$310+ Cheap flights from Des Moines to Lexington (DSM - LEX)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — LEX
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Lexington with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Lexington
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Cheapest flights from Des Moines to LexingtonExplore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Des Moines to Lexington. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:14 pm -
1 stop6h 38m
Tue 10/135:29 am -
1 stop4h 27m
Deal found 9/6![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:08 am -
1 stop4h 30m
Mon 10/198:03 pm -
1 stop4h 55m
Deal found 9/4![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm -
1 stop4h 00m
Sat 9/2610:11 am -
1 stop5h 04m
Deal found 9/6![United Airlines logo]()
$382
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:54 pm -
1 stop4h 05m
Thu 10/295:12 pm -
1 stop4h 28m
Deal found 9/7![Delta logo]()
$389
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:30 pm -
1 stop6h 20m
Fri 10/95:57 pm -
1 stop7h 01m
Deal found 9/3![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:35 am -
1 stop12h 11m
Sun 10/48:13 pm -
1 stop4h 39m
Deal found 9/3![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:30 pm -
1 stop6h 20m
Tue 9/223:10 pm -
1 stop5h 38m
Deal found 9/3![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:08 pm -
1 stop4h 35m
Tue 9/86:59 pm -
1 stop6h 21m
Deal found 9/3![American Airlines logo]()
$439
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:28 am -
2 stops10h 55m
Thu 10/298:45 am -
1 stop24h 40m
Deal found 9/7![Allegiant Air logo]()
$459
Best flights from Des Moines to LexingtonDiscover carefully curated flight deals from Des Moines to Lexington that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Des Moines to Lexington that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/172:01 pm -
2 stops8h 56m
Mon 10/198:03 pm -
1 stop4h 55m
Deal found 9/4![American Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:54 pm -
1 stop4h 05m
Thu 10/295:12 pm -
1 stop4h 28m
Deal found 9/7![Delta logo]()
$389
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop4h 10m
Wed 2/38:45 am -
1 stop6h 49m
Deal found 9/3![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:05 am -
1 stop15h 41m
Fri 10/95:57 pm -
1 stop7h 01m
Deal found 9/3![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:30 pm -
1 stop6h 20m
Tue 9/223:10 pm -
1 stop5h 38m
Deal found 9/3![American Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:22 pm -
1 stop4h 06m
Tue 9/227:00 am -
1 stop6h 16m
Deal found 9/3![United Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:27 pm -
1 stop7h 42m
Sun 9/276:00 am -
1 stop5h 31m
Deal found 9/6![United Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/103:11 pm -
1 stop4h 17m
Sun 10/116:00 am -
1 stop5h 30m
Deal found 9/5![United Airlines logo]()
$524
Last-minute flights from Des Moines to LexingtonDiscover last-minute flight deals from Des Moines to Lexington. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Lexington. Data last updated September 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/31:08 pm -
1 stop4h 35m
Tue 9/86:59 pm -
1 stop6h 21m
Deal found 9/3![American Airlines logo]()
$439
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:30 pm -
1 stop6h 20m
Tue 9/223:10 pm -
1 stop5h 38m
Deal found 9/3![American Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:55 pm -
1 stop4h 00m
Sat 9/2610:11 am -
1 stop5h 04m
Deal found 9/6![United Airlines logo]()
$382
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:35 am -
1 stop12h 11m
Sun 10/48:13 pm -
1 stop4h 39m
Deal found 9/3![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/21:30 pm -
1 stop6h 20m
Fri 10/95:57 pm -
1 stop7h 01m
Deal found 9/3![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:14 pm -
1 stop6h 38m
Tue 10/135:29 am -
1 stop4h 27m
Deal found 9/6![American Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/177:08 am -
1 stop4h 30m
Mon 10/198:03 pm -
1 stop4h 55m
Deal found 9/4![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:54 pm -
1 stop4h 05m
Thu 10/295:12 pm -
1 stop4h 28m
Deal found 9/7![Delta logo]()
$389
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:28 am -
2 stops10h 55m
Thu 10/298:45 am -
1 stop24h 40m
Deal found 9/7![Allegiant Air logo]()
$459
One-way flights from Des Moines to LexingtonSearch for one-way flight options from Des Moines to Lexington. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Des Moines to Lexington. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:55 pm -
1 stop4h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![United Airlines logo]()
$310
Find flight deals from Des Moines to Lexington
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Lexington (LEX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $319 (American Airlines) |
One-way from | $310 |
Popular in | October |
Cheapest in | September |
Average price | $308 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Lexington that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Des Moines to Lexington that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Wed 10/7
6:55 pm-11:55 pm
1 stop4h 00m
Lexington Blue Grass
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$310
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Sat 10/17
2:01 pm-11:57 pm
2 stops8h 56m
Lexington Blue Grass
Mon 10/19
8:03 pm-11:58 pm
1 stop4h 55m
$324
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Thu 10/22
6:54 pm-11:59 pm
1 stop4h 05m
Lexington Blue Grass
Thu 10/29
5:12 pm-8:40 pm
1 stop4h 28m
$389
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Sat 1/30
8:00 am-1:10 pm
1 stop4h 10m
Lexington Blue Grass
Wed 2/3
8:45 am-2:34 pm
1 stop6h 49m
$399
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Thu 10/1
7:05 am-11:46 pm
1 stop15h 41m
Lexington Blue Grass
Fri 10/9
5:57 pm-11:58 pm
1 stop7h 01m
$412
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Fri 9/18
1:30 pm-8:50 pm
1 stop6h 20m
Lexington Blue Grass
Tue 9/22
3:10 pm-7:48 pm
1 stop5h 38m
$423
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Fri 9/18
3:22 pm-8:28 pm
1 stop4h 06m
Lexington Blue Grass
Tue 9/22
7:00 am-12:16 pm
1 stop6h 16m
$474
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Fri 9/25
1:27 pm-10:09 pm
1 stop7h 42m
Lexington Blue Grass
Sun 9/27
6:00 am-10:31 am
1 stop5h 31m
$523
Des MoinesLexington
DSM Des Moines - LEX Lexington Blue Grass
DSMLEX
Des Moines
Sat 10/10
3:11 pm-8:28 pm
1 stop4h 17m
Lexington Blue Grass
Sun 10/11
6:00 am-10:30 am
1 stop5h 30m
$524
Sorted by cheapest first
Compare providers for flights from Des Moines to Lexington
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Lexington in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Lexington flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Lexington flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Lexington flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Lexington flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Lexington flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Lexington
Have a flexible travel schedule? Discover the best time to fly to Lexington from Des Moines with our price prediction graph.
DSM-LEX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Lexington
Get insights into the airlines that provide service to Lexington. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Lexington. Reviews last updated September 7, 2026.
See what other customers who have flown with United Airlines and American Airlines from Des Moines to Lexington have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.4
Comfort
7.3
Food
6.6
Crew
8.1
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Comfort
7.3
Food
6.6
Crew
8.1
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Overall
7.4
Comfort
7.3
Food
6.6
Crew
8.1
Entertainment
7.1
Boarding
7.7
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Lexington. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Lexington?
Book flights to Lexington if you plan to visit one of these locationsSomerset
Richmond
Danville
Berea
Frankfort
Georgetown
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Other flights to Lexington
Explore flights to Lexington departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Des Moines and Lexington flights
Browse other Des Moines and Lexington flight options. Last updated on September 7, 2026.
Other flights from Des Moines
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Top 2 airlines flying from Des Moines to Lexington
Discover the top 2 airlines that operate flights from Des Moines to Lexington. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$521 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$578 | FlexibilityNo cancel fee | On-time69% |