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$79+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
nov. 29 — dic. 61
sáb. 11/29
sáb. 12/6
1 adult, Economy
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Find flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/206:13 pmCHS - DSM
1 stop19h 42mMultiple Airlines
lun. 11/246:40 amDSM - CHS
1 stop9h 38mMultiple Airlines
Deal found 10/30$203
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/45:49 pmCLT - DSM
1 stop26h 14mMultiple Airlines
jue. 12/112:56 pmDSM - CLT
1 stop8h 03mMultiple Airlines
Deal found 10/29$204
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/218:49 amCLT - CID
1 stop9h 54mMultiple Airlines
lun. 11/246:38 pmCID - CLT
2 stops21h 12mMultiple Airlines
Deal found 10/29$212
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/205:59 pmCLT - CID
1 stop24h 44mMultiple Airlines
lun. 11/246:38 pmCID - CLT
2 stops21h 12mMultiple Airlines
Deal found 10/29$214
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/253:11 pmCLT - DSM
1 stop9h 13mMultiple Airlines
lun. 12/16:53 pmDSM - CLT
1 stop18h 13mMultiple Airlines
Deal found 10/28$232
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/206:09 pmCLT - DSM
1 stop23h 31mMultiple Airlines
lun. 11/246:40 amDSM - CLT
1 stop15h 28mMultiple Airlines
Deal found 10/29$233
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/1310:38 amGSP - CID
1 stop4h 55mAmerican Airlines
mar. 12/165:00 amCID - GSP
1 stop5h 31mAmerican Airlines
Deal found 10/28$249
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/210:45 amCLT - CID
1 stop24h 42mMultiple Airlines
mié. 12/1011:17 amCID - CLT
1 stop25h 24mMultiple Airlines
Deal found 10/30$259
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/135:35 amGSP - CID
2 stops11h 10mDelta
mar. 12/165:50 amCID - GSP
2 stops10h 59mDelta
Deal found 10/28$259
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/2611:56 amCLT - DSM
1 stop27h 10mMultiple Airlines
lun. 12/16:53 pmDSM - CLT
1 stop18h 13mMultiple Airlines
Deal found 10/27$264
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/2111:56 amCLT - DSM
1 stop29h 42mMultiple Airlines
lun. 11/246:40 amDSM - CLT
1 stop15h 28mMultiple Airlines
Deal found 10/29$267
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/246:00 amCLT - DSM
1 stop7h 55mMultiple Airlines
lun. 12/16:53 pmDSM - CLT
1 stop18h 13mMultiple Airlines
Deal found 10/27$273

Cheap flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated octubre 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$79
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Iowa
Search Deals
One-way flight from South Carolina to Iowa
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Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

South Carolina

Fly to

Iowa

Route

Depart

Return

Price

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

jue. 11/20

6:13 pm-12:55 pm

1 stop19h 42m

Des Moines

lun. 11/24

6:40 am-5:18 pm

1 stop9h 38m

$203

CharlotteCedar Rapids

CLT - CID

CLTCID

Charlotte Douglas

jue. 11/20

5:59 pm-5:43 pm

1 stop24h 44m

Cedar Rapids

lun. 11/24

6:38 pm-4:50 pm

2 stops21h 12m

$223

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

mar. 11/25

3:11 pm-11:24 pm

1 stop9h 13m

Des Moines

lun. 12/1

6:53 pm-2:06 pm

1 stop18h 13m

$232

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

jue. 12/4

3:42 pm-12:55 pm

2 stops22h 13m

Des Moines

jue. 12/11

2:56 pm-11:59 pm

1 stop8h 03m

$246

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

mié. 4/1

5:35 pm-9:54 pm

1 stop5h 19m

Cedar Rapids

sáb. 4/4

5:45 am-11:20 am

1 stop4h 35m

$279

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

lun. 12/22

7:30 am-6:09 pm

1 stop11h 39m

Cedar Rapids

vie. 1/2

7:16 pm-2:57 pm

1 stop18h 41m

$282

ColumbiaCedar Rapids

CAE - CID

CAECID

Columbia Metropolitan

mié. 11/12

5:24 pm-9:29 pm

1 stop5h 05m

Cedar Rapids

dom. 11/16

6:30 am-2:15 pm

2 stops6h 45m

$284

CharlotteCedar Rapids

CLT - CID

CLTCID

Charlotte Douglas

vie. 12/12

8:54 am-5:07 pm

1 stop9h 13m

Cedar Rapids

sáb. 1/10

10:52 am-1:03 pm

2 stops25h 11m

$294

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

vie. 12/5

8:03 pm-9:48 am

1 stop14h 45m

Des Moines

jue. 12/11

2:56 pm-8:49 pm

2 stops28h 53m

$303

GreenvilleCedar Rapids

GSP - CID

GSPCID

Greenville

mié. 4/15

5:05 pm-9:50 pm

1 stop5h 45m

Cedar Rapids

sáb. 4/18

12:05 pm-10:00 pm

2 stops8h 55m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in December is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 30, 2025.

When flying from South Carolina to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 27% versus a flight in the morning.

What is the cheapest day to fly from South Carolina to Iowa?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Iowa. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Iowa flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated octubre 30, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Overall

7.9

Entertainment

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like Delta, Allegiant Air, and United Airlines fly from South Carolina to Iowa in about 5h 05m. The time it takes to get you to your destination can typically vary by up to 6h 34m. South Carolina and Iowa are separated by a distance of 794 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $79. American Airlines flights start at $157 while deals on Delta start at $157 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in December is currently the most expensive (average of $378). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$350FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$399FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$480FlexibilityNo cancel feeOn-time69%

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