$58+ Cheap flights from Indiana to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
abr. 5 — abr. 121
Round-trip
1 adult, Economy
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Find cheap flights from Indiana to South Carolina with Cheapflights
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Indiana to South Carolina
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Cheapest flights from Indiana to South CarolinaExplore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 6, 2026.
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on marzo 6, 2026.
This Super.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/237:11 pm
ORD
- CLT
Nonstop2h 02m
Frontier
lun. 3/3010:52 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Deal found 3/2![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/246:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
lun. 3/3010:52 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Deal found 3/1![Multiple Airlines logo]()
$99
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/91:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
sáb. 4/117:09 pm
CLT
- ORD
Nonstop2h 30m
Frontier
Deal found 3/3![Frontier logo]()
$100
This Expedia deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/122:09 pm
ORD
- CLT
1 stop6h 52m
Multiple Airlines
vie. 5/159:26 pm
CLT
- ORD
Nonstop2h 27m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$102
This Super.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/201:12 pm
ORD
- CLT
Nonstop2h 10m
Frontier
jue. 4/234:19 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/1![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/166:22 pm
ORD
- CLT
Nonstop2h 17m
Frontier
lun. 4/205:17 pm
CLT
- ORD
Nonstop2h 33m
Frontier
Deal found 3/5![Frontier logo]()
$104
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/912:53 pm
ORD
- CLT
1 stop9h 51m
Multiple Airlines
vie. 5/159:26 pm
CLT
- ORD
Nonstop2h 27m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$105
This Priceline deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/36:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
vie. 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$106
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
dom. 4/196:10 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Deal found 3/3![Frontier logo]()
$107
This Expedia deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/15:15 am
ORD
- CLT
1 stop15h 13m
Frontier
dom. 5/34:41 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/4![Frontier logo]()
$108
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
jue. 4/1610:24 pm
CLT
- ORD
Nonstop2h 20m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$109
This Super.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
lun. 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Frontier
Deal found 3/3![Frontier logo]()
$111
Best flights from Indiana to South CarolinaDiscover carefully curated flight deals from Indiana to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated marzo 6, 2026.
Discover carefully curated flight deals from Indiana to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated marzo 6, 2026.
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/275:15 am
ORD
- CLT
1 stop4h 56m
Delta
sáb. 5/26:00 am
CLT
- ORD
1 stop5h 19m
Delta
Deal found 3/2![Delta logo]()
$187
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/197:30 pm
MDW
- CLT
Nonstop2h 00m
Southwest
jue. 4/237:30 am
CLT
- MDW
Nonstop2h 15m
Southwest
Deal found 3/4![Southwest logo]()
$197
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/95:45 pm
ORD
- CLT
Nonstop2h 12m
United Airlines
dom. 4/126:15 am
CLT
- ORD
Nonstop2h 28m
United Airlines
Deal found 3/2![United Airlines logo]()
$217
This Contour deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Contour is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 6/2511:20 am
ORD
- CLT
1 stop4h 40m
Contour
lun. 6/296:05 pm
CLT
- ORD
1 stop23h 10m
Contour
Deal found 3/5![Contour logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/265:01 am
ORD
- MYR
2 stops32h 12m
Multiple Airlines
lun. 3/309:49 pm
MYR
- ORD
1 stop11h 12m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/276:00 am
MDW
- CLT
1 stop4h 11m
Delta
jue. 4/306:56 pm
CLT
- MDW
1 stop4h 32m
Delta
Deal found 3/1![Delta logo]()
$197
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/17:05 pm
MDW
- CLT
Nonstop1h 55m
Southwest
sáb. 5/210:55 am
CLT
- MDW
1 stop4h 45m
Southwest
Deal found 3/3![Southwest logo]()
$227
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/181:55 pm
ORD
- GSP
Nonstop1h 59m
United Airlines
lun. 4/2010:36 am
GSP
- ORD
Nonstop2h 20m
United Airlines
Deal found 3/4![United Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/187:10 am
ORD
- GSP
1 stop6h 07m
Delta
lun. 4/207:59 pm
GSP
- ORD
1 stop5h 00m
Delta
Deal found 3/5![Delta logo]()
$213
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/176:50 am
ORD
- GSP
Nonstop1h 56m
United Airlines
lun. 4/2010:36 am
GSP
- ORD
Nonstop2h 20m
United Airlines
Deal found 3/4![United Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/22:32 pm
ORD
- GSP
1 stop6h 20m
Delta
jue. 4/97:59 pm
GSP
- ORD
1 stop4h 55m
Delta
Deal found 3/4![Delta logo]()
$213
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/105:55 pm
MDW
- CLT
1 stop3h 45m
Southwest
lun. 4/137:00 pm
CLT
- MDW
Nonstop2h 05m
Southwest
Deal found 3/3![Southwest logo]()
$247
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/236:00 am
MDW
- CLT
1 stop4h 11m
Delta
dom. 4/266:00 am
CLT
- MDW
1 stop3h 47m
Delta
Deal found 3/5![Delta logo]()
$217
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/215:45 pm
ORD
- GSP
Nonstop2h 02m
United Airlines
mar. 4/2810:33 am
GSP
- ORD
1 stop4h 54m
United Airlines
Deal found 3/4![United Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/181:55 pm
ORD
- GSP
1 stop5h 45m
Southwest
lun. 4/206:25 am
GSP
- ORD
1 stop7h 25m
Southwest
Deal found 3/5![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/226:50 am
ORD
- GSP
Nonstop1h 56m
United Airlines
mar. 4/282:53 pm
GSP
- ORD
1 stop4h 51m
United Airlines
Deal found 3/4![United Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/132:40 pm
ORD
- GSP
1 stop6h 35m
Southwest
jue. 4/166:25 am
GSP
- ORD
2 stops10h 05m
Southwest
Deal found 3/1![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/302:40 pm
ORD
- GSP
1 stop5h 54m
Delta
mié. 4/85:40 am
GSP
- ORD
1 stop3h 50m
Delta
Deal found 3/3![Delta logo]()
$248
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/252:18 pm
ORD
- CLT
Nonstop2h 04m
United Airlines
vie. 3/276:15 am
CLT
- ORD
Nonstop2h 26m
United Airlines
Deal found 3/2![United Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/256:15 pm
MDW
- CLT
Nonstop1h 50m
Southwest
vie. 3/278:40 pm
CLT
- MDW
1 stop4h 25m
Southwest
Deal found 3/2![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/28:15 am
ORD
- HHH
1 stop6h 05m
Delta
mié. 5/612:08 pm
HHH
- ORD
1 stop5h 34m
Delta
Deal found 3/1![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/83:50 pm
MDW
- CLT
1 stop5h 50m
Southwest
dom. 5/106:10 am
CLT
- MDW
2 stops7h 00m
Southwest
Deal found 3/3![Southwest logo]()
$282
This United Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/277:05 am
ORD
- GSP
Nonstop1h 56m
United Airlines
vie. 4/36:30 am
GSP
- ORD
Nonstop2h 24m
United Airlines
Deal found 3/5![United Airlines logo]()
$287
This KAYAK deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/1212:51 pm
MDW
- CLT
1 stop6h 27m
Delta
jue. 5/141:00 pm
CLT
- MDW
1 stop6h 33m
Delta
Deal found 3/4![Delta logo]()
$282
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/256:00 am
ORD
- SAV
2 stops11h 55m
Southwest
mar. 4/281:05 pm
SAV
- ORD
2 stops9h 50m
Southwest
Deal found 3/3![Southwest logo]()
$300
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/97:00 am
ORD
- MYR
Nonstop2h 18m
United Airlines
lun. 4/133:15 pm
MYR
- ORD
Nonstop2h 31m
United Airlines
Deal found 3/3![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/169:15 am
MDW
- CLT
2 stops11h 00m
Southwest
jue. 5/2110:50 am
CLT
- MDW
2 stops10h 45m
Southwest
Deal found 3/1![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/128:45 am
ORD
- CLT
1 stop4h 23m
United Airlines
jue. 5/148:05 am
CLT
- ORD
Nonstop2h 18m
United Airlines
Deal found 3/4![United Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/147:07 am
ORD
- HHH
1 stop7h 15m
Delta
mar. 5/194:05 pm
HHH
- ORD
1 stop7h 31m
Delta
Deal found 3/3![Delta logo]()
$318
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/302:12 pm
ORD
- CLT
Nonstop2h 12m
United Airlines
sáb. 4/48:05 am
CLT
- ORD
Nonstop2h 18m
United Airlines
Deal found 3/1![United Airlines logo]()
$307
Last-minute flights from Indiana to South CarolinaDiscover last-minute flight deals from Indiana to South Carolina. Data last updated marzo 6, 2026 and is based on user searches.
Discover last-minute flight deals from Indiana to South Carolina. Data last updated marzo 6, 2026 and is based on user searches.
This Super.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 3/237:11 pm
ORD
- CLT
Nonstop2h 02m
Frontier
lun. 3/3010:52 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Deal found 3/2![Frontier logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 3/246:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
lun. 3/3010:52 pm
CLT
- ORD
Nonstop2h 31m
Multiple Airlines
Deal found 3/1![Multiple Airlines logo]()
$99
This Priceline deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/36:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
vie. 4/1010:43 pm
CLT
- ORD
Nonstop2h 21m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$106
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/91:02 pm
ORD
- CLT
Nonstop2h 10m
Frontier
sáb. 4/117:09 pm
CLT
- ORD
Nonstop2h 30m
Frontier
Deal found 3/3![Frontier logo]()
$100
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
dom. 4/196:10 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Deal found 3/3![Frontier logo]()
$107
This Priceline deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Multiple Airlines
jue. 4/166:30 am
CLT
- ORD
1 stop7h 35m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$108
This Super.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/113:00 pm
ORD
- CLT
Nonstop2h 14m
Frontier
lun. 4/139:40 pm
CLT
- ORD
Nonstop2h 27m
Frontier
Deal found 3/3![Frontier logo]()
$111
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:01 pm
ORD
- CLT
1 stop4h 52m
Multiple Airlines
jue. 4/1610:24 pm
CLT
- ORD
Nonstop2h 20m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/166:22 pm
ORD
- CLT
Nonstop2h 17m
Frontier
lun. 4/205:17 pm
CLT
- ORD
Nonstop2h 33m
Frontier
Deal found 3/5![Frontier logo]()
$104
This Frontier deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/175:16 pm
ORD
- CLT
Nonstop2h 15m
Frontier
dom. 4/196:10 pm
CLT
- ORD
Nonstop2h 31m
Frontier
Deal found 3/2![Frontier logo]()
$112
This Super.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/201:12 pm
ORD
- CLT
Nonstop2h 10m
Frontier
jue. 4/234:19 pm
CLT
- ORD
Nonstop2h 34m
Frontier
Deal found 3/1![Frontier logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/297:30 am
MDW
- CLT
1 stop10h 44m
Frontier
lun. 5/45:30 pm
CLT
- MDW
1 stop20h 30m
Frontier
Deal found 3/3![Frontier logo]()
$128
One-way flights from Indiana to South CarolinaSearch for one-way flight options from Indiana to South Carolina. Find affordable one-way fares based on user searches. Data last updated marzo 6, 2026.
Search for one-way flight options from Indiana to South Carolina. Find affordable one-way fares based on user searches. Data last updated marzo 6, 2026.
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 4/65:30 pm
ORD
- CLT
Nonstop2h 15m
Frontier
Deal found 3/3![Frontier logo]()
$58
This Super.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/256:01 pm
ORD
- CLT
1 stop4h 52m
Spirit Airlines
Deal found 3/3![Spirit Airlines logo]()
$59
This Cheapflightsfares deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/76:01 pm
ORD
- CLT
1 stop4h 52m
Spirit Airlines
Deal found 3/3![Spirit Airlines logo]()
$60
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/157:30 am
MDW
- CLT
1 stop10h 44m
Frontier
Deal found 3/3![Frontier logo]()
$65
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/212:53 pm
ORD
- CLT
1 stop9h 51m
Spirit Airlines
Deal found 3/2![Spirit Airlines logo]()
$65
This Mytrip deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:01 pm
ORD
- CHS
1 stop16h 07m
Spirit Airlines
Deal found 3/1![Spirit Airlines logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 5/47:30 am
MDW
- CLT
1 stop10h 44m
Frontier
Deal found 3/3![Frontier logo]()
$66
This Super.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/36:01 pm
ORD
- CLT
1 stop4h 52m
Spirit Airlines
Deal found 3/4![Spirit Airlines logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/27:30 am
MDW
- CLT
1 stop10h 44m
Frontier
Deal found 3/3![Frontier logo]()
$67
This Expedia deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/166:22 pm
ORD
- CLT
Nonstop2h 17m
Frontier
Deal found 3/1![Frontier logo]()
$67
This Kiwi.com deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/67:30 am
MDW
- CLT
1 stop10h 40m
Frontier
Deal found 3/4![Frontier logo]()
$68
This Cheapflightsfares deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/152:09 pm
ORD
- CLT
1 stop6h 52m
Spirit Airlines
Deal found 3/3![Spirit Airlines logo]()
$68
Find flight deals from Indiana to South Carolina
Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated marzo 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $97 (Super.com) |
One-way from | $58 (Expedia) |
Popular in | March |
Cheapest in | August |
Average price | $367 |
Good round-trip deal | $144 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 6, 2026.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
lun. 4/27
5:15 am-11:11 am
1 stop4h 56m
Charlotte Douglas
sáb. 5/2
6:00 am-10:19 am
1 stop5h 19m
$187
Quickest round-trip
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
dom. 4/19
7:30 pm-10:30 pm
Nonstop2h 00m
Charlotte Douglas
jue. 4/23
7:30 am-8:45 am
Nonstop2h 15m
$197
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
lun. 4/27
6:00 am-11:11 am
1 stop4h 11m
Charlotte Douglas
jue. 4/30
6:56 pm-10:28 pm
1 stop4h 32m
$197
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
sáb. 4/18
7:10 am-2:17 pm
1 stop6h 07m
Greenville
lun. 4/20
7:59 pm-11:59 pm
1 stop5h 00m
$213
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
jue. 4/2
2:32 pm-9:52 pm
1 stop6h 20m
Greenville
jue. 4/9
7:59 pm-11:54 pm
1 stop4h 55m
$213
ChicagoCharlotte
ORD - CLT
ORDCLT
Chicago O'Hare Intl
jue. 4/9
5:45 pm-8:57 pm
Nonstop2h 12m
Charlotte Douglas
dom. 4/12
6:15 am-7:43 am
Nonstop2h 28m
$217
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
jue. 4/23
6:00 am-11:11 am
1 stop4h 11m
Charlotte Douglas
dom. 4/26
6:00 am-8:47 am
1 stop3h 47m
$217
ChicagoCharlotte
MDW - CLT
MDWCLT
Chicago Midway
vie. 5/1
7:05 pm-10:00 pm
Nonstop1h 55m
Charlotte Douglas
sáb. 5/2
10:55 am-2:40 pm
1 stop4h 45m
$227
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
sáb. 4/18
1:55 pm-4:54 pm
Nonstop1h 59m
Greenville
lun. 4/20
10:36 am-11:56 am
Nonstop2h 20m
$229
ChicagoGreenville
ORD - GSP
ORDGSP
Chicago O'Hare Intl
vie. 4/17
6:50 am-9:46 am
Nonstop1h 56m
Greenville
lun. 4/20
10:36 am-11:56 am
Nonstop2h 20m
$229
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indiana to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
ORD-CLT
MDW-CLT
ORD-MYR
ORD-GSP
ORD-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indiana to South Carolina
USIN-USSC
ORD-CLT
MDW-CLT
ORD-MYR
ORD-GSP
What is the cheapest month to book a flight from Indiana to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $49). Flying from Indiana to South Carolina in November is currently the most expensive (average of $222). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IN to SC?
Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated marzo 6, 2026.
One of the essential ways to save on airfare from Indiana to South Carolina is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 40% on airfare.
What is the cheapest day to fly from Indiana to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Indiana to South Carolina. Price data was last updated on July 27, 2025.
Travelers seeking maximum savings on their Indiana to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated marzo 6, 2026.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Delta, United Airlines, and Allegiant Air. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Entertainment
7.8
Crew
8.5
Comfort
7.9
Overall
7.9
Boarding
8.1
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Indiana to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Indiana to South Carolina by cabin class
Find flights from Indiana to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indiana and South Carolina flights
Browse other Indiana and South Carolina flight options. Last updated on marzo 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Indiana after your stay in South Carolina
Indiana to South Carolina flights
Consider these flights traveling from Indiana to South Carolina.
Top 6 airlines flying from Indiana to South Carolina
Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated marzo 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$58 | Average$118 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$95 | Average$179 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$151 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$166 | Average$405 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$198 | Average$346 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$247 | Average$429 | FlexibilityNo cancel fee | On-time63% |