$174+ Cheap flights from Des Moines to Louisville (DSM - SDF)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Aug 3 — Aug 101
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Louisville
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Cheapest flights from Des Moines to LouisvilleExplore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 4, 2026.
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 4, 2026.
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:00 am
DSM
- SDF
1 stop4h 03m
American Airlines
Wed 7/297:10 pm
SDF
- DSM
1 stop5h 51m
American Airlines
Deal found 7/1![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:40 pm
DSM
- SDF
1 stop4h 55m
Southwest
Tue 8/185:30 am
SDF
- DSM
2 stops7h 20m
Southwest
Deal found 6/30![Southwest logo]()
$278
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am
DSM
- SDF
2 stops9h 55m
Southwest
Sat 10/2410:55 am
SDF
- DSM
2 stops10h 50m
Southwest
Deal found 7/1![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:40 am
DSM
- SDF
1 stop5h 41m
Delta
Tue 8/258:05 am
SDF
- DSM
1 stop7h 00m
Delta
Deal found 7/4![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:10 am
DSM
- SDF
2 stops9h 10m
Southwest
Tue 8/256:45 pm
SDF
- DSM
1 stop4h 10m
Southwest
Deal found 7/4![Southwest logo]()
$294
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:00 am
DSM
- SDF
1 stop4h 36m
American Airlines
Sat 8/86:28 am
SDF
- DSM
1 stop4h 32m
American Airlines
Deal found 7/2![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:10 am
DSM
- SDF
1 stop4h 10m
Southwest
Fri 9/253:20 pm
SDF
- DSM
2 stops7h 50m
Southwest
Deal found 7/1![Southwest logo]()
$315
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:40 am
DSM
- SDF
1 stop3h 45m
Southwest
Sun 8/94:05 pm
SDF
- DSM
2 stops7h 45m
Southwest
Deal found 7/1![Southwest logo]()
$323
Best flights from Des Moines to LouisvilleDiscover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 4, 2026.
Discover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 4, 2026.
This Southwest deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:10 am
DSM
- SDF
2 stops9h 10m
Southwest
Tue 8/255:30 am
SDF
- DSM
2 stops7h 20m
Southwest
Deal found 7/4![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:00 am
DSM
- SDF
1 stop6h 51m
Delta
Sun 8/237:05 am
SDF
- DSM
1 stop4h 38m
Delta
Deal found 7/1![Delta logo]()
$347
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/93:24 pm
DSM
- SDF
1 stop3h 59m
United Airlines
Fri 8/147:10 am
SDF
- DSM
1 stop6h 10m
United Airlines
Deal found 7/1![United Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:10 am
DSM
- SDF
2 stops6h 15m
Southwest
Sat 8/86:45 am
SDF
- DSM
2 stops13h 40m
Southwest
Deal found 7/3![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:37 pm
DSM
- SDF
1 stop4h 49m
Delta
Sun 7/266:00 am
SDF
- DSM
1 stop5h 45m
Delta
Deal found 7/2![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/165:40 am
DSM
- SDF
1 stop3h 45m
Southwest
Sun 8/234:05 pm
SDF
- DSM
2 stops7h 45m
Southwest
Deal found 7/1![Southwest logo]()
$393
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:40 pm
DSM
- SDF
2 stops6h 50m
Southwest
Sun 7/268:00 pm
SDF
- DSM
1 stop4h 50m
Southwest
Deal found 6/30![Southwest logo]()
$413
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Mon 7/2710:45 am
SDF
- DSM
2 stops13h 50m
Southwest
Deal found 7/3![Southwest logo]()
$434
Last-minute flights from Des Moines to LouisvilleDiscover last-minute flight deals from Des Moines to Louisville. Data last updated July 4, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisville. Data last updated July 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/225:00 am
DSM
- SDF
1 stop4h 03m
American Airlines
Wed 7/297:10 pm
SDF
- DSM
1 stop5h 51m
American Airlines
Deal found 7/1![American Airlines logo]()
$273
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:00 am
DSM
- SDF
1 stop4h 36m
American Airlines
Sat 8/86:28 am
SDF
- DSM
1 stop4h 32m
American Airlines
Deal found 7/2![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:10 am
DSM
- SDF
2 stops6h 55m
Southwest
Sat 8/89:00 am
SDF
- DSM
1 stop3h 30m
Southwest
Deal found 7/2![Southwest logo]()
$356
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:40 am
DSM
- SDF
1 stop3h 45m
Southwest
Sun 8/94:05 pm
SDF
- DSM
2 stops7h 45m
Southwest
Deal found 7/1![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:40 pm
DSM
- SDF
1 stop4h 55m
Southwest
Tue 8/185:30 am
SDF
- DSM
2 stops7h 20m
Southwest
Deal found 6/30![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:00 am
DSM
- SDF
1 stop6h 51m
Delta
Sun 8/237:05 am
SDF
- DSM
1 stop4h 38m
Delta
Deal found 7/1![Delta logo]()
$347
This Delta deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:40 am
DSM
- SDF
1 stop5h 41m
Delta
Tue 8/258:05 am
SDF
- DSM
1 stop7h 00m
Delta
Deal found 7/4![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 7/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:10 am
DSM
- SDF
2 stops9h 10m
Southwest
Tue 8/256:45 pm
SDF
- DSM
1 stop4h 10m
Southwest
Deal found 7/4![Southwest logo]()
$294
One-way flights from Des Moines to LouisvilleSearch for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated July 4, 2026.
Search for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated July 4, 2026.
This Delta deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:28 am
DSM
- SDF
1 stop4h 32m
Delta
Deal found 7/3![Delta logo]()
$174
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:40 am
DSM
- SDF
2 stops8h 50m
Southwest
Deal found 7/1![Southwest logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:08 pm
DSM
- SDF
3 stops38h 28m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$188
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
DSM
- SDF
1 stop6h 42m
Delta
Deal found 7/2![Delta logo]()
$194
This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:40 pm
DSM
- SDF
2 stops6h 50m
Southwest
Deal found 7/2![Southwest logo]()
$199
This United Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
DSM
- SDF
2 stops12h 15m
United Airlines
Deal found 7/3![United Airlines logo]()
$214
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:50 pm
DSM
- SDF
1 stop4h 09m
United Airlines
Deal found 7/1![United Airlines logo]()
$230
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- SDF
2 stops6h 50m
Southwest
Deal found 7/3![Southwest logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:08 pm
DSM
- SDF
3 stops38h 28m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- SDF
2 stops26h 59m
Multiple Airlines
Deal found 6/30![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- SDF
3 stops38h 56m
Multiple Airlines
Deal found 7/2![Multiple Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:20 am
DSM
- SDF
1 stop3h 45m
Southwest
Deal found 7/3![Southwest logo]()
$290
Find flight deals from Des Moines to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $273 (American Airlines) |
One-way from | $174 (Delta) |
Popular in | December |
Cheapest in | January |
Average price | $435 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 4, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Tue 8/18
6:10 am-4:20 pm
2 stops9h 10m
Louisville Intl
Tue 8/25
5:30 am-11:50 am
2 stops7h 20m
$299
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sun 8/16
6:00 am-1:51 pm
1 stop6h 51m
Louisville Intl
Sun 8/23
7:05 am-10:43 am
1 stop4h 38m
$347
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sun 8/2
5:10 am-12:25 pm
2 stops6h 15m
Louisville Intl
Sat 8/8
6:45 am-7:25 pm
2 stops13h 40m
$375
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 7/24
6:37 pm-12:26 am
1 stop4h 49m
Louisville Intl
Sun 7/26
6:00 am-10:45 am
1 stop5h 45m
$387
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sun 8/16
5:40 am-10:25 am
1 stop3h 45m
Louisville Intl
Sun 8/23
4:05 pm-10:50 pm
2 stops7h 45m
$393
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 7/24
4:40 pm-12:30 am
2 stops6h 50m
Louisville Intl
Sun 7/26
8:00 pm-11:50 pm
1 stop4h 50m
$413
Quickest round-trip
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Sun 8/9
3:24 pm-8:23 pm
1 stop3h 59m
Louisville Intl
Fri 8/14
7:10 am-12:20 pm
1 stop6h 10m
$417
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Wed 7/22
5:20 am-10:05 am
1 stop3h 45m
Louisville Intl
Mon 7/27
10:45 am-11:35 pm
2 stops13h 50m
$434
Cheapest one-way
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 8/7
11:23 am-6:56 pm
1 stop6h 33m
$174
Des MoinesLouisville
DSM - SDF
DSMSDF
Des Moines
Fri 8/28
11:28 am-5:00 pm
1 stop4h 32m
$174
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisville
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated July 4, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Delta,United Airlines, andAmerican Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Comfort
7.8
Food
7.2
Overall
7.8
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsCorydon
Shepherdsville
Elizabethtown
Jeffersonville
Bardstown
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Des Moines and Louisville flights
Browse other Des Moines and Louisville flight options. Last updated on July 4, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on July 4, 2026.
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Top 3 airlines flying from Des Moines to Louisville
Discover the top 3 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$109 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$129 | Average$328 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$260 | Average$402 | FlexibilityNo cancel fee | On-time71% |