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$74+ Cheap flights from South Carolina to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — DSM
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from South Carolina to Iowa

Keep the following information in mind while searching for South Carolina to Iowa flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$189
(Kiwi.com)

One-way from

$74
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Des Moines flight deals.
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From South Carolina to Iowa
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One-way flight from South Carolina to Iowa
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Find flight deals from South Carolina to Iowa

Cheapest flights from South Carolina to Iowa
Explore the most affordable flight options available from South Carolina to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:46 pm
CLT
-
OMA
2 stops26h 19m
Frontier
Sun 3/89:04 pm
OMA
-
CLT
1 stop20h 44m
Frontier
Deal found 1/13$229
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/121:17 pm
CLT
-
OMA
2 stops30h 12m
Frontier
Sun 2/221:43 pm
OMA
-
CLT
1 stop25h 35m
Frontier
Deal found 1/13$237
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/51:24 pm
CLT
-
DSM
1 stop10h 22m
Multiple Airlines
Mon 2/911:09 am
DSM
-
CLT
2 stops36h 31m
Multiple Airlines
Deal found 1/12$238
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/309:24 pm
CLT
-
CID
1 stop21h 31m
Multiple Airlines
Mon 5/46:45 pm
CID
-
CLT
1 stop12h 41m
Multiple Airlines
Deal found 1/14$244
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:55 am
CLT
-
CID
1 stop10h 00m
Multiple Airlines
Mon 4/276:45 pm
CID
-
CLT
1 stop12h 41m
Multiple Airlines
Deal found 1/14$246
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/155:13 pm
CLT
-
OMA
1 stop26h 21m
Frontier
Sun 2/221:43 pm
OMA
-
CLT
2 stops29h 00m
Frontier
Deal found 1/14$265
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/18:04 pm
CLT
-
OMA
1 stop15h 16m
Multiple Airlines
Fri 2/67:46 pm
OMA
-
CLT
1 stop13h 09m
Multiple Airlines
Deal found 1/12$278
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/112:46 pm
CLT
-
OMA
2 stops20h 51m
Frontier
Wed 2/185:00 pm
OMA
-
CLT
1 stop22h 18m
Frontier
Deal found 1/12$289
This Delta deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:30 pm
CHS
-
MLI
1 stop7h 01m
Delta
Mon 5/1811:00 am
MLI
-
CHS
1 stop4h 51m
Delta
Deal found 1/12$289
This Kiwi.com deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:18 pm
CLT
-
OMA
1 stop22h 53m
Multiple Airlines
Mon 4/206:01 pm
OMA
-
CLT
1 stop15h 16m
Multiple Airlines
Deal found 1/13$296
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/135:55 am
CLT
-
CID
1 stop13h 35m
Multiple Airlines
Mon 2/167:20 pm
CID
-
CLT
1 stop12h 06m
Multiple Airlines
Deal found 1/12$298
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2810:31 am
CHS
-
MLI
1 stop6h 55m
Delta
Sun 2/15:11 pm
MLI
-
CHS
1 stop5h 44m
Delta
Deal found 1/13$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from South Carolina to Iowa that are best for you.

Fly from

South Carolina

Fly to

Iowa

Route

Depart

Return

Price

CharlotteOmaha

CLT - OMA

CLTOMA

Charlotte Douglas

Thu 2/12

1:17 pm-6:29 pm

2 stops30h 12m

Omaha Eppley Airfield

Sun 2/22

1:43 pm-4:18 pm

1 stop25h 35m

$237

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 2/5

1:24 pm-10:46 pm

1 stop10h 22m

Des Moines

Mon 2/9

11:09 am-12:40 am

2 stops36h 31m

$238

CharlotteCedar Rapids

CLT - CID

CLTCID

Charlotte Douglas

Thu 4/30

9:24 pm-5:55 pm

1 stop21h 31m

Cedar Rapids

Mon 5/4

6:45 pm-8:26 am

1 stop12h 41m

$244

CharlestonMoline

CHS - MLI

CHSMLI

Charleston

Wed 1/28

10:31 am-4:26 pm

1 stop6h 55m

Moline Quad-City

Sun 2/1

5:11 pm-11:55 pm

1 stop5h 44m

$299

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Wed 4/1

8:07 am-1:46 pm

2 stops30h 39m

Des Moines

Mon 4/6

7:40 pm-9:35 am

1 stop12h 55m

$303

CharlestonMoline

CHS - MLI

CHSMLI

Charleston

Wed 1/28

2:37 pm-10:23 pm

2 stops8h 46m

Moline Quad-City

Sun 2/1

6:00 am-2:25 pm

1 stop7h 25m

$304

CharlestonDes Moines

CHS - DSM

CHSDSM

Charleston

Tue 2/10

10:15 am-2:33 pm

1 stop5h 18m

Des Moines

Tue 2/17

8:00 am-1:52 pm

1 stop4h 52m

$317

GreenvilleOmaha

GSP - OMA

GSPOMA

Greenville

Wed 3/4

7:29 am-6:44 pm

1 stop12h 15m

Omaha Eppley Airfield

Mon 3/9

1:58 pm-7:46 pm

1 stop4h 48m

$321

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Wed 3/25

8:56 am-1:29 pm

1 stop29h 33m

Des Moines

Sun 3/29

3:22 pm-8:03 am

2 stops15h 41m

$325

SavannahDes Moines

SAV - DSM

SAVDSM

Savannah/Hilton Head

Sat 2/7

7:45 am-2:55 pm

2 stops8h 10m

Des Moines

Sat 2/14

6:10 am-6:15 pm

2 stops11h 05m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Iowa

What is the cheapest month to book a flight from South Carolina to Iowa?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IA?

Find hourly flight availability from South Carolina to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 14, 2026.

When flying from South Carolina to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 27% versus a flight in the evening.

What is the cheapest day to fly from South Carolina to Iowa?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Iowa. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their South Carolina to Iowa flight should consider departing on Saturday afternoons when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated January 14, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from South Carolina to Iowa have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,040 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,040 reviews
Delta
7.9
Good
8,040 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,156 reviews
Delta
7.9
Good
8,040 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,119 reviews
Delta
7.9
Good
8,040 reviews

Boarding

8.1

Overall

7.9

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from South Carolina to Iowa?

    Airlines like Frontier, Delta, and American Airlines fly from South Carolina to Iowa in about 6h 55m. The time it takes to get you to your destination can typically vary by up to 23h 17m. South Carolina and Iowa are separated by a distance of 824 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Iowa one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $203. American Airlines flights start at $207 while deals on Delta start at $257 one-way.

  • Can I find deals for flights from South Carolina to Iowa that include hotel bookings?

    Yes. In addition to deals on South Carolina to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Iowa.

  • Can I find deals for business class flights from South Carolina to Iowa?

    Yes. Cheapflights offers flight deals from South Carolina to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Iowa?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Iowa (average of $162). Flying from South Carolina to Iowa in February is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for South Carolina to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from South Carolina to Iowa

Discover the top 3 airlines that operate flights from South Carolina to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$204Average$390FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$368FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$326Average$571FlexibilityNo cancel feeOn-time69%

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