$271+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Sep 29 — Oct 61
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to South America
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 30, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 30, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop7h 35m
Mon 10/191:35 pm -
1 stop8h 24m
Deal found 8/27![American Airlines logo]()
$696
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:40 am -
2 stops14h 55m
Tue 10/205:35 am -
2 stops15h 47m
Deal found 8/29![Delta logo]()
$712
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:43 pm -
2 stops36h 18m
Sat 10/2412:05 pm -
1 stop20h 29m
Deal found 8/26![Multiple Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
1 stop7h 35m
Tue 10/201:35 pm -
1 stop8h 24m
Deal found 8/29![American Airlines logo]()
$721
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:26 pm -
2 stops20h 09m
Fri 10/161:35 pm -
1 stop8h 24m
Deal found 8/27![American Airlines logo]()
$726
This LATAM Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:09 am -
2 stops24h 56m
Thu 11/59:00 am -
2 stops25h 45m
Deal found 8/29![LATAM Airlines logo]()
$757
This Expedia deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:45 pm -
1 stop27h 10m
Sun 10/188:55 am -
2 stops31h 33m
Deal found 8/27![LATAM Airlines logo]()
$758
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop17h 26m
Fri 11/1312:46 am -
1 stop19h 15m
Deal found 8/27![American Airlines logo]()
$765
This Expedia deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:07 pm -
1 stop27h 13m
Sun 11/2911:30 pm -
2 stops42h 00m
Deal found 8/29![LATAM Airlines logo]()
$772
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:09 am -
2 stops12h 16m
Sat 11/148:40 pm -
2 stops27h 19m
Deal found 8/27![LATAM Airlines logo]()
$775
This LATAM Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:09 am -
2 stops14h 11m
Sat 10/241:30 pm -
2 stops20h 24m
Deal found 8/26![LATAM Airlines logo]()
$780
This KAYAK deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:45 pm -
2 stops47h 01m
Tue 10/205:10 am -
2 stops14h 35m
Deal found 8/28![Copa Airlines logo]()
$811
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 30, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 30, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:00 am -
1 stop7h 35m
Mon 10/191:35 pm -
1 stop8h 24m
Deal found 8/27![American Airlines logo]()
$696
This Delta deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:40 am -
2 stops14h 55m
Tue 10/205:35 am -
2 stops15h 47m
Deal found 8/29![Delta logo]()
$712
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:43 pm -
2 stops36h 18m
Sat 10/2412:05 pm -
1 stop20h 29m
Deal found 8/26![Multiple Airlines logo]()
$714
This LATAM Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/111:50 am -
1 stop17h 10m
Thu 11/59:00 am -
2 stops25h 45m
Deal found 8/29![LATAM Airlines logo]()
$757
This KAYAK deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:45 pm -
2 stops47h 01m
Tue 10/205:10 am -
2 stops14h 35m
Deal found 8/28![Copa Airlines logo]()
$811
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:20 am -
2 stops12h 40m
Tue 11/36:25 am -
2 stops15h 32m
Deal found 8/27![United Airlines logo]()
$849
This Avianca deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:45 am -
2 stops33h 35m
Wed 11/411:55 am -
2 stops36h 04m
Deal found 8/28![Avianca logo]()
$1,176
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:55 pm -
2 stops18h 40m
Fri 10/161:35 pm -
2 stops20h 30m
Deal found 8/27![American Airlines logo]()
$726
This LATAM Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:09 am -
2 stops24h 56m
Fri 11/1312:15 am -
2 stops17h 07m
Deal found 8/25![LATAM Airlines logo]()
$775
This Ovago deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/104:49 pm -
3 stops20h 26m
Sat 10/177:30 pm -
3 stops20h 46m
Deal found 8/26![GOL logo]()
$1,559
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:13 pm -
2 stops18h 22m
Tue 10/201:35 pm -
1 stop8h 24m
Deal found 8/29![American Airlines logo]()
$726
This LATAM Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:09 am -
2 stops14h 11m
Sat 10/241:30 pm -
2 stops20h 24m
Deal found 8/26![LATAM Airlines logo]()
$780
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop17h 26m
Fri 11/1312:46 am -
1 stop19h 15m
Deal found 8/27![American Airlines logo]()
$765
This SmartFares deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/117:45 pm -
1 stop27h 10m
Sat 10/1712:05 am -
1 stop9h 44m
Deal found 8/27![LATAM Airlines logo]()
$786
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/217:35 pm -
2 stops35h 15m
Wed 2/310:45 pm -
2 stops37h 05m
Deal found 8/29![United Airlines logo]()
$1,008
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:34 pm -
2 stops16h 41m
Sun 11/2911:10 pm -
1 stop18h 05m
Deal found 8/27![Delta logo]()
$1,065
This SmartFares deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 am -
2 stops24h 55m
Sun 11/298:40 pm -
2 stops27h 17m
Deal found 8/29![LATAM Airlines logo]()
$803
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:40 pm -
2 stops61h 10m
Sat 12/510:45 pm -
2 stops37h 16m
Deal found 8/25![United Airlines logo]()
$1,015
This Avianca deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:45 am -
2 stops26h 00m
Wed 11/47:25 am -
2 stops40h 34m
Deal found 8/28![Avianca logo]()
$1,176
This Delta deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:23 pm -
1 stop12h 52m
Mon 10/198:40 pm -
1 stop21h 48m
Deal found 8/28![Delta logo]()
$1,087
This Ovago deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:35 pm -
2 stops27h 25m
Thu 11/192:07 am -
2 stops35h 23m
Deal found 8/27![Copa Airlines logo]()
$1,319
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/187:00 am -
1 stop22h 20m
Mon 2/110:05 pm -
1 stop14h 57m
Deal found 8/28![United Airlines logo]()
$1,098
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/315:36 pm -
1 stop13h 24m
Sun 2/1411:45 pm -
1 stop18h 49m
Deal found 8/29![American Airlines logo]()
$1,035
This Delta deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:35 am -
2 stops21h 25m
Fri 10/168:15 am -
2 stops16h 44m
Deal found 8/25![Delta logo]()
$1,147
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/121:55 pm -
1 stop18h 25m
Mon 11/1610:25 pm -
1 stop15h 05m
Deal found 8/29![United Airlines logo]()
$1,153
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:00 am -
1 stop25h 10m
Mon 10/199:30 pm -
2 stops18h 51m
Deal found 8/28![American Airlines logo]()
$1,056
This LATAM Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2412:23 pm -
2 stops17h 02m
Thu 10/18:50 am -
2 stops16h 05m
Deal found 8/26![LATAM Airlines logo]()
$1,087
This Booking.com deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2110:51 am -
3 stops50h 14m
Sat 11/284:45 pm -
3 stops33h 14m
Deal found 8/25![Air Canada logo]()
$3,257
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1012:05 pm -
1 stop17h 25m
Sat 10/179:30 pm -
1 stop14h 07m
Deal found 8/26![United Airlines logo]()
$1,214
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/101:39 pm -
1 stop17h 31m
Sat 10/179:30 pm -
2 stops19h 48m
Deal found 8/26![American Airlines logo]()
$1,112
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated August 30, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated August 30, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:12 pm -
1 stop11h 48m
Sun 9/612:05 am -
1 stop22h 47m
Deal found 8/27![Delta logo]()
$1,188
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/24:22 pm -
2 stops12h 48m
Mon 9/710:00 pm -
2 stops14h 31m
Deal found 8/27![American Airlines logo]()
$1,233
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/32:21 pm -
2 stops33h 39m
Mon 9/149:45 am -
2 stops26h 05m
Deal found 8/27![United Airlines logo]()
$1,012
This KAYAK deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:40 pm -
2 stops32h 20m
Mon 9/149:45 am -
2 stops26h 05m
Deal found 8/30![Copa Airlines logo]()
$1,049
This LATAM Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:01 pm -
2 stops17h 59m
Sun 9/137:45 pm -
2 stops16h 33m
Deal found 8/28![LATAM Airlines logo]()
$1,087
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:40 pm -
1 stop19h 35m
Mon 9/141:35 pm -
2 stops20h 42m
Deal found 8/27![American Airlines logo]()
$1,194
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:06 am -
1 stop9h 09m
Thu 9/101:35 pm -
1 stop8h 32m
Deal found 8/26![American Airlines logo]()
$898
This Orbitz deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:25 pm -
3 stops25h 50m
Wed 9/3012:35 am -
2 stops17h 53m
Deal found 8/26![LATAM Airlines logo]()
$1,153
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:12 am -
2 stops20h 48m
Thu 10/19:30 pm -
1 stop26h 37m
Deal found 8/26![American Airlines logo]()
$1,181
This LATAM Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:08 pm -
2 stops14h 32m
Fri 10/98:45 am -
2 stops16h 14m
Deal found 8/27![LATAM Airlines logo]()
$1,117
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
1 stop24h 00m
Fri 10/99:30 pm -
1 stop16h 39m
Deal found 8/25![American Airlines logo]()
$1,277
This Delta deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:26 am -
1 stop20h 49m
Fri 10/98:45 am -
2 stops16h 14m
Deal found 8/26![Delta logo]()
$1,302
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated August 30, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated August 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:33 am -
2 stops12h 51m
Deal found 8/26![Multiple Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:13 pm -
3 stops21h 47m
Deal found 8/26![Multiple Airlines logo]()
$392
This FlightHub deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:25 pm -
2 stops22h 55m
Deal found 8/26![Avianca logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
2 stops23h 10m
Deal found 8/29![Multiple Airlines logo]()
$462
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/172:55 pm -
3 stops45h 10m
Deal found 8/28![Multiple Airlines logo]()
$471
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop17h 25m
Deal found 8/30![American Airlines logo]()
$491
This eDestinos deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:10 am -
2 stops12h 15m
Deal found 8/30![LATAM Airlines logo]()
$497
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:40 pm -
2 stops54h 15m
Deal found 8/27![United Airlines logo]()
$542
This eDestinos deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:10 am -
3 stops32h 55m
Deal found 8/27![Multiple Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/179:13 am -
2 stops22h 57m
Deal found 8/28![American Airlines logo]()
$619
This Kiwi.com deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/3110:00 am -
3 stops39h 15m
Deal found 8/28![Multiple Airlines logo]()
$689
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop25h 10m
Deal found 8/29![American Airlines logo]()
$710
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated August 30, 2026.
Round-trip from | $696 (American Airlines) |
|---|---|
One-way from | $271 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 30, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Fri 10/16
6:00 am-12:35 pm
1 stop7h 35m
Cartagena Rafael Nunez
Mon 10/19
1:35 pm-10:59 pm
1 stop8h 24m
$696
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Tue 10/13
5:40 am-7:35 pm
2 stops14h 55m
Cartagena Rafael Nunez
Tue 10/20
5:35 am-10:22 pm
2 stops15h 47m
$712
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 10/17
5:43 pm-5:01 am
2 stops36h 18m
Lima J Chavez Intl
Sat 10/24
12:05 pm-9:34 am
1 stop20h 29m
$714
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Fri 10/9
6:55 pm-12:35 pm
2 stops18h 40m
Cartagena Rafael Nunez
Fri 10/16
1:35 pm-11:05 am
2 stops20h 30m
$726
KnoxvilleCartagena
TYS Knoxville McGhee Tyson - CTG Cartagena Rafael Nunez
TYSCTG
Knoxville McGhee Tyson
Tue 10/13
7:13 pm-12:35 pm
2 stops18h 22m
Cartagena Rafael Nunez
Tue 10/20
1:35 pm-10:59 pm
1 stop8h 24m
$726
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sun 11/1
11:50 am-5:00 am
1 stop17h 10m
Lima J Chavez Intl
Thu 11/5
9:00 am-10:45 am
2 stops25h 45m
$757
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Fri 11/6
6:00 am-11:26 pm
1 stop17h 26m
Lima J Chavez Intl
Fri 11/13
12:46 am-8:01 pm
1 stop19h 15m
$765
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Fri 11/6
7:09 am-8:05 am
2 stops24h 56m
Lima J Chavez Intl
Fri 11/13
12:15 am-5:22 pm
2 stops17h 07m
$775
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 10/17
7:09 am-8:20 pm
2 stops14h 11m
Lima J Chavez Intl
Sat 10/24
1:30 pm-10:54 am
2 stops20h 24m
$780
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sun 10/11
7:45 pm-9:55 pm
1 stop27h 10m
Lima J Chavez Intl
Sat 10/17
12:05 am-10:49 am
1 stop9h 44m
$786
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-CTG
TYS-LIM
TYS-PEI
TYS-AXM
TYS-CWB
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-CTG
TYS-LIM
TYS-PEI
TYS-AXM
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated August 30, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on August 30, 2026.
Popular flight searches
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Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$1,029 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$488 | Average$812 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$622 | Average$715 | FlexibilityNo cancel fee | On-time81% |