
10:10 am-11:55 pm
2 stops12h 45m
$650
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Wed 9/9
5:45 pm-1:15 pm
1 stop20h 30m
Cartagena Rafael Nunez
Fri 9/18
11:50 am-11:55 pm
2 stops11h 05m
$653
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Mon 11/23
3:55 pm-5:00 am
1 stop13h 05m
Lima J Chavez Intl
Mon 11/30
1:30 pm-11:06 am
2 stops21h 36m
$688
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Thu 10/15
12:06 pm-5:00 am
1 stop17h 54m
Lima J Chavez Intl
Thu 10/29
1:00 am-5:36 pm
2 stops15h 36m
$723
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Sat 8/29
3:57 pm-12:10 am
2 stops33h 13m
Lima J Chavez Intl
Sat 9/5
12:05 pm-9:44 am
1 stop20h 39m
$742
KnoxvilleSao Paulo
TYS - GRU
TYSGRU
Knoxville McGhee Tyson
Fri 9/25
8:20 am-5:00 am
1 stop19h 40m
Sao Paulo Guarulhos Intl
Tue 9/29
11:10 am-1:01 pm
2 stops26h 51m
$758
Showing 1-10 of 43 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-CTG
TYS-LIM
TYS-GRU
TYS-SCL
TYS-PEI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-CTG
TYS-LIM
TYS-GRU
TYS-SCL
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 17, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Overall
7.8
Boarding
8.1
Crew
8.5
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on July 17, 2026.
Popular flight searches
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Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$931 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$488 | Average$812 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$622 | Average$715 | FlexibilityNo cancel fee | On-time81% |