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$69+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Expedia deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:43 pmCLT - DSM
1 stop13h 36mFrontier
Sun 1/410:17 amDSM - CLT
1 stop9h 21mFrontier
Deal found 11/12$208
This Delta deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/75:34 amCAE - DSM
1 stop6h 04mDelta
Sun 12/145:34 amDSM - CAE
1 stop5h 34mDelta
Deal found 11/13$249
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:55 amCLT - OMA
2 stops29h 36mMultiple Airlines
Thu 1/152:37 pmOMA - CLT
1 stop19h 39mMultiple Airlines
Deal found 11/11$253
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/183:57 pmCAE - CID
1 stop17h 35mAllegiant Air
Fri 1/27:16 pmCID - CAE
1 stop12h 00mAllegiant Air
Deal found 11/12$254
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:55 pmCLT - DSM
1 stop13h 53mMultiple Airlines
Sun 1/184:30 pmDSM - CLT
2 stops21h 40mMultiple Airlines
Deal found 11/11$263
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/253:35 pmCLT - DSM
2 stops30h 34mMultiple Airlines
Sun 11/308:55 amDSM - CLT
1 stop21h 23mMultiple Airlines
Deal found 11/11$268
This Kiwi.com deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:54 amCLT - CID
1 stop9h 13mMultiple Airlines
Sun 12/148:58 amCID - CLT
2 stops28h 14mMultiple Airlines
Deal found 11/13$272
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:10 amCAE - DSM
1 stop6h 14mDelta
Mon 12/16:32 pmDSM - CAE
1 stop3h 59mDelta
Deal found 11/12$275
This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/288:00 pmCAE - DSM
1 stop5h 21mAmerican Airlines
Tue 12/23:18 pmDSM - CAE
1 stop6h 52mAmerican Airlines
Deal found 11/13$279
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:00 amCLT - DSM
1 stop16h 21mMultiple Airlines
Fri 12/127:28 pmDSM - CLT
2 stops13h 11mMultiple Airlines
Deal found 11/12$296
This Expedia deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:43 pmCLT - DSM
1 stop13h 36mFrontier
Tue 12/3011:14 amDSM - CLT
1 stop25h 42mFrontier
Deal found 11/12$298
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2510:13 amCLT - DSM
1 stop14h 11mMultiple Airlines
Mon 12/16:53 pmDSM - CLT
1 stop18h 13mMultiple Airlines
Deal found 11/11$300

Cheap flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$208
(Expedia)

One-way from

$69
(Frontier)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Des Moines flights.
Search Deals
From South Carolina to Iowa
Search Deals
One-way flight from South Carolina to Iowa
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

South Carolina

Fly to

Iowa

Route

Depart

Return

Price

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Mon 12/22

9:43 pm-10:19 am

1 stop13h 36m

Des Moines

Sun 1/4

10:17 am-8:38 pm

1 stop9h 21m

$208

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

Wed 4/1

3:50 pm-9:54 pm

1 stop7h 04m

Cedar Rapids

Sat 4/4

5:30 am-1:25 pm

1 stop6h 55m

$249

ColumbiaCedar Rapids

CAE - CID

CAECID

Columbia Metropolitan

Thu 12/18

3:57 pm-8:32 am

1 stop17h 35m

Cedar Rapids

Fri 1/2

7:16 pm-8:16 am

1 stop12h 00m

$254

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Tue 11/25

3:35 pm-9:09 pm

2 stops30h 34m

Des Moines

Sun 11/30

8:55 am-7:18 am

1 stop21h 23m

$268

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Thu 11/27

7:10 am-12:24 pm

1 stop6h 14m

Des Moines

Mon 12/1

6:32 pm-11:31 pm

1 stop3h 59m

$275

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Fri 11/28

8:00 pm-12:21 am

1 stop5h 21m

Des Moines

Tue 12/2

3:18 pm-11:10 pm

1 stop6h 52m

$279

ColumbiaDes Moines

CAE - DSM

CAEDSM

Columbia Metropolitan

Sun 12/7

5:34 am-2:19 pm

2 stops9h 45m

Des Moines

Sun 12/14

6:17 am-4:51 pm

2 stops9h 34m

$314

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Sun 12/21

9:33 pm-7:44 pm

2 stops23h 11m

Des Moines

Tue 12/30

3:45 pm-9:39 am

1 stop16h 54m

$317

ColumbiaCedar Rapids

CAE - CID

CAECID

Columbia Metropolitan

Wed 4/15

6:33 pm-9:26 pm

1 stop3h 53m

Cedar Rapids

Sat 4/18

1:37 pm-9:45 pm

1 stop7h 08m

$319

SavannahCedar Rapids

SAV - CID

SAVCID

Savannah/Hilton Head

Fri 12/19

7:30 am-5:54 pm

1 stop11h 24m

Cedar Rapids

Mon 12/29

6:44 pm-1:42 pm

1 stop17h 58m

$326

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

When flying from South Carolina to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 27% versus a flight in the morning.

What is the cheapest day to fly from South Carolina to Iowa?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Iowa. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Iowa flight should consider departing on Saturday afternoons when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated November 13, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Crew

8.5

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like Frontier, Delta, and Allegiant Air fly from South Carolina to Iowa in about 7h 04m. The time it takes to get you to your destination can typically vary by up to 10h 31m. South Carolina and Iowa are separated by a distance of 887 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $85. United Airlines flights start at $164 while deals on American Airlines start at $170 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$354FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$399FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$268Average$452FlexibilityNo cancel feeOn-time69%

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