HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Lexington

$271+ Cheap flights from Des Moines to Lexington (DSM - LEX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
Aug 28 — Sep 41
Fri 8/28
Fri 9/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Lexington with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Lexington

Cheapest flights from Des Moines to Lexington
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.

This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/811:32 am
DSM
-
LEX
1 stop4h 39m
United Airlines
Sun 9/135:57 pm
LEX
-
DSM
1 stop4h 31m
United Airlines
Deal found 7/27$319
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:08 pm
DSM
-
LEX
1 stop6h 43m
American Airlines
Sat 9/126:00 am
LEX
-
DSM
2 stops8h 59m
American Airlines
Deal found 7/27$324
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:30 am
DSM
-
LEX
1 stop5h 22m
Delta
Sat 11/218:30 am
LEX
-
DSM
1 stop6h 33m
Delta
Deal found 7/29$339
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:08 pm
DSM
-
LEX
1 stop6h 43m
American Airlines
Sun 8/166:48 am
LEX
-
DSM
1 stop4h 08m
American Airlines
Deal found 7/27$349
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/189:27 am
DSM
-
LEX
2 stops10h 25m
American Airlines
Sat 11/215:16 am
LEX
-
DSM
1 stop4h 37m
American Airlines
Deal found 7/29$358
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/71:08 pm
DSM
-
LEX
1 stop4h 35m
American Airlines
Sun 8/97:01 pm
LEX
-
DSM
1 stop6h 19m
American Airlines
Deal found 7/25$379
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/310:30 am
DSM
-
LEX
2 stops9h 21m
American Airlines
Tue 9/85:00 pm
LEX
-
DSM
2 stops8h 20m
American Airlines
Deal found 7/26$413

Find flight deals from Des Moines to Lexington

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

One-way from

$284
(United Airlines)

Popular in

October

Cheapest in

September

Average price

$363
Provider with most accurate pricing for Des Moines-Lexington Blue Grass flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Lexington Blue Grass flights.
Search Deals
From Des Moines to Lexington Blue Grass
Search Deals
One-way flight from Des Moines to Lexington Blue Grass
Search Deals
High demand for flights, 9% potential price rise
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 9/3

1:08 pm-6:43 pm

1 stop4h 35m

Lexington Blue Grass

Tue 9/8

6:59 pm-12:20 am

1 stop6h 21m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 9/9

5:45 am-11:44 am

1 stop4h 59m

Lexington Blue Grass

Wed 9/16

7:00 am-10:46 am

1 stop4h 46m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 9/8

11:32 am-5:11 pm

1 stop4h 39m

Lexington Blue Grass

Sun 9/13

5:57 pm-9:28 pm

1 stop4h 31m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 9/8

1:08 pm-6:43 pm

1 stop4h 35m

Lexington Blue Grass

Sun 9/13

5:00 am-10:19 am

1 stop6h 19m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 9/2

10:23 am-5:21 pm

1 stop5h 58m

Lexington Blue Grass

Sat 9/12

10:55 am-3:15 pm

1 stop5h 20m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Fri 10/23

3:03 pm-9:32 pm

1 stop5h 29m

Lexington Blue Grass

Mon 10/26

5:52 pm-8:49 pm

1 stop3h 57m

$319

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 9/2

1:08 pm-8:51 pm

1 stop6h 43m

Lexington Blue Grass

Sat 9/12

6:00 am-1:59 pm

2 stops8h 59m

$324

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Wed 8/12

1:08 pm-8:51 pm

1 stop6h 43m

Lexington Blue Grass

Sun 8/16

6:48 am-9:56 am

1 stop4h 08m

$349
Quickest round-trip

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Thu 12/31

8:00 am-1:13 pm

1 stop4h 13m

Lexington Blue Grass

Sun 1/3

5:50 pm-9:21 pm

1 stop4h 31m

$459
Cheapest one-way

Des MoinesLexington

DSM - LEX

DSMLEX

Des Moines

Tue 9/8

7:49 pm-10:42 am

1 stop13h 53m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 14 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Lexington

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Lexington in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Lexington flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Lexington flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Lexington flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Lexington flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Lexington flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Lexington

Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Lexington

Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated July 29, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
10,052 reviews

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Crew

8.1

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
United Airlines
7.4
Good
10,052 reviews
United Airlines
7.4
Good
10,052 reviews

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Crew

8.1

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this
American Airlines
7.1
Good
11,839 reviews
United Airlines
7.4
Good
10,052 reviews

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Crew

8.1

Overall

7.4

Reviews

1 / 20
6.0
Good

ROHIT,Jun 2026

IND - EWR

It should not be delayed by 2 hours. I missed the important event due to this

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Lexington?

    American Airlines, Delta, and United Airlines can get you from Des Moines to Lexington in just under 4h 35m. Your travel time can differ by up to 24m. The distance between Des Moines and Lexington is about 537 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Lexington round-trip?

    American Airlines, at $248, was found to be the cheapest airline from Des Moines to Lexington. An alternate airline flying to your destination would be United Airlines. You may be able to fly from Des Moines to Lexington for 54% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Lexington that include hotel bookings?

    Yes. In addition to deals on Des Moines to Lexington flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Lexington?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Lexington.

  • Can I find deals for business class flights from Des Moines to Lexington?

    Yes. Cheapflights offers flight deals from Des Moines to Lexington by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Lexington?

Book flights to Lexington if you plan to visit one of these locations
Somerset
Richmond
Danville
Berea
Georgetown
Frankfort

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 2 airlines flying from Des Moines to Lexington

Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$511FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$308Average$550FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.