$90+ Cheap flights from Des Moines (DSM) to Indiana
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — IND
May 23 — May 301
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to IndianaExplore the most affordable flight options available from Des Moines to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from Des Moines to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- ORD
1 stop26h 03m
Multiple Airlines
Sat 6/67:52 pm
ORD
- DSM
1 stop27h 00m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- ORD
1 stop6h 16m
Multiple Airlines
Wed 5/278:05 am
ORD
- DSM
2 stops38h 26m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$207
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:03 pm
DSM
- ORD
Nonstop1h 43m
American Airlines
Wed 5/2710:31 pm
ORD
- DSM
Nonstop1h 37m
American Airlines
Deal found 4/20![American Airlines logo]()
$209
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:56 am
DSM
- ORD
1 stop5h 55m
Delta
Wed 5/206:24 am
ORD
- DSM
1 stop3h 52m
Delta
Deal found 4/21![Delta logo]()
$229
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:56 am
DSM
- ORD
Nonstop1h 40m
American Airlines
Wed 5/2710:31 pm
ORD
- DSM
Nonstop1h 37m
American Airlines
Deal found 4/22![American Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:10 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Thu 6/410:10 am
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:35 pm
DSM
- MDW
Nonstop1h 25m
Southwest
Tue 6/910:10 am
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/22![Southwest logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:07 pm
DSM
- CVG
2 stops16h 07m
Multiple Airlines
Sun 8/236:15 am
CVG
- DSM
1 stop9h 07m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$243
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:15 pm
DSM
- IND
1 stop3h 50m
United Airlines
Wed 6/37:59 pm
IND
- DSM
1 stop4h 17m
United Airlines
Deal found 4/21![United Airlines logo]()
$250
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/612:29 pm
DSM
- MDW
1 stop6h 04m
Delta
Tue 6/91:16 pm
MDW
- DSM
1 stop4h 07m
Delta
Deal found 4/22![Delta logo]()
$251
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:56 am
DSM
- ORD
1 stop5h 55m
Delta
Thu 5/148:42 am
ORD
- DSM
1 stop3h 42m
Delta
Deal found 4/21![Delta logo]()
$251
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:20 pm
DSM
- ORD
Nonstop1h 32m
United Airlines
Mon 5/1812:57 pm
ORD
- DSM
Nonstop1h 27m
United Airlines
Deal found 4/20![United Airlines logo]()
$253
Best flights from Des Moines to IndianaDiscover carefully curated flight deals from Des Moines to Indiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from Des Moines to Indiana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
DSM
- ORD
Nonstop1h 40m
United Airlines
Mon 5/255:50 pm
ORD
- DSM
Nonstop1h 35m
United Airlines
Deal found 4/22![United Airlines logo]()
$253
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:26 am
DSM
- ORD
1 stop6h 03m
Delta
Mon 5/186:24 am
ORD
- DSM
1 stop6h 00m
Delta
Deal found 4/21![Delta logo]()
$273
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:20 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Mon 5/189:45 pm
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/22![Southwest logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:01 pm
DSM
- CVG
2 stops42h 13m
Multiple Airlines
Sun 6/149:00 pm
CVG
- DSM
1 stop25h 06m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$290
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:48 pm
DSM
- SDF
2 stops7h 39m
American Airlines
Fri 6/58:08 pm
SDF
- DSM
1 stop5h 02m
American Airlines
Deal found 4/22![American Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/138:30 am
DSM
- RFD
1 stop11h 53m
Allegiant Air
Sun 7/1911:27 am
RFD
- DSM
1 stop28h 23m
Allegiant Air
Deal found 4/20![Allegiant Air logo]()
$383
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:15 am
DSM
- MDW
1 stop6h 27m
Delta
Tue 6/309:54 am
MDW
- DSM
1 stop4h 11m
Delta
Deal found 4/23![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:15 pm
DSM
- ORD
Nonstop1h 43m
United Airlines
Sun 6/78:08 pm
ORD
- DSM
Nonstop1h 32m
United Airlines
Deal found 4/23![United Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/32:36 pm
DSM
- CVG
1 stop30h 15m
Multiple Airlines
Thu 5/78:40 pm
CVG
- DSM
2 stops17h 51m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:25 am
DSM
- IND
1 stop6h 05m
Southwest
Fri 5/296:35 pm
IND
- DSM
2 stops5h 30m
Southwest
Deal found 4/21![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:04 pm
DSM
- ORD
1 stop6h 16m
Delta
Fri 5/225:41 pm
ORD
- DSM
1 stop3h 31m
Delta
Deal found 4/20![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:56 am
DSM
- DAY
2 stops9h 16m
American Airlines
Sat 5/912:53 pm
DAY
- DSM
1 stop6h 42m
American Airlines
Deal found 4/20![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:15 am
DSM
- ORD
1 stop6h 41m
Delta
Tue 5/266:24 am
ORD
- DSM
1 stop6h 00m
Delta
Deal found 4/22![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
DSM
- SDF
1 stop6h 09m
United Airlines
Wed 5/207:15 am
SDF
- DSM
1 stop4h 22m
United Airlines
Deal found 4/20![United Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:30 am
DSM
- IND
1 stop5h 35m
Southwest
Fri 5/152:15 pm
IND
- DSM
2 stops9h 50m
Southwest
Deal found 4/20![Southwest logo]()
$325
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
DSM
- AZO
1 stop3h 56m
Delta
Sun 7/123:00 pm
AZO
- DSM
1 stop6h 49m
Delta
Deal found 4/21![Delta logo]()
$298
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:10 am
DSM
- MDW
Nonstop1h 20m
Southwest
Sun 6/710:05 am
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/18![Southwest logo]()
$329
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:03 pm
DSM
- AZO
1 stop3h 22m
American Airlines
Mon 6/223:48 pm
AZO
- DSM
2 stops9h 22m
American Airlines
Deal found 4/23![American Airlines logo]()
$362
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:15 pm
DSM
- IND
1 stop3h 50m
United Airlines
Thu 6/46:00 am
IND
- DSM
1 stop5h 27m
United Airlines
Deal found 4/20![United Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:00 am
DSM
- RFD
1 stop13h 20m
Allegiant Air
Mon 6/158:35 am
RFD
- DSM
1 stop14h 02m
Allegiant Air
Deal found 4/22![Allegiant Air logo]()
$429
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:10 am
DSM
- AZO
1 stop4h 40m
Delta
Sat 5/96:15 pm
AZO
- DSM
1 stop3h 21m
Delta
Deal found 4/20![Delta logo]()
$308
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:10 am
DSM
- MDW
Nonstop1h 20m
Southwest
Fri 6/1210:10 am
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/21![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/268:30 pm
DSM
- IND
1 stop3h 50m
United Airlines
Sun 6/289:15 pm
IND
- DSM
1 stop4h 30m
United Airlines
Deal found 4/20![United Airlines logo]()
$347
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/64:25 pm
DSM
- ORD
1 stop4h 55m
Delta
Sat 6/136:30 am
ORD
- DSM
1 stop3h 44m
Delta
Deal found 4/22![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/256:00 am
DSM
- IND
1 stop5h 54m
United Airlines
Tue 6/304:25 pm
IND
- DSM
1 stop4h 00m
United Airlines
Deal found 4/21![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Mon 6/298:05 pm
SDF
- DSM
1 stop4h 25m
Southwest
Deal found 4/20![Southwest logo]()
$347
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:59 pm
DSM
- RFD
1 stop20h 01m
Allegiant Air
Sun 5/310:37 am
RFD
- DSM
1 stop11h 29m
Allegiant Air
Deal found 4/23![Allegiant Air logo]()
$465
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/221:37 pm
DSM
- DAY
1 stop7h 29m
American Airlines
Mon 5/254:16 pm
DAY
- DSM
1 stop4h 16m
American Airlines
Deal found 4/22![American Airlines logo]()
$461
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:00 am
DSM
- IND
1 stop6h 54m
United Airlines
Sun 5/248:00 am
IND
- DSM
1 stop5h 13m
United Airlines
Deal found 4/21![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:20 am
DSM
- IND
2 stops9h 10m
Southwest
Fri 7/172:55 pm
IND
- DSM
1 stop8h 25m
Southwest
Deal found 4/18![Southwest logo]()
$352
Last-minute flights from Des Moines to IndianaDiscover last-minute flight deals from Des Moines to Indiana. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Indiana. Data last updated April 23, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- ORD
1 stop6h 16m
Multiple Airlines
Wed 5/278:05 am
ORD
- DSM
2 stops38h 26m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$207
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:56 am
DSM
- ORD
Nonstop1h 40m
American Airlines
Wed 5/2710:31 pm
ORD
- DSM
Nonstop1h 37m
American Airlines
Deal found 4/22![American Airlines logo]()
$231
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:20 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Wed 5/278:50 pm
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 4/22![Southwest logo]()
$265
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:04 pm
DSM
- ORD
1 stop3h 47m
Delta
Tue 5/196:24 am
ORD
- DSM
1 stop6h 00m
Delta
Deal found 4/21![Delta logo]()
$229
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:56 am
DSM
- ORD
1 stop5h 55m
Delta
Thu 5/148:42 am
ORD
- DSM
1 stop3h 42m
Delta
Deal found 4/21![Delta logo]()
$251
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:00 am
DSM
- ORD
Nonstop1h 41m
American Airlines
Mon 5/182:59 pm
ORD
- DSM
Nonstop1h 32m
American Airlines
Deal found 4/21![American Airlines logo]()
$255
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:20 pm
DSM
- ORD
Nonstop1h 32m
United Airlines
Mon 5/1812:57 pm
ORD
- DSM
Nonstop1h 27m
United Airlines
Deal found 4/20![United Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:03 pm
DSM
- ORD
Nonstop1h 43m
American Airlines
Wed 5/2710:31 pm
ORD
- DSM
Nonstop1h 37m
American Airlines
Deal found 4/20![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:35 am
DSM
- MDW
Nonstop1h 20m
Southwest
Thu 6/410:05 pm
MDW
- DSM
Nonstop1h 25m
Southwest
Deal found 4/22![Southwest logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- IND
2 stops41h 40m
Multiple Airlines
Mon 6/82:49 pm
IND
- DSM
1 stop9h 38m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:43 am
DSM
- ORD
Nonstop1h 49m
American Airlines
Fri 5/296:40 am
ORD
- DSM
Nonstop1h 33m
American Airlines
Deal found 4/21![American Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- ORD
1 stop26h 03m
Multiple Airlines
Sat 6/67:52 pm
ORD
- DSM
1 stop27h 00m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$191
One-way flights from Des Moines to IndianaSearch for one-way flight options from Des Moines to Indiana. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from Des Moines to Indiana. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
- ORD
1 stop6h 16m
Frontier
Deal found 4/21![Frontier logo]()
$90
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:20 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$105
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:11 am
DSM
- ORD
Nonstop1h 34m
American Airlines
Deal found 4/21![American Airlines logo]()
$105
This Super.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:16 pm
DSM
- ORD
1 stop6h 16m
Frontier
Deal found 4/20![Frontier logo]()
$110
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:15 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 4/20![Southwest logo]()
$114
This Southwest deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:55 am
DSM
- IND
1 stop5h 20m
Southwest
Deal found 4/19![Southwest logo]()
$114
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:01 am
DSM
- MDW
1 stop6h 18m
Delta
Deal found 4/21![Delta logo]()
$115
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:15 am
DSM
- ORD
1 stop4h 14m
Delta
Deal found 4/21![Delta logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:01 pm
DSM
- MDW
2 stops43h 11m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$126
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:44 am
DSM
- IND
1 stop5h 05m
American Airlines
Deal found 4/21![American Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:01 pm
DSM
- ORD
2 stops40h 02m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$126
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:00 am
DSM
- ORD
Nonstop1h 32m
United Airlines
Deal found 4/22![United Airlines logo]()
$127
Find flight deals from Des Moines to Indiana
Keep the following information in mind while searching for Des Moines to Indiana flight deals. Data was last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (Kiwi.com) |
One-way from | $90 (Frontier) |
Popular in | March |
Cheapest in | September |
Average price | $297 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Des Moines to Indiana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesChicago
DSM - ORD
DSMORD
Des Moines
Sat 5/23
6:00 am-7:40 am
Nonstop1h 40m
Chicago O'Hare Intl
Mon 5/25
5:50 pm-7:25 pm
Nonstop1h 35m
$253
Des MoinesChicago
DSM - ORD
DSMORD
Des Moines
Thu 5/14
10:26 am-4:29 pm
1 stop6h 03m
Chicago O'Hare Intl
Mon 5/18
6:24 am-12:24 pm
1 stop6h 00m
$273
Quickest round-trip
Des MoinesChicago
DSM - MDW
DSMMDW
Des Moines
Thu 5/14
4:20 pm-5:40 pm
Nonstop1h 20m
Chicago Midway
Mon 5/18
9:45 pm-11:05 pm
Nonstop1h 20m
$283
Des MoinesChicago
DSM - MDW
DSMMDW
Des Moines
Wed 5/27
6:15 am-12:42 pm
1 stop6h 27m
Chicago Midway
Tue 6/30
9:54 am-2:05 pm
1 stop4h 11m
$289
Des MoinesChicago
DSM - ORD
DSMORD
Des Moines
Wed 5/20
1:04 pm-7:20 pm
1 stop6h 16m
Chicago O'Hare Intl
Fri 5/22
5:41 pm-9:12 pm
1 stop3h 31m
$289
Des MoinesChicago
DSM - ORD
DSMORD
Des Moines
Sun 5/24
6:15 am-12:56 pm
1 stop6h 41m
Chicago O'Hare Intl
Tue 5/26
6:24 am-12:24 pm
1 stop6h 00m
$289
Des MoinesCincinnati
DSM - CVG
DSMCVG
Des Moines
Sun 6/7
4:01 pm-11:14 am
2 stops42h 13m
Cincinnati Cinci./N. Kentucky
Sun 6/14
9:00 pm-9:06 pm
1 stop25h 06m
$290
Des MoinesChicago
DSM - ORD
DSMORD
Des Moines
Mon 6/1
8:15 pm-9:58 pm
Nonstop1h 43m
Chicago O'Hare Intl
Sun 6/7
8:08 pm-9:40 pm
Nonstop1h 32m
$291
Des MoinesKalamazoo
DSM - AZO
DSMAZO
Des Moines
Thu 7/9
6:00 am-10:56 am
1 stop3h 56m
Kalamazoo Intl
Sun 7/12
3:00 pm-8:49 pm
1 stop6h 49m
$298
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sat 5/30
1:48 pm-10:27 pm
2 stops7h 39m
Louisville Intl
Fri 6/5
8:08 pm-12:10 am
1 stop5h 02m
$300
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Indiana
Have a flexible travel schedule? Discover the best time to fly to Indiana from Des Moines with our price prediction graph.
DSM-ORD
DSM-MDW
DSM-IND
DSM-CVG
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Indiana
DSM-USIN
DSM-ORD
DSM-MDW
DSM-IND
DSM-CVG
What is the cheapest month to book a flight from Des Moines to Indiana?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $158). Flying from Des Moines to Indiana in March is currently the most expensive (average of $344). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Indiana?
Reviews of airlines servicing Indiana
Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated April 23, 2026.
Read through reviews of airlines operating flights from Des Moines to Indiana, such as Delta,United Airlines, andAmerican Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Crew
8.5
Boarding
8.1
Comfort
7.9
Entertainment
7.8
Overall
7.9
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Indiana
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Complete your trip
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Des Moines and Indiana flights
Browse other Des Moines and Indiana flight options. Last updated on April 23, 2026.
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Des Moines to Indiana flights
Consider these flights traveling from Des Moines to Indiana.
Top 3 airlines flying from Des Moines to Indiana
Discover the top 3 airlines that operate flights from Des Moines to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$196 | Average$321 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$308 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$210 | Average$358 | FlexibilityNo cancel fee | On-time69% |