South America

$261+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
mag 17 — mag 241
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Cheap flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on aprile 17, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/149:40 pm
TYS
-
CTG
1 stop15h 46m
Multiple Airlines
gio 5/211:31 pm
CTG
-
TYS
1 stop28h 03m
Multiple Airlines
Deal found 4/14$395
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sab 5/911:56 am
TYS
-
CTG
1 stop25h 30m
Multiple Airlines
lun 5/111:31 pm
CTG
-
TYS
2 stops19h 09m
Multiple Airlines
Deal found 4/14$450
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 5/181:15 pm
TYS
-
CTG
2 stops10h 45m
Multiple Airlines
mer 5/271:31 pm
CTG
-
TYS
1 stop21h 42m
Multiple Airlines
Deal found 4/13$497
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/36:00 am
TYS
-
CTG
1 stop7h 35m
American Airlines
lun 9/142:05 pm
CTG
-
TYS
1 stop8h 26m
American Airlines
Deal found 4/14$582
This KAYAK deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/35:30 am
TYS
-
CTG
2 stops16h 40m
LATAM Airlines
lun 9/1410:10 am
CTG
-
TYS
2 stops12h 37m
LATAM Airlines
Deal found 4/15$604
This American Airlines deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 6/116:00 am
TYS
-
CTG
1 stop7h 35m
American Airlines
mar 6/163:13 pm
CTG
-
TYS
1 stop7h 46m
American Airlines
Deal found 4/12$606
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 9/35:30 am
TYS
-
CTG
2 stops15h 05m
Delta
lun 9/1410:10 am
CTG
-
TYS
2 stops12h 37m
Delta
Deal found 4/13$616
This BusinessClass deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 7/305:40 am
TYS
-
CTG
2 stops18h 55m
LATAM Airlines
mar 8/410:10 am
CTG
-
TYS
2 stops12h 42m
LATAM Airlines
Deal found 4/14$618
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 5/289:19 pm
TYS
-
AXM
2 stops18h 31m
Multiple Airlines
gio 6/41:56 pm
AXM
-
TYS
1 stop27h 41m
Multiple Airlines
Deal found 4/13$654
This LATAM Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 8/117:07 am
TYS
-
LIM
2 stops14h 48m
LATAM Airlines
gio 8/201:30 pm
LIM
-
TYS
2 stops20h 35m
LATAM Airlines
Deal found 4/13$657
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 8/510:26 am
TYS
-
LIM
2 stops22h 39m
Delta
mar 8/1812:10 am
LIM
-
TYS
2 stops22h 40m
Delta
Deal found 4/16$665
This KAYAK deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 8/57:33 am
TYS
-
LIM
2 stops15h 02m
LATAM Airlines
gio 8/208:55 am
LIM
-
TYS
2 stops13h 52m
LATAM Airlines
Deal found 4/16$690

Find flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated aprile 17, 2026.

Round-trip from

$395
(Kiwi.com)

One-way from

$261
(Kiwi.com)
From Knoxville McGhee Tyson to South America
One-way flight from Knoxville McGhee Tyson to South America

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated aprile 17, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

gio 9/3

6:00 am-2:15 pm

1 stop9h 15m

Cartagena Rafael Nunez

lun 9/14

2:05 pm-11:31 pm

1 stop8h 26m

$582

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

gio 6/11

6:00 am-2:13 pm

1 stop9h 13m

Cartagena Rafael Nunez

mar 6/16

3:13 pm-10:48 am

2 stops18h 35m

$611

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

gio 9/3

5:30 am-7:35 pm

2 stops15h 05m

Cartagena Rafael Nunez

lun 9/14

10:10 am-11:47 pm

2 stops12h 37m

$616

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

sab 5/23

6:07 pm-12:35 pm

2 stops19h 28m

Cartagena Rafael Nunez

sab 5/30

1:35 pm-10:48 am

2 stops20h 13m

$625

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

ven 7/3

3:54 pm-1:08 pm

1 stop22h 14m

Cartagena Rafael Nunez

mar 7/7

9:25 am-11:52 pm

2 stops13h 27m

$634

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

mer 8/5

7:00 am-12:35 pm

1 stop6h 35m

Cartagena Rafael Nunez

dom 8/9

3:17 pm-7:23 pm

1 stop27h 06m

$639

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

mar 8/25

5:57 pm-5:00 am

1 stop12h 03m

Lima J Chavez Intl

ven 8/28

12:05 pm-11:47 pm

1 stop10h 42m

$695

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

dom 9/6

5:57 pm-10:00 pm

2 stops29h 03m

Lima J Chavez Intl

dom 9/13

12:15 pm-6:17 pm

2 stops29h 02m

$713

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

dom 9/6

7:07 am-9:35 pm

2 stops15h 28m

Lima J Chavez Intl

dom 9/13

12:05 pm-9:11 am

1 stop20h 06m

$725

KnoxvillePereira

TYS - PEI

TYSPEI

Knoxville McGhee Tyson

gio 5/7

7:05 am-8:20 pm

2 stops14h 15m

Pereira Matecana

dom 5/10

5:15 am-11:44 pm

2 stops17h 29m

$924

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/14

Showing 1-10 of 47 resultsSorted by cheapest first
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, August is the cheapest month in which you can book a flight from Knoxville to South America (average of $488). Flying from Knoxville to South America in November is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated aprile 17, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

7.8

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Entertainment

7.8

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Entertainment

7.8

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Entertainment

7.8

Crew

8.5

Overall

7.9

Boarding

8.1

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • How long is the flight from Knoxville to South America?

    There are many flights that can get you from Knoxville to South America in 9h 15m. Fly via American Airlines, Delta, or LATAM Airlines to get the fastest option. The distance between Knoxville and South America is about 1830 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Knoxville to South America?

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to South America (average of $488). Flying from Knoxville to South America in November is currently the most expensive (average of $703). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated aprile 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$488Average$876FlexibilityNo cancel feeOn-time71%
DeltaCheapest$599Average$880FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$622Average$830FlexibilityNo cancel feeOn-time81%

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