What are the cheapest airlines to fly from Des Moines to Florida one-way?

The cheapest airlines for a one-way flight from Des Moines to Florida are Allegiant Air ($59), Delta ($109), and Frontier ($109).

What are the most popular routes from Des Moines to Florida?

Most travelers choose Des Moines - Orlando, Des Moines - Miami or Des Moines - Tampa when deciding on the best route from Des Moines to Florida.

What are the cheapest flights from Des Moines to Florida?

Looking for the cheapest flight from Des Moines to Florida? While on average our users pay $401, our data indicates the cheapest price to be $225. The most popular route (Des Moines - Orlando), is priced around $200.

What are the most reliable airlines from Des Moines to Florida?

Consider American Airlines (44%), Qatar Airways (44%) or Envoy Air (44%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Florida.

What are the most popular airlines that fly from Des Moines to Florida?

Consider American Airlines, Delta or Frontier when booking your flight. These represent the most popular airlines when flying from Des Moines to Florida.

How far in advance should I book a flight from Des Moines to Florida?

To save on the cost of your flight from Des Moines to Florida, book at least 42 days before your planned departure. Booking around this time can save you about 39% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $201 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $287.

What is the cheapest month to fly from Des Moines to Florida?

May can be a great time to fly to Florida from Des Moines with a flight ticket averaging about $311. Cheapflights users have found deals in the month of May for as cheap as $149. The most expensive prices can be found in the month of December.

What airport do you fly from for flights from Des Moines to Florida?

Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida.

Can I find deals for flights from Des Moines to Florida that include hotel bookings?

Yes. In addition to deals on Des Moines to Florida flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Florida?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida.

Can I find deals for business class flights from Des Moines to Florida?

Yes. Cheapflights offers flight deals from Des Moines to Florida by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$59+ Flights from Des Moines to Florida

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Cheap flight deals from Des Moines to Florida

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$86 (Booking.com)
One-way from	$59 (lastminute.com)
Popular in	December
Cheapest in	May
Average price	$249
Good round-trip deal	$90 or less
Good one-way deal	$49 or less

Provider with most accurate pricing for Des Moines-Orlando (ORL) flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Orlando (ORL) flights.

Search Deals

From Des Moines to Florida

Search Deals

One-way flight from Des Moines to Florida

Search Deals

Highest demand for flights based on searches. 15% potential increase in price ($55 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

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Price to beat on a round-trip flight from Des Moines to Florida.

Search Deals

Price to beat on a one-way flight from Des Moines to Florida.

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Find flight deals from Des Moines to Florida

Cheapest flights from Des Moines to Florida
Explore the most affordable flight options available from Des Moines to Florida. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Sun 6/228:30 amDSM - JAX

Nonstop2h 37mAllegiant Air

Thu 6/2612:57 pmJAX - DSM

Nonstop2h 52mAllegiant Air

Deal found 4/30

$86

Thu 7/177:54 pmDSM - PIE

Nonstop2h 45mAllegiant Air

Mon 7/216:50 amPIE - DSM

Nonstop2h 50mAllegiant Air

Deal found 4/30

$107

Fri 8/19:39 amDSM - FLL

Nonstop3h 10mAllegiant Air

Fri 8/86:30 amFLL - DSM

Nonstop3h 19mAllegiant Air

Deal found 4/30

$146

Sat 6/219:00 amDSM - SRQ

Nonstop2h 41mAllegiant Air

Sat 6/281:31 pmSRQ - DSM

Nonstop2h 56mAllegiant Air

Deal found 4/29

$156

Wed 5/2810:32 amDSM - MCO

1 stop5h 22mMultiple Airlines

Wed 6/49:38 pmMCO - DSM

1 stop25h 59mMultiple Airlines

Deal found 4/30

$172

Mon 5/57:20 pmDSM - TPA

1 stop9h 14mFrontier

Mon 5/126:30 amTPA - DSM

1 stop13h 00mFrontier

Deal found 4/30

$198

Mon 5/57:20 pmDSM - MCO

1 stop9h 43mFrontier

Fri 5/96:00 amMCO - DSM

1 stop13h 30mFrontier

Deal found 4/30

$198

Sun 6/18:30 amDSM - JAX

Nonstop2h 37mMultiple Airlines

Thu 6/59:44 amJAX - DSM

2 stops28h 02mMultiple Airlines

Deal found 4/30

$208

Fri 5/167:20 pmDSM - MIA

1 stop9h 02mFrontier

Wed 5/216:00 amMIA - DSM

1 stop13h 30mFrontier

Deal found 4/30

$208

Fri 6/66:30 amDSM - FLL

Nonstop3h 14mMultiple Airlines

Mon 6/97:00 amFLL - DSM

1 stop15h 24mMultiple Airlines

Deal found 4/30

$212

Fri 6/276:47 pmDSM - MIA

1 stop5h 10mDelta

Wed 7/25:50 pmMIA - DSM

1 stop6h 13mDelta

Deal found 4/30

$217

Wed 6/46:25 amDSM - MIA

1 stop7h 49mUnited Airlines

Sat 6/76:30 amMIA - DSM

1 stop8h 45mUnited Airlines

Deal found 4/30

$257

Best flights from Des Moines to Florida
Discover carefully curated flight deals from Des Moines to Florida that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Sun 6/228:30 amDSM - JAX

Nonstop2h 37mAllegiant Air

Thu 6/2612:57 pmJAX - DSM

Nonstop2h 52mAllegiant Air

Deal found 4/30

$86

Wed 5/2810:32 amDSM - MCO

1 stop5h 22mMultiple Airlines

Wed 6/49:38 pmMCO - DSM

1 stop25h 59mMultiple Airlines

Deal found 4/30

$172

Fri 5/167:20 pmDSM - MIA

1 stop9h 02mFrontier

Wed 5/216:00 amMIA - DSM

1 stop13h 30mFrontier

Deal found 4/30

$208

Thu 7/177:54 pmDSM - PIE

Nonstop2h 45mAllegiant Air

Mon 7/216:50 amPIE - DSM

Nonstop2h 50mAllegiant Air

Deal found 4/30

$107

Fri 6/276:47 pmDSM - MIA

1 stop5h 10mDelta

Wed 7/25:50 pmMIA - DSM

1 stop6h 13mDelta

Deal found 4/30

$217

Wed 6/46:25 amDSM - MIA

1 stop7h 49mUnited Airlines

Sat 6/76:30 amMIA - DSM

1 stop8h 45mUnited Airlines

Deal found 4/30

$257

Wed 6/42:01 pmDSM - RSW

1 stop7h 11mAmerican Airlines

Wed 6/119:58 amRSW - DSM

1 stop7h 17mAmerican Airlines

Deal found 4/30

$285

Thu 5/295:30 pmDSM - RSW

1 stop4h 20mSouthwest

Tue 6/35:40 pmRSW - DSM

1 stop5h 25mSouthwest

Deal found 4/30

$301

Fri 8/19:39 amDSM - FLL

Nonstop3h 10mAllegiant Air

Fri 8/86:30 amFLL - DSM

Nonstop3h 19mAllegiant Air

Deal found 4/30

$146

Sat 6/219:00 amDSM - SRQ

Nonstop2h 41mAllegiant Air

Sat 6/281:31 pmSRQ - DSM

Nonstop2h 56mAllegiant Air

Deal found 4/29

$156

Sun 6/18:30 amDSM - JAX

Nonstop2h 37mMultiple Airlines

Thu 6/59:44 amJAX - DSM

2 stops28h 02mMultiple Airlines

Deal found 4/30

$208

Mon 5/127:20 pmDSM - TPA

1 stop9h 14mFrontier

Mon 5/196:30 amTPA - DSM

1 stop13h 00mFrontier

Deal found 4/30

$218

Last-minute flights from Des Moines to Florida
Discover last-minute flight deals from Des Moines to Florida. Data last updated May 1, 2025 and is based on user searches.

Mon 5/53:53 pmDSM - PIE

Nonstop2h 45mAllegiant Air

Mon 5/128:28 pmPIE - DSM

Nonstop2h 53mAllegiant Air

Deal found 4/30

$181

Mon 5/53:53 pmDSM - PIE

Nonstop2h 45mMultiple Airlines

Sun 5/111:15 pmPIE - DSM

3 stops33h 43mMultiple Airlines

Deal found 4/30

$408

Mon 5/57:20 pmDSM - TPA

1 stop9h 14mFrontier

Mon 5/126:30 amTPA - DSM

1 stop13h 00mFrontier

Deal found 4/30

$198

Mon 5/57:20 pmDSM - MCO

1 stop9h 43mFrontier

Fri 5/96:00 amMCO - DSM

1 stop13h 30mFrontier

Deal found 4/30

$198

Wed 5/77:30 pmDSM - MIA

1 stop8h 52mFrontier

Mon 5/126:00 amMIA - DSM

1 stop13h 30mFrontier

Deal found 4/30

$228

Wed 5/77:20 amDSM - TPA

1 stop13h 06mAmerican Airlines

Sat 5/177:20 amTPA - DSM

1 stop7h 28mAmerican Airlines

Deal found 4/30

$523

Thu 5/82:15 pmDSM - ECP

1 stop5h 33mDelta

Tue 5/135:30 pmECP - DSM

1 stop5h 00mDelta

Deal found 4/30

$567

Thu 5/88:00 amDSM - PNS

1 stop8h 12mUnited Airlines

Tue 5/132:05 pmPNS - DSM

1 stop20h 25mUnited Airlines

Deal found 4/29

$571

Fri 5/97:20 pmDSM - MCO

1 stop9h 43mFrontier

Fri 5/166:00 amMCO - DSM

1 stop13h 20mFrontier

Deal found 4/30

$258

Fri 5/91:31 pmDSM - MCO

1 stop8h 15mMultiple Airlines

Mon 5/123:02 pmMCO - DSM

1 stop9h 11mMultiple Airlines

Deal found 4/30

$264

Sat 5/108:48 amDSM - MIA

2 stops10h 46mUnited Airlines

Sun 5/189:30 amMIA - DSM

1 stop7h 44mUnited Airlines

Deal found 4/30

$446

Sat 5/108:30 amDSM - MIA

1 stop4h 35mSouthwest

Sun 5/185:15 amMIA - DSM

2 stops11h 45mSouthwest

Deal found 4/30

$447

One-way flights from Des Moines to Florida
Search for one-way flight options from Des Moines to Florida. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Sat 7/196:00 amDSM - PIE

Nonstop2h 43mAllegiant Air

Deal found 4/29

$59

Mon 7/286:30 amDSM - FLL

Nonstop3h 10mAllegiant Air

Deal found 4/30

$65

Thu 6/56:30 amDSM - TPA

1 stop13h 31mMultiple Airlines

Deal found 4/30

$93

Sat 6/141:15 pmDSM - MIA

1 stop21h 22mMultiple Airlines

Deal found 4/30

$96

Fri 6/65:19 pmDSM - MCO

1 stop19h 48mMultiple Airlines

Deal found 4/30

$97

Fri 5/167:20 pmDSM - TPA

1 stop9h 14mFrontier

Deal found 4/30

$109

Fri 5/301:07 pmDSM - MIA

1 stop8h 48mDelta

Deal found 5/1

$109

Wed 5/217:30 pmDSM - MCO

1 stop9h 33mFrontier

Deal found 4/30

$119

Sat 8/26:45 amDSM - MIA

Nonstop3h 24mAmerican Airlines

Deal found 4/29

$139

Wed 7/238:00 amDSM - SRQ

1 stop6h 10mUnited Airlines

Deal found 4/29

$143

Tue 6/172:20 pmDSM - TPA

1 stop7h 43mDelta

Deal found 4/30

$143

Wed 7/302:57 pmDSM - MCO

1 stop6h 03mUnited Airlines

Deal found 4/30

$143

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sun 6/22

8:30 am-12:07 pm

Nonstop2h 37m

Jacksonville

Thu 6/26

12:57 pm-2:49 pm

Nonstop2h 52m

$86

Des MoinesTampa

DSM - PIE

DSMPIE

Des Moines

Thu 7/17

7:54 pm-11:39 pm

Nonstop2h 45m

Tampa St. Petersburg

Mon 7/21

6:50 am-8:40 am

Nonstop2h 50m

$107

Des MoinesFort Lauderdale

DSM - FLL

DSMFLL

Des Moines

Fri 8/1

9:39 am-1:49 pm

Nonstop3h 10m

Fort Lauderdale

Fri 8/8

6:30 am-8:49 am

Nonstop3h 19m

$146

Des MoinesSarasota

DSM - SRQ

DSMSRQ

Des Moines

Sat 6/21

9:00 am-12:41 pm

Nonstop2h 41m

Sarasota Bradenton Intl

Sat 6/28

1:31 pm-3:27 pm

Nonstop2h 56m

$156

Des MoinesOrlando

DSM - MCO

DSMMCO

Des Moines

Wed 5/28

10:32 am-4:54 pm

1 stop5h 22m

Orlando

Wed 6/4

9:38 pm-10:37 pm

1 stop25h 59m

$172

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 5/16

7:20 pm-5:22 am

1 stop9h 02m

Miami

Wed 5/21

6:00 am-6:30 pm

1 stop13h 30m

$208

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sun 6/1

8:30 am-12:07 pm

Nonstop2h 37m

Jacksonville

Thu 6/5

9:44 am-12:46 pm

2 stops28h 02m

$208

Des MoinesFort Lauderdale

DSM - FLL

DSMFLL

Des Moines

Fri 6/6

6:30 am-10:44 am

Nonstop3h 14m

Fort Lauderdale

Mon 6/9

7:00 am-9:24 pm

1 stop15h 24m

$212

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 6/27

6:47 pm-12:57 am

1 stop5h 10m

Miami

Wed 7/2

5:50 pm-11:03 pm

1 stop6h 13m

$217

Des MoinesTampa

DSM - TPA

DSMTPA

Des Moines

Mon 5/12

7:20 pm-5:34 am

1 stop9h 14m

Tampa

Mon 5/19

6:30 am-6:30 pm

1 stop13h 00m

$218

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 60 results

...

Best time to book a flight from Des Moines to Florida

Have a flexible travel schedule? Discover the best time to fly to Florida from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida

What is the cheapest month to book a flight from Des Moines to Florida?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Florida (average of $228). Flying from Des Moines to Florida in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to FL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Florida as you normally would.

Rainfall in Florida by month

In terms of precipitation, rainfall in Florida ranges from 2.4 - 8.7 inches per month. June is typically the wettest month, when rainfall can reach 8.7 in. November is typically the driest time to visit Florida when rainfall is around 2.4 in.

Temperature in Florida by month

If weather is an important factor for your trip to Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 60.8 F).

Reviews of airlines servicing Florida

Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to Florida by reading reviews from past customers. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Southwest

8.0

Very good

4,294 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Delta

8.0

Very good

7,934 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

United Airlines

7.4

Good

8,696 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Allegiant Air

7.3

Good

734 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

What airport do you fly from for flights from Des Moines to Florida?
Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida.
What are the cheapest airlines to fly from Des Moines to Florida one-way?
The cheapest airlines for a one-way flight from Des Moines to Florida are Allegiant Air ($59), Delta ($109), and Frontier ($109).
What are the most popular routes from Des Moines to Florida?
Most travelers choose Des Moines - Orlando, Des Moines - Miami or Des Moines - Tampa when deciding on the best route from Des Moines to Florida.
What are the most reliable airlines from Des Moines to Florida?
Consider American Airlines (44%), Qatar Airways (44%) or Envoy Air (44%) when booking your flight. These represent the most reliable airlines when flying from Des Moines to Florida.
What are the cheapest flights from Des Moines to Florida?
Looking for the cheapest flight from Des Moines to Florida? While on average our users pay $401, our data indicates the cheapest price to be $225. The most popular route (Des Moines - Orlando), is priced around $200.
Can I find deals for flights from Des Moines to Florida that include hotel bookings?
Yes. In addition to deals on Des Moines to Florida flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Florida?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida.
Can I find deals for business class flights from Des Moines to Florida?
Yes. Cheapflights offers flight deals from Des Moines to Florida by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Florida?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Florida (average of $228). Flying from Des Moines to Florida in March is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Des Moines to Florida

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$70	Average$220	FlexibilityNo cancel fee	On-time88%
Frontier	Cheapest$118	Average$258	FlexibilityNo cancel fee	On-time62%
United Airlines	Cheapest$221	Average$446	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$221	Average$394	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$260	Average$404	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$305	Average$440	FlexibilityNo cancel fee	On-time63%

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$59+ Cheap flights from Des Moines (DSM) to Florida

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Florida with Cheapflights

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3. Compare prices and book

Cheap flight deals from Des Moines to Florida

Keep the following information in mind while searching for Des Moines to Florida flight deals. Data was last updated May 1, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Des Moines to Florida

Cheapest flights from Des Moines to FloridaExplore the most affordable flight options available from Des Moines to Florida. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from Des Moines to Florida. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Florida that are best for you.

Best time to book a flight from Des Moines to Florida

Have a flexible travel schedule? Discover the best time to fly to Florida from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida

What is the cheapest month to book a flight from Des Moines to Florida?

What is the cheapest time of day to fly from DSM to FL?

Find hourly flight availability from Des Moines to Florida. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in Florida by month

Plan your trip to Florida by taking into account the average rainfall totals by month.

Temperature in Florida by month

Plan your trip to Florida by taking into account the average temperature totals by month.

Reviews of airlines servicing Florida

Get insights into the airlines that provide service to Florida. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida. Reviews last updated May 1, 2025.

Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to Florida by reading reviews from past customers. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Des Moines to Florida?

What are the cheapest airlines to fly from Des Moines to Florida one-way?

What are the most popular routes from Des Moines to Florida?

What are the most reliable airlines from Des Moines to Florida?

What are the cheapest flights from Des Moines to Florida?

Can I find deals for flights from Des Moines to Florida that include hotel bookings?

How can I find direct flights from Des Moines to Florida?

Can I find deals for business class flights from Des Moines to Florida?

What is the cheapest month to book a flight from Des Moines to Florida?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Florida

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Des Moines to Florida

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Cheapest flights from Des Moines to Florida
Explore the most affordable flight options available from Des Moines to Florida. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.