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South America

$134+ Cheap flights from Knoxville (TYS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — BOG
Jun 28 — Jul 51
Sat 6/28
Sat 7/5
1 adult, Economy
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Cheap flight deals from Knoxville to South America

Keep the following information in mind while searching for Knoxville to South America flight deals. Data was last updated June 23, 2025.

Round-trip from

$367
(Kiwi.com)

One-way from

$134
(Kiwi.com)
From Knoxville McGhee Tyson to South America
Search Deals
One-way flight from Knoxville McGhee Tyson to South America
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Find flight deals from Knoxville to South America

Cheapest flights from Knoxville to South America
Explore the most affordable flight options available from Knoxville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 23, 2025.

This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/148:52 pmTYS - CTG
1 stop16h 36mMultiple Airlines
Sat 8/231:36 pmCTG - TYS
1 stop23h 58mMultiple Airlines
Deal found 6/23$367
This United deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/139:30 amTYS - LPB
2 stops16h 40mMultiple Airlines
Fri 9/193:20 amLPB - TYS
2 stops16h 33mMultiple Airlines
Deal found 6/22$753
This LATAM Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/144:02 pmTYS - LIM
1 stop14h 38mLATAM Airlines
Mon 7/218:50 amLIM - TYS
2 stops31h 34mLATAM Airlines
Deal found 6/21$770
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1410:59 amTYS - LIM
1 stop19h 01mDelta
Sun 7/2012:05 amLIM - TYS
2 stops16h 19mDelta
Deal found 6/21$798
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/134:00 pmTYS - MVD
2 stops16h 30mDelta
Sun 11/162:25 amMVD - TYS
2 stops32h 46mDelta
Deal found 6/21$816
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:58 pmTYS - SCL
2 stops13h 07mAmerican Airlines
Mon 8/189:55 pmSCL - TYS
2 stops19h 54mAmerican Airlines
Deal found 6/21$903
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/25:46 pmTYS - LIM
2 stops30h 14mUnited Airlines
Thu 7/1012:40 amLIM - TYS
2 stops32h 37mUnited Airlines
Deal found 6/22$908
This Mytrip deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/128:49 pmTYS - EZE
3 stops47h 41mMultiple Airlines
Tue 9/234:45 pmEZE - TYS
2 stops28h 59mMultiple Airlines
Deal found 6/23$928
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/55:49 pmTYS - SCL
1 stop13h 11mDelta
Mon 8/188:40 pmSCL - TYS
1 stop16h 28mDelta
Deal found 6/22$974
This Avianca deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:00 amTYS - IBE
2 stops24h 23mAvianca
Wed 11/195:12 pmIBE - TYS
2 stops30h 47mAvianca
Deal found 6/20$989
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/125:20 pmTYS - EZE
1 stop13h 40mUnited Airlines
Tue 9/239:00 pmEZE - TYS
1 stop17h 38mUnited Airlines
Deal found 6/23$1,015
This Copa Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:45 amTYS - SCL
2 stops23h 17mCopa Airlines
Thu 8/212:26 amSCL - TYS
2 stops18h 30mCopa Airlines
Deal found 6/21$1,086

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2025.
Use the filters below to find and compare flights from Knoxville to South America that are best for you.

Fly from

Knoxville

Fly to

South America

Route

Depart

Return

Price

KnoxvilleCartagena

TYS - CTG

TYSCTG

Knoxville McGhee Tyson

Thu 8/14

8:52 pm-12:28 pm

1 stop16h 36m

Cartagena Rafael Nunez

Sat 8/23

1:36 pm-2:34 pm

1 stop23h 58m

$367

KnoxvilleLa Paz

TYS - LPB

TYSLPB

Knoxville McGhee Tyson

Sat 9/13

9:30 am-2:10 am

2 stops16h 40m

La Paz El Alto Intl

Fri 9/19

3:20 am-7:53 pm

2 stops16h 33m

$753

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 7/14

4:02 pm-5:40 am

1 stop14h 38m

Lima J Chavez Intl

Mon 7/21

8:50 am-5:24 pm

2 stops31h 34m

$770

KnoxvilleLima

TYS - LIM

TYSLIM

Knoxville McGhee Tyson

Mon 7/14

10:59 am-5:00 am

1 stop19h 01m

Lima J Chavez Intl

Sun 7/20

12:05 am-5:24 pm

2 stops16h 19m

$798

KnoxvilleMontevideo

TYS - MVD

TYSMVD

Knoxville McGhee Tyson

Thu 11/13

4:00 pm-10:30 am

2 stops16h 30m

Montevideo Carrasco

Sun 11/16

2:25 am-9:11 am

2 stops32h 46m

$816

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/5

5:58 pm-7:05 am

2 stops13h 07m

Santiago Arturo Merino Benitez

Mon 8/18

9:55 pm-5:49 pm

2 stops19h 54m

$903

KnoxvilleBuenos Aires

TYS - EZE

TYSEZE

Knoxville McGhee Tyson

Fri 9/12

8:49 pm-9:30 pm

3 stops47h 41m

Buenos Aires Ministro Pistarini

Tue 9/23

4:45 pm-8:44 pm

2 stops28h 59m

$928

KnoxvilleSantiago

TYS - SCL

TYSSCL

Knoxville McGhee Tyson

Tue 8/5

5:49 pm-7:00 am

1 stop13h 11m

Santiago Arturo Merino Benitez

Mon 8/18

8:40 pm-1:08 pm

1 stop16h 28m

$974

KnoxvilleIbagué

TYS - IBE

TYSIBE

Knoxville McGhee Tyson

Sat 11/15

7:00 am-7:23 am

2 stops24h 23m

Ibague

Wed 11/19

5:12 pm-11:59 pm

2 stops30h 47m

$989

KnoxvilleBuenos Aires

TYS - EZE

TYSEZE

Knoxville McGhee Tyson

Fri 9/12

5:20 pm-8:00 am

1 stop13h 40m

Buenos Aires Ministro Pistarini

Tue 9/23

9:00 pm-1:38 pm

1 stop17h 38m

$1,015

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/21

Showing 1-10 of 31 results
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Best time to book a flight from Knoxville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to South America

What is the cheapest month to book a flight from Knoxville to South America?

Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SA?

Find hourly flight availability from Knoxville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 23, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 23, 2025.
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,965 reviews
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,791 reviews
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,460 reviews
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,831 reviews
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,965 reviews

Overall

8.0

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to South America?

    If you book a flight to South America from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville.

  • What are the most popular routes from Knoxville to South America?

    Most travelers choose Knoxville McGhee Tyson - Santiago Arturo Merino Benitez, Knoxville McGhee Tyson - Sao Paulo Guarulhos Intl or Knoxville McGhee Tyson - Lima J Chavez Intl when deciding on the best route from Knoxville to South America.

  • Can I find deals for flights from Knoxville to South America that include hotel bookings?

    Yes. In addition to deals on Knoxville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to South America.

  • Can I find deals for business class flights from Knoxville to South America?

    Yes. Cheapflights offers flight deals from Knoxville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to South America?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to South America (average of $359). Flying from Knoxville to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Knoxville to South America

Discover the top 3 airlines that operate flights from Knoxville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$409Average$821FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$590Average$856FlexibilityNo cancel feeOn-time81%
DeltaCheapest$599Average$968FlexibilityNo cancel feeOn-timeN/A

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