$129+ Cheap flights from Des Moines to Louisville (DSM - SDF)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDF
Oct 9 — Oct 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Louisville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Louisville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to LouisvilleExplore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
Explore the most affordable flight options available from Des Moines to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 9, 2026.
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:27 am -
1 stop4h 22m
Thu 10/222:36 pm -
1 stop7h 04m
Deal found 9/8![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
1 stop3h 30m
Wed 10/143:55 pm -
2 stops7h 05m
Deal found 9/7![Southwest logo]()
$262
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
1 stop3h 30m
Thu 10/225:35 am -
2 stops6h 35m
Deal found 9/8![Southwest logo]()
$297
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:10 pm -
2 stops13h 55m
Thu 10/228:20 am -
1 stop3h 50m
Deal found 9/8![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:57 am -
1 stop6h 02m
Sat 10/315:59 pm -
1 stop5h 34m
Deal found 9/7![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
2 stops5h 40m
Tue 10/138:35 am -
1 stop3h 55m
Deal found 9/6![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:35 am -
2 stops9h 55m
Sat 10/315:35 am -
2 stops13h 10m
Deal found 9/4![Southwest logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:05 am -
1 stop9h 57m
Fri 9/2510:25 am -
2 stops12h 43m
Deal found 9/5![Multiple Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:25 am -
1 stop3h 40m
Sun 11/88:45 am -
1 stop3h 45m
Deal found 9/6![Southwest logo]()
$352
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:11 pm -
1 stop4h 20m
Sun 10/115:15 am -
1 stop6h 15m
Deal found 9/8![United Airlines logo]()
$361
Best flights from Des Moines to LouisvilleDiscover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
Discover carefully curated flight deals from Des Moines to Louisville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 9, 2026.
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:54 pm -
1 stop4h 05m
Wed 10/146:00 am -
1 stop5h 42m
Deal found 9/7![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
1 stop3h 30m
Wed 10/213:55 pm -
2 stops7h 05m
Deal found 9/8![Southwest logo]()
$297
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/179:55 am -
1 stop6h 02m
Wed 11/183:24 pm -
1 stop6h 12m
Deal found 9/8![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:54 pm -
1 stop4h 05m
Sat 10/317:00 am -
1 stop4h 11m
Deal found 9/9![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:10 am -
1 stop4h 00m
Mon 11/28:45 am -
1 stop3h 45m
Deal found 9/4![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:00 pm -
1 stop4h 15m
Sat 10/319:15 am -
1 stop3h 35m
Deal found 9/4![Southwest logo]()
$327
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:25 am -
1 stop3h 40m
Sun 11/88:45 am -
1 stop3h 45m
Deal found 9/6![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
2 stops5h 40m
Tue 10/133:55 pm -
2 stops7h 05m
Deal found 9/6![Southwest logo]()
$362
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
2 stops9h 55m
Thu 10/225:35 am -
2 stops6h 35m
Deal found 9/8![Southwest logo]()
$362
Last-minute flights from Des Moines to LouisvilleDiscover last-minute flight deals from Des Moines to Louisville. Data last updated September 9, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Louisville. Data last updated September 9, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:05 am -
1 stop9h 57m
Fri 9/2510:25 am -
2 stops12h 43m
Deal found 9/5![Multiple Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:35 am -
2 stops5h 40m
Tue 10/138:35 am -
1 stop3h 55m
Deal found 9/6![Southwest logo]()
$332
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am -
1 stop3h 30m
Wed 10/143:55 pm -
2 stops7h 05m
Deal found 9/7![Southwest logo]()
$262
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:11 pm -
1 stop4h 20m
Sun 10/115:15 am -
1 stop6h 15m
Deal found 9/8![United Airlines logo]()
$361
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/197:10 pm -
2 stops13h 55m
Thu 10/228:20 am -
1 stop3h 50m
Deal found 9/8![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:27 am -
1 stop4h 22m
Thu 10/222:36 pm -
1 stop7h 04m
Deal found 9/8![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:35 am -
1 stop3h 30m
Thu 10/225:35 am -
2 stops6h 35m
Deal found 9/8![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:57 am -
1 stop6h 02m
Sat 10/315:59 pm -
1 stop5h 34m
Deal found 9/7![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:35 am -
2 stops9h 55m
Sat 10/315:35 am -
2 stops13h 10m
Deal found 9/4![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:10 am -
1 stop4h 00m
Sun 11/17:55 pm -
1 stop4h 05m
Deal found 9/5![Southwest logo]()
$352
One-way flights from Des Moines to LouisvilleSearch for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
Search for one-way flight options from Des Moines to Louisville. Find affordable one-way fares based on user searches. Data last updated September 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:05 am -
1 stop9h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$129
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop6h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Delta logo]()
$148
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:10 pm -
2 stops14h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Southwest logo]()
$159
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
2 stops6h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Southwest logo]()
$270
This KAYAK deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:54 pm -
1 stop4h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$292
This KAYAK deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:00 am -
1 stop7h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Delta logo]()
$293
This KAYAK deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/232:29 pm -
1 stop7h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:24 am -
1 stop5h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$393
Find flight deals from Des Moines to Louisville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Louisville (SDF). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $257 (Delta) |
One-way from | $129 (Kiwi.com) |
Popular in | December |
Cheapest in | January |
Average price | $376 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
Use the filters below to find and compare flights from Des Moines to Louisville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Mon 9/28
10:05 am-9:02 pm
1 stop9h 57m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$129
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Fri 10/23
6:00 am-1:53 pm
1 stop6h 53m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$148
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Fri 10/23
7:10 pm-10:20 am
2 stops14h 10m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$159
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Wed 10/7
6:54 pm-11:59 pm
1 stop4h 05m
Louisville Intl
Wed 10/14
6:00 am-10:42 am
1 stop5h 42m
$257
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Tue 10/27
6:54 pm-11:59 pm
1 stop4h 05m
Louisville Intl
Sat 10/31
7:00 am-10:11 am
1 stop4h 11m
$257
Quickest round-trip
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Mon 9/14
6:54 pm-11:59 pm
1 stop4h 05m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$292
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Tue 9/22
6:00 am-2:07 pm
1 stop7h 07m
Louisville Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$293
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Wed 10/21
5:35 am-10:05 am
1 stop3h 30m
Louisville Intl
Wed 10/21
3:55 pm-10:00 pm
2 stops7h 05m
$297
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Tue 11/17
9:55 am-4:57 pm
1 stop6h 02m
Louisville Intl
Wed 11/18
3:24 pm-8:36 pm
1 stop6h 12m
$327
Des MoinesLouisville
DSM Des Moines - SDF Louisville Intl
DSMSDF
Des Moines
Thu 10/29
5:10 am-10:10 am
1 stop4h 00m
Louisville Intl
Mon 11/2
8:45 am-11:30 am
1 stop3h 45m
$327
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Louisville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Louisville in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Louisville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Louisville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Louisville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Louisville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Louisville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Louisville
Have a flexible travel schedule? Discover the best time to fly to Louisville from Des Moines with our price prediction graph.
DSM-SDF
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Louisville
Reviews of airlines servicing Louisville
Get insights into the airlines that provide service to Louisville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Louisville. Reviews last updated September 9, 2026.
Read through reviews of airlines operating flights from Des Moines to Louisville, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Louisville?
Book flights to Louisville if you plan to visit one of these locationsShepherdsville
Elizabethtown
Jeffersonville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Louisville flight routes
Other flight options
Other flights from Des Moines
Popular flights
Alternative routes for Des Moines to Louisville
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Louisville by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Louisville by cabin class
Find flights from Des Moines to Louisville, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to Louisville
Explore flights to Louisville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Des Moines and Louisville flights
Browse other Des Moines and Louisville flight options. Last updated on September 9, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Louisville
Discover the top 4 airlines that operate flights from Des Moines to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$250 | Average$346 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$260 | Average$452 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$409 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$288 | Average$446 | FlexibilityNo cancel fee | On-timeN/A |