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$103+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:54 pm
CLT
-
CID
1 stop21h 01m
Multiple Airlines
Mon 5/186:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Deal found 3/15$197
This Booking.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:18 pm
CLT
-
OMA
1 stop26h 46m
Frontier
Sun 4/198:58 pm
OMA
-
CLT
1 stop19h 25m
Frontier
Deal found 3/12$213
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:56 am
CLT
-
DSM
1 stop8h 04m
Multiple Airlines
Sun 4/198:30 am
DSM
-
CLT
1 stop23h 40m
Multiple Airlines
Deal found 3/14$236
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:28 am
CLT
-
CID
1 stop12h 27m
Multiple Airlines
Mon 5/186:45 pm
CID
-
CLT
1 stop13h 25m
Multiple Airlines
Deal found 3/15$241
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:56 am
CLT
-
DSM
1 stop8h 04m
Multiple Airlines
Sun 4/268:30 am
DSM
-
CLT
1 stop23h 40m
Multiple Airlines
Deal found 3/12$250
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:54 pm
CLT
-
DSM
1 stop19h 06m
Multiple Airlines
Mon 4/202:04 pm
DSM
-
CLT
2 stops19h 13m
Multiple Airlines
Deal found 3/15$254
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:56 am
CLT
-
DSM
1 stop8h 04m
Multiple Airlines
Mon 4/202:04 pm
DSM
-
CLT
2 stops19h 13m
Multiple Airlines
Deal found 3/15$259
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:54 pm
CLT
-
DSM
1 stop25h 12m
Multiple Airlines
Sun 5/32:36 pm
DSM
-
CLT
1 stop17h 34m
Multiple Airlines
Deal found 3/11$260
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/145:30 pm
CLT
-
MLI
1 stop20h 46m
Multiple Airlines
Sat 4/185:17 pm
MLI
-
CLT
1 stop13h 52m
Multiple Airlines
Deal found 3/11$264
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:28 am
CLT
-
DSM
1 stop9h 47m
Multiple Airlines
Sun 5/107:45 am
DSM
-
CLT
1 stop11h 34m
Multiple Airlines
Deal found 3/14$268
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/89:00 pm
CLT
-
DSM
1 stop26h 06m
Multiple Airlines
Mon 4/139:07 pm
DSM
-
CLT
2 stops23h 56m
Multiple Airlines
Deal found 3/15$278
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:56 am
CLT
-
CID
1 stop9h 59m
Multiple Airlines
Mon 5/46:45 pm
CID
-
CLT
1 stop16h 20m
Multiple Airlines
Deal found 3/13$284

Find flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$197
(Kiwi.com)

One-way from

$103
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Iowa
Search Deals
One-way flight from South Carolina to Iowa
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Tue 5/5

3:14 pm-9:38 pm

1 stop7h 24m

Omaha Eppley Airfield

Wed 5/13

6:00 am-2:18 pm

1 stop7h 18m

$305

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Tue 5/5

12:19 pm-7:05 pm

2 stops7h 46m

Omaha Eppley Airfield

Wed 5/13

5:07 pm-10:24 pm

1 stop4h 17m

$316

Myrtle BeachDes Moines

MYR - DSM

MYRDSM

Myrtle Beach Intl

Wed 5/27

3:08 pm-9:40 pm

1 stop7h 32m

Des Moines

Tue 6/9

6:00 am-2:12 pm

1 stop7h 12m

$319

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Wed 4/15

11:00 am-3:39 pm

1 stop5h 39m

Omaha Eppley Airfield

Sat 4/18

8:00 am-2:17 pm

1 stop5h 17m

$321

CharlestonCedar Rapids

CHS - CID

CHSCID

Charleston

Sat 3/28

6:45 pm-11:20 pm

1 stop5h 35m

Cedar Rapids

Mon 3/30

5:00 am-1:53 pm

2 stops7h 53m

$324

Myrtle BeachOmaha

MYR - OMA

MYROMA

Myrtle Beach Intl

Sat 5/9

9:19 am-1:43 pm

1 stop5h 24m

Omaha Eppley Airfield

Tue 5/19

4:19 pm-11:02 pm

1 stop5h 43m

$329

CharlestonOmaha

CHS - OMA

CHSOMA

Charleston

Tue 4/14

5:00 pm-10:02 pm

1 stop6h 02m

Omaha Eppley Airfield

Tue 4/28

3:22 pm-9:25 pm

1 stop5h 03m

$335

GreenvilleDes Moines

GSP - DSM

GSPDSM

Greenville

Tue 5/5

6:30 am-12:55 pm

1 stop7h 25m

Des Moines

Sat 5/9

2:16 pm-7:46 pm

1 stop4h 30m

$337

ColumbiaOmaha

CAE - OMA

CAEOMA

Columbia Metropolitan

Thu 7/9

5:40 am-9:58 am

1 stop5h 18m

Omaha Eppley Airfield

Sun 7/12

5:35 am-12:28 pm

1 stop5h 53m

$339

CharlestonOmaha

CHS - OMA

CHSOMA

Charleston

Tue 4/14

3:40 pm-10:10 pm

1 stop7h 30m

Omaha Eppley Airfield

Tue 4/28

5:30 am-3:00 pm

2 stops8h 30m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 16, 2026.

When flying from South Carolina to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 22% versus a flight in the evening.

What is the cheapest day to fly from South Carolina to Iowa?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Iowa. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their South Carolina to Iowa flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated March 16, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,296 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,296 reviews
Delta
7.9
Good
8,296 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,428 reviews
Delta
7.9
Good
8,296 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,467 reviews
Delta
7.9
Good
8,296 reviews

Boarding

8.1

Comfort

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like United Airlines, American Airlines, and Delta fly from South Carolina to Iowa in about 5h 18m. The time it takes to get you to your destination can typically vary by up to 2h 28m. South Carolina and Iowa are separated by a distance of 952 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $191. American Airlines flights start at $217 while deals on Delta start at $356 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $274). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$204Average$392FlexibilityNo cancel feeOn-time71%
DeltaCheapest$208Average$366FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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