HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$49+ Cheap flights from Indiana to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Indiana to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Indiana to South Carolina

Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated November 2, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$84
(Priceline)

One-way from

$49
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$346

Good round-trip deal

$99 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
Search Deals
From Indiana to South Carolina
Search Deals
One-way flight from Indiana to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Indiana to South Carolina.
Search Deals

Find flight deals from Indiana to South Carolina

Cheapest flights from Indiana to South Carolina
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This Priceline deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:15 amORD - CLT
Nonstop2h 07mFrontier
Mon 12/83:07 pmCLT - ORD
1 stop9h 50mFrontier
Deal found 10/31$82
This Frontier deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2412:29 pmORD - CLT
Nonstop2h 03mFrontier
Thu 11/274:17 pmCLT - ORD
Nonstop2h 22mFrontier
Deal found 11/1$87
This Frontier deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:50 amORD - CLT
Nonstop2h 07mFrontier
Mon 12/812:52 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 10/31$88
This Kiwi.com deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:50 amORD - CLT
Nonstop2h 07mFrontier
Sun 12/712:57 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/2$89
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1511:51 amORD - CLT
Nonstop2h 05mMultiple Airlines
Wed 11/195:45 amCLT - ORD
1 stop6h 35mMultiple Airlines
Deal found 10/31$97
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:26 pmORD - CLT
1 stop7h 33mMultiple Airlines
Sun 12/712:57 pmCLT - ORD
Nonstop2h 13mMultiple Airlines
Deal found 11/1$99
This Frontier deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:53 amORD - CLT
Nonstop2h 05mFrontier
Mon 11/244:17 pmCLT - ORD
Nonstop2h 22mFrontier
Deal found 11/1$101
This CheapOair deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:00 amORD - CLT
1 stop8h 54mFrontier
Sun 12/712:57 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/2$102
This Mytrip deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/151:00 pmCVG - CLT
1 stop20h 02mFrontier
Wed 11/197:54 pmCLT - CVG
1 stop15h 06mFrontier
Deal found 10/31$119
This Booking.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:30 pmCVG - CLT
1 stop19h 02mFrontier
Wed 11/197:54 pmCLT - CVG
1 stop15h 06mFrontier
Deal found 11/1$121
This Priceline deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:05 amMDW - CLT
1 stop9h 22mFrontier
Mon 12/83:07 pmCLT - MDW
1 stop8h 11mFrontier
Deal found 11/1$124
This Frontier deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/149:15 amMDW - CLT
1 stop11h 41mFrontier
Sat 11/1510:51 pmCLT - MDW
1 stop9h 39mFrontier
Deal found 10/31$128

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.

Fly from

Indiana

Fly to

South Carolina

Route

Depart

Return

Price

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Tue 12/2

2:15 pm-5:20 pm

Nonstop2h 05m

Charlotte Douglas

Tue 12/9

5:28 pm-6:54 pm

Nonstop2h 26m

$139

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Sun 12/7

8:20 pm-11:10 pm

Nonstop1h 50m

Charlotte Douglas

Tue 12/9

6:10 am-7:15 am

Nonstop2h 05m

$151

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Mon 12/15

6:00 pm-8:50 pm

Nonstop1h 50m

Charlotte Douglas

Tue 12/16

6:10 am-7:15 am

Nonstop2h 05m

$151

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Fri 12/12

9:30 am-12:25 pm

Nonstop1h 55m

Charlotte Douglas

Sun 12/14

6:55 pm-11:30 pm

1 stop5h 35m

$173

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Fri 12/5

11:25 am-5:40 pm

1 stop5h 15m

Charlotte Douglas

Mon 12/8

6:10 am-7:15 am

Nonstop2h 05m

$173

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Thu 12/4

11:25 am-5:40 pm

1 stop5h 15m

Charlotte Douglas

Sun 12/7

5:50 am-6:50 am

Nonstop2h 00m

$173

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Wed 12/24

1:35 pm-9:50 pm

1 stop7h 15m

Charlotte Douglas

Thu 12/25

9:45 am-12:54 pm

1 stop4h 09m

$177

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 11/27

6:45 am-1:30 pm

1 stop5h 45m

Charlotte Douglas

Wed 12/3

11:38 am-4:42 pm

1 stop6h 04m

$177

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Thu 11/27

1:14 pm-6:28 pm

1 stop4h 14m

Charlotte Douglas

Tue 12/2

5:27 am-8:39 am

1 stop4h 12m

$177

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Fri 1/16

6:00 pm-8:50 pm

Nonstop1h 50m

Charlotte Douglas

Mon 1/19

6:20 pm-7:25 pm

Nonstop2h 05m

$177

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/31

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Indiana to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to South Carolina

What is the cheapest month to book a flight from Indiana to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $47). Flying from Indiana to South Carolina in January is currently the most expensive (average of $190). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SC?

Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

One of the essential ways to save on airfare from Indiana to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 8% on airfare.

What is the cheapest day to fly from Indiana to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Indiana to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indiana to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 2, 2025.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
7,997 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
United Airlines
7.4
Good
8,993 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,033 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Allegiant Air
7.2
Good
694 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Spirit Airlines
6.3
Okay
8,121 reviews
Delta
7.9
Good
7,997 reviews

Food

7.3

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to South Carolina flight route?

    This flight path from Indiana to South Carolina was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indiana to South Carolina?

    Airlines like United Airlines, Southwest, and Delta fly from Indiana to South Carolina in about 1h 50m. The time it takes to get you to your destination can typically vary by up to 5h 25m. Indiana and South Carolina are separated by a distance of 583 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to South Carolina one-way?

    $61 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Southwest and United Airlines, with prices starting from $70 and $70, respectively.

  • Can I find deals for flights from Indiana to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indiana to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to South Carolina.

  • Can I find deals for business class flights from Indiana to South Carolina?

    Yes. Cheapflights offers flight deals from Indiana to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $47). Flying from Indiana to South Carolina in January is currently the most expensive (average of $190). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Indiana to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Fort Lauderdale flights
Los Angeles to John F Kennedy Intl flights
Newark to Fort Lauderdale flights
John F Kennedy Intl to Miami flights
Newark to Miami flights
John F Kennedy Intl to Orlando flights
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Dallas/Fort Worth flights
Los Angeles to Newark flights
Dallas/Fort Worth to John F Kennedy Intl flights
LaGuardia to Fort Lauderdale flights
Newark to Dallas/Fort Worth flights
LaGuardia to Miami flights
San Francisco to Los Angeles flights
John F Kennedy Intl to O'Hare Intl flights
John F Kennedy Intl to Las Vegas flights
Dallas/Fort Worth to LaGuardia flights
Dallas/Fort Worth to Newark flights
San Francisco to John F Kennedy Intl flights
Newark to Los Angeles flights
Dallas/Fort Worth to Las Vegas flights
John F Kennedy Intl to West Palm Beach flights
John F Kennedy Intl to San Francisco flights
Los Angeles to Dallas/Fort Worth flights
O'Hare Intl to John F Kennedy Intl flights
Seattle to Los Angeles flights
Newark to Orlando flights
John F Kennedy Intl to Atlanta flights
Los Angeles to San Francisco flights
Atlanta to John F Kennedy Intl flights
LaGuardia to Dallas/Fort Worth flights
Hobby to LaGuardia flights
Newark to Las Vegas flights
Hobby to Newark flights
Los Angeles to LaGuardia flights
Hobby to John F Kennedy Intl flights
O'Hare Intl to Dallas/Fort Worth flights
Fort Lauderdale to Newark flights
LaGuardia to Orlando flights
Newark to West Palm Beach flights
Los Angeles to Honolulu flights
LaGuardia to Hobby flights
Los Angeles to Seattle flights
San Francisco to Newark flights
Newark to Hobby flights
San Francisco to Ontario flights
Newark to San Francisco flights
LaGuardia to Tampa flights
Dulles Intl to Miami flights
John F Kennedy Intl to Tampa flights

Top 6 airlines flying from Indiana to South Carolina

Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$128Average$209FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$166Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$343FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$362FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$401FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.