$306+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
May 29 — Jun 51
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santo Domingo with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Santo Domingo
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Best
Last-minute
One-way
Cheapest flights from Des Moines to Santo DomingoExplore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:30 am
DSM
- SDQ
1 stop32h 00m
Multiple Airlines
Wed 6/312:41 pm
SDQ
- DSM
2 stops35h 17m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$451
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:30 am
DSM
- SDQ
1 stop32h 00m
Multiple Airlines
Wed 7/812:41 pm
SDQ
- DSM
2 stops35h 26m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$586
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
- SDQ
1 stop18h 29m
Multiple Airlines
Thu 6/1812:21 pm
SDQ
- DSM
1 stop10h 26m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$596
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:44 pm
DSM
- SDQ
2 stops47h 34m
Multiple Airlines
Fri 6/196:10 am
SDQ
- DSM
1 stop8h 40m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$620
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:33 pm
DSM
- SDQ
1 stop22h 12m
American Airlines
Wed 6/171:45 pm
SDQ
- DSM
1 stop9h 13m
American Airlines
Deal found 4/26![American Airlines logo]()
$650
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:34 am
DSM
- SDQ
1 stop16h 07m
Delta
Wed 6/32:48 pm
SDQ
- DSM
1 stop8h 44m
Delta
Deal found 4/25![Delta logo]()
$652
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:02 pm
DSM
- SDQ
2 stops16h 13m
American Airlines
Tue 6/167:00 am
SDQ
- DSM
2 stops15h 23m
American Airlines
Deal found 4/29![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:27 pm
DSM
- SDQ
1 stop22h 18m
American Airlines
Fri 6/1910:25 am
SDQ
- DSM
2 stops11h 18m
American Airlines
Deal found 4/29![American Airlines logo]()
$677
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:35 am
DSM
- SDQ
1 stop20h 54m
Multiple Airlines
Fri 6/196:10 am
SDQ
- DSM
1 stop8h 40m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$697
Best flights from Des Moines to Santo DomingoDiscover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
Discover carefully curated flight deals from Des Moines to Santo Domingo that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:30 am
DSM
- SDQ
1 stop32h 00m
Multiple Airlines
Wed 6/312:41 pm
SDQ
- DSM
2 stops35h 17m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$451
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:34 am
DSM
- SDQ
1 stop16h 07m
Delta
Wed 6/32:48 pm
SDQ
- DSM
1 stop8h 44m
Delta
Deal found 4/25![Delta logo]()
$652
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:02 pm
DSM
- SDQ
2 stops16h 13m
American Airlines
Tue 6/167:00 am
SDQ
- DSM
2 stops16h 52m
American Airlines
Deal found 4/25![American Airlines logo]()
$655
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:37 pm
DSM
- SDQ
1 stop18h 29m
Multiple Airlines
Thu 6/1812:21 pm
SDQ
- DSM
1 stop10h 26m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:33 pm
DSM
- SDQ
1 stop22h 12m
American Airlines
Wed 6/177:00 am
SDQ
- DSM
2 stops18h 10m
American Airlines
Deal found 4/26![American Airlines logo]()
$655
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:10 am
DSM
- SDQ
2 stops14h 45m
American Airlines
Fri 6/1910:25 am
SDQ
- DSM
2 stops11h 18m
American Airlines
Deal found 4/29![American Airlines logo]()
$655
Last-minute flights from Des Moines to Santo DomingoDiscover last-minute flight deals from Des Moines to Santo Domingo. Data last updated April 29, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santo Domingo. Data last updated April 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1511:11 am
DSM
- SDQ
2 stops10h 40m
American Airlines
Sat 5/234:18 pm
SDQ
- DSM
1 stop8h 22m
American Airlines
Deal found 4/25![American Airlines logo]()
$715
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:26 am
DSM
- SDQ
2 stops13h 12m
Delta
Sat 5/236:05 am
SDQ
- DSM
2 stops15h 17m
Delta
Deal found 4/26![Delta logo]()
$755
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:30 am
DSM
- SDQ
1 stop32h 00m
Multiple Airlines
Wed 6/312:41 pm
SDQ
- DSM
2 stops35h 17m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$451
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:34 am
DSM
- SDQ
1 stop16h 07m
Delta
Wed 6/32:48 pm
SDQ
- DSM
1 stop8h 44m
Delta
Deal found 4/25![Delta logo]()
$652
One-way flights from Des Moines to Santo DomingoSearch for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
Search for one-way flight options from Des Moines to Santo Domingo. Find affordable one-way fares based on user searches. Data last updated April 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/410:23 am
DSM
- SDQ
2 stops34h 17m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:00 am
DSM
- SDQ
2 stops11h 35m
American Airlines
Deal found 4/29![American Airlines logo]()
$438
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:45 am
DSM
- SDQ
1 stop6h 27m
Delta
Deal found 4/29![Delta logo]()
$453
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/135:35 am
DSM
- SDQ
1 stop6h 41m
Delta
Deal found 4/29![Delta logo]()
$581
Find flight deals from Des Moines to Santo Domingo
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $451 (Kiwi.com) |
One-way from | $306 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Thu 5/28
7:30 am-4:30 pm
1 stop32h 00m
Santo Domingo Las Americas
Wed 6/3
12:41 pm-10:58 pm
2 stops35h 17m
$451
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Thu 6/11
3:37 pm-11:06 am
1 stop18h 29m
Santo Domingo Las Americas
Thu 6/18
12:21 pm-9:47 pm
1 stop10h 26m
$596
Quickest round-trip
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Thu 5/28
7:34 am-12:41 am
1 stop16h 07m
Santo Domingo Las Americas
Wed 6/3
2:48 pm-10:32 pm
1 stop8h 44m
$652
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Mon 6/1
8:02 pm-1:15 pm
2 stops16h 13m
Santo Domingo Las Americas
Tue 6/16
7:00 am-10:52 pm
2 stops16h 52m
$655
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Wed 6/10
1:33 pm-12:45 pm
1 stop22h 12m
Santo Domingo Las Americas
Wed 6/17
7:00 am-12:10 am
2 stops18h 10m
$655
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Fri 6/5
7:10 am-10:55 pm
2 stops14h 45m
Santo Domingo Las Americas
Fri 6/19
10:25 am-8:43 pm
2 stops11h 18m
$655
Cheapest one-way
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Mon 5/4
10:23 am-9:40 pm
2 stops34h 17m
$306
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Sat 6/13
6:00 am-6:35 pm
2 stops11h 35m
$438
Quickest one-way
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Mon 5/4
5:45 am-1:12 pm
1 stop6h 27m
$453
Des MoinesSanto Domingo
DSM - SDQ
DSMSDQ
Des Moines
Sat 6/13
5:35 am-1:16 pm
1 stop6h 41m
$581
Sorted by cheapest first
Compare providers for flights from Des Moines to Santo Domingo
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santo Domingo
Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
DSM-SDQ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santo Domingo
Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated April 29, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Overall
7.9
Entertainment
7.8
Boarding
8.1
Crew
8.5
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Santo Domingo?
Book flights to Santo Domingo if you plan to visit one of these locationsJuan Dolio
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Complete your trip
Complete your trip to Santo Domingo by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Santo Domingo flights
Browse other Des Moines and Santo Domingo flight options. Last updated on April 29, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santo Domingo
Explore flights to Santo Domingo departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 29, 2026.
Top 2 airlines flying from Des Moines to Santo Domingo
Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$514 | Average$613 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$613 | Average$643 | FlexibilityNo cancel fee | On-time71% |