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Lexington

$228+ Cheap flights from Des Moines to Lexington (DSM - LEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
May 29 — Jun 51
Fri 5/29
Fri 6/5
1 adult, Economy
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Cheap flight deals from Des Moines to Lexington

Cheapest flights from Des Moines to Lexington
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
-
LEX
1 stop19h 33m
Allegiant Air
Thu 6/49:31 pm
LEX
-
DSM
1 stop21h 57m
Allegiant Air
Deal found 4/27$309
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:37 pm
DSM
-
LEX
2 stops8h 22m
American Airlines
Sat 10/2412:05 pm
LEX
-
DSM
1 stop5h 15m
American Airlines
Deal found 4/28$314
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:55 am
DSM
-
LEX
1 stop4h 43m
American Airlines
Fri 7/36:53 pm
LEX
-
DSM
1 stop6h 08m
American Airlines
Deal found 4/26$329
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:33 pm
DSM
-
LEX
1 stop6h 33m
Delta
Sun 5/175:52 pm
LEX
-
DSM
1 stop3h 44m
Delta
Deal found 4/28$339
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
-
LEX
1 stop19h 33m
Multiple Airlines
Thu 6/43:06 pm
LEX
-
DSM
2 stops26h 53m
Multiple Airlines
Deal found 4/27$343
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:44 am
DSM
-
LEX
2 stops8h 34m
American Airlines
Sun 5/177:00 am
LEX
-
DSM
1 stop4h 31m
American Airlines
Deal found 4/28$344
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:00 am
DSM
-
LEX
1 stop4h 25m
American Airlines
Sat 10/248:03 pm
LEX
-
DSM
1 stop5h 04m
American Airlines
Deal found 4/28$354
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
DSM
-
LEX
1 stop6h 10m
United Airlines
Sun 9/61:53 pm
LEX
-
DSM
1 stop6h 31m
United Airlines
Deal found 4/26$359
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:41 pm
DSM
-
LEX
1 stop4h 18m
Delta
Sun 6/77:05 am
LEX
-
DSM
1 stop4h 38m
Delta
Deal found 4/27$384

Find flight deals from Des Moines to Lexington

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$309
(Kiwi.com)

One-way from

$228
(Kiwi.com)

Popular in

February

Cheapest in

September

Average price

$521
Provider with most accurate pricing for Des Moines-Lexington Blue Grass flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lexington Blue Grass flights.
Search Deals
From Des Moines to Lexington Blue Grass
Search Deals
One-way flight from Des Moines to Lexington Blue Grass
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($178 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 8/13

11:23 am-4:54 pm

1 stop4h 31m

Lexington Blue Grass

Sat 8/22

5:20 am-10:11 am

1 stop5h 51m

$309

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 10/17

12:11 pm-7:31 pm

1 stop6h 20m

Lexington Blue Grass

Sat 10/24

8:03 pm-12:07 am

1 stop5h 04m

$329

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 5/13

2:33 pm-10:06 pm

1 stop6h 33m

Lexington Blue Grass

Sun 5/17

5:52 pm-8:36 pm

1 stop3h 44m

$339

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 9/3

6:00 am-1:10 pm

1 stop6h 10m

Lexington Blue Grass

Sun 9/6

1:53 pm-7:24 pm

1 stop6h 31m

$359

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 6/5

6:41 pm-11:59 pm

1 stop4h 18m

Lexington Blue Grass

Sun 6/7

7:05 am-10:43 am

1 stop4h 38m

$384

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 9/3

2:15 pm-9:23 pm

1 stop6h 08m

Lexington Blue Grass

Tue 9/8

3:45 pm-10:26 pm

1 stop7h 41m

$384
Quickest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 8/29

6:50 pm-12:09 am

1 stop4h 19m

Lexington Blue Grass

Wed 9/2

6:00 pm-9:12 pm

1 stop4h 12m

$389

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 7/1

6:55 am-4:05 pm

2 stops8h 10m

Lexington Blue Grass

Fri 7/3

5:01 pm-12:06 am

2 stops8h 05m

$412

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Sat 6/6

4:48 pm-11:18 pm

1 stop5h 30m

Lexington Blue Grass

Mon 6/8

8:10 pm-12:10 am

1 stop5h 00m

$425

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 8/7

1:08 pm-8:51 pm

1 stop6h 43m

Lexington Blue Grass

Sun 8/9

8:08 pm-11:48 pm

1 stop4h 40m

$425

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/24

Showing 1-10 of 15 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Lexington

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Lexington in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Lexington flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Lexington flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Lexington flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Lexington flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Lexington flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Lexington

Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Lexington

How much does it cost to fly round-trip from Des Moines to Lexington?

Reviews of airlines servicing Lexington

Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated April 29, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,680 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
United Airlines
7.4
Good
9,680 reviews
United Airlines
7.4
Good
9,680 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.
American Airlines
7.1
Good
11,678 reviews
United Airlines
7.4
Good
9,680 reviews

Entertainment

7.1

Food

6.6

Crew

8.1

Overall

7.4

Comfort

7.3

Boarding

7.7

Reviews

1 / 20
8.0
Excellent

Anonymous,Apr 2026

DFW - EWR

The flight was on time. Crew was friendly. Will fly again. The seats was comfortable.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Lexington?

    United Airlines, American Airlines, and Delta can get you from Des Moines to Lexington in just under 4h 31m. Your travel time can differ by up to 2h 02m. The distance between Des Moines and Lexington is about 537 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Lexington round-trip?

    United Airlines, at $225, was found to be the cheapest airline from Des Moines to Lexington. An alternate airline flying to your destination would be American Airlines. You may be able to fly from Des Moines to Lexington for 51% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Lexington that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lexington flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lexington?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lexington.

  • Can I find deals for business class flights from Des Moines to Lexington?

    Yes. Cheapflights offers flight deals from Des Moines to Lexington by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Somerset
Danville
Berea
Georgetown
Frankfort

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Top 2 airlines flying from Des Moines to Lexington

Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$225Average$432FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$421FlexibilityNo cancel feeOn-time71%

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