$444+ Cheap flights from San Diego to Florence, SC (SAN - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
Oct 19 — Oct 261
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Diego to Florence
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Best
Last-minute
One-way
Cheapest flights from San Diego to FlorenceExplore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 19, 2026.
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 19, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop7h 26m
Deal found 9/16![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop10h 03m
Deal found 9/15![American Airlines logo]()
$753
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:58 pm -
1 stop7h 00m
Tue 10/66:30 am -
2 stops14h 47m
Deal found 9/17![American Airlines logo]()
$779
Best flights from San Diego to FlorenceDiscover carefully curated flight deals from San Diego to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 19, 2026.
Discover carefully curated flight deals from San Diego to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 19, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop7h 26m
Deal found 9/15![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:58 pm -
1 stop7h 00m
Tue 10/63:19 pm -
1 stop9h 18m
Deal found 9/18![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop10h 03m
Deal found 9/15![American Airlines logo]()
$753
Last-minute flights from San Diego to FlorenceDiscover last-minute flight deals from San Diego to Florence. Data last updated September 19, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to Florence. Data last updated September 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop7h 26m
Deal found 9/16![American Airlines logo]()
$701
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:58 pm -
1 stop7h 00m
Mon 10/52:34 pm -
1 stop10h 03m
Deal found 9/15![American Airlines logo]()
$753
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:58 pm -
1 stop7h 00m
Tue 10/66:30 am -
2 stops14h 47m
Deal found 9/17![American Airlines logo]()
$779
One-way flights from San Diego to FlorenceSearch for one-way flight options from San Diego to Florence. Find affordable one-way fares based on user searches. Data last updated September 19, 2026.
Search for one-way flight options from San Diego to Florence. Find affordable one-way fares based on user searches. Data last updated September 19, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/237:53 am -
2 stops13h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/226:15 am -
2 stops14h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$466
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:45 pm -
2 stops12h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$472
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:10 pm -
2 stops21h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$528
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:46 pm -
2 stops21h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$577
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:00 am -
2 stops11h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$587
Find flight deals from San Diego to Florence
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 19, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $675 (American Airlines) |
One-way from | $444 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 19, 2026.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Tue 2/23
7:53 am-11:59 pm
2 stops13h 06m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$444
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Mon 2/22
6:15 am-11:59 pm
2 stops14h 44m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$466
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Mon 11/30
10:45 pm-2:09 pm
2 stops12h 24m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$472
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Tue 12/1
10:45 pm-10:59 pm
2 stops21h 14m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$472
Quickest round-trip
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Tue 9/29
12:58 pm-10:58 pm
1 stop7h 00m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$545
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Wed 12/2
11:29 am-10:59 pm
1 stop8h 30m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$545
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Wed 2/24
1:37 pm-11:59 pm
1 stop7h 22m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$545
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Thu 10/1
10:46 pm-10:58 pm
2 stops21h 12m
Florence
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$577
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Wed 9/30
12:58 pm-10:58 pm
1 stop7h 00m
Florence
Mon 10/5
2:34 pm-7:00 pm
1 stop7h 26m
$701
San DiegoFlorence
SAN San Diego - FLO Florence
SANFLO
San Diego
Fri 10/2
12:58 pm-10:58 pm
1 stop7h 00m
Florence
Tue 10/6
3:19 pm-9:37 pm
1 stop9h 18m
$701
Showing 1-10 of 11 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on San Diego-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Diego-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from San Diego-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
SAN-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Florence if you plan to visit one of these locationsSumter
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