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South Carolina

$40+ Cheap flights from Indiana to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
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Cheap flight deals from Indiana to South Carolina

Keep the following information in mind while searching for Indiana to South Carolina flight deals. Data was last updated November 17, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$77
(Kiwi.com)

One-way from

$40
(Priceline)

Popular in

December

Cheapest in

August

Average price

$371

Good round-trip deal

$99 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indiana to South Carolina
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One-way flight from Indiana to South Carolina
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Highest demand for flights based on searches. 12% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Price to beat on a round-trip flight from Indiana to South Carolina.
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Find flight deals from Indiana to South Carolina

Cheapest flights from Indiana to South Carolina
Explore the most affordable flight options available from Indiana to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This Super.com deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:50 amORD - CLT
Nonstop2h 07mFrontier
Mon 12/1512:52 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/17$74
This Frontier deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/128:50 amORD - CLT
Nonstop2h 07mFrontier
Sun 12/1412:57 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/15$78
This CheapOair deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:50 amORD - CLT
Nonstop2h 07mFrontier
Sun 1/182:05 pmCLT - ORD
Nonstop2h 22mFrontier
Deal found 11/15$87
This Breeze Airways deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:03 pmCVG - CHS
Nonstop1h 40mBreeze Airways
Sun 12/77:05 amCHS - CVG
Nonstop1h 54mBreeze Airways
Deal found 11/15$88
This Frontier deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/148:55 amORD - CLT
Nonstop2h 07mFrontier
Mon 12/1512:52 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/17$90
This Priceline deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:15 amORD - CLT
Nonstop2h 07mFrontier
Mon 12/153:07 pmCLT - ORD
1 stop9h 50mFrontier
Deal found 11/15$91
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:26 pmORD - CLT
1 stop7h 33mMultiple Airlines
Mon 12/1512:52 pmCLT - ORD
Nonstop2h 13mMultiple Airlines
Deal found 11/16$93
This CheapOair deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:15 amORD - CLT
Nonstop2h 07mFrontier
Sun 12/1412:57 pmCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/17$94
This Super.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:50 amORD - CLT
Nonstop2h 07mFrontier
Thu 12/119:17 amCLT - ORD
Nonstop2h 13mFrontier
Deal found 11/16$95
This Breeze Airways deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/219:03 pmCVG - CHS
Nonstop1h 40mBreeze Airways
Thu 12/257:05 amCHS - CVG
Nonstop1h 54mBreeze Airways
Deal found 11/17$103
This Super.com deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/113:10 pmMDW - CLT
1 stop5h 28mFrontier
Mon 12/153:07 pmCLT - MDW
1 stop8h 11mFrontier
Deal found 11/15$109
This Cheapflightsfares deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1812:35 pmCVG - CHS
Nonstop1h 38mAllegiant Air
Tue 12/234:16 pmCHS - CVG
Nonstop1h 43mAllegiant Air
Deal found 11/16$114

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indiana to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Indiana to South Carolina that are best for you.

Fly from

Indiana

Fly to

South Carolina

Route

Depart

Return

Price

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Thu 12/4

9:03 pm-10:43 pm

Nonstop1h 40m

Charleston

Sun 12/7

7:05 am-8:59 am

Nonstop1h 54m

$88

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Sun 12/21

9:03 pm-10:43 pm

Nonstop1h 40m

Charleston

Thu 12/25

7:05 am-8:59 am

Nonstop1h 54m

$103

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Thu 12/18

9:03 pm-10:43 pm

Nonstop1h 40m

Charleston

Tue 12/23

7:05 am-8:59 am

Nonstop1h 54m

$128

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Thu 3/5

10:33 am-12:12 pm

Nonstop1h 39m

Charleston

Sun 3/8

8:00 am-9:53 am

Nonstop1h 53m

$133

ChicagoCharlotte

ORD - CLT

ORDCLT

Chicago O'Hare Intl

Sat 2/14

7:10 am-10:26 am

Nonstop2h 16m

Charlotte Douglas

Thu 2/19

6:15 am-7:41 am

Nonstop2h 26m

$139

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Thu 1/1

9:03 pm-10:43 pm

Nonstop1h 40m

Charleston

Sun 1/4

7:05 am-8:59 am

Nonstop1h 54m

$143

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Sat 2/14

2:10 pm-9:35 pm

2 stops6h 25m

Charlotte Douglas

Thu 2/19

5:50 am-6:55 am

Nonstop2h 05m

$154

CincinnatiCharleston

CVG - CHS

CVGCHS

Cincinnati Cinci./N. Kentucky

Tue 12/30

9:03 pm-10:43 pm

Nonstop1h 40m

Charleston

Sun 1/4

7:05 am-8:59 am

Nonstop1h 54m

$163

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Tue 1/6

1:30 pm-4:20 pm

Nonstop1h 50m

Charlotte Douglas

Tue 1/13

5:50 pm-6:55 pm

Nonstop2h 05m

$169

ChicagoMyrtle Beach

ORD - MYR

ORDMYR

Chicago O'Hare Intl

Thu 12/11

5:00 am-5:48 pm

1 stop11h 48m

Myrtle Beach Intl

Fri 12/12

2:15 pm-9:48 pm

1 stop8h 33m

$175

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/16

Showing 1-10 of 60 results
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Best time to book a flight from Indiana to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indiana with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indiana to South Carolina

What is the cheapest month to book a flight from Indiana to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $47). Flying from Indiana to South Carolina in November is currently the most expensive (average of $222). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IN to SC?

Find hourly flight availability from Indiana to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 17, 2025.

One of the essential ways to save on airfare from Indiana to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight at noon could potentially save you up to 8% on airfare.

What is the cheapest day to fly from Indiana to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Indiana to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indiana to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 17, 2025.
Read through reviews of airlines operating flights from Indiana to South Carolina, such as Delta, United Airlines, and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,006 reviews
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,014 reviews
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,044 reviews
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Allegiant Air
7.2
Good
700 reviews
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Spirit Airlines
6.3
Okay
8,144 reviews
Delta
7.9
Good
8,006 reviews

Crew

8.5

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Indiana to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Indiana to South Carolina flight route?

    This flight path from Indiana to South Carolina was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indiana to South Carolina?

    Airlines like Breeze Airways, United Airlines, and Southwest fly from Indiana to South Carolina in about 1h 40m. The time it takes to get you to your destination can typically vary by up to 4h 45m. Indiana and South Carolina are separated by a distance of 497 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Indiana to South Carolina one-way?

    $44 is the cheapest one-way deal found within the past few days, from Breeze Airways. You may also be able to find cheap deals on Allegiant Air and Frontier, with prices starting from $53 and $61, respectively.

  • Can I find deals for flights from Indiana to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indiana to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indiana to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indiana to South Carolina.

  • Can I find deals for business class flights from Indiana to South Carolina?

    Yes. Cheapflights offers flight deals from Indiana to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indiana to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indiana to South Carolina (average of $47). Flying from Indiana to South Carolina in November is currently the most expensive (average of $222). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Indiana to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indiana to South Carolina

Discover the top 6 airlines that operate flights from Indiana to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$128Average$209FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$166Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$343FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$198Average$362FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$401FlexibilityNo cancel feeOn-time63%

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