$549+ Cheap flights from Florence, SC to San Diego (FLO - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/18. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAN
Nov 18 — Nov 251
Round-trip
1 adult, Economy
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Find cheap flights from Florence to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Florence to San DiegoExplore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:24 am -
1 stop7h 15m
Sat 11/79:26 am -
2 stops10h 33m
Deal found 10/19![American Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/12:35 pm -
1 stop7h 29m
Thu 11/510:40 pm -
2 stops12h 30m
Deal found 10/16![American Airlines logo]()
$1,216
Best flights from Florence to San DiegoDiscover carefully curated flight deals from Florence to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Florence to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:24 am -
2 stops12h 17m
Sat 11/78:00 am -
2 stops11h 59m
Deal found 10/19![American Airlines logo]()
$719
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/12:35 pm -
1 stop7h 29m
Thu 11/510:40 pm -
2 stops12h 30m
Deal found 10/16![American Airlines logo]()
$1,216
Last-minute flights from Florence to San DiegoDiscover last-minute flight deals from Florence to San Diego. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to San Diego. Data last updated October 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/12:35 pm -
1 stop7h 29m
Thu 11/510:40 pm -
2 stops12h 30m
Deal found 10/16![American Airlines logo]()
$1,216
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:24 am -
1 stop7h 15m
Sat 11/79:26 am -
2 stops10h 33m
Deal found 10/19![American Airlines logo]()
$637
One-way flights from Florence to San DiegoSearch for one-way flight options from Florence to San Diego. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Florence to San Diego. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:09 am -
1 stop19h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/18![American Airlines logo]()
$549
Find flight deals from Florence to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $637 (American Airlines) |
One-way from | $549 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Florence to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
FlorenceSan Diego
FLO Florence - SAN San Diego
FLOSAN
Florence
Fri 12/18
5:09 am-9:51 pm
1 stop19h 42m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$549
FlorenceSan Diego
FLO Florence - SAN San Diego
FLOSAN
Florence
Tue 11/3
6:24 am-3:41 pm
2 stops12h 17m
San Diego
Sat 11/7
8:00 am-10:59 pm
2 stops11h 59m
$719
FlorenceSan Diego
FLO Florence - SAN San Diego
FLOSAN
Florence
Sun 11/1
2:35 pm-7:04 pm
1 stop7h 29m
San Diego
Thu 11/5
10:40 pm-2:10 pm
2 stops12h 30m
$1,216
Sorted by cheapest first
Compare providers for flights from Florence to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Diego in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Florence, South Carolina-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Florence with our price prediction graph.
FLO-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated October 19, 2026.
Get a feel of what it's like to fly with American Airlines from Florence to San Diego by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Overall
7.0
Entertainment
6.8
Boarding
7.4
Comfort
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Crew
7.9
Food
6.4
Overall
7.0
Entertainment
6.8
Boarding
7.4
Comfort
7.1
Reviews
1 / 20
2.0
MediocreAnonymous,Mar 2026
MIA - SFO
Related info for your journey
Find useful and relevant information for your journey from Florence to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Top airline flying from Florence to San Diego
Discover the top airline that operate flights from Florence to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$553 | Average$663 | FlexibilityNo cancel fee | On-time71% |