How long is the flight from Des Moines to Indianapolis?

A quick flight from Des Moines to Indianapolis can take about 5h 44m. Delta provides one of the quickest options available for as low as $251. Des Moines and Indianapolis are separated by a distance of 406 mi. This flight may include one or multiple stops.

What are the cheapest airlines flying from Des Moines to Indianapolis round-trip?

Our cheapest airline available from Des Moines to Indianapolis is Delta. Our recent data shows that you can find tickets from as low as $193 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $196 and $210 round-trip. You may be able to fly from Des Moines to Indianapolis for 40% less than the average price by searching for these airlines.

What are the cheapest airlines to fly from Des Moines to Indianapolis one-way?

$98 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $123 and $125, respectively.

In terms of precipitation, rainfall in Indianapolis ranges from 2.3 - 5.1 inches per month. May is typically the wettest month, when rainfall can reach 5.1 in. February is typically the driest time to visit Indianapolis when rainfall is around 2.3 in.

If weather is an important factor for your trip to Indianapolis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

What are the most popular airlines that fly from Des Moines to Indianapolis?

When booking a flight from Des Moines to Indianapolis, you may want to consider flying on American Airlines, Delta or United Airlines as they are the most popular for this route.

Most accurate provider : When it comes to deals on Des Moines-Indianapolis flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Indianapolis flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Indianapolis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Indianapolis flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Indianapolis that include hotel bookings?

Yes. In addition to deals on Des Moines to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Indianapolis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Indianapolis.

Can I find deals for business class flights from Des Moines to Indianapolis?

Yes. Cheapflights offers flight deals from Des Moines to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$115+ Flights from Des Moines to Indianapolis

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Cheap flight deals from Des Moines to Indianapolis

Cheapest flights from Des Moines to Indianapolis
Explore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Fri 12/265:55 pmDSM - IND

1 stop4h 28mDelta

Thu 1/16:35 amIND - DSM

1 stop5h 53mDelta

Deal found 12/25

$383

Fri 12/265:55 pmDSM - IND

1 stop4h 28mDelta

Fri 1/212:49 pmIND - DSM

1 stop4h 52mDelta

Deal found 12/25

$517

Fri 12/265:30 amDSM - IND

2 stops6h 10mSouthwest

Fri 1/24:35 pmIND - DSM

1 stop7h 35mSouthwest

Deal found 12/25

$522

Fri 12/265:30 amDSM - IND

2 stops6h 10mSouthwest

Thu 1/17:10 amIND - DSM

2 stops5h 15mSouthwest

Deal found 12/25

$547

Best flights from Des Moines to Indianapolis
Discover carefully curated flight deals from Des Moines to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

Tue 2/104:22 pmDSM - IND

1 stop5h 44mDelta

Tue 2/176:15 amIND - DSM

1 stop4h 41mDelta

Deal found 12/27

$251

Tue 1/277:40 amDSM - IND

1 stop7h 37mAmerican Airlines

Sat 1/312:22 pmIND - DSM

1 stop6h 40mAmerican Airlines

Deal found 12/25

$251

Tue 1/276:10 amDSM - IND

2 stops10h 50mSouthwest

Sat 1/316:10 amIND - DSM

1 stop7h 05mSouthwest

Deal found 12/25

$282

Tue 2/243:24 pmDSM - IND

1 stop3h 39mUnited Airlines

Thu 2/269:05 amIND - DSM

1 stop6h 22mUnited Airlines

Deal found 12/24

$324

Sun 1/112:58 pmDSM - IND

1 stop27h 33mMultiple Airlines

Thu 1/155:10 amIND - DSM

1 stop18h 36mMultiple Airlines

Deal found 12/27

$328

Fri 1/93:34 pmDSM - IND

1 stop17h 50mAllegiant Air

Sun 1/112:31 pmIND - DSM

1 stop9h 36mAllegiant Air

Deal found 12/25

$331

Tue 2/176:19 amDSM - IND

1 stop4h 09mDelta

Thu 2/197:00 amIND - DSM

1 stop4h 17mDelta

Deal found 12/25

$264

Mon 2/95:49 pmDSM - IND

1 stop5h 18mDelta

Mon 2/163:40 pmIND - DSM

1 stop6h 09mDelta

Deal found 12/26

$302

Mon 2/911:09 amDSM - IND

2 stops34h 39mMultiple Airlines

Mon 2/163:06 pmIND - DSM

1 stop8h 24mMultiple Airlines

Deal found 12/26

$333

Last-minute flights from Des Moines to Indianapolis
Discover last-minute flight deals from Des Moines to Indianapolis. Data last updated December 28, 2025 and is based on user searches.

Fri 12/265:55 pmDSM - IND

1 stop4h 28mDelta

Thu 1/16:35 amIND - DSM

1 stop5h 53mDelta

Deal found 12/25

$383

Fri 1/93:34 pmDSM - IND

1 stop17h 50mAllegiant Air

Sun 1/112:31 pmIND - DSM

1 stop9h 36mAllegiant Air

Deal found 12/25

$331

Sun 1/112:58 pmDSM - IND

1 stop27h 33mMultiple Airlines

Thu 1/155:10 amIND - DSM

1 stop18h 36mMultiple Airlines

Deal found 12/27

$328

Fri 1/165:01 pmDSM - IND

1 stop16h 37mAmerican Airlines

Mon 1/196:34 pmIND - DSM

1 stop5h 49mAmerican Airlines

Deal found 12/27

$339

Mon 1/268:00 amDSM - IND

1 stop5h 57mUnited Airlines

Mon 2/25:50 pmIND - DSM

1 stop5h 00mUnited Airlines

Deal found 12/25

$277

Mon 1/268:35 amDSM - IND

1 stop7h 30mSouthwest

Mon 2/210:30 amIND - DSM

2 stops11h 40mSouthwest

Deal found 12/25

$363

Tue 1/277:40 amDSM - IND

1 stop7h 37mAmerican Airlines

Sat 1/312:22 pmIND - DSM

1 stop6h 40mAmerican Airlines

Deal found 12/25

$251

Tue 1/276:10 amDSM - IND

2 stops10h 50mSouthwest

Sat 1/316:10 amIND - DSM

1 stop7h 05mSouthwest

Deal found 12/25

$282

One-way flights from Des Moines to Indianapolis
Search for one-way flight options from Des Moines to Indianapolis. Find affordable one-way fares based on user searches. Data last updated December 28, 2025.

Thu 1/16:46 pmDSM - IND

1 stop3h 58mUnited Airlines

Deal found 12/25

$115

Tue 1/276:24 amDSM - IND

1 stop4h 06mDelta

Deal found 12/27

$126

Tue 1/278:35 amDSM - IND

2 stops12h 30mSouthwest

Deal found 12/27

$144

Sun 1/45:21 pmDSM - IND

1 stop4h 33mDelta

Deal found 12/25

$249

Sun 1/43:44 pmDSM - IND

2 stops24h 58mMultiple Airlines

Deal found 12/25

$258

Tue 1/273:35 pmDSM - IND

3 stops18h 13mUnited Airlines

Deal found 12/27

$268

Fri 1/23:14 pmDSM - IND

1 stop5h 45mUnited Airlines

Deal found 12/27

$269

Tue 12/305:30 amDSM - IND

2 stops6h 10mSouthwest

Deal found 12/26

$274

Thu 1/112:56 pmDSM - IND

2 stops7h 00mAmerican Airlines

Deal found 12/27

$306

Fri 1/26:44 pmDSM - IND

3 stops59h 29mMultiple Airlines

Deal found 12/27

$443

Tue 12/303:45 pmDSM - IND

3 stops47h 11mMultiple Airlines

Deal found 12/26

$514

Find flight deals from Des Moines to Indianapolis

Most accurate provider	Mytrip 3 stars
Most trusted provider	Mytrip 3 stars
Round-trip from	$251 (American Airlines)
One-way from	$115 (United Airlines)
Popular in	November
Cheapest in	September
Average price	$308

Provider with most accurate pricing for Des Moines-Indianapolis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Indianapolis flights.

Search Deals

From Des Moines to Indianapolis

Search Deals

One-way flight from Des Moines to Indianapolis

Search Deals

Highest demand for flights based on searches. 8% potential increase in price ($28 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 2/10

4:22 pm-11:06 pm

1 stop5h 44m

Indianapolis

Tue 2/17

6:15 am-9:56 am

1 stop4h 41m

$251

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 1/27

7:40 am-4:17 pm

1 stop7h 37m

Indianapolis

Sat 1/31

2:22 pm-8:02 pm

1 stop6h 40m

$251

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 2/17

6:19 am-11:28 am

1 stop4h 09m

Indianapolis

Thu 2/19

7:00 am-10:17 am

1 stop4h 17m

$264

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 1/27

6:10 am-6:00 pm

2 stops10h 50m

Indianapolis

Sat 1/31

6:10 am-12:15 pm

1 stop7h 05m

$282

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 2/9

5:49 pm-12:07 am

1 stop5h 18m

Indianapolis

Mon 2/16

3:40 pm-8:49 pm

1 stop6h 09m

$302

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 2/24

3:24 pm-8:03 pm

1 stop3h 39m

Indianapolis

Thu 2/26

9:05 am-2:27 pm

1 stop6h 22m

$324

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sun 1/11

2:58 pm-7:31 pm

1 stop27h 33m

Indianapolis

Thu 1/15

5:10 am-10:46 pm

1 stop18h 36m

$328

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Fri 1/9

3:34 pm-10:24 am

1 stop17h 50m

Indianapolis

Sun 1/11

2:31 pm-11:07 pm

1 stop9h 36m

$331

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Mon 2/9

11:09 am-10:48 pm

2 stops34h 39m

Indianapolis

Mon 2/16

3:06 pm-10:30 pm

1 stop8h 24m

$333

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 1/27

6:24 am-11:30 am

1 stop4h 06m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 20 results

Compare providers for flights from Des Moines to Indianapolis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Indianapolis in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Mytrip	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Indianapolis flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Indianapolis flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Indianapolis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Indianapolis flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Indianapolis

What is the cheapest month to book a flight from Des Moines to Indianapolis?

Currently, June is the cheapest month in which you can book a flight from Des Moines to Indianapolis (average of $130). Flying from Des Moines to Indianapolis in May is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to IND?

It’s optimal to fly from Des Moines to Indianapolis in the evening. By choosing this option you can save up to 82% on the cost of your flight, compared to a flight in the afternoon.

Reviews of airlines servicing Indianapolis

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Indianapolis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,019 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

United Airlines

7.4

Good

9,113 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,072 reviews

Delta

7.9

Good

8,019 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Des Moines to Indianapolis?
A quick flight from Des Moines to Indianapolis can take about 5h 44m. Delta provides one of the quickest options available for as low as $251. Des Moines and Indianapolis are separated by a distance of 406 mi. This flight may include one or multiple stops.
What are the cheapest airlines flying from Des Moines to Indianapolis round-trip?
Our cheapest airline available from Des Moines to Indianapolis is Delta. Our recent data shows that you can find tickets from as low as $193 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $196 and $210 round-trip. You may be able to fly from Des Moines to Indianapolis for 40% less than the average price by searching for these airlines.
What are the cheapest airlines to fly from Des Moines to Indianapolis one-way?
$98 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $123 and $125, respectively.
Can I find deals for flights from Des Moines to Indianapolis that include hotel bookings?
Yes. In addition to deals on Des Moines to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Indianapolis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Indianapolis.
Can I find deals for business class flights from Des Moines to Indianapolis?
Yes. Cheapflights offers flight deals from Des Moines to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Indianapolis?
Currently, June is the cheapest month in which you can book a flight from Des Moines to Indianapolis (average of $130). Flying from Des Moines to Indianapolis in May is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Terre Haute

Muncie

Noblesville

Fishers

Greenwood

Plainfield

Anderson

Kokomo

Franklin

Carmel

Crawfordsville

Bloomington

Speedway

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Top 3 airlines flying from Des Moines to Indianapolis

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$196	Average$308	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$196	Average$319	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$210	Average$367	FlexibilityNo cancel fee	On-time69%

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$115+ Cheap flights from Des Moines to Indianapolis (DSM - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Indianapolis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Indianapolis

Cheapest flights from Des Moines to IndianapolisExplore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Explore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

Find flight deals from Des Moines to Indianapolis

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Indianapolis that are best for you.

Compare providers for flights from Des Moines to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Indianapolis in December.

Best time to book a flight from Des Moines to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Indianapolis

What is the cheapest month to book a flight from Des Moines to Indianapolis?

What is the cheapest time of day to fly from DSM to IND?

Reviews of airlines servicing Indianapolis

Get a feel of what it's like to fly with Delta, United Airlines, and American Airlines from Des Moines to Indianapolis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Des Moines to Indianapolis?

What are the cheapest airlines flying from Des Moines to Indianapolis round-trip?

What are the cheapest airlines to fly from Des Moines to Indianapolis one-way?

Can I find deals for flights from Des Moines to Indianapolis that include hotel bookings?

How can I find direct flights from Des Moines to Indianapolis?

Can I find deals for business class flights from Des Moines to Indianapolis?

What is the cheapest month to book a flight from Des Moines to Indianapolis?

Traveling to a place near Indianapolis?

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Alternative routes for Des Moines to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Des Moines to Indianapolis

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Cheapest flights from Des Moines to Indianapolis
Explore the most affordable flight options available from Des Moines to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.