HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$574+ Cheap flights from San Diego to Florence, SC (SAN - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
May 29 — Jun 51
Fri 5/29
Fri 6/5
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Diego to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Diego to Florence

Cheapest flights from San Diego to Florence
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2026.

This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1312:03 pm
SAN
-
FLO
1 stop6h 44m
American Airlines
Mon 5/184:16 pm
FLO
-
SAN
1 stop7h 34m
American Airlines
Deal found 4/28$661
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Mon 6/292:35 pm
FLO
-
SAN
1 stop7h 12m
American Airlines
Deal found 4/28$1,569
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Mon 6/292:35 pm
FLO
-
SAN
1 stop7h 12m
American Airlines
Deal found 4/28$1,685
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Wed 7/12:35 pm
FLO
-
SAN
2 stops11h 04m
American Airlines
Deal found 4/28$1,689
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Sat 6/275:05 am
FLO
-
SAN
1 stop6h 59m
American Airlines
Deal found 4/28$1,750
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Tue 6/305:05 am
FLO
-
SAN
2 stops12h 15m
American Airlines
Deal found 4/28$1,755
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/107:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Thu 7/22:35 pm
FLO
-
SAN
2 stops11h 02m
American Airlines
Deal found 4/28$1,785
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/127:15 am
SAN
-
FLO
2 stops11h 45m
American Airlines
Wed 7/12:35 pm
FLO
-
SAN
2 stops11h 04m
American Airlines
Deal found 4/28$1,805
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:15 am
SAN
-
FLO
2 stops12h 45m
American Airlines
Mon 6/292:35 pm
FLO
-
SAN
1 stop7h 12m
American Airlines
Deal found 4/28$1,811

Find flight deals from San Diego to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$661
(American Airlines)

One-way from

$574
(American Airlines)
Provider with most accurate pricing for San Diego-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Florence flights.
Search Deals
From San Diego to Florence
Search Deals
One-way flight from San Diego to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2026.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 5/13

12:03 pm-9:47 pm

1 stop6h 44m

Florence

Mon 5/18

4:16 pm-11:56 pm

2 stops10h 40m

$666

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 6/10

7:15 am-10:00 pm

2 stops11h 45m

Florence

Sat 6/27

5:05 am-9:04 am

1 stop6h 59m

$1,750

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Wed 6/10

7:15 am-10:00 pm

2 stops11h 45m

Florence

Thu 7/2

2:35 pm-10:37 pm

2 stops11h 02m

$1,785

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Thu 6/11

6:15 am-10:00 pm

2 stops12h 45m

Florence

Sun 6/28

5:05 am-9:04 am

1 stop6h 59m

$2,148

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Mon 6/15

8:05 am-10:00 pm

2 stops10h 55m

Florence

Sat 6/27

5:05 am-9:04 am

1 stop6h 59m

$2,322

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Mon 6/15

7:15 am-10:00 pm

2 stops11h 45m

Florence

Tue 6/30

5:05 am-2:20 pm

2 stops12h 15m

$2,327
Cheapest one-way
Quickest one-way

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Mon 5/18

12:03 pm-9:47 pm

1 stop6h 44m

$574

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/26

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on San Diego-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Diego-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from San Diego-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Florence, South Carolina?

    Airlines like American Airlines fly from San Diego to Florence, South Carolina in about 6h 44m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2149 mi.

  • Can I find deals for flights from San Diego to Florence that include hotel bookings?

    Yes. In addition to deals on San Diego to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florence.

  • Can I find deals for business class flights from San Diego to Florence?

    Yes. Cheapflights offers flight deals from San Diego to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to Charlotte flights
San Francisco to Charlotte flights
Ontario to Charlotte flights
San Diego to Charlotte flights
Sacramento to Charlotte flights
Las Vegas to Charlotte flights
Los Angeles to Myrtle Beach flights
Los Angeles to Charleston flights
San Francisco to Charleston flights
Santa Ana to Charlotte flights
San Jose to Charlotte flights
Los Angeles to Savannah flights
San Francisco to Savannah flights
San Diego to Charleston flights
San Francisco to Myrtle Beach flights
Ontario to Savannah flights
Ontario to Greenville flights
Ontario to Myrtle Beach flights
San Diego to Savannah flights
Los Angeles to Columbia flights
Burbank to Charlotte flights
San Francisco to Greenville flights
Los Angeles to Greenville flights
San Diego to Myrtle Beach flights
Sacramento to Columbia flights
Reno to Savannah flights
Burbank to Myrtle Beach flights
Fresno to Charlotte flights
Palm Springs to Charlotte flights
Sacramento to Charleston flights
Oakland to Charlotte flights
Las Vegas to Savannah flights
San Jose to Greenville flights
Sacramento to Myrtle Beach flights
Ontario to Columbia flights
Long Beach to Charlotte flights
Las Vegas to Charleston flights
San Francisco to Columbia flights
Reno to Charleston flights
Sacramento to Greenville flights
Las Vegas to Myrtle Beach flights
San Jose to Savannah flights
San Diego to Columbia flights
San Jose to Charleston flights
Los Angeles to Hilton Head Island flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.