$130+ Cheap flights from Des Moines to Indianapolis (DSM - IND)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — IND
Nov 11 — Nov 181
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Indianapolis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Indianapolis
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to IndianapolisExplore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
Explore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:31 pm -
1 stop3h 48m
Mon 11/29:03 pm -
1 stop4h 23m
Deal found 10/8![American Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:23 pm -
1 stop4h 23m
Sat 11/143:28 pm -
1 stop4h 25m
Deal found 10/10![American Airlines logo]()
$279
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:26 pm -
1 stop4h 12m
Wed 11/41:07 pm -
1 stop6h 49m
Deal found 10/8![American Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:30 pm -
1 stop6h 45m
Mon 11/22:25 pm -
2 stops9h 35m
Deal found 10/8![Southwest logo]()
$291
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop6h 40m
Sat 11/145:45 am -
2 stops15h 00m
Deal found 10/10![Southwest logo]()
$295
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:00 am -
1 stop3h 44m
Mon 11/26:33 pm -
1 stop4h 22m
Deal found 10/9![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:11 am -
1 stop6h 51m
Mon 11/309:04 pm -
1 stop4h 15m
Deal found 10/10![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:10 am -
2 stops8h 35m
Sun 12/2011:40 am -
2 stops12h 50m
Deal found 10/10![Southwest logo]()
$363
Best flights from Des Moines to IndianapolisDiscover carefully curated flight deals from Des Moines to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
Discover carefully curated flight deals from Des Moines to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop6h 40m
Sat 11/145:45 am -
2 stops15h 00m
Deal found 10/10![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:26 pm -
1 stop4h 12m
Wed 11/41:07 pm -
1 stop6h 49m
Deal found 10/11![American Airlines logo]()
$308
This deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/158:00 am -
1 stop3h 43m
Mon 1/188:00 pm -
1 stop4h 14m
Deal found 10/8![United Airlines logo]()
$446
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:30 pm -
1 stop6h 45m
Mon 11/22:25 pm -
2 stops9h 35m
Deal found 10/9![Southwest logo]()
$308
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/152:39 pm -
1 stop4h 43m
Sun 1/178:52 pm -
1 stop4h 34m
Deal found 10/9![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/187:10 pm -
1 stop3h 15m
Sun 12/2011:40 am -
2 stops12h 50m
Deal found 10/10![Southwest logo]()
$308
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:11 am -
1 stop6h 51m
Mon 11/309:04 pm -
1 stop4h 15m
Deal found 10/12![American Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/153:45 pm -
1 stop5h 50m
Sun 1/1711:35 am -
2 stops11h 00m
Deal found 10/9![Southwest logo]()
$348
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:11 am -
1 stop3h 59m
Sun 11/299:04 pm -
1 stop4h 15m
Deal found 10/12![American Airlines logo]()
$488
Last-minute flights from Des Moines to IndianapolisDiscover last-minute flight deals from Des Moines to Indianapolis. Data last updated October 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Indianapolis. Data last updated October 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:31 pm -
1 stop3h 48m
Mon 11/29:03 pm -
1 stop4h 23m
Deal found 10/8![American Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:30 pm -
1 stop6h 45m
Mon 11/22:25 pm -
2 stops9h 35m
Deal found 10/8![Southwest logo]()
$291
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:00 am -
1 stop3h 44m
Mon 11/26:33 pm -
1 stop4h 22m
Deal found 10/9![United Airlines logo]()
$297
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:26 pm -
1 stop4h 12m
Wed 11/41:07 pm -
1 stop6h 49m
Deal found 10/8![American Airlines logo]()
$285
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:23 pm -
1 stop4h 23m
Sat 11/143:28 pm -
1 stop4h 25m
Deal found 10/10![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:45 pm -
1 stop6h 40m
Sat 11/145:45 am -
2 stops15h 00m
Deal found 10/10![Southwest logo]()
$295
This American Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:11 am -
1 stop6h 51m
Mon 11/309:04 pm -
1 stop4h 15m
Deal found 10/10![American Airlines logo]()
$338
One-way flights from Des Moines to IndianapolisSearch for one-way flight options from Des Moines to Indianapolis. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
Search for one-way flight options from Des Moines to Indianapolis. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
This CheapOair deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:30 pm -
1 stop17h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Frontier logo]()
$130
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2010:55 am -
1 stop5h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![Delta logo]()
$140
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:20 am -
2 stops7h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Southwest logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:25 pm -
2 stops15h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$218
This KAYAK deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:29 am -
1 stop3h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![American Airlines logo]()
$229
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/257:31 pm -
1 stop3h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![American Airlines logo]()
$245
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/208:00 am -
1 stop6h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/205:35 am -
2 stops7h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:07 pm -
2 stops18h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/11![United Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:30 am -
3 stops33h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/12![Multiple Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:55 pm -
1 stop3h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![United Airlines logo]()
$434
Find flight deals from Des Moines to Indianapolis
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $264 (American Airlines) |
One-way from | $117 (Southwest) |
Popular in | May |
Cheapest in | February |
Average price | $373 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Sat 11/14
8:00 am-12:47 pm
1 stop3h 47m
Indianapolis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$140
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Wed 1/20
12:52 pm-6:56 pm
1 stop5h 04m
Indianapolis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$140
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Sat 11/14
5:20 am-1:25 pm
2 stops7h 05m
Indianapolis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$145
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Sun 10/25
7:31 pm-12:19 am
1 stop3h 48m
Indianapolis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$245
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Sat 11/7
12:45 pm-8:25 pm
1 stop6h 40m
Indianapolis
Sat 11/14
5:45 am-7:45 pm
2 stops15h 00m
$295
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Sun 11/1
7:26 pm-12:38 am
1 stop4h 12m
Indianapolis
Wed 11/4
1:07 pm-6:56 pm
1 stop6h 49m
$308
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Fri 10/30
4:30 pm-12:15 am
1 stop6h 45m
Indianapolis
Mon 11/2
2:25 pm-11:00 pm
2 stops9h 35m
$308
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Fri 12/18
7:10 pm-11:25 pm
1 stop3h 15m
Indianapolis
Sun 12/20
11:40 am-11:30 pm
2 stops12h 50m
$308
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Tue 10/20
8:00 am-3:14 pm
1 stop6h 14m
Indianapolis
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$334
Des MoinesIndianapolis
DSM Des Moines - IND Indianapolis
DSMIND
Des Moines
Fri 1/15
2:39 pm-8:22 pm
1 stop4h 43m
Indianapolis
Sun 1/17
8:52 pm-12:26 am
1 stop4h 34m
$337
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Indianapolis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Indianapolis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Indianapolis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Indianapolis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Indianapolis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Indianapolis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Indianapolis
Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Des Moines with our price prediction graph.
DSM-IND
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Indianapolis
What is the cheapest month to book a flight from Des Moines to Indianapolis?
Currently, February is the cheapest month in which you can book a flight from Des Moines to Indianapolis (average of $308). Flying from Des Moines to Indianapolis in May is currently the most expensive (average of $606). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Indianapolis?
Airfare is below average for this route at the moment.
Des Moines to Indianapolis flights typically cost between $360 and $420 in October.The cheapest round-trip price found within the last 5 days was $264 on American Airlines (Oct 30-Nov 2).
Reviews of airlines servicing Indianapolis
Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated October 12, 2026.
Get a feel of what it's like to fly with Delta,United Airlines, andAmerican Airlines from Des Moines to Indianapolis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Boarding
8.1
Comfort
7.8
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Indianapolis?
Book flights to Indianapolis if you plan to visit one of these locationsGreenwood
Plainfield
Terre Haute
Fishers
Muncie
Kokomo
Westfield
Franklin
Mooresville
Crawfordsville
Anderson
Carmel
Bloomington
Noblesville
Speedway
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Indianapolis flight routes
Other flight options
Other flights from Des Moines
Popular flights
Alternative routes for Des Moines to Indianapolis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Indianapolis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Indianapolis by cabin class
Find flights from Des Moines to Indianapolis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Indianapolis
Explore flights to Indianapolis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 12, 2026.
Des Moines and Indianapolis flights
Browse other Des Moines and Indianapolis flight options. Last updated on October 12, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Indianapolis
Discover the top 3 airlines that operate flights from Des Moines to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$272 | Average$358 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$344 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$276 | Average$372 | FlexibilityNo cancel fee | On-time71% |