$109+ Cheap flights from Indiana to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
IND — DSM
Aug 27 — Sep 31
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Indiana to Des MoinesExplore the most affordable flight options available from Indiana to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
Explore the most affordable flight options available from Indiana to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3011:00 am
ORD
- DSM
Nonstop1h 34m
United Airlines
Tue 10/66:55 pm
DSM
- ORD
Nonstop1h 38m
United Airlines
Deal found 7/24![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:35 pm
MDW
- DSM
Nonstop1h 25m
Southwest
Tue 9/156:10 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/24![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:45 pm
ORD
- DSM
Nonstop1h 35m
American Airlines
Mon 8/247:49 pm
DSM
- ORD
Nonstop1h 48m
American Airlines
Deal found 7/26![American Airlines logo]()
$238
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:41 pm
ORD
- DSM
1 stop22h 53m
Frontier
Mon 8/242:19 pm
DSM
- ORD
1 stop23h 17m
Frontier
Deal found 7/26![Frontier logo]()
$240
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/511:54 am
ORD
- DSM
Nonstop1h 31m
American Airlines
Sun 9/66:10 am
DSM
- ORD
Nonstop1h 50m
American Airlines
Deal found 7/26![American Airlines logo]()
$242
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:40 am
MDW
- DSM
1 stop7h 15m
Southwest
Wed 9/166:10 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/26![Southwest logo]()
$247
This Frontier deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:16 pm
IND
- DSM
1 stop18h 40m
Frontier
Mon 9/212:51 pm
DSM
- IND
1 stop27h 30m
Frontier
Deal found 7/23![Frontier logo]()
$254
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:15 am
ORD
- DSM
Nonstop1h 39m
American Airlines
Thu 10/152:01 pm
DSM
- ORD
Nonstop1h 38m
American Airlines
Deal found 7/23![American Airlines logo]()
$255
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm
ORD
- DSM
1 stop6h 51m
Delta
Wed 9/166:00 am
DSM
- ORD
1 stop4h 37m
Delta
Deal found 7/26![Delta logo]()
$257
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:59 am
MDW
- DSM
1 stop4h 07m
Delta
Tue 10/66:00 am
DSM
- MDW
1 stop6h 47m
Delta
Deal found 7/27![Delta logo]()
$257
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am
ORD
- DSM
1 stop4h 18m
Delta
Sun 9/66:00 am
DSM
- ORD
1 stop4h 42m
Delta
Deal found 7/27![Delta logo]()
$262
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:55 pm
ORD
- DSM
1 stop6h 51m
Delta
Tue 9/156:00 am
DSM
- ORD
1 stop6h 59m
Delta
Deal found 7/24![Delta logo]()
$267
Best flights from Indiana to Des MoinesDiscover carefully curated flight deals from Indiana to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
Discover carefully curated flight deals from Indiana to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 28, 2026.
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:00 am
ORD
- DSM
Nonstop1h 26m
United Airlines
Mon 8/2411:32 am
DSM
- ORD
Nonstop1h 43m
United Airlines
Deal found 7/25![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:05 am
MDW
- DSM
Nonstop1h 20m
Southwest
Mon 8/245:40 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/27![Southwest logo]()
$237
This Frontier deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:16 pm
IND
- DSM
1 stop18h 40m
Frontier
Mon 9/212:51 pm
DSM
- IND
1 stop27h 30m
Frontier
Deal found 7/23![Frontier logo]()
$254
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm
ORD
- DSM
1 stop6h 51m
Delta
Wed 9/166:00 am
DSM
- ORD
1 stop4h 37m
Delta
Deal found 7/26![Delta logo]()
$257
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:29 am
SDF
- DSM
1 stop4h 30m
American Airlines
Tue 9/157:05 am
DSM
- SDF
1 stop5h 38m
American Airlines
Deal found 7/26![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:15 am
CVG
- DSM
1 stop9h 07m
Multiple Airlines
Sun 8/231:55 pm
DSM
- CVG
2 stops22h 30m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:30 am
MDW
- DSM
Nonstop1h 20m
Southwest
Thu 9/33:50 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/27![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:00 am
ORD
- DSM
1 stop4h 18m
Delta
Thu 8/2710:23 am
DSM
- ORD
1 stop5h 54m
Delta
Deal found 7/23![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:05 am
MDW
- DSM
Nonstop1h 20m
Southwest
Thu 9/173:50 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/27![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2312:54 pm
ORD
- DSM
Nonstop1h 26m
United Airlines
Fri 9/256:00 am
DSM
- ORD
Nonstop1h 41m
United Airlines
Deal found 7/27![United Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:59 am
MDW
- DSM
1 stop4h 07m
Delta
Tue 10/66:00 am
DSM
- MDW
1 stop6h 47m
Delta
Deal found 7/25![Delta logo]()
$267
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:40 am
MDW
- DSM
1 stop7h 15m
Southwest
Wed 9/166:10 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/26![Southwest logo]()
$247
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:00 am
IND
- DSM
1 stop4h 31m
United Airlines
Wed 9/236:24 am
DSM
- IND
1 stop3h 33m
United Airlines
Deal found 7/23![United Airlines logo]()
$273
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/208:30 am
CVG
- DSM
1 stop5h 55m
American Airlines
Sun 8/231:55 pm
DSM
- CVG
1 stop6h 23m
American Airlines
Deal found 7/26![American Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:15 pm
MDW
- DSM
1 stop6h 50m
Southwest
Tue 10/65:35 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/25![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:35 am
IND
- DSM
1 stop4h 03m
Delta
Mon 9/215:35 pm
DSM
- IND
1 stop5h 29m
Delta
Deal found 7/23![Delta logo]()
$273
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:00 pm
ORD
- DSM
Nonstop1h 28m
United Airlines
Sun 10/46:55 pm
DSM
- ORD
Nonstop1h 38m
United Airlines
Deal found 7/23![United Airlines logo]()
$288
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/312:29 pm
IND
- DSM
1 stop5h 21m
Delta
Tue 9/84:20 pm
DSM
- IND
1 stop5h 45m
Delta
Deal found 7/28![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/810:30 am
MDW
- DSM
Nonstop1h 20m
Southwest
Tue 9/157:15 am
DSM
- MDW
1 stop7h 05m
Southwest
Deal found 7/24![Southwest logo]()
$259
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:45 am
ORD
- DSM
Nonstop1h 35m
United Airlines
Thu 8/206:00 am
DSM
- ORD
Nonstop1h 36m
United Airlines
Deal found 7/27![United Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:15 am
IND
- DSM
1 stop4h 26m
Delta
Mon 11/165:29 pm
DSM
- IND
1 stop5h 44m
Delta
Deal found 7/27![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:40 am
FWA
- DSM
1 stop5h 51m
United Airlines
Wed 10/143:11 pm
DSM
- FWA
1 stop6h 01m
United Airlines
Deal found 7/24![United Airlines logo]()
$299
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:40 am
MDW
- DSM
1 stop7h 15m
Southwest
Wed 8/197:15 am
DSM
- MDW
2 stops9h 45m
Southwest
Deal found 7/27![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am
IND
- DSM
1 stop4h 17m
Delta
Sat 10/36:00 am
DSM
- IND
1 stop4h 31m
Delta
Deal found 7/26![Delta logo]()
$279
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:00 am
AZO
- DSM
2 stops7h 24m
American Airlines
Sat 8/157:56 pm
DSM
- AZO
1 stop3h 45m
American Airlines
Deal found 7/26![American Airlines logo]()
$422
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:35 am
FWA
- DSM
1 stop5h 51m
United Airlines
Sat 8/2211:32 am
DSM
- FWA
1 stop3h 48m
United Airlines
Deal found 7/24![United Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:09 pm
IND
- DSM
1 stop5h 40m
Delta
Mon 11/165:29 pm
DSM
- IND
1 stop5h 44m
Delta
Deal found 7/27![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:05 pm
MDW
- DSM
1 stop7h 15m
Southwest
Sat 9/195:30 am
DSM
- MDW
Nonstop1h 15m
Southwest
Deal found 7/25![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2012:50 pm
ORD
- DSM
Nonstop1h 26m
United Airlines
Sun 8/236:00 am
DSM
- ORD
Nonstop1h 36m
United Airlines
Deal found 7/27![United Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:00 pm
IND
- DSM
1 stop4h 50m
Delta
Tue 11/176:55 am
DSM
- IND
1 stop3h 45m
Delta
Deal found 7/27![Delta logo]()
$279
Last-minute flights from Indiana to Des MoinesDiscover last-minute flight deals from Indiana to Des Moines. Data last updated July 28, 2026 and is based on user searches.
Discover last-minute flight deals from Indiana to Des Moines. Data last updated July 28, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1510:10 am
MDW
- DSM
Nonstop1h 20m
Southwest
Mon 8/173:50 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/25![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:54 am
ORD
- DSM
Nonstop1h 31m
American Airlines
Wed 8/196:55 am
DSM
- ORD
Nonstop1h 50m
American Airlines
Deal found 7/27![American Airlines logo]()
$242
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:30 am
MDW
- DSM
Nonstop1h 20m
Southwest
Wed 8/197:15 am
DSM
- MDW
2 stops9h 45m
Southwest
Deal found 7/27![Southwest logo]()
$252
This United Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:45 am
ORD
- DSM
Nonstop1h 35m
United Airlines
Thu 8/273:20 pm
DSM
- ORD
Nonstop1h 43m
United Airlines
Deal found 7/23![United Airlines logo]()
$237
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:05 am
MDW
- DSM
Nonstop1h 20m
Southwest
Mon 8/245:40 am
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/27![Southwest logo]()
$237
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:45 pm
ORD
- DSM
Nonstop1h 35m
American Airlines
Mon 8/247:49 pm
DSM
- ORD
Nonstop1h 48m
American Airlines
Deal found 7/26![American Airlines logo]()
$238
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/202:41 pm
ORD
- DSM
1 stop22h 53m
Frontier
Mon 8/242:19 pm
DSM
- ORD
1 stop23h 17m
Frontier
Deal found 7/26![Frontier logo]()
$240
This Southwest deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/222:05 pm
MDW
- DSM
1 stop6h 40m
Southwest
Sat 8/2912:10 pm
DSM
- MDW
Nonstop1h 20m
Southwest
Deal found 7/25![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:25 pm
MDW
- DSM
1 stop3h 53m
Delta
Sat 8/2912:30 pm
DSM
- MDW
1 stop6h 03m
Delta
Deal found 7/25![Delta logo]()
$257
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/241:59 pm
ORD
- DSM
1 stop6h 40m
Delta
Mon 8/314:20 pm
DSM
- ORD
1 stop5h 27m
Delta
Deal found 7/27![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:50 pm
MDW
- DSM
1 stop5h 10m
Southwest
Tue 9/17:15 am
DSM
- MDW
2 stops9h 45m
Southwest
Deal found 7/28![Southwest logo]()
$262
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:46 pm
ORD
- DSM
Nonstop1h 33m
American Airlines
Fri 8/287:49 pm
DSM
- ORD
Nonstop1h 48m
American Airlines
Deal found 7/27![American Airlines logo]()
$269
One-way flights from Indiana to Des MoinesSearch for one-way flight options from Indiana to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
Search for one-way flight options from Indiana to Des Moines. Find affordable one-way fares based on user searches. Data last updated July 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am
ORD
- DSM
1 stop13h 54m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:25 am
ORD
- DSM
1 stop12h 32m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$112
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:00 pm
ORD
- DSM
Nonstop1h 35m
United Airlines
Deal found 7/25![United Airlines logo]()
$119
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/78:50 pm
MDW
- DSM
Nonstop1h 25m
Southwest
Deal found 7/26![Southwest logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:50 am
ORD
- DSM
1 stop7h 52m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$123
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/69:00 am
ORD
- DSM
Nonstop1h 26m
United Airlines
Deal found 7/26![United Airlines logo]()
$124
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:50 pm
MDW
- DSM
Nonstop1h 20m
Southwest
Deal found 7/26![Southwest logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/236:00 am
ORD
- DSM
1 stop13h 54m
Multiple Airlines
Deal found 7/25![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:55 am
ORD
- DSM
1 stop14h 02m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$128
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:28 am
ORD
- DSM
1 stop5h 36m
Delta
Deal found 7/27![Delta logo]()
$129
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:31 pm
MDW
- DSM
1 stop3h 31m
Delta
Deal found 7/28![Delta logo]()
$129
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/228:28 am
ORD
- DSM
1 stop5h 36m
Delta
Deal found 7/24![Delta logo]()
$134
Find flight deals from Indiana to Des Moines
Keep the following information in mind while searching for Indiana to Des Moines flight deals. Data was last updated July 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (United Airlines) |
One-way from | $109 (Kiwi.com) |
Popular in | April |
Cheapest in | May |
Average price | $411 |
Cheapflights Fare Finder
Customize your flight search to find flights from Indiana to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Indiana to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoDes Moines
ORD - DSM
ORDDSM
Chicago O'Hare Intl
Thu 8/20
9:00 am-10:26 am
Nonstop1h 26m
Des Moines
Mon 8/24
11:32 am-1:15 pm
Nonstop1h 43m
$237
Quickest round-trip
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Thu 8/20
10:05 am-11:25 am
Nonstop1h 20m
Des Moines
Mon 8/24
5:40 am-7:00 am
Nonstop1h 20m
$237
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Tue 9/1
10:30 am-11:50 am
Nonstop1h 20m
Des Moines
Thu 9/3
3:50 pm-5:10 pm
Nonstop1h 20m
$237
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Thu 9/17
10:05 am-11:25 am
Nonstop1h 20m
Des Moines
Thu 9/17
3:50 pm-5:10 pm
Nonstop1h 20m
$237
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Wed 9/9
6:40 am-1:55 pm
1 stop7h 15m
Des Moines
Wed 9/16
6:10 am-7:30 am
Nonstop1h 20m
$247
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Wed 9/30
2:15 pm-9:05 pm
1 stop6h 50m
Des Moines
Tue 10/6
5:35 am-6:55 am
Nonstop1h 20m
$247
IndianapolisDes Moines
IND - DSM
INDDSM
Indianapolis
Sun 9/13
8:16 pm-1:56 pm
1 stop18h 40m
Des Moines
Mon 9/21
2:51 pm-7:21 pm
1 stop27h 30m
$254
ChicagoDes Moines
ORD - DSM
ORDDSM
Chicago O'Hare Intl
Wed 9/9
1:55 pm-8:46 pm
1 stop6h 51m
Des Moines
Wed 9/16
6:00 am-10:37 am
1 stop4h 37m
$257
ChicagoDes Moines
ORD - DSM
ORDDSM
Chicago O'Hare Intl
Thu 8/20
6:00 am-10:18 am
1 stop4h 18m
Des Moines
Thu 8/27
10:23 am-4:17 pm
1 stop5h 54m
$257
ChicagoDes Moines
MDW - DSM
MDWDSM
Chicago Midway
Tue 9/8
10:30 am-11:50 am
Nonstop1h 20m
Des Moines
Tue 9/15
7:15 am-2:20 pm
1 stop7h 05m
$259
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indiana to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Indiana with our price prediction graph.
MDW-DSM
ORD-DSM
SDF-DSM
CVG-DSM
FWA-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indiana to Des Moines
USIN-DSM
MDW-DSM
ORD-DSM
SDF-DSM
CVG-DSM
What is the cheapest month to book a flight from Indiana to Des Moines?
Currently, September is the cheapest month in which you can book a flight from Indiana to Des Moines (average of $278). Flying from Indiana to Des Moines in January is currently the most expensive (average of $517). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Indiana to Des Moines?
Airfare is below average for this route at the moment.
Indiana to Des Moines flights typically cost between $356 and $482 in September.The cheapest round-trip price found within the last 5 days was $254 on Frontier (Sep 13-Sep 21).
Related info for your journey
Find useful and relevant information for your journey from Indiana to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
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Alternative routes for Indiana to Des Moines
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on July 28, 2026.
Search flights from Indiana to Des Moines by cabin class
Find flights from Indiana to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indiana and Des Moines flights
Browse other Indiana and Des Moines flight options. Last updated on July 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Indiana to Des Moines flights
Consider these flights traveling from Indiana to Des Moines.
Top 3 airlines flying from Indiana to Des Moines
Discover the top 3 airlines that operate flights from Indiana to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$183 | Average$323 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$228 | Average$351 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$250 | Average$386 | FlexibilityNo cancel fee | On-time71% |