$353+ Cheap flights from Knoxville (TYS) to South America
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Nov 12 — Nov 191
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to South America
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Cheapest flights from Knoxville to South AmericaExplore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop17h 10m
Tue 11/311:55 pm -
1 stop19h 05m
Deal found 10/10![American Airlines logo]()
$649
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:12 pm -
2 stops21h 20m
Sun 11/224:34 pm -
2 stops18h 47m
Deal found 10/12![American Airlines logo]()
$676
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:30 am -
1 stop17h 57m
Wed 12/211:55 pm -
1 stop16h 44m
Deal found 10/11![American Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:45 am -
2 stops16h 50m
Tue 12/11:30 am -
2 stops22h 29m
Deal found 10/11![United Airlines logo]()
$712
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop16h 55m
Wed 12/21:50 am -
1 stop20h 07m
Deal found 10/12![United Airlines logo]()
$786
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
1 stop15h 32m
Thu 12/37:00 am -
2 stops14h 48m
Deal found 10/12![American Airlines logo]()
$790
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
1 stop7h 35m
Fri 10/301:35 pm -
1 stop8h 24m
Deal found 10/12![American Airlines logo]()
$793
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:35 pm -
1 stop16h 59m
Sat 12/263:15 pm -
1 stop9h 24m
Deal found 10/11![American Airlines logo]()
$815
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop15h 40m
Tue 12/112:10 pm -
1 stop10h 07m
Deal found 10/9![Delta logo]()
$831
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop17h 26m
Sat 11/147:00 am -
1 stop16h 59m
Deal found 10/8![American Airlines logo]()
$836
This BusinessClass deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:38 pm -
2 stops19h 56m
Sat 12/263:15 pm -
1 stop9h 24m
Deal found 10/11![GOL logo]()
$841
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:06 pm -
2 stops27h 14m
Mon 12/2812:20 pm -
1 stop21h 44m
Deal found 10/12![Multiple Airlines logo]()
$903
Best flights from Knoxville to South AmericaDiscover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
Discover carefully curated flight deals from Knoxville to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop17h 10m
Tue 11/311:55 pm -
1 stop19h 05m
Deal found 10/10![American Airlines logo]()
$649
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:45 am -
2 stops16h 50m
Tue 12/11:30 am -
2 stops22h 29m
Deal found 10/11![United Airlines logo]()
$712
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:57 pm -
2 stops22h 23m
Sat 1/234:50 am -
2 stops18h 56m
Deal found 10/11![Delta logo]()
$736
This BusinessClass deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:37 pm -
1 stop18h 38m
Sun 1/243:15 pm -
2 stops20h 13m
Deal found 10/11![GOL logo]()
$767
This KAYAK deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/56:30 am -
2 stops14h 29m
Mon 1/253:30 am -
2 stops14h 53m
Deal found 10/10![Multiple Airlines logo]()
$890
This Avianca deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:45 am -
2 stops25h 15m
Tue 11/32:25 pm -
2 stops21h 05m
Deal found 10/8![Avianca logo]()
$953
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:22 pm -
2 stops21h 08m
Tue 11/1710:35 am -
2 stops25h 20m
Deal found 10/10![LATAM Airlines logo]()
$1,286
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/286:00 am -
1 stop9h 38m
Mon 2/14:38 pm -
1 stop7h 21m
Deal found 10/9![American Airlines logo]()
$665
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:30 am -
1 stop17h 57m
Wed 12/27:50 am -
2 stops15h 03m
Deal found 10/11![American Airlines logo]()
$703
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/175:57 pm -
1 stop12h 03m
Mon 3/2912:05 pm -
1 stop10h 41m
Deal found 10/12![Delta logo]()
$796
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/86:15 am -
2 stops38h 09m
Fri 2/128:35 pm -
2 stops25h 03m
Deal found 10/12![United Airlines logo]()
$808
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1612:00 pm -
1 stop18h 00m
Thu 4/112:05 pm -
1 stop20h 07m
Deal found 10/12![Delta logo]()
$796
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:14 pm -
2 stops20h 20m
Sun 11/224:34 pm -
1 stop8h 18m
Deal found 10/12![American Airlines logo]()
$725
This BusinessClass deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/118:00 pm -
2 stops18h 15m
Sat 12/263:15 pm -
1 stop9h 24m
Deal found 10/9![GOL logo]()
$892
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:06 pm -
2 stops27h 14m
Mon 12/2812:20 pm -
1 stop21h 44m
Deal found 10/12![Multiple Airlines logo]()
$903
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/2511:53 am -
1 stop12h 02m
Wed 1/271:50 am -
1 stop16h 33m
Deal found 10/11![United Airlines logo]()
$856
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop15h 40m
Tue 12/112:10 pm -
1 stop10h 07m
Deal found 10/9![Delta logo]()
$831
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/245:28 pm -
1 stop30h 27m
Wed 1/271:50 am -
1 stop20h 09m
Deal found 10/11![United Airlines logo]()
$867
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/197:20 pm -
1 stop9h 58m
Mon 3/2911:51 pm -
1 stop19h 25m
Deal found 10/13![American Airlines logo]()
$811
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2012:00 pm -
1 stop18h 00m
Sun 3/2812:05 pm -
1 stop10h 41m
Deal found 10/12![Delta logo]()
$846
This BusinessClass deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:17 pm -
2 stops19h 17m
Tue 12/293:15 pm -
1 stop9h 24m
Deal found 10/8![GOL logo]()
$1,091
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop17h 26m
Sat 11/147:00 am -
1 stop16h 59m
Deal found 10/8![American Airlines logo]()
$836
This LATAM Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:00 am -
2 stops22h 00m
Sun 11/2911:10 pm -
2 stops26h 47m
Deal found 10/11![LATAM Airlines logo]()
$1,312
This Ovago deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:20 am -
2 stops20h 00m
Mon 11/3011:55 pm -
1 stop24h 02m
Deal found 10/11![Multiple Airlines logo]()
$1,326
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/117:35 pm -
1 stop18h 56m
Sun 1/176:00 am -
1 stop14h 15m
Deal found 10/10![American Airlines logo]()
$912
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:59 am -
1 stop18h 51m
Thu 12/310:45 pm -
2 stops20h 15m
Deal found 10/12![United Airlines logo]()
$1,145
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2112:00 pm -
1 stop17h 40m
Wed 2/311:10 pm -
1 stop21h 03m
Deal found 10/10![Delta logo]()
$1,096
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:05 pm -
2 stops18h 31m
Sat 1/302:00 pm -
1 stop10h 59m
Deal found 10/12![American Airlines logo]()
$916
This oojo deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/184:00 pm -
2 stops22h 00m
Sun 2/285:35 pm -
2 stops17h 37m
Deal found 10/10![LATAM Airlines logo]()
$1,595
This United deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/106:30 am -
2 stops35h 15m
Sat 1/309:00 am -
3 stops27h 45m
Deal found 10/11![Multiple Airlines logo]()
$1,496
Last-minute flights from Knoxville to South AmericaDiscover last-minute flight deals from Knoxville to South America. Data last updated October 13, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to South America. Data last updated October 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:00 am -
1 stop7h 35m
Fri 10/301:35 pm -
1 stop8h 24m
Deal found 10/12![American Airlines logo]()
$793
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:00 am -
1 stop17h 10m
Tue 11/311:55 pm -
1 stop19h 05m
Deal found 10/10![American Airlines logo]()
$649
This Avianca deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:45 am -
2 stops25h 15m
Tue 11/32:25 pm -
2 stops21h 05m
Deal found 10/8![Avianca logo]()
$953
This LATAM Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/14:11 pm -
1 stop12h 49m
Wed 11/412:15 am -
2 stops21h 53m
Deal found 10/10![LATAM Airlines logo]()
$1,041
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:00 am -
1 stop17h 26m
Sat 11/147:00 am -
1 stop16h 59m
Deal found 10/8![American Airlines logo]()
$836
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:45 am -
2 stops40h 30m
Fri 11/1311:55 pm -
2 stops20h 59m
Deal found 10/9![United Airlines logo]()
$931
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:12 pm -
2 stops21h 20m
Sun 11/224:34 pm -
2 stops18h 47m
Deal found 10/12![American Airlines logo]()
$676
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:40 am -
1 stop15h 40m
Tue 12/112:10 pm -
1 stop10h 07m
Deal found 10/9![Delta logo]()
$831
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:30 am -
1 stop17h 57m
Wed 12/211:55 pm -
1 stop16h 44m
Deal found 10/11![American Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:45 am -
2 stops16h 50m
Tue 12/11:30 am -
2 stops22h 29m
Deal found 10/11![United Airlines logo]()
$712
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop16h 55m
Wed 12/21:50 am -
1 stop20h 07m
Deal found 10/12![United Airlines logo]()
$786
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:00 am -
1 stop15h 32m
Thu 12/37:00 am -
2 stops14h 48m
Deal found 10/12![American Airlines logo]()
$790
One-way flights from Knoxville to South AmericaSearch for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated October 13, 2026.
Search for one-way flight options from Knoxville to South America. Find affordable one-way fares based on user searches. Data last updated October 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:08 pm -
2 stops22h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Multiple Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:55 am -
2 stops27h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Multiple Airlines logo]()
$398
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:57 pm -
2 stops27h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:17 pm -
2 stops22h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:20 am -
3 stops22h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![United Airlines logo]()
$414
This Kiwi.com deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:10 am -
2 stops40h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Multiple Airlines logo]()
$423
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:00 am -
3 stops20h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Multiple Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:00 am -
2 stops35h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$430
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:20 am -
1 stop11h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![United Airlines logo]()
$436
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:17 pm -
2 stops22h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![Delta logo]()
$443
This eDestinos deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/219:10 am -
2 stops41h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/13![Multiple Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:15 am -
1 stop16h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![American Airlines logo]()
$528
Find flight deals from Knoxville to South America
Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated October 13, 2026.
Round-trip from | $649 (American Airlines) |
|---|---|
One-way from | $353 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Wed 11/11
10:55 am-1:55 pm
2 stops27h 00m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$398
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Tue 12/8
6:20 am-5:10 am
3 stops22h 50m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$414
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Wed 12/9
6:20 am-5:10 am
3 stops22h 50m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$414
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Thu 12/10
11:00 am-7:05 am
3 stops20h 05m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$424
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Sat 12/12
6:17 pm-4:20 pm
2 stops22h 03m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$443
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Wed 12/9
2:07 pm-11:15 am
1 stop21h 08m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$465
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Fri 12/11
8:00 am-5:00 am
3 stops21h 00m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$475
KnoxvilleBogotá
TYS Knoxville McGhee Tyson - BOG Bogotá El Dorado
TYSBOG
Knoxville McGhee Tyson
Wed 12/9
9:10 am-9:20 am
2 stops24h 10m
Bogotá El Dorado
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$500
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Sat 11/21
9:10 am-2:31 am
2 stops41h 21m
Lima J Chavez Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$509
KnoxvilleLima
TYS Knoxville McGhee Tyson - LIM Lima J Chavez Intl
TYSLIM
Knoxville McGhee Tyson
Mon 1/4
5:15 am-9:23 pm
1 stop16h 08m
Lima J Chavez Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$528
Showing 1-10 of 48 resultsSorted by cheapest first
Best time to book a flight from Knoxville to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
TYS-BOG
TYS-CTG
TYS-LIM
TYS-SCL
TYS-GYE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to South America
TYS-0SA
TYS-BOG
TYS-CTG
TYS-LIM
TYS-SCL
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 13, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andAmerican Airlines from Knoxville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Comfort
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Knoxville to South America by cabin class
Find flights from Knoxville to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and South America flights
Browse other Knoxville and South America flight options. Last updated on October 13, 2026.
Popular flight searches
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Fly to South America countries
Consider these flights traveling to countries located in South America.
Knoxville to South America flights
Consider these flights traveling from Knoxville to South America.
Top 3 airlines flying from Knoxville to South America
Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$393 | Average$1,126 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$488 | Average$828 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$619 | Average$715 | FlexibilityNo cancel fee | On-time81% |