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South Carolina

$66+ Cheap flights from Indiana to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Indiana to South Carolina

Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated September 17, 2025.

Round-trip from

$111
(Cheapflightsfares)

One-way from

$66
(United Airlines)

Popular in

December

Cheapest in

August

Average price

$259

Good round-trip deal

$99 or less
From Indiana to South Carolina
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One-way flight from Indiana to South Carolina
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Highest demand for flights based on searches. 11% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Indiana to South Carolina.
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Find flight deals from Indiana to South Carolina

Cheapest flights from Indiana to South Carolina
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:50 amORD - CLT
Nonstop2h 10mFrontier
Thu 10/2310:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/16$111
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amORD - CLT
Nonstop2h 08mFrontier
Sun 10/1910:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/17$112
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/511:52 amORD - CLT
Nonstop2h 07mFrontier
Sun 12/73:54 pmCLT - ORD
Nonstop2h 22mFrontier
Deal found 9/15$113
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:50 amORD - CLT
Nonstop2h 10mFrontier
Sun 10/198:59 amCLT - ORD
1 stop14h 18mFrontier
Deal found 9/16$114
This Cheapflightsfares deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:50 amORD - CLT
Nonstop2h 10mFrontier
Fri 10/245:34 pmCLT - ORD
1 stop8h 25mFrontier
Deal found 9/16$115
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:00 amORD - CLT
Nonstop2h 08mFrontier
Mon 10/205:34 pmCLT - ORD
1 stop8h 25mFrontier
Deal found 9/16$116
This Cheapflightsfares deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:50 amORD - CLT
Nonstop2h 10mFrontier
Sun 10/2610:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/15$118
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:00 amORD - CLT
Nonstop2h 08mFrontier
Mon 10/2710:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/16$119
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/195:50 amORD - CLT
1 stop9h 40mFrontier
Mon 10/2010:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/15$120
This Priceline deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:50 amORD - CLT
Nonstop2h 10mFrontier
Mon 10/2710:03 amCLT - ORD
Nonstop2h 15mFrontier
Deal found 9/16$121
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/57:40 amORD - CLT
Nonstop2h 20mFrontier
Sun 10/128:59 amCLT - ORD
1 stop14h 18mFrontier
Deal found 9/15$122
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 pmMDW - CLT
Nonstop1h 50mSouthwest
Sat 11/151:10 pmCLT - MDW
Nonstop2h 05mSouthwest
Deal found 9/14$139

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.

Fly from

Indiana

Fly to

South Carolina

Route

Depart

Return

Price

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 11/12

6:00 pm-8:50 pm

Nonstop1h 50m

Charlotte Douglas

Sat 11/15

1:10 pm-2:15 pm

Nonstop2h 05m

$139

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Wed 10/22

6:20 pm-9:41 pm

Nonstop2h 21m

Charlotte Douglas

Sat 10/25

5:30 pm-6:55 pm

Nonstop2h 25m

$139

CincinnatiCharlotte

CVG - CLT

CVGCLT

Cincinnati Cinci./N. Kentucky

Mon 10/20

12:01 pm-6:34 pm

1 stop6h 33m

Charlotte Douglas

Fri 10/24

5:34 pm-1:49 am

1 stop8h 15m

$143

CincinnatiCharlotte

CVG - CLT

CVGCLT

Cincinnati Cinci./N. Kentucky

Fri 10/17

12:01 pm-6:29 pm

1 stop6h 28m

Charlotte Douglas

Mon 10/20

5:34 pm-1:39 am

1 stop8h 05m

$144

CincinnatiCharlotte

CVG - CLT

CVGCLT

Cincinnati Cinci./N. Kentucky

Mon 9/29

5:20 am-1:01 pm

1 stop7h 41m

Charlotte Douglas

Sat 10/4

2:01 pm-9:17 pm

1 stop7h 16m

$144

CincinnatiCharlotte

CVG - CLT

CVGCLT

Cincinnati Cinci./N. Kentucky

Fri 9/26

5:20 am-1:01 pm

1 stop7h 41m

Charlotte Douglas

Mon 9/29

2:01 pm-12:57 am

1 stop10h 56m

$144

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 10/15

10:35 am-1:25 pm

Nonstop1h 50m

Charlotte Douglas

Wed 10/22

6:10 pm-7:10 pm

Nonstop2h 00m

$149

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Wed 10/15

7:15 am-10:31 am

Nonstop2h 16m

Charlotte Douglas

Wed 10/22

5:10 pm-6:35 pm

Nonstop2h 25m

$149

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Sun 10/19

8:25 pm-11:15 pm

Nonstop1h 50m

Charlotte Douglas

Tue 10/21

6:00 am-6:55 am

Nonstop1h 55m

$151

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Mon 10/20

7:15 am-10:31 am

Nonstop2h 16m

Charlotte Douglas

Tue 10/21

5:10 pm-6:35 pm

Nonstop2h 25m

$151

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to South Carolina

What is the cheapest month to book a flight from Indiana to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SC?

Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from Indiana to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
699 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,023 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Overall

8.0

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to South Carolina flight route?

    This flight path from Indiana to South Carolina was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indiana to South Carolina?

    Airlines like Southwest, United Airlines, and Frontier fly from Indiana to South Carolina in about 1h 50m. The time it takes to get you to your destination can typically vary by up to 4h 43m. Indiana and South Carolina are separated by a distance of 583 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to South Carolina one-way?

    $66 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Southwest and Frontier, with prices starting from $70 and $72, respectively.

  • Can I find deals for flights from Indiana to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indiana to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to South Carolina.

  • Can I find deals for business class flights from Indiana to South Carolina?

    Yes. Cheapflights offers flight deals from Indiana to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $217). Flying from Indiana to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indiana to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indiana to South Carolina

Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$134Average$211FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$166Average$393FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$325FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$375FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$401FlexibilityNo cancel feeOn-time63%

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