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Santo Domingo

$572+ Cheap flights from Des Moines (DSM) to Santo Domingo (SDQ)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SDQ
Aug 28 — Sep 41
Fri 8/28
Fri 9/4
1 adult, Economy
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Find cheap flights from Des Moines to Santo Domingo with Cheapflights

1. Tell us where you want to go

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Cheap flight deals from Des Moines to Santo Domingo

Cheapest flights from Des Moines to Santo Domingo
Explore the most affordable flight options available from Des Moines to Santo Domingo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:58 pm
DSM
-
SDQ
2 stops52h 20m
Multiple Airlines
Thu 9/174:35 pm
SDQ
-
DSM
1 stop22h 39m
Multiple Airlines
Deal found 7/28$572
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:55 am
DSM
-
SDQ
2 stops11h 51m
United Airlines
Tue 11/36:00 am
SDQ
-
DSM
2 stops15h 16m
United Airlines
Deal found 7/26$615
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am
DSM
-
SDQ
2 stops13h 46m
United Airlines
Thu 9/176:00 am
SDQ
-
DSM
2 stops16h 33m
United Airlines
Deal found 7/28$650
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am
DSM
-
SDQ
2 stops15h 46m
United Airlines
Wed 9/166:00 am
SDQ
-
DSM
2 stops12h 28m
United Airlines
Deal found 7/24$652
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:45 am
DSM
-
SDQ
1 stop6h 42m
Delta
Wed 9/162:53 pm
SDQ
-
DSM
1 stop8h 33m
Delta
Deal found 7/24$700
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:08 am
DSM
-
SDQ
2 stops13h 42m
American Airlines
Tue 11/312:59 pm
SDQ
-
DSM
1 stop11h 47m
American Airlines
Deal found 7/26$705
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:05 am
DSM
-
SDQ
2 stops10h 29m
American Airlines
Thu 9/1710:21 am
SDQ
-
DSM
2 stops14h 43m
American Airlines
Deal found 7/27$706
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/225:35 am
DSM
-
SDQ
1 stop6h 57m
Delta
Tue 11/33:57 pm
SDQ
-
DSM
1 stop8h 36m
Delta
Deal found 7/26$710
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:45 am
DSM
-
SDQ
1 stop6h 42m
Delta
Fri 9/187:35 pm
SDQ
-
DSM
2 stops16h 11m
Delta
Deal found 7/28$715
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:58 pm
DSM
-
SDQ
2 stops18h 19m
American Airlines
Sun 9/277:34 pm
SDQ
-
DSM
2 stops19h 25m
American Airlines
Deal found 7/28$730
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:45 am
DSM
-
SDQ
1 stop6h 42m
Delta
Sun 9/272:53 pm
SDQ
-
DSM
1 stop8h 33m
Delta
Deal found 7/28$740

Find flight deals from Des Moines to Santo Domingo

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santo Domingo (SDQ). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$572
(Kiwi.com)
Provider with most accurate pricing for Des Moines-Santo Domingo Las Americas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santo Domingo Las Americas flights.
Search Deals
From Des Moines to Santo Domingo Las Americas
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santo Domingo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Des Moines to Santo Domingo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 9/10

1:58 pm-7:18 pm

2 stops52h 20m

Santo Domingo Las Americas

Thu 9/17

4:35 pm-2:14 pm

1 stop22h 39m

$572

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 9/10

8:00 am-10:46 pm

2 stops13h 46m

Santo Domingo Las Americas

Thu 9/17

6:00 am-9:33 pm

2 stops16h 33m

$650

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 9/8

6:00 am-10:46 pm

2 stops15h 46m

Santo Domingo Las Americas

Wed 9/16

6:00 am-5:28 pm

2 stops12h 28m

$652

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Tue 9/8

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Wed 9/16

7:35 pm-10:46 am

2 stops16h 11m

$705

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 10/22

5:35 am-1:32 pm

1 stop6h 57m

Santo Domingo Las Americas

Tue 11/3

3:57 pm-10:33 pm

1 stop8h 36m

$710

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 9/11

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Fri 9/18

7:35 pm-10:46 am

2 stops16h 11m

$715

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Fri 8/14

6:33 am-6:44 pm

2 stops11h 11m

Santo Domingo Las Americas

Sat 8/22

4:24 pm-11:25 pm

1 stop8h 01m

$795

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Mon 9/28

6:00 am-10:46 pm

2 stops15h 46m

Santo Domingo Las Americas

Thu 10/1

3:20 pm-10:31 am

2 stops20h 11m

$825
Quickest round-trip

Des MoinesSanto Domingo

DSM - SDQ

DSMSDQ

Des Moines

Thu 9/10

5:45 am-1:27 pm

1 stop6h 42m

Santo Domingo Las Americas

Thu 9/17

2:53 pm-10:26 pm

1 stop8h 33m

$830

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Sorted by cheapest first

Compare providers for flights from Des Moines to Santo Domingo

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santo Domingo in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santo Domingo flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santo Domingo flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santo Domingo flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santo Domingo flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santo Domingo flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santo Domingo

Have a flexible travel schedule? Discover the best time to fly to Santo Domingo from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santo Domingo

Get insights into the airlines that provide service to Santo Domingo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santo Domingo. Reviews last updated July 29, 2026.
Read reviews from past customers who have flown American Airlines from Des Moines to Santo Domingo. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,839 reviews

Food

6.4

Boarding

7.5

Overall

7.1

Crew

7.9

Entertainment

6.8

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,839 reviews
American Airlines
7.1
Good
11,839 reviews

Food

6.4

Boarding

7.5

Overall

7.1

Crew

7.9

Entertainment

6.8

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santo Domingo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Santo Domingo?

    United Airlines and Delta can get you from Des Moines to Santo Domingo in just under 6h 42m. Your travel time can differ by up to 7h 04m. The distance between Des Moines and Santo Domingo is about 2131 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Des Moines to Santo Domingo round-trip?

    American Airlines, at $542, was found to be the cheapest airline from Des Moines to Santo Domingo..

  • Can I find deals for flights from Des Moines to Santo Domingo that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santo Domingo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santo Domingo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santo Domingo.

  • Can I find deals for business class flights from Des Moines to Santo Domingo?

    Yes. Cheapflights offers flight deals from Des Moines to Santo Domingo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Santo Domingo?

Book flights to Santo Domingo if you plan to visit one of these locations
Juan Dolio

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Top airline flying from Des Moines to Santo Domingo

Discover the top airline that operate flights from Des Moines to Santo Domingo. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$542Average$633FlexibilityNo cancel feeOn-time71%

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