$600+ Cheap flights from Florence, SC to San Diego (FLO - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAN
Oct 2 — Oct 91
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest
Best
Last-minute
Cheapest flights from Florence to San DiegoExplore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
Explore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 2, 2026.
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:34 pm -
1 stop7h 26m
Wed 10/1410:40 pm -
2 stops12h 29m
Deal found 8/28![American Airlines logo]()
$600
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:43 pm -
1 stop7h 39m
Sun 9/201:41 pm -
1 stop7h 16m
Deal found 9/1![American Airlines logo]()
$875
Best flights from Florence to San DiegoDiscover carefully curated flight deals from Florence to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
Discover carefully curated flight deals from Florence to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 2, 2026.
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:34 pm -
1 stop7h 26m
Wed 10/1410:40 pm -
2 stops12h 29m
Deal found 8/28![American Airlines logo]()
$600
Last-minute flights from Florence to San DiegoDiscover last-minute flight deals from Florence to San Diego. Data last updated September 2, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to San Diego. Data last updated September 2, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/161:43 pm -
1 stop7h 39m
Sun 9/201:41 pm -
1 stop7h 16m
Deal found 9/1![American Airlines logo]()
$875
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:34 pm -
1 stop7h 26m
Wed 10/1410:40 pm -
2 stops12h 29m
Deal found 8/28![American Airlines logo]()
$600
Find flight deals from Florence to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $600 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
Use the filters below to find and compare flights from Florence to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
FlorenceSan Diego
FLO Florence - SAN San Diego
FLOSAN
Florence
Fri 10/9
2:34 pm-7:00 pm
1 stop7h 26m
San Diego
Wed 10/14
10:40 pm-2:09 pm
2 stops12h 29m
$600
Sorted by cheapest first
Compare providers for flights from Florence to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Diego in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Florence, South Carolina-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Florence with our price prediction graph.
FLO-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 2, 2026.
Get a feel of what it's like to fly with American Airlines from Florence to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Comfort
7.2
Overall
7.1
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Food
6.4
Comfort
7.2
Overall
7.1
Entertainment
6.8
Boarding
7.5
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Florence to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top airline flying from Florence to San Diego
Discover the top airline that operate flights from Florence to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$464 | Average$608 | FlexibilityNo cancel fee | On-time71% |