$277+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Jun 27 — Jul 41
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South America with Cheapflights
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 28, 2026.
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
TYS
- CTG
1 stop9h 15m
American Airlines
Mon 9/141:35 pm
CTG
- TYS
1 stop7h 23m
American Airlines
Deal found 5/26![American Airlines logo]()
$582
This LATAM Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:55 pm
TYS
- LIM
1 stop14h 05m
LATAM Airlines
Wed 11/412:00 pm
LIM
- TYS
1 stop11h 46m
LATAM Airlines
Deal found 5/24![LATAM Airlines logo]()
$716
This LATAM Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/253:55 pm
TYS
- LIM
2 stops14h 05m
LATAM Airlines
Tue 10/2712:15 am
LIM
- TYS
2 stops22h 31m
LATAM Airlines
Deal found 5/25![LATAM Airlines logo]()
$720
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
TYS
- LIM
2 stops16h 55m
Delta
Wed 7/298:55 am
LIM
- TYS
2 stops13h 57m
Delta
Deal found 5/25![Delta logo]()
$778
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- LIM
2 stops15h 40m
Delta
Sun 7/2612:05 am
LIM
- TYS
2 stops17h 39m
Delta
Deal found 5/26![Delta logo]()
$783
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
TYS
- LIM
2 stops16h 55m
Delta
Mon 7/2712:05 am
LIM
- TYS
2 stops16h 50m
Delta
Deal found 5/25![Delta logo]()
$846
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
TYS
- LIM
1 stop15h 30m
American Airlines
Tue 7/286:30 am
LIM
- TYS
1 stop16h 29m
American Airlines
Deal found 5/26![American Airlines logo]()
$872
This Avianca deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:45 am
TYS
- CTG
3 stops31h 50m
Avianca
Mon 9/149:00 am
CTG
- TYS
2 stops23h 57m
Avianca
Deal found 5/28![Avianca logo]()
$901
This Avianca deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:45 am
TYS
- IBE
2 stops34h 35m
Avianca
Wed 9/234:15 pm
IBE
- TYS
2 stops40h 30m
Avianca
Deal found 5/23![Avianca logo]()
$910
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2812:18 pm
TYS
- SCL
1 stop17h 27m
American Airlines
Thu 1/1411:45 pm
SCL
- TYS
1 stop19h 53m
American Airlines
Deal found 5/24![American Airlines logo]()
$965
This LATAM Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:55 pm
TYS
- GRU
1 stop12h 45m
LATAM Airlines
Wed 10/1410:05 am
GRU
- TYS
2 stops14h 41m
LATAM Airlines
Deal found 5/27![LATAM Airlines logo]()
$1,011
This KAYAK deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:30 pm
TYS
- SCL
2 stops13h 25m
LATAM Airlines
Fri 10/97:15 am
SCL
- TYS
2 stops17h 31m
LATAM Airlines
Deal found 5/26![LATAM Airlines logo]()
$1,016
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 28, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 28, 2026.
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
TYS
- CTG
1 stop7h 35m
American Airlines
Mon 9/141:35 pm
CTG
- TYS
1 stop7h 23m
American Airlines
Deal found 5/25![American Airlines logo]()
$582
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:40 am
TYS
- LIM
2 stops15h 40m
Delta
Wed 7/112:05 pm
LIM
- TYS
1 stop10h 49m
Delta
Deal found 5/26![Delta logo]()
$778
This Avianca deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:45 am
TYS
- IBE
2 stops34h 35m
Avianca
Wed 9/234:15 pm
IBE
- TYS
2 stops40h 30m
Avianca
Deal found 5/23![Avianca logo]()
$910
This LATAM Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/712:00 pm
TYS
- GRU
2 stops19h 50m
LATAM Airlines
Wed 10/1410:05 am
GRU
- TYS
2 stops14h 41m
LATAM Airlines
Deal found 5/27![LATAM Airlines logo]()
$1,011
This Kiwi.com deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:27 pm
TYS
- GRU
2 stops31h 23m
Multiple Airlines
Sun 8/3011:40 am
GRU
- TYS
1 stop32h 23m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$1,031
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:42 am
TYS
- GRU
1 stop21h 58m
United Airlines
Wed 10/149:30 pm
GRU
- TYS
1 stop18h 07m
United Airlines
Deal found 5/27![United Airlines logo]()
$1,053
This KAYAK deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/157:19 pm
TYS
- CWB
2 stops21h 41m
Azul
Mon 8/176:45 pm
CWB
- TYS
2 stops27h 08m
Azul
Deal found 5/24![Azul logo]()
$1,350
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
TYS
- LIM
2 stops16h 55m
Delta
Wed 7/298:55 am
LIM
- TYS
2 stops13h 57m
Delta
Deal found 5/25![Delta logo]()
$778
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- LIM
2 stops15h 40m
Delta
Sun 7/2612:05 am
LIM
- TYS
2 stops17h 39m
Delta
Deal found 5/26![Delta logo]()
$783
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
TYS
- LIM
1 stop17h 25m
American Airlines
Tue 7/286:30 am
LIM
- TYS
1 stop16h 29m
American Airlines
Deal found 5/24![American Airlines logo]()
$872
This KAYAK deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:30 pm
TYS
- SCL
2 stops13h 25m
LATAM Airlines
Fri 10/97:15 am
SCL
- TYS
2 stops17h 31m
LATAM Airlines
Deal found 5/26![LATAM Airlines logo]()
$1,016
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:40 am
TYS
- LIM
2 stops16h 55m
Delta
Mon 7/2712:05 am
LIM
- TYS
2 stops16h 50m
Delta
Deal found 5/25![Delta logo]()
$846
This KAYAK deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:42 am
TYS
- GRU
1 stop21h 58m
Multiple Airlines
Sun 10/410:20 pm
GRU
- TYS
1 stop23h 40m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$1,082
This deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/313:40 pm
TYS
- EZE
1 stop15h 20m
United Airlines
Mon 9/149:00 pm
EZE
- TYS
1 stop16h 47m
United Airlines
Deal found 5/24![United Airlines logo]()
$1,097
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:43 pm
TYS
- SCL
2 stops17h 07m
American Airlines
Fri 10/99:30 pm
SCL
- TYS
2 stops16h 26m
American Airlines
Deal found 5/25![American Airlines logo]()
$1,045
This LATAM Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/241:59 pm
TYS
- GRU
1 stop14h 41m
LATAM Airlines
Wed 7/18:15 am
GRU
- TYS
2 stops16h 39m
LATAM Airlines
Deal found 5/25![LATAM Airlines logo]()
$1,053
This United Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/306:02 pm
TYS
- EZE
2 stops36h 58m
United Airlines
Mon 9/149:00 pm
EZE
- TYS
1 stop16h 47m
United Airlines
Deal found 5/24![United Airlines logo]()
$1,119
This LATAM Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:57 pm
TYS
- GRU
2 stops21h 18m
LATAM Airlines
Sun 10/411:45 pm
GRU
- TYS
2 stops19h 32m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$1,053
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:41 pm
TYS
- GRU
1 stop14h 59m
United Airlines
Wed 7/19:30 pm
GRU
- TYS
1 stop14h 12m
United Airlines
Deal found 5/25![United Airlines logo]()
$1,133
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/304:30 pm
TYS
- SCL
2 stops20h 35m
Delta
Fri 10/98:40 pm
SCL
- TYS
1 stop15h 26m
Delta
Deal found 5/24![Delta logo]()
$1,055
This KAYAK deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/1810:26 am
TYS
- GRU
1 stop18h 14m
LATAM Airlines
Tue 7/2810:50 pm
GRU
- TYS
1 stop13h 20m
LATAM Airlines
Deal found 5/27![LATAM Airlines logo]()
$1,228
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:00 am
TYS
- GRU
1 stop26h 40m
United Airlines
Fri 7/3110:20 pm
GRU
- TYS
1 stop23h 24m
United Airlines
Deal found 5/23![United Airlines logo]()
$1,253
This Travelocity deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:43 pm
TYS
- GRU
2 stops30h 07m
LATAM Airlines
Fri 7/3112:55 pm
GRU
- TYS
2 stops35h 49m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$1,300
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/147:15 am
TYS
- EZE
1 stop23h 45m
United Airlines
Tue 8/189:00 pm
EZE
- TYS
1 stop22h 17m
United Airlines
Deal found 5/26![United Airlines logo]()
$1,437
This LATAM Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:00 pm
TYS
- EZE
2 stops22h 45m
LATAM Airlines
Sun 9/277:35 am
EZE
- TYS
2 stops26h 36m
LATAM Airlines
Deal found 5/23![LATAM Airlines logo]()
$1,387
This United Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:15 am
TYS
- EZE
1 stop23h 45m
United Airlines
Sun 9/279:00 pm
EZE
- TYS
1 stop15h 17m
United Airlines
Deal found 5/23![United Airlines logo]()
$1,437
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:43 pm
TYS
- CWB
3 stops20h 02m
American Airlines
Mon 8/177:10 pm
CWB
- TYS
3 stops21h 47m
American Airlines
Deal found 5/24![American Airlines logo]()
$4,610
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated May 28, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated May 28, 2026 and is based on user searches.
This Orbitz deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/295:45 am
TYS
- EZE
2 stops22h 55m
Multiple Airlines
Sat 6/68:10 pm
EZE
- TYS
1 stop14h 28m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$1,538
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
TYS
- LIM
1 stop15h 30m
American Airlines
Tue 7/286:30 am
LIM
- TYS
1 stop16h 29m
American Airlines
Deal found 5/26![American Airlines logo]()
$872
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:40 am
TYS
- LIM
2 stops17h 00m
Delta
Mon 7/2712:05 am
LIM
- TYS
2 stops17h 46m
Delta
Deal found 5/26![Delta logo]()
$892
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:34 am
TYS
- LIM
1 stop12h 21m
Delta
Wed 7/18:55 am
LIM
- TYS
2 stops13h 59m
Delta
Deal found 5/26![Delta logo]()
$897
This LATAM Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:40 am
TYS
- GRU
2 stops13h 20m
Multiple Airlines
Sat 6/2711:45 pm
GRU
- TYS
2 stops25h 09m
Multiple Airlines
Deal found 5/26![Multiple Airlines logo]()
$1,088
This FlightHub deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:08 pm
TYS
- GRU
1 stop34h 32m
LATAM Airlines
Sat 6/279:30 pm
GRU
- TYS
2 stops27h 24m
LATAM Airlines
Deal found 5/26![LATAM Airlines logo]()
$1,157
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:54 pm
TYS
- GRU
1 stop18h 46m
United Airlines
Sat 6/279:30 pm
GRU
- TYS
1 stop17h 57m
United Airlines
Deal found 5/26![United Airlines logo]()
$1,562
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:40 am
TYS
- LIM
2 stops15h 40m
Delta
Wed 7/112:05 pm
LIM
- TYS
1 stop10h 49m
Delta
Deal found 5/26![Delta logo]()
$778
This LATAM Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/246:08 pm
TYS
- GRU
2 stops21h 07m
LATAM Airlines
Wed 7/18:15 am
GRU
- TYS
2 stops16h 39m
LATAM Airlines
Deal found 5/25![LATAM Airlines logo]()
$1,053
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:41 pm
TYS
- GRU
1 stop14h 59m
United Airlines
Wed 7/19:30 pm
GRU
- TYS
1 stop14h 12m
United Airlines
Deal found 5/25![United Airlines logo]()
$1,133
This Mytrip deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:15 am
TYS
- GRU
3 stops25h 35m
Multiple Airlines
Wed 7/17:35 am
GRU
- TYS
3 stops27h 52m
Multiple Airlines
Deal found 5/25![Multiple Airlines logo]()
$1,760
This Delta deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- LIM
2 stops15h 40m
Delta
Sun 7/2612:05 am
LIM
- TYS
2 stops17h 39m
Delta
Deal found 5/26![Delta logo]()
$783
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated May 28, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated May 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2012:53 pm
TYS
- LIM
3 stops36h 37m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$277
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/167:00 am
TYS
- LIM
2 stops23h 01m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:49 pm
TYS
- LIM
2 stops13h 06m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/88:00 am
TYS
- LIM
2 stops16h 40m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:42 pm
TYS
- LIM
2 stops31h 13m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/274:52 pm
TYS
- LIM
3 stops32h 58m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:05 pm
TYS
- LIM
2 stops27h 25m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/612:53 pm
TYS
- LIM
2 stops35h 47m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/149:26 am
TYS
- LIM
3 stops17h 19m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:54 pm
TYS
- LIM
2 stops35h 46m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:08 pm
TYS
- LIM
2 stops30h 32m
Multiple Airlines
Deal found 5/23![Multiple Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/74:55 pm
TYS
- MVD
3 stops40h 38m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$541
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated May 28, 2026.
Round-trip from | $582 (American Airlines) |
|---|---|
One-way from | $277 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleCartagena
TYS - CTG
TYSCTG
Knoxville McGhee Tyson
Thu 9/3
6:00 am-12:35 pm
1 stop7h 35m
Cartagena Rafael Nunez
Mon 9/14
1:35 pm-9:58 pm
1 stop7h 23m
$582
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Wed 6/24
5:40 am-8:20 pm
2 stops15h 40m
Lima J Chavez Intl
Wed 7/1
12:05 pm-11:54 pm
1 stop10h 49m
$778
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Wed 7/1
5:40 am-9:35 pm
2 stops16h 55m
Lima J Chavez Intl
Wed 7/29
8:55 am-11:52 pm
2 stops13h 57m
$778
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Tue 6/30
5:40 am-8:20 pm
2 stops15h 40m
Lima J Chavez Intl
Sun 7/26
12:05 am-6:44 pm
2 stops17h 39m
$783
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Wed 7/1
5:40 am-9:35 pm
2 stops16h 55m
Lima J Chavez Intl
Mon 7/27
12:05 am-5:55 pm
2 stops16h 50m
$846
KnoxvilleLima
TYS - LIM
TYSLIM
Knoxville McGhee Tyson
Tue 6/9
6:00 am-10:25 pm
1 stop17h 25m
Lima J Chavez Intl
Tue 7/28
6:30 am-11:59 pm
1 stop16h 29m
$872
KnoxvilleIbagué
TYS - IBE
TYSIBE
Knoxville McGhee Tyson
Sat 9/19
5:45 am-3:20 pm
2 stops34h 35m
Ibague
Wed 9/23
4:15 pm-9:45 am
2 stops40h 30m
$910
KnoxvilleSao Paulo
TYS - GRU
TYSGRU
Knoxville McGhee Tyson
Wed 10/7
12:00 pm-8:50 am
2 stops19h 50m
Sao Paulo Guarulhos Intl
Wed 10/14
10:05 am-11:46 pm
2 stops14h 41m
$1,011
KnoxvilleSantiago
TYS - SCL
TYSSCL
Knoxville McGhee Tyson
Wed 9/30
4:30 pm-6:55 am
2 stops13h 25m
Santiago Arturo Merino Benitez
Fri 10/9
7:15 am-11:46 pm
2 stops17h 31m
$1,016
KnoxvilleSao Paulo
TYS - GRU
TYSGRU
Knoxville McGhee Tyson
Mon 8/24
6:27 pm-2:50 am
2 stops31h 23m
Sao Paulo Guarulhos Intl
Sun 8/30
11:40 am-7:03 pm
1 stop32h 23m
$1,031
Showing 1-10 of 41 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-LIM
TYS-MVD
TYS-GRU
TYS-CWB
TYS-EZE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-LIM
TYS-MVD
TYS-GRU
TYS-CWB
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 28, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Comfort
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on May 28, 2026.
Popular flight searches
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Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$488 | Average$835 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$622 | Average$715 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$696 | Average$880 | FlexibilityNo cancel fee | On-timeN/A |