$348+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Santo Domingo
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Best
Last-minute
One-way
Cheapest flights from Des Moines to Santo DomingoExplore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:00 am -
2 stops13h 46m
Mon 10/196:00 am -
2 stops16h 23m
Deal found 9/7![United Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
2 stops16h 56m
Fri 11/204:18 pm -
2 stops20h 14m
Deal found 9/6![United Airlines logo]()
$815
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops13h 50m
Mon 10/191:35 pm -
1 stop10h 08m
Deal found 9/7![American Airlines logo]()
$847
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:16 pm -
2 stops21h 03m
Sat 11/286:00 am -
2 stops18h 28m
Deal found 9/5![American Airlines logo]()
$911
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:55 pm -
2 stops16h 00m
Wed 9/306:00 am -
2 stops12h 48m
Deal found 9/6![United Airlines logo]()
$921
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:30 am -
2 stops12h 16m
Fri 1/86:00 am -
2 stops16h 10m
Deal found 9/3![United Airlines logo]()
$969
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:30 am -
2 stops12h 16m
Fri 1/86:00 am -
2 stops16h 10m
Deal found 9/3![United Airlines logo]()
$1,027
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:45 am -
1 stop6h 42m
Wed 9/302:53 pm -
1 stop8h 33m
Deal found 9/6![Delta logo]()
$1,050
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/157:00 am -
1 stop10h 53m
Fri 1/810:58 am -
1 stop15h 01m
Deal found 9/3![American Airlines logo]()
$1,101
Best flights from Des Moines to Santo DomingoDiscover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/85:45 am -
1 stop6h 30m
Fri 1/227:30 am -
2 stops15h 22m
Deal found 9/3![Delta logo]()
$715
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:14 pm -
2 stops19h 04m
Fri 1/2912:42 pm -
2 stops12h 21m
Deal found 9/7![American Airlines logo]()
$715
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 pm -
2 stops16h 56m
Fri 11/204:18 pm -
2 stops20h 14m
Deal found 9/6![United Airlines logo]()
$815
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1512:30 pm -
2 stops10h 00m
Fri 1/293:40 pm -
1 stop8h 49m
Deal found 9/6![Delta logo]()
$764
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:30 pm -
2 stops27h 16m
Fri 1/292:53 pm -
3 stops28h 48m
Deal found 9/7![United Airlines logo]()
$835
Last-minute flights from Des Moines to Santo DomingoDiscover last-minute flight deals from Des Moines to Santo Domingo. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santo Domingo. Data last updated September 7, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:55 pm -
2 stops16h 00m
Wed 9/306:00 am -
2 stops12h 48m
Deal found 9/6![United Airlines logo]()
$921
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/275:45 am -
1 stop6h 42m
Wed 9/302:53 pm -
1 stop8h 33m
Deal found 9/6![Delta logo]()
$1,050
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/158:00 am -
2 stops13h 46m
Mon 10/196:00 am -
2 stops16h 23m
Deal found 9/7![United Airlines logo]()
$695
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops13h 50m
Mon 10/191:35 pm -
1 stop10h 08m
Deal found 9/7![American Airlines logo]()
$847
This Delta deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:35 am -
1 stop6h 57m
Mon 10/192:57 pm -
1 stop8h 36m
Deal found 9/7![Delta logo]()
$1,128
One-way flights from Des Moines to Santo DomingoSearch for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:20 am -
1 stop7h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Delta logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:40 am -
3 stops30h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$422
Find flight deals from Des Moines to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $690 (Delta) |
One-way from | $348 (Delta) |
Popular in | August |
Cheapest in | January |
Average price | $805 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 12/4
5:20 am-2:32 pm
1 stop7h 12m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$348
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 12/4
10:40 am-7:18 pm
3 stops30h 38m
Santo Domingo Las Americas
Wed 12/31
12:00 am-10:30 pm
Nonstop0h 00m
$422
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 1/8
5:45 am-2:15 pm
1 stop6h 30m
Santo Domingo Las Americas
Fri 1/22
7:30 am-8:52 pm
2 stops15h 22m
$715
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 1/15
6:14 pm-3:18 pm
2 stops19h 04m
Santo Domingo Las Americas
Fri 1/29
12:42 pm-11:03 pm
2 stops12h 21m
$715
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 1/15
12:30 pm-12:30 am
2 stops10h 00m
Santo Domingo Las Americas
Fri 1/29
3:40 pm-10:29 pm
1 stop8h 49m
$764
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Mon 11/16
6:45 pm-1:41 pm
2 stops16h 56m
Santo Domingo Las Americas
Fri 11/20
4:18 pm-10:32 am
2 stops20h 14m
$815
Des MoinesSanto Domingo
DSM Des Moines - SDQ Santo Domingo Las Americas
DSMSDQ
Des Moines
Fri 1/15
6:30 pm-11:46 pm
2 stops27h 16m
Santo Domingo Las Americas
Fri 1/29
2:53 pm-5:41 pm
3 stops28h 48m
$835
Sorted by cheapest first
Compare providers for flights from Des Moines to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
DSM-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated September 7, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Entertainment
7.8
Food
7.2
Comfort
7.8
Overall
7.8
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Des Moines to Santo Domingo
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Complete your trip
Complete your trip to Santo Domingo by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Santo Domingo by cabin class
Find flights from Des Moines to Santo Domingo, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Santo Domingo flights
Browse other Des Moines and Santo Domingo flight options. Last updated on September 7, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Top 2 airlines flying from Des Moines to Santo Domingo
Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$537 | Average$805 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$542 | Average$633 | FlexibilityNo cancel fee | On-time71% |