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$525+ Cheap flights from San Diego to Florence, SC (SAN - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — FLO
Jul 18 — Jul 251
Sat 7/18
Sat 7/25
1 adult, Economy
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Cheap flight deals from San Diego to Florence

Cheapest flights from San Diego to Florence
Explore the most affordable flight options available from San Diego to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.

This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:47 pm
SAN
-
FLO
1 stop7h 12m
American Airlines
Sat 9/191:43 pm
FLO
-
SAN
1 stop8h 34m
American Airlines
Deal found 6/16$525
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/101:19 pm
SAN
-
FLO
1 stop7h 18m
American Airlines
Thu 7/235:17 am
FLO
-
SAN
1 stop6h 43m
American Airlines
Deal found 6/17$661
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:19 pm
SAN
-
FLO
1 stop7h 14m
American Airlines
Mon 7/65:17 am
FLO
-
SAN
1 stop6h 43m
American Airlines
Deal found 6/17$723

Find flight deals from San Diego to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 18, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$525
(American Airlines)
Provider with most accurate pricing for San Diego-Florence flight deals.
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Provider most trusted by Cheapflights users for San Diego-Florence flights.
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From San Diego to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from San Diego to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Tue 9/1

12:47 pm-10:59 pm

1 stop7h 12m

Florence

Sat 9/19

1:43 pm-7:17 pm

1 stop8h 34m

$525
Quickest round-trip

San DiegoFlorence

SAN - FLO

SANFLO

San Diego

Fri 7/10

1:19 pm-11:37 pm

1 stop7h 18m

Florence

Thu 7/23

5:17 am-9:00 am

1 stop6h 43m

$661

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on San Diego-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on San Diego-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from San Diego-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Diego-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Diego to Florence, South Carolina?

    Airlines like American Airlines fly from San Diego to Florence, South Carolina in about 7h 12m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 2149 mi.

  • Can I find deals for flights from San Diego to Florence that include hotel bookings?

    Yes. In addition to deals on San Diego to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Florence.

  • Can I find deals for business class flights from San Diego to Florence?

    Yes. Cheapflights offers flight deals from San Diego to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

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