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$92+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Travelocity deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:17 pmCLT - OMA
1 stop8h 30mFrontier
Mon 1/511:11 amOMA - CLT
1 stop28h 31mFrontier
Deal found 12/13$213
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:20 amCAE - CID
1 stop5h 14mUnited Airlines
Wed 12/315:28 pmCID - CAE
1 stop5h 58mUnited Airlines
Deal found 12/15$345
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:38 pmCLT - DSM
1 stop26h 32mMultiple Airlines
Sun 1/46:30 pmDSM - CLT
1 stop27h 59mMultiple Airlines
Deal found 12/14$353
This Frontier deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2112:17 pmCLT - OMA
1 stop8h 57mFrontier
Mon 12/2211:11 amOMA - CLT
1 stop8h 47mFrontier
Deal found 12/15$373
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amAGS - MLI
1 stop8h 51mAmerican Airlines
Wed 12/316:20 amMLI - AGS
1 stop8h 35mAmerican Airlines
Deal found 12/15$387
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amSAV - CID
1 stop12h 54mAllegiant Air
Fri 1/27:16 pmCID - SAV
1 stop18h 41mAllegiant Air
Deal found 12/14$405
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:24 amCLT - DSM
2 stops14h 46mMultiple Airlines
Sun 1/46:30 pmDSM - CLT
1 stop27h 59mMultiple Airlines
Deal found 12/14$412
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 pmCLT - OMA
1 stop20h 48mAmerican Airlines
Sat 1/103:26 pmOMA - CLT
Nonstop2h 27mAmerican Airlines
Deal found 12/13$414
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/139:40 pmCLT - OMA
Nonstop2h 48mAmerican Airlines
Sat 1/173:26 pmOMA - CLT
Nonstop2h 27mAmerican Airlines
Deal found 12/13$421
This Frontier deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2212:17 pmCLT - DSM
1 stop8h 27mFrontier
Tue 12/3011:14 amDSM - CLT
1 stop8h 15mFrontier
Deal found 12/14$422
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:46 pmMYR - OMA
1 stop5h 13mAmerican Airlines
Thu 1/15:38 pmOMA - MYR
1 stop5h 17mAmerican Airlines
Deal found 12/13$423
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:55 pmSAV - CID
1 stop5h 39mUnited Airlines
Fri 1/28:00 amCID - SAV
2 stops10h 27mUnited Airlines
Deal found 12/15$429

Find flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$208
(Kiwi.com)

One-way from

$92
(Trip.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Iowa
Search Deals
One-way flight from South Carolina to Iowa
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

South Carolina

Fly to

Iowa

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/8

1:24 pm-10:46 pm

1 stop10h 22m

Des Moines

Sun 1/11

2:58 pm-8:11 am

1 stop16h 13m

$208

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 1/8

9:06 am-10:46 pm

2 stops14h 40m

Des Moines

Mon 1/12

11:09 am-10:55 am

2 stops22h 46m

$237

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

Thu 4/23

4:54 pm-10:54 pm

1 stop7h 00m

Cedar Rapids

Sun 4/26

8:15 am-2:29 pm

1 stop5h 14m

$281

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

Thu 1/15

4:46 pm-9:34 pm

1 stop5h 48m

Cedar Rapids

Sun 1/18

8:00 am-2:38 pm

1 stop5h 38m

$287

SavannahOmaha

SAV - OMA

SAVOMA

Savannah/Hilton Head

Wed 1/14

6:05 am-10:05 am

1 stop5h 00m

Omaha Eppley Airfield

Tue 1/20

2:15 pm-7:10 pm

1 stop3h 55m

$309

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Tue 2/10

4:00 pm-9:16 pm

1 stop6h 16m

Omaha Eppley Airfield

Wed 2/18

6:05 am-12:11 pm

1 stop5h 06m

$309

SavannahOmaha

SAV - OMA

SAVOMA

Savannah/Hilton Head

Wed 1/14

10:10 am-2:25 pm

1 stop5h 15m

Omaha Eppley Airfield

Tue 1/20

3:21 pm-9:36 pm

1 stop5h 15m

$309

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Sat 2/14

5:11 am-11:53 am

2 stops7h 42m

Omaha Eppley Airfield

Tue 2/17

3:03 pm-10:56 pm

1 stop6h 53m

$314

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Sat 1/17

6:00 am-11:20 am

1 stop6h 20m

Omaha Eppley Airfield

Tue 1/20

7:00 am-3:10 pm

1 stop7h 10m

$320

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Wed 2/11

10:33 am-4:47 pm

1 stop7h 14m

Omaha Eppley Airfield

Tue 2/17

6:05 am-12:11 pm

1 stop5h 06m

$337

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/14

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

When flying from South Carolina to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 25% versus a flight in the morning.

What is the cheapest day to fly from South Carolina to Iowa?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Iowa. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Iowa flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 15, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,092 reviews
Delta
7.9
Good
8,008 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,008 reviews

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like United Airlines, Southwest, and Delta fly from South Carolina to Iowa in about 5h. The time it takes to get you to your destination can typically vary by up to 2h. South Carolina and Iowa are separated by a distance of 1028 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$204Average$388FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$344FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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