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Santo Domingo

$453+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Apr 4 — Apr 111
Sab 4/4
Sab 4/11
1 adult, Economy
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Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Maret 5, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Min 3/293:22 pm
DSM
-
SDQ
2 stops17h 19m
Multiple Airlines
Sab 4/43:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 2/28$453
This WAYA deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 4/23:21 pm
DSM
-
SDQ
1 stop9h 17m
Multiple Airlines
Kam 4/92:20 pm
SDQ
-
DSM
1 stop8h 46m
Multiple Airlines
Deal found 3/3$491
This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/266:00 am
DSM
-
SDQ
1 stop18h 38m
Multiple Airlines
Sab 4/43:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 2/28$497
This Kiwi.com deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Jum 3/2710:26 am
DSM
-
SDQ
2 stops14h 24m
Multiple Airlines
Sab 4/43:55 am
SDQ
-
DSM
1 stop10h 51m
Multiple Airlines
Deal found 2/28$503

Find flight deals from Des Moines to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Maret 5, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$453
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$687
Provider with most accurate pricing for Des Moines-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santo Domingo Las Americas flights.
Search Deals
From Des Moines to Santo Domingo Las Americas
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($145 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($32 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Maret 5, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Min 3/29

6:30 am-1:38 am

1 stop18h 08m

Santo Domingo Las Americas

Sab 4/4

3:55 am-1:46 pm

1 stop10h 51m

$468

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sab 3/28

1:37 pm-9:00 am

2 stops18h 23m

Santo Domingo Las Americas

Sab 4/4

6:00 am-11:56 pm

1 stop18h 56m

$594

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Min 4/12

7:16 pm-2:10 pm

2 stops17h 54m

Santo Domingo Las Americas

Sab 4/18

1:10 pm-11:17 pm

2 stops11h 07m

$693

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Sab 3/28

5:35 am-2:26 pm

1 stop7h 51m

Santo Domingo Las Americas

Min 4/5

2:37 pm-10:38 pm

1 stop9h 01m

$709

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Min 3/22

5:35 am-1:10 pm

1 stop6h 35m

Santo Domingo Las Americas

Min 3/29

2:35 pm-10:38 pm

1 stop9h 03m

$729

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/28

Sorted by cheapest first

Compare providers for flights from Des Moines to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated Maret 5, 2026.
Read reviews from past customers who have flown Delta and American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,248 reviews

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,248 reviews
Delta
7.9
Good
8,248 reviews

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,381 reviews
Delta
7.9
Good
8,248 reviews

Boarding

8.1

Comfort

7.9

Food

7.2

Overall

7.9

Crew

8.5

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santo Domingo?

    Delta, American Airlines, and United Airlines can get you from Des Moines to Santo Domingo in just under 12h 43m. Your travel time can differ by up to 5h 11m. The distance between Des Moines and Santo Domingo is about 2131 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Santo Domingo round-trip?

    Delta, at $524, was found to be the cheapest airline from Des Moines to Santo Domingo. An alternate airline flying to your destination would be American Airlines. Delta is priced at 23% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

  • Can I find deals for business class flights from Des Moines to Santo Domingo?

    Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Alternative routes for Des Moines to Santo Domingo

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Top 2 airlines flying from Des Moines to Santo Domingo

Discover the top 2 airlines that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Maret 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$524Average$718FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$542Average$684FlexibilityNo cancel feeOn-time71%

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